| HS Code | 924996 |
| Chemicalname | Poloxamer 407 |
| Casnumber | 9003-11-6 |
| Othernames | Pluronic F127, Synperonic PE/F 127 |
| Appearance | White, waxy solid or powder |
| Solubilityinwater | Highly soluble |
| Molecularformula | (C3H6O·C2H4O)n |
| Averagemolecularweight | Approximately 12,600 Da |
| Meltingpoint | 52°C - 57°C |
| Ph | 5.0 - 7.4 (5% solution) |
| Hlbvalue | 18-23 |
| Density | 1.1 - 1.2 g/cm³ |
| Function | Non-ionic surfactant and emulsifier |
As an accredited Poloxam 407 factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Poloxam 407 is typically packaged in a 1 kg white plastic drum with a secure screw cap and detailed product labeling. |
| Shipping | Poloxam 407 is typically shipped in tightly sealed, high-density polyethylene drums or containers to prevent contamination or moisture uptake. Containers are clearly labeled and stored in cool, dry conditions. Shipping complies with all local and international regulations for non-dangerous goods, ensuring safe and secure transportation throughout the process. |
| Storage | Poloxam 407 should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from incompatible substances. Protect it from moisture, heat, and direct sunlight. Optimal storage temperatures are generally between 15°C and 30°C. Avoid freezing or excessive heat to maintain product integrity. Always adhere to manufacturer guidelines and safety data sheet (SDS) recommendations. |
Competitive Poloxam 407 prices that fit your budget—flexible terms and customized quotes for every order.
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Our team has spent decades working with block copolymers, following the manufacturing process from raw ethylene oxide and propylene oxide all the way to the finished products that support countless industries. Among these polymers, Poloxam 407 stands out for its combination of performance and consistency. This material is also widely recognized by the designation Poloxamer 407, and belongs to the nonionic surfactant family. As a manufacturer, we maintain direct oversight of each stage, from sourcing to purification. Our facility employs continuous monitoring and tight process controls, aiming for reproducible molecular weights, low residual monomers, and narrow polydispersity. These parameters remain critical since even small changes can affect end user results, particularly in pharmaceutical and high-purity applications.
Poloxam 407 offers a clear advantage when it comes to both the consistency of supply and its functional profile. Unlike short-chain surfactants or lower-grade nonionics, this material brings a high molecular weight and an orderly triblock structure, resulting in rheological properties and solubility behavior prized across multiple industries. Our technical team relies on real-time analytical data—such as nuclear magnetic resonance and gel permeation chromatography—to ensure each batch matches the characteristics customers have come to trust. This scientific vigilance has been essential in meeting strict standards demanded by both pharmaceutical and personal care markets.
Poloxam 407 takes the form of a white, free-flowing powder, dissolving in water to form clear gels at certain concentrations. Its unique structure—a central hydrophobic chain of polyoxypropylene surrounded by hydrophilic polyoxyethylene chains—produces an unusual thermal gelation behavior. At low temperatures, it remains a liquid. As temperature increases, it thickens and transforms into a robust, stable gel. For formulation scientists, this brings a level of flexibility that most polymers cannot match, making it especially popular in creating thermoreversible gels, injectable solutions, ophthalmic preparations, and controlled release matrices.
We’ve observed that many personal care formulators reach for Poloxam 407 when seeking viscosity control without stickiness or oily residue. The same qualities make it a staple in topical pharmaceuticals, where a transparent appearance and rapid skin feel are crucial. Across the broader chemical manufacturing landscape, customers rely on the surfactant’s wetting and emulsifying abilities to stabilize suspensions, disperse actives, or solubilize oily substances in aqueous systems. Its chemical inertness supports compatibility with a variety of active ingredients and preservatives, which has become a top consideration for formulations destined for sensitive users.
Our process ensures that the molecular weight distribution of Poloxam 407 stays tightly within the optimal range. The block lengths of polyoxyethylene and polyoxypropylene influence not only viscosity and solubility but also its biocompatibility. We track and tune these variables at the polymerization stage, targeting the specification that delivers the best gelation temperature, clarity, and purity. Purity profiles receive special attention, tested by advanced analytical techniques like HPLC and wet chemistry. Endotoxin levels are kept low in line with the strictest pharmaceutical guidelines, and we routinely monitor for trace levels of ethylene oxide and dioxane. By maintaining these controls, we protect both the integrity of our customers’ products and the health of the people using them.
While other block copolymers exist, Poloxam 407 takes the lead due to its balance of hydrophilic and hydrophobic segments. Lower-numbered poloxamers, like 188 or 338, may offer different rheological profiles or application windows, but the 407 variant brings a well-established record in drug delivery, topical formulations, diagnostics, and cleaning products. Its gel-forming capacity rivals carbomers and cellulose derivatives, yet lacks their sensitivity to electrolytes and pH shifts. That extra reliability helps reduce troubleshooting and reformulation later on, saving both time and material costs for our partners.
Our customers span the spectrum from large multinational pharmas down to contract research organizations and boutique startups. We have seen Poloxam 407 adapted for injectables designed for rapid drug absorption, nasal sprays requiring mucoadhesion, long-lasting topical creams, and even advanced diagnostics that rely on thermoresponsive micelles. The same properties that contribute to pharmaceutical success—clarity, low irritancy, absence of taste and odor—support its growing use in foods and beverages, especially for specialty emulsions and flavor-encapsulation systems. In laboratory settings, this copolymer supports membrane protein extraction, sample stabilization, and cell lysis protocols, valued for its ability to disrupt lipid bilayers gently without protein denaturation.
Environmental safety remains at the core of our operation. The surfactant profile of Poloxam 407 provides biodegradability benefits over more persistent synthetic polymers. Our in-house risk assessment teams routinely review lifecycle data, and we track regulatory developments in environmental stewardship so customers meet not only current but also future compliance standards. We collaborate with downstream users to minimize environmental impacts, including target recycling and wastewater treatment strategies.
In recent years, supply chain instability and raw material shortages raise concerns industry-wide. By managing polymerization and finishing in our own facilities, we keep pricing stable and guarantee full traceability for each lot. Audits by regulatory agencies review not only our production records, but also our documentation on trace impurities and Good Manufacturing Practice compliance. Our batch records stay available for customer reviews during qualification and scale-up, giving full transparency required for regulated applications.
Shifts in regulatory frameworks and customer requirements can change raw material sourcing and downstream testing. In the face of these changes, our technical support group maintains close relationships with regulatory consultants in North America, Europe, and Asia-Pacific. Experienced formulation chemists reach out directly to discuss the implications of new regulations, such as emerging requirements for nitrosamine testing or solvent residue limits. We back up our statements not only with certificates of analysis, but also with detailed validation data and third-party testing.
Routine analytical runs cover not just the basics of identity and content, but also residual solvents, heavy metals, and specific by-products. Our laboratory equipment includes high-performance liquid chromatography, Fourier-transform infrared spectroscopy, and inductively coupled plasma mass spectrometry for elemental impurities. Every lot can be traced back to its starting monomers, and all manufacturing steps are documented for audit review. This attention to detail proves especially important for companies relying on a consistent product profile through multiple batches or contract manufacturing partners.
Our technical support goes beyond basic product supply. Customers approach us for pre-formulation studies, scale-up guidance, or advice on optimizing gel structure and active dispersion. Our in-house R&D participates in collaborative projects to address new challenges: tailoring gelation points to novel dosage forms, lowering viscosity for injectables, boosting solubilization power for hydrophobic actives, and strengthening compatibility with sensitive biologicals.
Other families of surfactants or water-soluble polymers attract attention, such as polysorbates, polyethylene glycols, or carbomers. Many of these function well as solubilizers or thickeners in specific recipes, yet often struggle under varying electrolyte or temperature conditions. Polysorbates may suffer from oxidative instability or form undesirable degradation products. PEGs tend to lack the temperature-responsive gelling behavior offered by Poloxam 407, and can sometimes provoke irritation at higher concentrations. Carbomers, another popular gelling agent, demonstrate impressive thickening efficiency but typically create acidic gels unless neutralized—and can lose viscosity when even a small amount of electrolyte enters the mix.
Poloxam 407 forgoes these difficulties thanks to its robust thermal gelation, strong emulsifying power, and near-neutral pH upon dissolution. With consistent, non-yellowing appearance and no noticeable odor or taste, we see customers coming back to this material for new generations of product lines. Its nonionic nature avoids compatibility problems with cationic or anionic actives. Extra stability at freezing and elevated storage conditions gives users extended shelf-life flexibility compared to many natural gums or less pure synthetic derivatives.
A few hurdles persist in working with high-molecular-weight block copolymers. During the hydration process, Poloxam 407 can produce foam unless properly incorporated. Personnel in our plants and customer labs often benefit from adding the powder gradually, allowing time for wetting before subjecting to vigorous mixing. We share these best practices through direct technical outreach and detailed product bulletins, aiming to eliminate the most common operational headaches. Where high concentration gels slow down dissolving rates, proper temperature control and prewetting steps streamline the workflow.
End formulations sometimes demand specific gelation temperatures or particular viscosity benchmarks. By adjusting concentration or blending with lower or higher molecular weight poloxamers, chemists can fine-tune the texture and thermal profile. In cases where solubilization power must rise further, we advise on synergistic use with co-solvents or gentle surfactant boosters. Rather than promoting one-size-fits-all answers, our technical team works hands-on to run trials and collect the data needed for confident reformulation.
Whether destined for pharmaceutical, diagnostic, cosmetic, or industrial goods, each application of Poloxam 407 demands attention to both safety and performance. We invest heavily in ongoing toxicological studies, providing robust safety data packages to customers and supporting regulatory submissions worldwide. The absence of known irritancy or sensitization in standard toxicology tests reinforces its track record. Safety reviews also encompass residual impurities, with strict lot release criteria governed by international pharmacopeial standards. We keep these safety and quality attributes at the center of every production run.
A growing demand for transparency has prompted us to disclose full monomer origin, process aids, and impurity data on our product certificates. Customers benefit from end-to-end clarity, improving their own compliance positions and supporting quality over their supply chains. As international requirements grow more demanding, spanning REACH, US FDA, ICH, and even region-specific green chemistry regulations, we build partnerships that anticipate and solve compliance challenges rather than simply reacting to them under pressure.
R&D investments in block copolymer science open new opportunities. Our researchers explore novel architectures, aiming to pair the trusted attributes of Poloxam 407 with additional functionalities. Some projects target enhancement of drug delivery efficiency, investigating copolymer micelle carriers that extend circulation time or modulate release through external triggers. Other teams test formulations for wound healing, transdermal patches, or responsive cleansing agents intended to outperform conventional surfactants both in application and environmental impact. Each line of investigation draws on feedback from current customers working at the edge of innovation.
Supply continuity, robust documentation, commitment to customer success, and technical agility define the path forward. Competition, regulatory change, and market volatility can disrupt business plans, but a partnership built on reliable performance and regular communication shortens development cycles and minimizes risk. Our track record with Poloxam 407 across decades and markets places us in a unique position to offer both stable supply and a deep understanding of how manufacturers get the best out of this versatile polymer.
Throughout our years manufacturing Poloxam 407, we have seen the difference that direct experience makes, both in the product's quality and the support we offer. This block copolymer brings not just proven technical performance but also a wealth of real-world successes in pharmaceutical, personal care, diagnostics, and many other industries. Every lot reflects our ongoing commitment to safety, compliance, and advancing applications in collaboration with our customers. As technological, regulatory, and commercial trends continue to evolve, we remain dedicated to innovation, transparency, and the rigorous science that makes Poloxam 407 a trustworthy building block for your next solution.
