| HS Code | 916413 |
| Name | Matrine |
| Chemical Formula | C15H24N2O |
| Molecular Weight | 248.36 g/mol |
| Cas Number | 519-02-8 |
| Appearance | White crystalline powder |
| Solubility | Soluble in water, ethanol, and methanol |
| Melting Point | 76-77°C |
| Source | Extracted from Sophora flavescens |
| Purity | Typically ≥98% |
| Uses | Pesticide, anti-tumor, anti-inflammatory, antiviral |
| Storage Conditions | Store in a cool, dry place; keep container tightly closed |
| Boiling Point | 272°C (decomposes) |
| Ph Value | Neutral (when dissolved in water) |
| Toxicity | Low acute toxicity |
| Synonyms | (-)-Matrine, Sophocarpidine |
As an accredited Matrine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Matrine is packaged in a sealed, amber glass bottle containing 100 grams, with secure cap and clear labeling for safety and identification. |
| Shipping | Matrine is shipped in sealed, airtight containers, clearly labeled with hazard information. It should be stored and transported away from direct sunlight, heat sources, and incompatible substances. Standard precautions for shipping chemicals, including appropriate documentation and compliance with relevant regulations, are followed to ensure safety and product integrity during transit. |
| Storage | Matrine should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from direct sunlight and incompatible substances. Keep it at room temperature, avoiding excessive heat and moisture. Proper labeling and secure storage are essential to prevent accidental exposure. Follow local regulations and manufacturer instructions for safe handling and storage. |
Matrine, a bioactive alkaloid extracted from Sophora flavescens, is widely used in several regulated industrial sectors due to its unique insecticidal, antimicrobial, and anti-inflammatory properties. As a high-purity matrine manufacturer, we deliver standardized raw material quality for integration into diverse downstream manufacturing workflows. Below, we outline the principal application scenarios, specifying industry standards, realistic formulation practices, downstream process positions, and final goods outputs for industrial partners.
Plant protection product manufacturers incorporate matrine as an active ingredient in low-toxicity botanical pesticides for integrated pest management in agriculture. Downstream formulations hinge on matrine’s selective efficacy against aphids, whiteflies, and other sap-sucking insects, replacing synthetic actives in regions with strict residue and sustainability controls. Producers must ensure raw material is appropriately solubilized and stabilized during microemulsion or water-dispersible granule processing, given matrine’s natural alkaloid structure and environmental persistence considerations.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
Livestock pharmaceutical plants rely on matrine as a botanical active in external antiparasitic drugs and grooming solutions for animal health, especially in ruminant and poultry farming where synthetic drug residues are tightly regulated. Incorporation steps must safeguard the preservation of matrine’s bioactivity throughout solution blending, and producers verify batch purity according to pharmacopeial specifications for vet use. Finished goods must achieve uniform dispersal to maximize topical insect control while meeting zero-tolerance limits for prohibited veterinary drugs.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
Manufacturers of hard-surface and agricultural-use disinfectants employ matrine as a botanical biocidal additive in environmentally compliant formulations. The raw material demands standardized processing to ensure consistent antimicrobial response against fungal and bacterial threats on equipment, surfaces, and agricultural infrastructure. Downstream transfer points account for matrix compatibility to maintain biocidal integrity through blending, pH adjustment, and subsequent packaging under sterile conditions.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
Major grain storage and post-harvest handling operators integrate matrine as a natural botanical preservative additive in anti-mold and pest management preparations. Accurate dosing and thorough blending into carrier powders or sprayable liquids are essential to deliver long-lasting protection against Sitophilus and common storage fungi without synthetic chemical residues. The raw material undergoes controlled microparticulation or dissolution phases suitable for compatibility with mineral or organic carriers while maintaining uniform distribution throughout bulk grain treatment processes.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
Personal care and dermaceutical raw material producers include matrine as a plant-derived active in formulations targeting anti-inflammatory and anti-blemish skin care, leveraging its controlled botanical origin and safety record for topical application. Consistent potency levels support batch-to-batch reproducibility, and process controls maintain stability during blending with emollients, aqueous extracts, and preservatives. QC laboratories regularly test for specific purity markers, and blending steps optimize dispersion for high-aqueous-phase emulsions or serums destined for premium care formulations.
Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
Competitive Matrine prices that fit your budget—flexible terms and customized quotes for every order.
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Operating a factory brings you face to face with the raw reality of chemical production every day. Matrine stands out among the alkaloids our teams have handled. Its chemistry, extracted from Sophora flavescens roots, presents a stable profile and consistent outcome during processing—essential for anyone demanding reliability batch after batch. Years of running reactor halls and quality control labs, we have noticed Matrine’s resistance to light degradation holds up even under prolonged storage, reducing concerns about loss of potency before application.
Our facility produces Matrine with a content of not less than 98% by HPLC, which exceeded the norm we used to see on the domestic market. Every batch comes out crystalline white or milky powder with a faint odor, allowing users to spot purity intuitively, even before the lab report prints. Our staff learned to trust the material’s behavior: it flows easily, dissolves into most solvents we tried in the lab, and does not lump even after weeks on the shelf. This makes downstream production easier—for instance, premixing for pesticide formulations or blending with industrial carriers.
In contrast to technical-grade extracts often loaded with related alkaloids or plant residues, our refined Matrine sidesteps these headaches. Pure Matrine shows far less residue and emulsification complications in sprayer tanks or mixers compared to products that only claim plant source. We found that many inferior lots in circulation contain visible root dust, adding noise to assay reports and interfering with dosing accuracy on the production floor. Our commitment has always been eliminating that variability—every drum is tested under strict visual and instrumental panels.
Over the years, the requests we field from local agronomy specialists and pesticide formulators point to where Matrine shines most. Its core application in biological pest management keeps attracting steady demand. Some buyers want to suppress aphids or leafminers without resorting to heavily regulated organophosphates. Matrine stands apart for its insecticidal action paired with relatively gentle environmental impact, confirmed by exporting partners working under European and Japanese residue standards. In our own fields attached to the plant, technicians observed rapid leaf surface drying without persistent chemical odor—less come-back washing on equipment at the end of a long spray run.
We have shipped Matrine in micronized form for specialty foliar sprays where uniform droplet coverage becomes crucial, especially in regions facing rapid rain-off or UV exposure. The product handles easily in wettable powder and EC formulations, flowing through lines and nozzles without gumming up. Lab tests and pilot plant runs taught us the value of particle size control. Some competitors’ products leave undissolved particulates in tanks, causing site-level shutdowns and wasted batches. We take extra steps with our own wet-milling and screening, which is why client complaints about clogging dropped sharply after switching to our supply.
Besides plant healthcare, a smaller share of our output reaches veterinarians and niche pharmaceutical lines. Matrine’s molecular stability under moderate heat and its agreeable solubility at neutral and mildly basic pH offer clear advantages for formulation scientists. Years ago, a livestock supplement company shared case studies showing Matrine’s potential for parasite management in feed premixes, avoiding synthetic residues in meat. While our factory does not advise on animal dosing, our technical support team often helps customers check for ingredient compatibility and batch-to-batch reminders on trace impurity levels.
Manufacturers face a daily grind of avoiding blend failures, reducing waste and meeting ever-tougher inspection audits. Our Matrine undergoes multiple HPLC scans and organoleptic checks every shift. Back in the early years, we saw how harmless variations in root age or drying conditions could tilt the alkaloid spectrum unexpectedly. Some suppliers would pass those along to unwitting buyers, but we established sourcing contracts with only a handful of trusted Sophora growers, cutting back on out-of-spec consignment. This year, our plant adopted a digital batch registry, so every drum of Matrine carries a direct record of its processing parameters, operator signatures and final release values.
We focus on full transparency, knowing inspection teams from clients in Europe, Southeast Asia or the Middle East usually arrive unannounced. They routinely request sampling at random from finished goods and in-process drums. Based on decades of such audits, we regularly share COA data packs not only for the end material but also for Solvent Residue and Related Substances, as per ICH Q3A. No “proprietary blend” obfuscation: buyers see the same chromatogram profiles as our own lab. Such openness avoids post-shipment disputes and fosters more direct conversations with chemists and production managers who rely on solid, unaltered data.
As a chemical producer, we are keenly aware that not all Matrine is created equal. The origin of the Sophora root, details of solvent selection during extraction and time/temperature controls during concentration all leave their mark on purity and performance. In our experience, Matrine manufactured through tightly controlled multi-solvent extraction gives a lighter final color and reduces odor-producing side products. We adopted this process stream a decade ago after comparative field trials showed operators spent less time cleaning tanks of brownish deposits. Clients in food or cosmetic additive applications have commented repeatedly on this reduced background odor.
Market visits and failures in sample analyses from third-party suppliers have reinforced our belief in specifying every stage. Even minor deviations in drying or storage yield Matrine lots with lower assay, inconsistent fluidity, or interfering plant saponins that can throw off downstream formulation. Our batches pass a 30-point checklist including color, clarity, and residual moisture—factors sometimes overlooked by resellers focusing only on content value. Each decision to inspect more stringently comes from mistakes made early in our history: a costly shipping return from a southern client taught us the price of loose end-controls.
We also steer clear of blending Matrine with similar alkaloids to bulk up product claims. Some market imports present “total alkaloid” numbers that look attractive at first glance, but a closer look shows poor results in field or lab performance. True Matrine, pure and correctly processed, delivers reliable results in agricultural applications. Farmers or factory buyers often call us after working with inconsistent blends, reporting uneven field results and short shelf-life. Repeat orders and word-of-mouth references from those clients keep our Matrine division moving forward.
Today’s chemical production standards place great emphasis on minimizing environmental impact. Our Matrine line reflects this mindset. Wastewater from alkaloid separation can pose pollution risks, so modification of our plant’s water treatment process five years ago played a direct role in improving effluent values. Matrine’s limited persistence in the field compared to longer-lasting synthetic organics has allowed buyers to obtain regulatory approval for residue testing much more easily. We keep up with both national and international guidelines, ensuring our paperwork and real-world product match expectations.
We prepare detailed safety and environmental dossiers upon request. Some application sectors, like organic farming, have more rigorous review protocols. Over years of supplying to export clients, several have asked us to share primary extraction and purification records as proof of origin and compliance. We maintain an open-door approach for regulatory audits; clients and inspectors have toured our plant on multiple occasions, reviewing both production flow and on-site documentation of every Matrine batch. This long record of welcoming oversight keeps us on our toes and shapes many of the improvements in containment and documentation we’ve made.
The real judge of any chemical lies with the customer’s experience. Our advice staff fields regular calls from agronomists, growers, production chemists and even small-scale medical researchers with detailed Matrine-related questions. We keep a record of field trials and performance reports from long-term users, particularly from partners who tested our Matrine against tough local pest pressure. Common praise centers on its consistent crystal appearance and lack of caking seen in knockoff imports. Long-term customers also note that our technical support team responds fast, whether the issue is a failed lab readout or an unusual storage question.
Some challenging issues have shaped product improvements over time. In early years, we lacked sufficiently robust anti-static liners in the steel drums for Matrine. Several customers found excessive static buildup, leading to minor product loss on unpacking during dry winter conditions. Once we identified the problem, we revised our packing line and added regular humidity monitoring, reducing loss and user frustration. Small but repeated feedback like this teaches lessons that cannot be found in textbook process outlines.
We receive inquiries from labs interested in Matrine’s broader biological potentials, including anti-tumor and anti-inflammatory effects. While we produce Matrine only to industrial and agricultural grade, we make a point to discuss limits and suitability with such customers to ensure their applications align with our production standards. Some interested parties look for injectables or clinical use, which involves different purity regimes and documentation. We direct such requests to specialized GMP manufacturers. Clarity in these discussions prevents product misuse and protects our reputation.
Delivering Matrine extends beyond the manufacturing stage into ensuring its quality and usability at the end user’s site. Our staff takes care to advise on handling protocols direct from our experience moving bags and drums on factory floors. We recommend keeping the product sealed, away from direct sunlight, and choosing cool, dry storage to prolong stability. Customers who monitor humidity and avoid long-term exposure to ambient air report much longer shelf lives without performance drop. Our plant’s own long-term storage studies show less than 2% drop in content after 18 months in recommended conditions.
For bulk blend manufacturers, we encourage rotating Matrine stock in the order it reached their warehouse. Processing teams here use a “first out, first used” log. Avoiding clumping or stratification in the warehouse means less material wasted and fewer production disruptions, a point we reinforce during after-sales visits with our larger clients. Overdosing Matrine offers little benefit, as local crop science teams have shown yield improvements plateau once thresholds are met. Our technical documents offer typical working concentrations based on common crop types and pest loads.
Mixing Matrine with other agrochemical actives or adjuvants raises familiar questions every season. Formulators can safely combine our material with common spray oils and surfactants, based on plenty of in-house stability and compatibility tests. We invite regular visiting partners to bring their own blends for side-by-side tank testing—seeing outcomes firsthand helps avoid later surprises on the field. We keep an internal record of samples sent, tests run, and real-life feedback, shaping new batches to cope with current customer mixing trends.
The alkaloid field offers related compounds like oxymatrine and sophoridine, each vying for attention with their own claimed strengths. Our own research into these cousins revealed a key insight: while some offer similar spectrum biologically, Matrine consistently delivers sharper insect knockdown in comparative plot trials. We grant that the pure compounds have overlapping use ranges, but repeated field runs and solvent extractions in our plant suggest Matrine offers better batch-to-batch stability. Its crystalline form resists humidity-induced clumping better than oily or sticky analogs, simplifying transport and storage for export clients.
Some alternative products come as mixed alkaloid extracts with much lower main compound content. Our quality team often finds that these blends, though cheaper, show erratic results in plant health and insecticide trials. Finished goods formulated from clean, isolated Matrine draw fewer complaints of leaf spotting, uneven application or tank fouling. Clients from diverse regions who switched after performance failures with multi-alkaloid blends found increased satisfaction and repeatability. Our unapologetic focus on single-compound Matrine reflects what technicians, agronomists and spray teams report back to us year after year.
In the last five years, a trend toward traceability and data-backed marketing boosted demand for single-ingredient Matrine. Downstream manufacturers requested deeper batch documentation and longer shelf stability compared to what blended extracts can offer. Our record system and quality controls meet this demand. It pays off both in commercial trust and in reduced labor spent on responding to customer quality investigations.
Maintaining a Matrine line that meets the evolving needs of farmers, formulators and industrial users requires featuring every improvement directly into production. Technical groups within our plant operate under a system of shared feedback, so no field complaint or incident report gets overlooked. Weekly production review meetings bring together leaders from extraction, purification, bulk blending and logistics for open discussion. Each missed spec, each returned drum becomes a lesson that finds its way into improved procedures or material upgrades.
Our continuous data analysis on process yields, particle sizing and impurity trends informs halting and adjusting production runs before any off-grade Matrine reaches a truck or warehouse. This vigilance translates into long-term partnerships with key buyers who demand not low bid but consistent service. Client input shapes our production lines more than abstract trends; requests for cleaner packaging, faster documentation, and small-lot custom runs flow directly back to our investment in new equipment and staff training.
Looking ahead, we see Matrine’s place growing outside traditional pesticide markets. Industrial biocide users, specialty resin formulators and new categories of green chemistry platforms reach out with application requests. We stay open to innovation and collaboration, evaluating technical fit and advising on the realities of supply, purity, and regulatory timelines. Our commitment stays: keep manufacturing Matrine with every lesson learned, every improvement applied, and every customer’s real-world experience guiding our progress.