| HS Code | 295788 |
| Product Name | Water-Soluble Hirudin |
| Appearance | White to off-white powder |
| Solubility | Highly soluble in water |
| Purity | Typically ≥98% |
| Molecular Weight | Approximately 7 kDa |
| Source | Recombinant or natural extraction |
| Activity | Direct thrombin inhibitor |
| Storage Temperature | -20°C or 2-8°C (lyophilized form) |
| Ph Stability Range | pH 4.0-8.0 |
| Cas Number | 96099-13-3 |
| Use | Anticoagulant research and drug development |
| Form | Lyophilized powder |
| Endotoxin Level | <1.0 EU/μg |
| Amino Acid Sequence | Varies based on isoform |
| Recommended Diluent | Sterile distilled water |
As an accredited Water-Soluble Hirudin factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Water-Soluble Hirudin is packaged in a sterile, sealed 10mg vial, with clear labeling and protective outer box for safe transport. |
| Shipping | Water-Soluble Hirudin is typically shipped at ambient temperature as a lyophilized powder. For long-term preservation and product integrity, it is recommended to store the chemical at -20°C upon arrival. The package is securely sealed and padded to prevent moisture exposure and physical damage during transit. |
| Storage | Water-soluble Hirudin should be stored at –20°C in a tightly sealed container to maintain stability and prevent degradation. It should be kept away from light, moisture, and direct heat sources. For long-term storage, aliquotting is recommended to avoid repeated freeze-thaw cycles, which can compromise activity. Ensure proper labeling and handle under sterile conditions to prevent contamination. |
Competitive Water-Soluble Hirudin prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8615365186327 or mail to admin@ascent-chem.com.
We will respond to you as soon as possible.
Tel: +8615365186327
Email: admin@ascent-chem.com
Flexible payment, competitive price, premium service - Inquire now!
From years of hands-on experience at the heart of biochemical manufacturing, we know that not all proteins translate easily from the lab into a scalable, usable product. Hirudin offers a real case study in practical problem-solving. Traditional forms of hirudin, mainly extracted from leeches or expressed in bacteria, present hurdles—chiefly in purification and solubility. Clumping and inactivation happen often. Water-soluble hirudin, on the other hand, embodies a leap forward. It dissolves completely in aqueous solutions, avoiding the cumbersome re-solubilization steps and protein loss that slow down batch throughput. This streamlined step isn’t just an optimization on paper. It drives reliability, time savings, and higher recovery for downstream users.
As a direct manufacturer, we design each production run with a focus on purity and biological activity. Early in-house trials taught us that the wrong choice of expression system—or careless fermentation control—leads to low yields and costly failures. We fine-tune bacteria or yeast strains and apply protein engineering that prevents misfolding during translation. Our standard model offers a concentration of 10000 ATU/mg, based on our validated independent assays, which comes from years of running side-by-side comparisons with less refined alternatives. Specified as a lyophilized white powder, our water-soluble hirudin keeps its activity even after storage, as long as moisture is kept out.
Specifications for each lot aren’t arbitrary or copied from a competitor’s brochure. We tie the numbers directly to production realities: moisture content doesn’t exceed 5%, and heavy metal content is kept well below pharmaceutical thresholds. Keeping endotoxin levels low takes vigilance with raw material testing, aggressive filtration of buffers, and cleaning routines that rival those of sterile manufacturing. Our purification takes up a meaningful slice of overall cost, but the outcome—a consistently high-purity, bioactive protein—justifies every bit of it. Our experience shows that cutting corners on this stage punishes the final user with unpredictability batch-to-batch.
Most clients come to us with one pressing need: a form of hirudin that performs as expected in critical research and development stages. For instance, pharmaceutical teams working on anticoagulant candidates need water-soluble hirudin that can be reconstituted in saline or buffer without cloudiness or precipitation. Others need to inject it into animal models and monitor pharmacokinetics without worrying about undissolved particles causing artefacts. In these applications, every microgram counts, both for insight and safety.
Some bioscience startups use our water-soluble hirudin as a biological reference during high-throughput screening of antithrombotic drugs. Enzyme-linked assays and clotting time experiments depend on a consistent, well-characterized standard. In histopathology labs, teams preparing sample slides employ hirudin to prevent blood clotting during tissue fixation and sectioning, avoiding sample loss from clot contamination. These uses aren’t theoretical: they stem from repeated orders, documented study protocols, and direct feedback that shapes each batch we make.
Many in the chemical and life sciences fields know the headaches associated with legacy hirudin preparations. These older forms, often aggregated or derived from crude leech extracts, introduce inconsistencies in laboratory and clinical work. Some need harsh chemicals for re-dissolution, some never reach full solubility and require additional filtering—each workaround adds expense, risks protein degradation, and wastes operator time.
Our water-soluble hirudin stands apart in these key areas. First, its ready dissolution in pure water or physiological saline ensures researchers spend their time on experiments, not endless troubleshooting. Second, we keep contaminating proteins and fragments out through stepwise chromatographic purification, which distinguishes it from less refined offerings. Finally, stability after reconstitution allows for extended bench-top handling—each lot gets real-time stress trialled, as we have learned over the years that surprise precipitation mid-experiment is a failure we simply cannot allow.
Other manufacturers may label their material as “hirudin,” but without meticulous controls, the resulting mixture can contain truncated fragments or biologically inactive byproducts. Only feedback from end-use testing over hundreds of lots has taught us where to focus: reliability batch after batch matters most. No one wants to see drift in potency. Unlike generic or incomplete products, we support each shipment with a full batch record, including solubility testing performed in clinically relevant buffers, sidestepping the “paper specification” trap.
Our direct observation of the manufacturing process makes one point clear: margin for error remains slim when biological activity is mission-critical. Room temperature, pH of buffers, choice of lyophilization cycle, even the plastics used for packaging—each variable touches stability. Early attempts at lyophilizing hirudin taught us that residual moisture triggers slow deamidation and activity loss. Today, we guarantee anti-thrombin activity through controlled drying, with water content always confirmed via Karl Fischer titration. This is an old-school chemistry technique, but nothing else matches it for accuracy in protein powders.
Contamination remains a concern, especially in facilities that process different biologics on shared lines. That’s why we keep dedicated lines just for water-soluble hirudin, followed by months-long monitoring for cross-contamination—confirmed with chromatographic and spectrophotometric scans. There’s no shortcut here. If operators flag even a minor spectral anomaly during QC, the batch doesn’t leave our plant. Our on-site staff don’t hide behind layers of paperwork; we expect every operator to halt production if the numbers aren’t exactly where they should be.
Throughout our history, communication with major pharma partners taught us the value of transparency: we routinely share raw chromatograms, not just summary data, with experienced clients. Some bookings last for years, because the consistency we offer builds practical trust. Even small startup clients receive this same openness, allowing them to build robust protocols without doubt about the input material. Whether used in GLP-compliant research or nonclinical evaluations, water-soluble hirudin from our lines offers the certainty that only a manufacturer with direct line-of-sight over each step can deliver.
No product solves every challenge straight out of the gate. Water-soluble hirudin does not fully sidestep the inherent complexities of biological proteins: even trace protease contamination, if introduced, erodes shelf life. Our ongoing R&D investigates next-gen expression systems, aiming to increase yields and further minimize host cell protein traces. We recently piloted an engineered yeast strain that pushes typical yields severalfold higher without sacrificing purity. This wouldn’t be possible without direct process feedback from every staff technician who touches production.
Another practical point: the protein’s susceptibility to high temperature and repeated freeze-thaw cycles. We’ve addressed this with single-use aliquoting and packaging in vacuum-sealed vials. Old experience lingers—one client lost half a kilo of material due to a single thawing incident—so our advice and product sheets don’t sugarcoat the risks. Customers running clinical studies also sometimes ask for additional analytical support or document packs. Since maintaining full traceability for each lot is standard, we can turn around custom documentation packages to meet their compliance reviews, without holding up urgent research timelines.
The reality is, no two laboratories run exactly the same protocol, yet every one of them counts on reagents that behave as described. We keep close contact with client R&D teams—calls, site visits, sample shipments—because product support goes far beyond shipping paperwork. When a new assay technique surfaces, or a customer reports an unexpected solubility issue, we take it straight from the lab bench to the production floor and update our internal guidance.
Our on-site technical support comes from staff involved in actual hands-on production or QC. They know how water-soluble hirudin behaves in real-world workflows. This keeps tech support rooted in the actual qualities of the product, not disconnected call center scripts. Our team addresses specific method questions about handling, storage, or co-solvent compatibility. When questions arise, we answer based on practical trial—not simply what was published in a data sheet years ago.
Too many products seem similar at a surface glance, yet the experience of using them often tells a different story. A ready-to-use, water-soluble form of hirudin lets small labs and major pharma companies alike build experimental schedules without fearing unpredictable lags or material waste. This isn’t just cost-discussion. Lost time in re-solubilizing misbehaving protein, adjusting for activity drift, or having to repeat critical animal studies burns budgets and frays research timelines.
By removing aggregation and solubility concerns, water-soluble hirudin becomes a workhorse for both exploratory science and tightly regulated preclinical work. Whether used as a research standard, anticoagulant control, or foundation for developing next-generation anticoagulants, its ability to combine seamless handling with consistent biological activity brings measurable stability to research outcomes. This trust builds up batch after batch and becomes the backbone for more ambitious scientific goals.
Over the years, our team has seen how end users integrate water-soluble hirudin into everything from in vitro diagnostic platforms to specialized research protocols. Some researchers add it directly to freshly drawn blood to standardize coagulation assays, others rely on it to block thrombin in cell culture systems. Pharmaceutical companies incorporate it into structure-activity relationship studies for drug development pipelines. Custom pack sizes, delivered in break-resistant vials, reflect the wide spread of customer needs—tiny research labs can get gram-level amounts, while larger operations opt for scaled-up kilogram shipments. Packaging looks simple, but clients running a multi-site clinical program know the value in batch consistency and matching certificates from start to finish.
Whenever a deviation or shipping query lands on our desk, we address it immediately through our operations or technical teams. Our field knowledge in how water-soluble hirudin behaves under “real world” stresses—transport across climates, mid-study reconstitution delays, and repeated freeze-thaw cycles—guides packaging choices and recommendations. We are regularly in touch with academic and industrial clients collecting feedback, running cross-site validation, and supporting start-to-finish integration into their protocols.
Being a direct manufacturer brings a different kind of responsibility. Every order doesn’t move just a kilogram of white powder; it brings years of technical investment and a promise of reliability. We continuously invest in upstream process tweaks, internal validation, and routine re-training—because each improvement, proven in trials and feedback from R&D staff, gets baked into the next production cycle. A recent initiative involved installing a dedicated cold chain line for all large-volume shipments. Feedback indicated that customers in tropical regions struggled with occasional temperature excursions. Now, with temperature loggers shipped inside every bulk order, clients in challenging climates have the same stability as those near our facility.
Sustainability also comes up more often. While biotech manufacturing will always use resources, we take care to minimize solvent use and recycle cooling water across production. Regular audits drive our waste stream minimization, and we prioritize responsible raw material sourcing whenever possible. The production reality is complex, but a factory that listens and adapts ensures that water-soluble hirudin continues to earn the trust of the scientific and pharmaceutical sectors.
Looking ahead, our ongoing collaborations with university research groups keep us aware of emerging requirements for hirudin in fields like microfluidics, regenerative medicine, and advanced diagnostics. Many scientists now require tailored modifications—PEGylation, site-directed mutagenesis, molecular fusions—for even more specialized work. We develop custom water-soluble hirudin analogues on a case-by-case basis, always grounding innovation in proven, large-scale batch experience. Every new variant undergoes the same rigor, as trust in the baseline product isn’t just a sales claim—it’s what keeps us accountable to every researcher and clinical developer who relies on our work.
