| HS Code | 856960 |
| Product Name | (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate |
| Cas Number | 114392-09-3 |
| Molecular Formula | C9H9NO5S |
| Molecular Weight | 243.24 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Purity | Typically ≥98% |
| Density | 1.46 g/cm³ |
| Optical Rotation | [α]D20 +28° (c=1, CHCl3) |
| Solubility | Soluble in organic solvents (e.g., dichloromethane, chloroform) |
| Storage Conditions | Store at 2-8°C, protect from light and moisture |
| Smiles | C1C(O1)COOS(=O)(=O)C2=CC=CC(=C2)[N+](=O)[O-] |
| Inchi | InChI=1S/C9H9NO5S/c11-10(12)8-3-1-2-7(4-8)16(13,14)15-6-5-9-17-9/h1-4,9H,5-6H2 |
| Chirality | S-enantiomer |
| Hazard Statements | Irritant to eyes, skin, and respiratory tract |
As an accredited (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 25g of (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate, supplied in a sealed amber glass bottle with tamper-evident cap. |
| Shipping | (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate should be shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. Transport in compliance with local, national, and international regulations for hazardous chemicals. Use appropriate hazard labels, and include safety documentation with the shipment. Store at recommended temperature, away from heat and sources of ignition. |
| Storage | (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate should be stored in a tightly sealed container, protected from light, moisture, and incompatible substances. Keep at 2–8°C (refrigerated conditions) in a well-ventilated, dry area designated for chemical storage. Avoid exposure to heat or direct sunlight. Store away from strong bases, acids, and oxidizing agents. Ensure proper labeling and secondary containment to prevent spills. |
As a direct manufacturer, we supply (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate to specialized downstream sectors where strict control of enantiomeric purity, reactivity, and process consistency is essential in synthesis workflows. Our industrial partners leverage this intermediate primarily in asymmetric organic synthesis, with deployment focused on scientifically validated chemical routes. The following application scenarios outline specific technical use-cases, compliance frameworks, recommended incorporation levels, process points, and end products for this raw material.
API manufacturers rely on this compound as a chiral building block for enantioselective alkylation reactions, which establish core asymmetric centers in several small-molecule drug analogs. The material typically enters at early or mid-stage routes for beta-blockers, anti-infectives, or CNS-targeted molecules. Its controlled reactivity, purifiable by crystallization or chromatographic techniques, ensures downstream product traceability and reproducibility required for regulatory submissions.
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Producers of high-value crop protection agents use this compound to initiate or elaborate stereospecific motifs in fungicidal, insecticidal, or herbicidal substances. It is specifically suited for cyclopropanation or epoxidation stages, affording enantioenriched intermediates that define the activity and safety profile of the active ingredient, with precise percentage loading tailored for process intensification.
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Specialty polymer manufacturers utilize this intermediate as a functionalized chiral auxiliary to influence polymer backbone stereochemistry and create materials with defined optical activity or secondary properties for advanced electronics and coatings. The raw material is typically dosed with precise control during radical or cationic polymerizations, assisting in chain propagation steps where chiral induction is necessary for end-use device performance.
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Manufacturers producing fine chemicals for use in flavors and fragrances often incorporate this chiral epoxide for asymmetric epoxidation or alkylation, setting up key intermediates with specific odorant or flavoring properties. Typical applications require careful loading to optimize between raw material costs, enantiomeric outcome, and compliance with sensory and purity regulations.
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Contract research organizations and fine chemical laboratories deploy this material as a building block for exploring novel asymmetric synthetic pathways, verifying catalytic activity, and constructing new heterocyclic frameworks. Researchers adjust loading ratios based on target molecule complexity, route efficiency, and scale, with integration ranging from manual bench addition to automated flow platforms.
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Competitive (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate prices that fit your budget—flexible terms and customized quotes for every order.
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Our team at the lab spends our days with glassware, reactors, and the hum of equipment—a constant reminder that every intermediate we produce carries weight on the bench of a research chemist somewhere. Among our specialized catalog, (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate has become a particular point of pride. Over the past decade, we've fielded direct feedback from synthetic chemists who wrestle with selective transformations, especially enantioselective processes. The product’s real-world value doesn’t come from flashy marketing but from straightforward, repeatable utility—faster routes to complex molecules and reliable chiral induction. Unlike generic epoxides or off-the-shelf sulfonate esters, this compound brings a robust and dependable selectivity profile, opening up asymmetric synthesis for researchers and production chemists alike.
Our product isn’t just produced for inventory; its design starts with the actual tasks researchers present. From the beginning, chemical control and reproducibility sit at the core of production. The epoxide core in (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate delivers a balance between reactivity and stability, setting it apart from racemic mixtures that undermine advanced synthesis plans. We often talk with university labs and pharmaceutical process scientists about headaches caused by unpredictable chiral induction in key reactions. Unlike racemates, ours gives a direct route to single-enantiomer endpoints, minimizing costly side separation or losses due to selectivity issues.
No mystery surrounds this compound in our facility. Manufactured using tightly monitored enantioselective synthesis, we maintain strict optical purities, with a typical enantiomeric excess above 99%. Purity checks go hand in hand with rigorous analytical monitoring—our HPLC and NMR archives back every certificate. While some competing products have broad purity specs or ambiguous optical rotation data, each batch leaving our warehouse comes with measured rotation and full chromatographic analysis. Solubility properties and melting point remain consistent every time, supporting formulation teams who base their methods on actual substance properties, not wildcards.
Watching chemists on the bench, it's easy to spot the frustrations created by unreliable reagents. The particular chemical structure—a chiral oxirane ring linked to a 3-nitrobenzenesulfonate ester—brings more than textbook value. The reactivity profile enables SN2-type ring openings with a range of nucleophiles, offering chirality transfer without complicated auxiliary strategies. Compared to simple terminal epoxides or standard alkyl sulfonates, our compound anchors a broader set of asymmetric syntheses. This makes scale-up for pharmaceutical intermediates or specialized agrochemical actives not only simpler, but less likely to fail quality or yield targets at the pilot stage. Data from our clients show sharp upticks in yields and reduced impurity generation in multi-step routes compared to less selective or less stable reagents.
Meeting the scrutiny of pharma and biotech regulation isn’t an afterthought. With years in the fine chemicals supply chain, our team has fielded inspections, audits, and regulatory queries that demand more than checkbox answers. Strict impurity profiles, verified enantiomeric ratios, and traceable analytical documentation all get baked into how we plan and record batches. This isn’t just about paper trails—missing a regulatory detail on a chiral component in a drug development pipeline can set back entire programs. We maintain all relevant documentation and make sure shipping and storage conditions keep the product stable for its full shelf life, with regular stability studies performed by our in-house staff. For highly regulated end uses, such as cGMP-sourced APIs, special production runs keep to full documentation and chain-of-custody protocols.
We’ve watched chemists juggle multiple reagents to chase down one that delivers consistent stereochemical outcomes. Ordinary epoxides rarely offer both chiral fidelity and the required downstream functionalization options. Many sulfonate esters offer functional group diversification, but without the orientation and reactivity of the (S)-(+)-oxirane system. Some competitors pitch racemates or unresolved isomers, which only complicates downstream separations or creates unpredictability in biological assays. Several of our customers originally came to us after seeing their own process yields collapse due to switching to cheaper, lower-purity epoxides or generic sulfonates.
This compound directly combines high optical purity, a crystalline and isolatable solid form, and a stable sulfonate group suited to a range of solubility needs. The nitro group, often considered a sensitive moiety, is installed using robust methods avoiding labile intermediates or contaminants that could poison subsequent transformations. The upshot—chemists can move forward into their optimizations without redoing their purification steps or troubleshooting column chromatography to chase elusive byproducts.
Feedback from in-house and client teams leads us to regular process reviews and analytical upgrades. We draw on daily lab experience with chiral synthons. In our group, any proposed process change needs to clear preparative chemistry tests—bench trials, not just theoretical models. Our QC team samples from every lot, confirming that each gram meets the spec seen in our catalog. One of the most common comments from clients centers on crystal morphology and batch-to-batch color consistency—a marker of careful, impurity-resistant oxidation and crystallization.
External chemistry teams, especially those at pharma scale-up facilities, share their run data with us. Among the recurring points: the product dissolves smoothly in media ranging from traditional organics to buffered aqueous platforms, not leaving suspensions or visible deposits. This cuts down on lost product and the need for repeated dissolution or filtration prior to reaction. Some clients in process development mention getting clear, clean NMR spectra without the need to filter or purify the substance once it arrives—this is not accidental but reflects our methodical isolation and drying procedures.
The real test of any starting material comes from the reaction flask. As we have observed—both in our own experiments and in our clients' published work—the use of (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate as a building block cuts down the number of synthetic steps. No need for chiral resolution post-reaction or for heavy-crutch protecting group chemistry when installing the nitro functionality. For nucleophilic ring openings or for cascades involving further transformations, the chiral center stays intact, provided users avoid strong acid catalysis. This single feature has convinced several pharma partners to shift development routes, skipping whole classes of unnecessary resolution or re-protection stages.
In one example, we watched a customer’s alkaloid target synthesis shrink from six steps to four, as the reactivity pattern of the sulfonate-free epoxide was avoided. Less time and material spent per batch—more resource savings at the kilogram scale. In academic circles, young chemists report sharper yields and greater confidence running full- or half-gram reactions, easing the route to submitting results and publishing new transformations. It pays off at the research grant stage by meeting timelines and budgets.
Producing high-purity chiral sulfonates at scale comes with hurdles. Our reactor operators talk about keeping absolute temperature controls during ring closure and avoiding trace moisture—both can easily lead to product racemization or hydrolysis. Drawing from experience, the plant team constantly adjusts reactor charging and solvent levels to get repeatable yields. Unlike generic esterifications or one-pot syntheses, this compound’s two-stage process benefits from hands-on adjustments and mid-batch sampling. Years back, we struggled with batch crystallization at high humidity. The lessons learned then get applied every week—controlled environments, careful monitoring, and prompt downstream isolation.
On the downstream side, our QC group tracks unwanted isomer formation and color point changes. If a batch presents with even a subtle deviation in melting range or chromatographic response, it gets flagged and reprocessed. This discipline pushes a tighter product than most importers or generalists can provide. Stringent requirements mean higher costs on the floor, but our customers come back less for warranty claims or unsatisfactory material—and more for bulk repeat orders.
The growing scrutiny of agrochemical and pharmaceutical supply chains means every step—especially those involving potentially hazardous intermediates—faces not only safety but end-of-life responsibility. By integrating safer nitro group installation routes and minimizing solvent load through in-house recycling systems, we've reduced the product’s environmental footprint. Some market options arrive with excessive packaging or unstable precursors, making end-user safety compliance more difficult and expensive.
By leveraging closed-system syntheses, strict water discharge controls, and spent acid neutralization plans, we keep workplace risk and environmental waste below the industry average. We encourage end clients to share their disposal data and support their own waste treatment audits, reflecting a belief that high-performing chemicals shouldn’t come with hidden environmental costs.
Working shoulder to shoulder with researchers, we trade tips not always found in published procedures. For smooth ring opening and substitution steps, we suggest prepping anhydrous reaction media, keeping nucleophile excesses moderate, and using minimal base. Our internal tests provide solvent preferences, with dichloromethane and THF showing highest yield consistency over greener yet sometimes less robust alternatives. For larger preparations, the addition of incremental nucleophiles instead of a single charge avoids runaway side reactions.
Users working at the milligram scale can store the compound under nitrogen in cold rooms, though we have kept retained samples for over 12 months at room temperature without detectable decomposition. Avoiding prolonged exposure to base or acid in storage further preserves chiral purity, based on our shelf-life studies. Any change in appearance—unexpected color or reduced solubility—warrants a prior test reaction before full-scale use. These operational nuances help drive both research success and production cost savings.
No compound, no matter how reliable, can rest on past performance. As suppliers working at the manufacturing source, we maintain quarterly reviews of our protocols, updating synthesis flows based on feedback from commercial and research users. Advances in online analytical technology now let us monitor reactions minute-by-minute, cutting out the guesswork and pushing faster, more reliable batch releases. Our technical support teams don’t rest at sales—they help troubleshoot, rerun analyses upon request, and supply expanded analytical validation data as needed.
We believe putting knowledge and transparency in the hands of users sets apart genuine manufacturing expertise from mere warehousing or repackaging operations. Every lesson learned in thermal control, batch aging, and scale-up brings measurable positive change for end-users, whether the next stop is a three-person lab or an industrial pilot suite.
Our belief in value flows from real-world chemistry and the hurdles that synthetic chemists face. (S)-(+)-Oxiran-2-ylmethyl-3-nitrobenzenesulfonate fills a defined need—reliable, high-organic-purity chiral intermediate sourcing without hand-wringing at every new batch. For us, each container represents weeks of careful chemistry and thousands of analytical checks, all aimed at making your next chemical challenge leaner and less uncertain. By keeping both product and knowledge flowing between our lab and yours, we keep the wheels of chemical innovation and discovery turning with confidence.
