| HS Code | 459146 |
| Name | Stephania Tetrandra Extract |
| Botanical Source | Stephania tetrandra |
| Main Active Component | Tetrandrine |
| Plant Family | Menispermaceae |
| Common Form | Powdered extract |
| Color | Yellow-brown |
| Solubility | Partially soluble in water |
| Used Part | Root |
| Origin | China |
| Standardization | Tetrandrine 98% |
| Extraction Method | Solvent extraction |
| Taste | Bitter |
| Odor | Light herbaceous |
| Shelf Life | 2 years |
| Storage Conditions | Cool, dry place away from sunlight |
As an accredited Stephania Tetrandra Extract factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Stephania Tetrandra Extract is packaged in a sealed, opaque 100g resealable pouch, clearly labeled with product name, purity, and safety information. |
| Shipping | Stephania Tetrandra Extract is shipped in sealed, food-grade containers, protected from light, moisture, and heat. Containers are securely packaged and clearly labeled with product details and handling instructions. International shipments comply with safety regulations and documentation requirements. Standard shipping methods include express or air freight, ensuring timely and safe delivery. |
| Storage | Stephania Tetrandra Extract should be stored in a tightly sealed container, protected from light, moisture, and excessive heat. Keep it in a cool, dry place, ideally at room temperature or below 25°C. Avoid exposure to air to prevent degradation and contamination. Ensure the storage area is well-ventilated and clearly labeled. Keep out of reach of children and unauthorized personnel. |
Stephania tetrandra extract, produced in our GMP-compliant facilities, is recognized for its critical roles in selected regulated manufacturing sectors. Below we detail applications within pharmaceutical APIs, veterinary feed additives, functional food supplementation, topical cosmetic formulations, and herbal nutraceuticals, including specific standards, usage ratios, process steps, and finished goods relevant to each industrial context.
In pharmaceutical manufacturing, active constituents from Stephania tetrandra, particularly tetrandrine, serve as intermediates in small-molecule anti-inflammatory drug synthesis. Manufacturers demand standardization by HPLC and stringent impurity controls. Our extract is commonly processed in the initial compound extraction, where its alkaloid concentration is adjusted based on downstream synthesis demands. Processing includes validated purification, solvent recovery, and intermediate mixing before API isolation for formulated capsules or tablets. Typical challenges include maintaining batch uniformity according to pharmacopeial standards.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
In the animal feed industry, Stephania tetrandra-derived alkaloids are included as natural anti-inflammatory and immunomodulating feed additives, especially in swine and poultry nutrition programs. Formulators require consistent plant source traceability and absence of prohibited contaminants. Feed integrators homogenize precisely measured extracts in the pre-mix blending stage. The additive must withstand pelletization and maintain alkaloid activity under extrusion or steam processing, with QC monitoring for residue compliance and uniformity in the final compound feed products.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
In functional food manufacturing, controlled doses of Stephania tetrandra herbal extract are integrated as botanical actives targeting consumers guided by Traditional Chinese Medicine (TCM). Manufacturers prepare precise blends utilizing validated extraction yields for use in powdered sachets and RTDs. Rigorous allergen screening and heavy metal residual testing are mandatory prior to integration. Processing steps include aqueous or alcoholic extraction, standardized drying, and microencapsulation for taste masking, essential for beverage clarity and shelf-life requirements.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
In the personal care and cosmetics industry, Stephania tetrandra extract is employed as an active botanical in skin soothing and anti-swelling formulations, favored in creams and gels designed for sensitive or post-treatment skin. Cosmetic chemists require extracts with controlled pesticide content, low heavy metals, and conformance to preservative regulations. The extract enters production at the water phase of emulsification under closed-system blending. Downstream, it is stabilized using cosolvents or encapsulation to maintain bioactivity over shelf life. QC assays address both microbiological stability and active marker retention.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
Within the herbal supplement sector, Stephania tetrandra extract aligns with finished nutraceutical capsule and tablet manufacturing for use in joint care and swelling support. Finished product manufacturers require documentation of origin, solvent residue test results, and batch-level alkaloid marker specification as core purchasing parameters. The extract is included at the dry blending stage and pressed with excipient matrices under controlled low-humidity conditions to prevent degradation. Detailed trace element and solvent residue certificates support export to markets with heightened supplement regulatory requirements.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
Competitive Stephania Tetrandra Extract prices that fit your budget—flexible terms and customized quotes for every order.
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Stephania tetrandra, often called Han Fang Ji, has played a part in traditional practices for centuries. As a chemical manufacturer who works every day with plant-based extracts, I see the gap between raw traditional material and the kind of finely-crafted, industry-ready ingredient the modern world demands. Customers bring a range of expectations, from strict purity requirements to trust in traceable sourcing. Listening and responding to these needs has shaped the way we approach our Stephania tetrandra extract.
Our approach puts the root at the center of careful manufacturing, not simply as a commodity but a valued source of specific alkaloids. We process Stephania tetrandra tuber to extract high concentrations of tetrandrine and fangchinoline, two notable bisbenzylisoquinoline alkaloids. Once harvest logistics and species identification get sorted out on our end, each batch undergoes tested, practical procedures for cleaning, chopping, and drying. Using extraction solvents, followed by filtration and concentration under controlled conditions, preserves the targeted compounds and supports batch consistency. This goes well beyond basic holism, supporting full-spectrum content while removing plant debris and possible agricultural contaminants.
We may work with Stephania tetrandra extract powder at 10:1 or 20:1 extract ratios, but over the years, it's our standardized extract, titrated to at least 98% tetrandrine by HPLC, that most customers come back for. Only careful cascading filtration and analytical method validation let us confirm that content. If the specification calls for less processed grades, we offer a 10%–30% tetrandrine variety, which retains more secondary alkaloids for researchers and product formulating teams looking for a broader matrix.
As manufacturers, we control the incoming root identity using TLC and HPLC fingerprinting, avoiding confusion with related species like Aristolochia, which are not just ineffective but can introduce nephrotoxic risks. The final extract runs through microbial testing, residual solvent checks, and heavy metal monitoring. SAP records and QC batch numbers allow each kilogram to be traced back to its origin harvest. This kind of practical data-driven routine matters to any partner focused on finished product safety and regulatory compliance, especially exporters to markets with distinct pharmacopeia standards.
Our Stephania tetrandra extract finds its way into oral capsules, topical gels, and research settings seeking anti-inflammatory characteristics. The standardized 98% tetrandrine version appeals to pharmaceutical formulation teams who rely on repeatable input every time. Some clients in the supplement field prefer the 10:1 root extract, which offers broader plant chemistry, aiming at traditional consumer bases.
Over the last decade, I've worked closely with teams formulating creams and sprays aimed at joint comfort and topical swelling. They often appreciate our pesticide residue controls, since dermal uses typically face greater scrutiny from regulators in North America and Europe. We certify batches on gluten, heavy metal, and allergen status, using enzyme-linked immunosorbent testing and third-party analysis if needed. Reliable documentation matters—especially to those marketing to sensitive populations or athletes.
We never rely on single-batch checks or casual spot testing. Our reputation as a manufacturer ultimately depends on batch-to-batch consistency and transparency. Every kilo undergoes sampling using a statistically valid square-root-n + 1 protocol. Each test result feeds back into our in-plant dashboard, and validation files are ready for any audit. Our on-site HPLC benches and mass spectrometry capabilities give control over more than just the headline marker. Our teams can flag unknown alkaloids for further research or eliminate outlier profiles before anything leaves our stockroom.
Meeting regulatory rules is never just a box-ticking exercise. Stephania tetrandra contains regulated alkaloids, some of which can pose toxicity issues at high or misused doses. Our team follows protocols for safe handling and monitors country-specific substance regulations before shipping bulk. Countries such as the United States and Australia have restrictions on certain extracts, so we assist partners by supplying both technical and compliance documentation for border and customs offices. Having documentation ahead of time smooths the process, avoids extra costs, and prevents supply interruptions for multinational firms.
As a working manufacturer, I've spent years learning what detail-oriented brands and scientists want from plant extracts. Products from simple traders or warehousers sometimes contain mixed-species batches or undeclared synthetic dilution. These products tend to fall short—either they test low for tetrandrine or carry unacceptable levels of heavy metals and agricultural chemicals.
Our long-standing direct supply relationship with contracted growers means we visit annual sowing and harvesting. We only accept root tubers from fields free of recent pesticide applications. Most issues with adulteration—especially Stephania root swapped out for cheaper substitutes—get caught before extraction. Direct oversight at the farm level makes up a big part of supply risk management. No batch ever gets processed until documentation checks out and random taproot slicing confirms color, aroma, and cross-sections match Stephania tetrandra, not related species or non-tuberous comfrey relatives.
Compared to generic supplier powders, customers immediately remark on our extract’s vibrant beige-yellow color, matched to pantone chips year after year. Unwanted particulate, off aromas, and batch dullness signal manufacturing shortcuts, which our process controls prevent. Tetrandrine standardized extracts benefit from final vacuum-spray drying, producing a free-flowing powder with little clumping or bridging, which helps in both bulk packaging and encapsulation lines.
Stephania tetrandra extract doesn’t fit every project, but firms working on pain relief, swelling, or vascular support formulas frequently bring new projects our way. Our team shares protocols and tips for optimal blending, solubility testing, and capsule homogeneity. Some partners use extract in preclinical animal research, where compound purity and published references drive choice. We don’t just supply product—we provide manufacturing tips, from recommended mesh sizes to cellulose blending percentages avoiding wet-milling at high speed, which tetrandrine does not tolerate well.
Pharmaceutical clients sometimes need low-ash, concentrated extracts for precision dosing and easy compliance with Good Manufacturing Practice (GMP) guidelines. Glycoside and alkaloid profiling gets done in-house, allowing us to answer questions within a working day. Custom micronization, and even sterile packaging in nitrogen-flushed drums, have been possible where supply chains require it. This attention to real-world application, not just theoretical paperwork, has kept seasoned formulators returning to our manufacturing floor each year.
Concerns over contamination and substitution shape our practices. Several years back, a cluster of product recalls involving misidentified Stephania tetrandra in Europe raised alarms about root authentication. Our company responded by mandating genetic ID on all new supply contracts, integrating DNA barcoding into seasonal procurement. It’s not overkill—contaminants and substitutions damage everyone’s reputation. Our practice ensures that only authentic tuber, grown under contract in monitored locations, makes it to extraction.
Environmental impact draws increasing scrutiny. Stephania tetrandra’s wild roots once experienced overharvesting, endangering regional stocks. We shifted sourcing to cultivated, IPM-certified farms, using sustainable digging methods and restoration plantings for each hectare harvested. Routine soil and water analysis ensures roots grown for our extracts never accumulate heavy metals above set thresholds. Partners in food and herbal supplement sectors continue pushing for traceability, so yearly audits and digital lot-trace systems keep us—and our clients—accountable.
Stephania tetrandra’s pharmacological profile continues to attract clinical research teams, prompting new collaborations. Some want tetrandrine-rich extracts to trial in respiratory comfort, cardiovascular health, and inflammation targeting projects. University teams and biotech labs periodically request certified reference samples, HPLC documentation, and bioburden results. We share not just technical sheets but also internal manufacturing notes, such as stepwise extraction details or compound loss rates during spray drying. Openness with data makes sense in a climate where reproducibility and independent replication matter more than ever before.
Industrial partners sometimes approach us with contract manufacturing ideas. Several have brought concepts for microencapsulation, designed for slow-release dosing in combination products. We work hand-in-hand adapting our extract for these specialty applications, tweaking particle size and providing stability data under multiple storage conditions. Our technical team regularly visits customer production lines to troubleshoot mixing, granulation, or finished appearance visibility. The experience proves that extraction quality alone doesn’t guarantee a good final product—but manufacturing insight and process adaptation keep things running smoothly.
Cutting corners in source plant verification or extraction steps always shows in the finished Stephania tetrandra extract. Only by knowing our growers, tightening raw material controls, and investing in analytical capability have we kept customer trust over decades. No amount of after-the-fact remediation fixes contaminated, mislabeled, or weak product—counterfeit extracts get caught in supply audits or, worse, endanger finished product safety.
Reliable, pure, well-characterized Stephania tetrandra extract meets regulatory scrutiny and user expectations. Tight controls on alkaloid content, contaminant exclusion, farm-level traceability, and open manufacturing data support confidence among professional buyers. Our focus stays on producing a product that integrates smoothly into research, nutraceutical, and health industry projects, delivering not just plant chemistry but also assurance and peace of mind.
