| HS Code | 855579 |
| Chemical Name | 1-Lauroyl-sn-glycero-3-phosphocholine |
| Synonyms | DLPC; Dilauroylphosphatidylcholine |
| Molecular Formula | C20H42NO7P |
| Molecular Weight | 439.52 g/mol |
| Cas Number | 17238-34-9 |
| Appearance | White to off-white powder |
| Solubility | Soluble in water and organic solvents |
| Storage Temperature | -20°C |
| Purity | Typically >98% |
| Application | Membrane studies, liposome preparation, biochemical research |
| Melting Point | Approx. 43-47°C |
| Smiles | CCCCCCCCCCCC(=O)OCC(COP(=O)(OCC[N+](C)(C)C)O)O |
As an accredited 1-Lauroyl-sn-glycero-3-phosphocholine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 1-Lauroyl-sn-glycero-3-phosphocholine is packaged in a 100 mg amber glass vial, sealed for light and moisture protection. |
| Shipping | The chemical **1-Lauroyl-sn-glycero-3-phosphocholine** is shipped at room temperature as a solid or powder, securely sealed in a protective container to prevent contamination or moisture absorption. It is packed in compliance with chemical safety regulations, and transport is arranged via standard or express courier services, depending on customer requirements. |
| Storage | **1-Lauroyl-sn-glycero-3-phosphocholine** should be stored at -20°C in a tightly closed container, protected from light and moisture. Avoid repeated freeze-thaw cycles to maintain stability. For short-term use, storage at 2-8°C may be acceptable, but long-term preservation requires freezing. Always handle under an inert atmosphere if possible and follow standard laboratory safety procedures. |
1-Lauroyl-sn-glycero-3-phosphocholine (LPC-12) serves as a specialty phospholipid surfactant and process aid in multiple industrial sectors. Manufactured to strict quality controls, LPC-12 integrates as a key additive or processing ingredient in regulated fields. Below, we detail established downstream applications and technical details based on direct industrial usage.
LPC-12 acts as a phospholipid emulsifier and solubilizer in sterile injectable drug product manufacturing, especially for liposomal APIs and poorly soluble actives. Downstream manufacturers incorporate it during liposome hydration and sizing, where the unique chain length and headgroup provide structural stability and controlled release profiles. Specialized equipment such as high-pressure homogenizers or microfluidizers disperse LPC-12 with cholesterol and other phospholipids, enabling encapsulation. Strict aseptic processing and in-process controls ensure batch consistency. Final parenteral products undergo full validation and compliance testing before release to global markets.
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Cosmetics manufacturers use LPC-12 as an O/W emulsifier and skin-conditioning agent in advanced formulations for facial serums and creams. The raw material supports stable encapsulation of hydrophobic actives, such as vitamins and botanical extracts, via cold or hot process emulsification. Processing involves pre-mixing with the oil phase, followed by high-shear blending or homogenization with the aqueous phase, in line with cosmetic GMP and safety evaluations. The resulting stable nanoemulsions display improved skin feel and active delivery, and pass stability, microbiological, and safety testing before market release.
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Food ingredient manufacturers utilize LPC-12 as a phospholipid encapsulation aid in the production of functional foods, especially for delivery of sensitive bioactives like DHA, plant oils, and micronutrients. In liquid or powder microcapsule systems, it supports creation of oil-in-water emulsions that are later spray-dried or cooled to yield stable, bioavailable powders. Compliance with food additive regulations and stringent hygiene protocols is required throughout. The raw material facilitates improved dispersibility, shelf life, and controlled release, with final QC including encapsulation efficiency and sensory analysis.
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Biopharmaceutical vaccine manufacturers use LPC-12 as a lipid component in the preparation of mRNA vaccine lipid nanoparticles (LNPs), where its bilayer properties support nucleic acid encapsulation and cellular delivery. During downstream production, formulation scientists blend LPC-12 with cationic and helper lipids, typically using ethanol injection or microfluidic mixing, under strict aseptic controls. The process requires continuous particle size monitoring and frequent sterility testing. As a component of clinically advanced formulations, the raw material must meet stringent virology-grade purity and characterization benchmarks.
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LPC-12 finds critical use in large-scale cell and gene therapy bioprocessing, particularly in the formulation of cell transfection agents and nanoparticle delivery complexes. Cell therapy facilities introduce the material at the complexation step, where it assists the formation of stable complexes with DNA, RNA, or oligonucleotide cargoes. Process parameters such as mixing time, temperature, and ionic strength require tight control, and batch records must document component traceability. Final bioprocessed materials undergo expansion in bioreactors, with ongoing quality checks for particle integrity and cell uptake efficiency under GMP cell therapy guidelines.
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Competitive 1-Lauroyl-sn-glycero-3-phosphocholine prices that fit your budget—flexible terms and customized quotes for every order.
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Stepping behind the lab doors at our manufacturing site, we see raw materials become workhorses in countless formulations. 1-Lauroyl-sn-glycero-3-phosphocholine (often referred to as DLPC by biochemists) has earned recognition among both industrial users and academic researchers. We produce it here in-house, not by moving drums or labels, but by running the reaction stages ourselves, monitoring, and adjusting until we see the purity and performance needed for critical applications.
From the earliest pilot batches, we noticed that the lauroyl chain in DLPC provides distinct physicochemical properties. Phospholipids are foundational in biological membranes, but swapping a 12-carbon lauroyl group into the sn-1 position unlocks fresh behavior. The chain length and headgroup charge have ripple effects—on micelle size, membrane fluidity, detergent power, and the way molecules interact in both water and organics.
Our approach focuses on small-layer chromatography, column purification, thorough characterizations by NMR, MS, TLC, and, finally, application-driven trials before we sign off on each lot. Any vendor can guarantee a percentage, but real users—whether they work in drug synthesis, cell biology, or cosmetics—depend on consistency batch to batch, not just a line on a certificate.
With phospholipids, a trace impurity or degradation can throw off everything downstream. Our QC team pulls random warehoused samples monthly for retesting. We look for short-chain or over-acylated byproducts and lysolipids, since these can alter solubility profiles or even trigger unwanted cell responses in biological work. Hydration and oxidation create another set of headaches, so we store DLPC under low-humidity, inert conditions and only ship in containers proven to prevent air and light ingress.
Many suppliers opt for large-scale synthesis followed by crude purification. By contrast, our synthesis is tuned so compositional drift remains below detection, and we issue reports showing actual percentage purity, not estimations. We document levels of diacyl-glycero phosphocholine, monoacyl variants, and free lauric acid, among others. End users in analytical and life sciences labs tell us that minor differences, overlooked by manufacturers chasing volume, often decide whether an experiment runs to completion or falls apart.
Let’s break down what’s unique about this molecular setup. The lauroyl chain—12 carbons, saturated—provides moderate hydrophobicity. Compared to octanoyl- or palmitoyl- chains, DLPC slots into lipid bilayers with less physical stiffness than longer acyl chains. This means lower transition temperatures and a tendency toward forming more dynamic, flexible vesicles or liposomes.
In our lab, DLPC has shown faster dissolution into aqueous systems than similar C16 or C18 phosphatidylcholines. At the bench, you watch liposomes form without the stringy aggregates, making this lipid a favorite for reconstituting proteins where gentle solubilization is key. We have collaborated on studies involving membrane protein assays, where only ultra-pure DLPC allowed transporter proteins to retain activity.
In detergent work, the zwitterionic nature of DLPC offers a mild disruption profile. Some of our cosmetic clients value its skin feel and compatibility—less greasy, spreadable, and emulsifying without the heavy after-feel of some longer chain variants. Our close control of acyl-group composition means less odor and a measured melting range, making formulation scaling predictable.
Many industry players source phospholipids from animal or plant extraction. That’s cost-driven but brings issues: batch-to-batch inconsistency, possible contamination, and variable availability. Our line follows a synthetic route instead. We chose this specifically after analyzing variability in soy- and egg-derived lecithins, where fatty acid ratios may shift with season, source, or DNA of starter strains. By starting from pure lauric acid and precise glycerol chemistry, we eliminate natural drift and trace pesticide or protein contamination.
We often hear concerns about animal-derived components, especially in pharmaceutical and personal care industries. We certify no genetically modified organisms enter our DLPC line. No animal-based processing aids. This peace of mind matters to bioassay developers and brands claiming “plant-only” or “vegan” credentials without hidden loopholes.
Our production scale allows us to offer DLPC in powder or pre-dissolved solution grades, with typical lots ranging from grams up to multi-kilogram units. Standard purity exceeds 98 percent by HPLC, and we guarantee water content and peroxides below 0.2 percent because oxidative breakdown can sabotage even skilled work. In practice, we see researchers gravitate to the powder for liposome prep, while process engineers appreciate the convenience and stability of our solution grade for continuous manufacturing lines.
Pack sizes grew from years of feedback—no arbitrary fixed weights. For high-sensitivity applications, we provide glass vials sealed under nitrogen, or foil-laminated sachets for bulk. We use in-house analyses to confirm lot-conformity instead of relying on legacy specs or one-off third-party verification.
Occasionally, partners ask about extended shelf-life beyond a year. We share real data. Stored at minus-20 degrees Celsius in inert gas, our DLPC loses less than 2 percent mass over 24 months, and we demonstrate retention of acyl-integrity via monthly FTIR scans.
This molecule has carved out an indispensable space for itself in areas like liposome formation, protein reconstitution, and as a helper in pharmaceutical excipient blends. What’s remarkable has been watching its role evolve. Five or ten years ago, only university membrane biologists wanted it. Now, production lines for new vaccines, skin formulations, and even botanically-inspired hair treatments draw on DLPC’s unique blend of emulsifying and solubilizing strengths.
Working alongside formulation experts, we’ve supplied material for encapsulating both hydrophilic and hydrophobic payloads. DLPC forms stable colloidal dispersions suitable for parenteral administration, a benefit in injectable therapeutics seeking to avoid aggregated particulate counts that can trigger immune responses. We know end-users care about compliance with pharmacopeial or food-grade expectations, so we keep solvent residues to the lowest levels possible, validated by GC analysis.
In the realm of analytical chemistry and protein science, we receive reports from clients who trust our DLPC to make functional model membranes for NMR or EPR studies—situations where trace ionic or organic impurities disrupt spectra or generate artifacts. Our customers tell us they return because other suppliers, aiming for volume, cut corners that show up in ignored technical issues: non-uniform dispersion, off-odors, or low yield in encapsulation.
Chemically similar but functionally distinct—this defines DLPC’s place against the background of other glycerophosphocholines. Our warehouse stocks a variety: di-palmitoyl (DPPC), di-oleoyl (DOPC), di-stearoyl (DSPC), and more. Picking the right chain length and unsaturation matters more than most new formulators realize. DLPC’s shorter lauric acid chains deliver a much lower gel-to-liquid crystalline transition point. In simple terms, this phospholipid remains more fluid at room temperature.
We see this in the narrower melting peaks by DSC measurement and in practical form: DLPC disperses readily without heating or extended sonication, which makes high-throughput workflows easier to manage. DPPC and DSPC, often chosen for drug-delivery vesicles, stay solid unless you increase temperature or mechanical mixing—a factor in scale-up operations balancing cost, risk, and time.
Solubility in polar and nonpolar solvents is another frequently overlooked difference. DLPC dissolves smoothly in both ethanol and isopropanol, where some longer acyl-chain phosphatidylcholines lag or demonstrate only partial solubility. This matters in final-product clarity, homogeneity, and stability, especially in emulsions slated for consumer-facing applications.
End-use tolerance varies with these features. For oral supplements, we receive formulations specifying a blend of DLPC and DOPC, capitalizing on the fluidizing effect of lauroyl chains while preserving membrane-mimicking properties from unsaturated chains. The right balance determines taste, shelf-life, and even absorption profiles.
We keep a dialog open with research customers. DLPC opens up spaces in studies on lipid signaling, mitochondrial membrane dynamics, and the construction of model organisms. Our pilot projects, working with geneticists and MD researchers, demonstrate how variations in acyl chain length impact biological function. DLPC, through its influence on membrane disorder, can help explain protein-lipid interactions often masked in traditional studies using only palmitoyl- or stearoyl-based systems.
In vaccine delivery, use of DLPC has grown as researchers seek lipid nanoparticles balancing stability with rapid payload release. Our collaborations with university spinouts have helped define new protocols where consistency in phospholipid source determines data integrity for peer-reviewed publication and regulatory submission alike.
Many peptide chemists we support rely on our product to keep hydrophobic sequences suspended in solution. In diagnostic assay kits, our pre-weighed and aliquoted DLPC speeds up manufacturing, reduces error, and increases output reliability—factors that influence everything from clinical timelines to product launch windows.
Scaling synthetic phospholipid production isn’t without hurdles. Sourcing high-purity starting materials, especially lauric acid and chlorophospholipids, often relies upon secure supply chains from regions vulnerable to seasonal crop fluctuations or trade interventions. We’ve responded by building vendor redundancy and qualifying synthetic pathways that start from petrochemical feedstocks if agricultural supply shortens.
Purification efficiencies matter hugely. As demand for high-purity and application-specific phospholipids increases—from injectable therapies to precision nutrition—the need for scalable, environmentally responsible techniques pushes us towards continuous chromatography and advanced filtration. We invest in R&D to probe greener solvent systems, reduce waste, and maximize yield, mindful of both the chemical and environmental bottom lines.
User feedback shapes many production tweaks. Years ago, storage and transport issues cost customers precious time; moisture ingress can hydrolyze acyl bonds in even tightly sealed drums. We reformulated packaging, shifting to vapor-barrier resins and vacuum-sealing for units headed abroad. Real-world stress testing measures how DLPC fares during a month on a ship or train, so the quality arriving at an Asian biotech mirrors what we see on the day of production.
Requests for product customization rise year by year. Some customers want isotopically labeled DLPC for metabolic tracing. Others need tighter controls on sodium, chloride, or trace-metal content for NMR or X-ray crystallography. By keeping our synthesis in-house, we flex quickly—tweaking purification or reprocessing lots that deviate from spec, drawing from a toolkit honed across hundreds of kilo-scale batches.
Phospholipid production intersects with broader debates about chemical sustainability. We track the carbon footprint of every major input, tracking back to plantation and chemical reactor. Our team is running life-cycle analyses now, seeking to offset or abate emissions at sourcing, transport, and processing nodes. Clients in Europe and the USA increasingly include sustainability in vendor assessments, demanding transparency not just in purity claims, but in full-chain stewardship.
Our regulatory teams maintain dossiers for REACH, TSCA, and FDA filings; we regularly reanalyze for emerging contaminants like per- and polyfluoroalkyl substances (PFAS) and residual process solvents, flagging lots as soon as concerns arise. This vigilance becomes especially important as more customers integrate DLPC into advanced therapies, pediatric products, or food applications, where authorities tighten ingredient scrutiny.
A tension persists between rigorous cleaning and environmental load; we experiment with aqueous-based wash protocols, minimizing reliance on chlorinated organics. Off-gases are scrubbed, and liquid effluents recycled in accordance with regional waste codes. Our scientists meet routinely with downstream partners to benchmark new purification resins and absorbent media, avoiding future regulatory snags.
We draw improvement ideas directly from hands-on users. Whether it comes via a troubleshooting call from a start-up, or field feedback from a legacy food brand, these tips flow straight back to process changes. Many applications in the cosmetic and pharmaceutical worlds now demand ingredient transparency at a level unheard of a decade ago. By building traceability into our supply chain, batch codes link every drum of DLPC to full production data: date, raw material sources, staff involved, and analytic runs.
Some of our longest-standing customers have run stability tests over multiple years, providing feedback on packaging, reactivity, and downstream performance. Real partnership means they loop us in ahead of major formulation reforms or rollout, allowing us to tweak particle size, surface character, or dispersibility per end-use conditions. Our technical teams visit client sites, troubleshoot pilot runs, and document how manufacturing realities shape results far more than the static images seen in product brochures.
Every kilogram of DLPC reflects not only chemical insight, but dialogue between manufacturing and front-line users. Our hands-on, iterative release program keeps us focused on what matters—traceable purity, reliable function, and open communication about origin and outcome. More sectors rely on phospholipids, especially specialty examples like 1-Lauroyl-sn-glycero-3-phosphocholine, as foundational to work at the cutting edge of healthcare, food science, and everyday beauty.
Day-to-day, it’s still our experience that guides updates, keeps shipments on time, and ensures every unit meets the mark. Industry requirements shift with science, regulation, and consumer need. We stand ready to support that evolution, sharing what we learn on the path from synthesis bench to real-world impact.
