| HS Code | 436707 |
| Chemicalname | 1-Octanoyl-sn-glycero-3-phosphocholine |
| Synonyms | LysoPC 8:0, Lyso-phosphatidylcholine (8:0), Octanoyl lysophosphatidylcholine |
| Molecularformula | C16H34NO7P |
| Molecularweight | 383.42 |
| Casnumber | 83480-37-9 |
| Appearance | White to off-white solid |
| Solubility | Soluble in water and organic solvents |
| Storagetemperature | -20°C |
| Purity | Typically ≥98% |
| Iupacname | 2-(Octanoyloxy)-3-(phosphocholine)propyl ester |
| Smiles | CCCCCCCC(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)O |
| Inchikey | GSSPPTNQYFQPGO-UHFFFAOYSA-N |
As an accredited 1-Octanoyl-sn-glycero-3-phosphocholine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1-Octanoyl-sn-glycero-3-phosphocholine is supplied in an amber glass vial, containing 25 mg, clearly labeled with product details. |
| Shipping | 1-Octanoyl-sn-glycero-3-phosphocholine is typically shipped at ambient temperature, unless otherwise specified for sensitive applications. It is securely packaged in sealed containers to prevent moisture or contamination, following standard chemical shipping regulations. Hazard classification is usually non-hazardous, but always consult the SDS and local regulations before shipping or handling. |
| Storage | 1-Octanoyl-sn-glycero-3-phosphocholine should be stored at -20°C, protected from light and moisture. It should be kept in a tightly sealed container, preferably under an inert gas such as nitrogen or argon to prevent oxidation and degradation. Proper labeling and secondary containment are recommended to ensure chemical integrity and laboratory safety. Avoid repeated freeze-thaw cycles. |
1-Octanoyl-sn-glycero-3-phosphocholine serves multiple roles in specialized chemical and life sciences manufacturing. As a phospholipid intermediate and functional additive, it addresses demand across pharmaceutical, diagnostic, research reagent, and formulation sectors. Below, we outline key downstream application areas with relevant technical and regulatory details.
Pharmaceutical companies utilize this material for building lipid bilayers in targeted drug delivery vehicles. Its balance of hydrophilic head group and octanoyl chain properties supports formulation stability and precise encapsulation of both hydrophilic and hydrophobic drugs. It often enters pilot and GMP-scale liposome manufacturing for injectable and oral delivery platforms, where batch-to-batch quality and purity directly impact the pharmacokinetic profile. Formulators choose chain length and ratio based on the drug’s solubility, stability requirements, and route of administration, strictly controlling precursor sourcing and in-process validation.
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Diagnostic reagent manufacturers employ this phosphocholine derivative as a functional surfactant and structural lipid in the preparation of biochemical assay reagents. Its controlled amphipathic profile enhances compatibility with both aqueous and organic assay components, supporting formation of micelles, microemulsions, and stabilizing enzyme or antibody interaction environments. Formulation scientists leverage lot-specific spectrometric and chromatographic data to maintain reproducibility in detection reagents, imaging substrates, and PCR master mixes, particularly for membrane-mimetic or biomarker quantification kits.
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This lipid is incorporated as a membrane component or growth factor carrier in custom cell culture and stem cell expansion supplements. Bioprocess engineers select the phosphocholine for its ability to modulate lipid raft assembly and membrane fluidity, crucial in the ex vivo expansion of human and animal cell lines. Raw material origin, endotoxin specification, and sterility validation remain priorities given direct contact with living biological systems. Products undergo controlled filtration, gamma irradiation, and release testing for residual solvents and impurities before blending into downstream media.
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Respiratory medicine formulators integrate this phospholipid as a component of synthetic pulmonary surfactant systems and as an emulsifier for inhalation drug delivery formulations. Its molecular structure mimics native alveolar surfactant, supporting lower surface tension, improved spreading on the air-lung interface, and enhanced aerosol stability. Raw material undergoes physicochemical QC, including HPLC purity, water content, and particle size screening, ensuring consistency in respirable formulations. Process engineers adjust component ratios for neonatal, adult critical care, or chronic pulmonary device applications based on clinical and regulatory feedback.
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Academic laboratories and contract research organizations use 1-Octanoyl-sn-glycero-3-phosphocholine as a certified reference material for lipidomics, mass spectrometry calibration, or membrane interaction studies. Authenticity, isotopic purity, and solvent trace analysis are critical for reproducibility in quantitative and qualitative assays. Manufacturers provide exhaustive certificates of analysis, including NMR, MS, and purity traceability. Application includes method qualification for LC-MS/MS, cell membrane biophysics, and simulation of phospholipid metabolism in vitro.
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Competitive 1-Octanoyl-sn-glycero-3-phosphocholine prices that fit your budget—flexible terms and customized quotes for every order.
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Manufacturing 1-Octanoyl-sn-glycero-3-phosphocholine brings us close to research teams shaping what can be achieved in biotech labs today. Every batch carries the expectations of scientists who rely on molecules that behave consistently and precisely under complex experimental conditions. This compound stands out because it captures a critical segment of the phospholipid landscape, bringing together manageable chain length and defined purity with careful reproducibility.
1-Octanoyl-sn-glycero-3-phosphocholine, sometimes listed as Lyso-PC 8:0, belongs to the lysophosphatidylcholine family. In practice, the C8 fatty acid tail makes it much more than another lipid. Shorter chains like these give researchers important physical and chemical flexibility, which larger-chain molecules simply cannot match. Our process requires controlled temperature profiles and tightly managed aqueous and organic phases to give consistent acyl chain placement at the sn-1 position. Decades of refining this workflow mean downstream purification captures just the monoacylated structure, free from unwanted diacyl or oxidized byproducts.
Lyso-PC 8:0 raises fewer solubility obstacles for bioassays compared to longer-chain Lyso-PCs. In formulation studies and membrane biophysics, this aspect drives rigorous preference for C8 molecules. The product’s shorter acyl tail keeps it fluid at much lower temperatures and dissolves with less force needed—saving precious time for those setting up artificial membrane systems or loading vesicles with sensitive reagents.
This feature means batch-to-batch comparisons stay valid across seasons and experimental runs. Even subtle impurities or shifts in pH can undermine results when working at these short chain lengths; this is where our approach stands apart. Small differences in how fatty acids are sourced, activated, or isolated end up visible on chromatograms, particularly at the C8 level. By controlling both feedstock selection and post-reaction purification, we help prevent the headaches that come from unexplained signal drop-offs or phase separation in model membrane applications.
Handling Lyso-PC 8:0 every week shows just how quickly a formula can succeed or fail based on lipid chemistry. Chain length shapes the molecule’s critical micelle concentration—shorter tails like C8 push this value upwards, meaning they form micelles at higher concentrations than long-chain analogs. For researchers, this gives leeway for creating stable colloids without triggering premature aggregation.
Thermal behavior steps forward, too, when measuring phase transitions. C8 lyso-phosphatidylcholine doesn’t turn waxy or rigid near refrigeration—researchers can chill, warm, and process it with near-total freedom from crystallization. This flexibility drives its appeal in pre-clinical protocols screening liposome-encapsulated drugs, generating vesicles, and refining membrane-associated protein studies.
Years in chemical production have taught us where small errors creep in. Highly unsaturated feedstocks oxidize quickly; batch cross-contamination can ruin critical parameters. Every order placed by a university or pharmaceutical team expects predictability, so our process relies on meticulously degassed solvents and tightly sealed reactors, meaning moisture and oxygen stay well away from the chain-transfer steps.
After acylation and work-up, we cycle every run through multiple layers of chromatography, then use precise NMR and HPLC analytics to match purity curves demanded by modern research. Having in-house spectral libraries, built up through thousands of batches, supports our ability to pinpoint subtle issues in chain location or unwanted lyso-lipid diastereomers.
Lyso-PC 8:0 hasn’t stayed locked on the shelf of academic biochemistry. Its properties drive innovation in drug delivery trials—mainly because the molecule helps shuttle water-insoluble compounds into cells without damaging viability. In some cases, membrane translocation experiments lose fidelity if conventional phospholipids precipitate or destabilize. C8 lyso-PC’s ability to integrate quickly, flip across bilayers, and resist oxidation has meant fewer failed experiments and less wasted material.
Many clinical researchers rely on Lyso-PC 8:0 to disrupt and reseal cellular membranes, constructing vehicles that deliver CRISPR/Cas complexes or fragile oligonucleotides. Membrane fusion studies benefit, too—using this compound to set the baseline for vesicle creation before stepping up to longer tails or polyunsaturated series. Our long history with quality control and in-line analytics cuts down time spent troubleshooting vessel handling artifacts, which lets researchers focus on data instead of supply worries.
Producing this lipid isn’t guesswork. Years spent dialing in the acylation reaction conditions now lets us minimize side reactions and confirm that the C8 tail always ends up at the sn-1 position—which isn’t guaranteed when sourcing from middlemen or through generic catalogues. We saw early on that cheap solvents triggered hydrolysis or rearrangement, which sometimes mimics loss of activity during an assay. Our teams stick to high-purity input materials, automated pH monitoring, and strict reagent tracking, avoiding variability found from less rigorous operations.
We hear from molecular pharmacologists and structural biologists about inconsistent stock solutions plaguing their long-term studies. By building shorter supply chains, our lab team keeps materials fresher and avoids delays caused by storage or transit at ambient temperature. All storage, even in transit, holds under conditions proven to stabilize lyso-phospholipids—an advantage for researchers needing to know each order reflects freshly produced inventory, not months-old residuals.
Choosing 1-Octanoyl-sn-glycero-3-phosphocholine isn’t about using just any lysophosphatidylcholine. Longer acyl chains, such as C14, C16, or C18, pack more tightly, show lower mobility, and resist mixing with aqueous buffers. These molecules demand extra steps to solubilize, raise risks of forming gels during preparation, and bump up the cost of formulation troubleshooting. Lyso-PC 8:0 avoids most of these by combining rapid solubility with a lower melting threshold. Even in mass spectrometry or nuclear magnetic resonance screens, its chain length gives cleaner signals, removing confusion over background peaks and overlapping fragmentation products.
Our experience confirms users notice fewer experimental artifacts with C8. The molecule’s hydrophilic/lipophilic balance gives sharper partitioning and avoids complicated extraction protocols—cutting down clean-up steps in lipidomics workflows. Reports from cell and membrane labs reflect this point: adding short-chain lyso-PCs always means fewer freeze-thaw cycles and less risk that temperature swings will wreck the day’s project.
In real research, variability kills projects—and nothing throws off a multi-step assay faster than inconsistent lipid batches. Lyso-PC 8:0 sees use in high-sensitivity assays, such as in phospholipase screening or binding affinity studies involving membrane mimetics. Purity, measured by mass spectrometry and free fatty acid content, must anchor every shipment. A skip in these controls means data loss or false positives that ripple through months of work.
Our manufacturing floor treats every run as a unique lot, not just bulk powder run off for anonymous blending. After synthesis, samples follow carefully documented bench protocols, ensuring purity, fatty acid location, and absence of short-chain byproducts right to the final tube. Keeping chain-of-custody tight—from raw stock to finished shipment—means researchers get molecular detail matching the information we supply.
Our regular dialogue with academic and industry partners taught us that shipping shortcuts or careless repackaging can upend an entire research year. That is why refrigeration runs from point of synthesis to final delivery. Researchers then receive Lyso-PC 8:0 at peak freshness, primed for direct use in their specific systems. No-mystery documentation, traceable analytics, and dedicated troubleshooting support make all the difference during complex, data-rich studies.
Working with Lyso-PC 8:0 at benchtop scale, users sometimes underestimate its tendency to absorb moisture. We educate partners to use desiccated conditions, rapid transfers, and air-tight containers. These steps block degradation, which often sneaks past visual inspection but shows up later by reduced assay efficiency. Our packing lines avoid static charges and unnecessary plastic contact, steps learned over years facing powder adhesion, bottle residue, and wasted product in early runs.
We encourage feedback on every delivery. Detailed responses have prompted us to rework sealing techniques, and batch presentation, and even adjust vessel size for lower-waste weighing protocols. Each lesson, such as reducing headspace in tubes or switching to amber containers for light-sensitive protocols, went right back into optimizing new runs, reducing user frustration and minimizing unexpected artifacts. Sharing these learnings directly with research teams keeps quality benchmarks moving forward.
Confidence in chemical supply builds on more than just paperwork. We keep our analytical data open and respond directly to technical inquiries from users handling Lyso-PC 8:0, whether for base lipid libraries or as a comparand in sophisticated biophysical testing. Updates about impurities, spectral signatures, or short-term storage support real-time troubleshooting and solve problems before they derail research.
Our team knows that transparent record-keeping—including chain-of-custody logs and real batch certificates—saves hours spent navigating paper trails if questions arise later. We invest in this approach because traceability underpins trust, and trust creates productive, lasting research partnerships.
We keep one eye on upcoming demands. CRISPR protocols, lipid nanoparticle innovation, and ultrasensitive diagnostics increasingly call for specific lipid building blocks. It’s why we routinely expand our analytical controls, adapt purification schedules for high-throughput demands, and coordinate product release directly with project start dates.
Newer experimental protocols require rapid adaptation: lyophilized formats, single-use aliquotting schemes, or multi-user packages. We built flexibility into our production streams, taking lessons from early customers who needed quick pilot runs or small-batch trials without full commercial deployment. By involving researchers in our scale-up discussions, we’ve anticipated pitfalls and ensured Lyso-PC 8:0 meets not just generic needs but precise, experiment-shaped requirements.
Researchers challenged us to improve kinetic profiling: now, we offer optional isomeric verification across runs, so repeat orders match exact specificity. This focus on continuous improvement, sparked by dialogue, transformed how we approach order fulfillment, product feedback, and post-project support.
Breakthroughs in biomembrane simulation, lipid-mediated drug transport, and protein-lipid interactions increasingly depend on having trusted access to pure, precisely tuned lyso-phospholipids. We’ve seen the shift firsthand, from small academic projects in lipid raft analysis to multi-phase commercial explorations for nano-carrier technology. Lyso-PC 8:0, by virtue of its chain length and reliable profile, takes on these demands as a “starting point” for broader molecular studies—anchoring protocols that then expand with longer or bulkier chains as new discoveries unfold.
Working to refine and deliver this product put the spotlight on technical mentorship, responsive troubleshooting, and co-development with scientific teams. Our response isn’t static: it changes as users describe new hurdles, publish findings, or request even finer batch-to-batch specificity. Scientific progress doesn’t pause, and neither does our drive for careful, user-driven manufacturing.
Supporting the next breakthroughs means commitment. We think through every specification, every shipment protocol, and every customer challenge as if it impacts our own research. The attention we give Lyso-PC 8:0 is an extension of the trust placed in us by the life science community. Listening, improving, and staying accountable keep our processes sharp, our shipments on point, and our promise of consistency alive with each new batch of this essential molecule.
