|
HS Code |
546872 |
| Cas Number | 51-35-4 |
| Iupac Name | 4-hydroxy-L-proline |
| Molecular Formula | C5H9NO3 |
| Molecular Weight | 131.13 g/mol |
| Appearance | White crystalline powder |
| Solubility In Water | Soluble |
| Melting Point | 287-300°C (dec.) |
| Ph Of 1 Solution | 5.0–7.0 |
| Specific Rotation | +80° to +87° (c=2, H2O) |
| Storage Conditions | Store at room temperature, dry and tightly closed |
| Odor | Odorless |
| Synonyms | Trans-4-hydroxy-L-proline |
As an accredited Hydroxyproline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Hydroxyproline is packaged in a sealed 100g amber glass bottle, labeled with product name, lot number, and safety information. |
| Shipping | Hydroxyproline is typically shipped in sealed, moisture-proof containers to prevent contamination and degradation. It should be kept in a cool, dry place and protected from direct sunlight. Shipping complies with relevant chemical transport regulations, ensuring safety and integrity throughout transit. Proper labeling and documentation are included for handling and identification. |
| Storage | Hydroxyproline should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry place, ideally at 2-8°C (refrigerated). Avoid extreme temperatures and sources of contamination. Proper storage ensures the compound’s stability and prevents degradation. Label the container clearly, and follow standard laboratory safety protocols when handling and storing hydroxyproline. |
Competitive Hydroxyproline prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8615365186327 or mail to sales3@ascent-chem.com.
We will respond to you as soon as possible.
Tel: +8615365186327
Email: sales3@ascent-chem.com
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Turning hydroxyproline from a lab concept into a reliable industrial product means paying close attention to detail, long hours on the production line, and learning through practical experience. Our team started small, refining production on the same batch reactors we maintain today. The hydroxyproline coming out of our process reflects years of steady hands and direct feedback from peptide and food industry partners. Seeing the shifts in demand, we’ve learned how different applications call for unique technical qualities—each requirement means another adjustment in our process, raw material sourcing, or final packaging.
Reliable hydroxyproline depends on in-house monitoring of every reaction stage. We select porcine gelatin from trusted local processors, giving us consistent quality and traceability. Unlike basic amino acids produced on contract, our hydroxyproline meets strict food, pharma, and analytical standards without compromise. Years ago, we switched to a proprietary enzymatic hydrolysis system, reducing batch variability and letting us repeatedly hit more consistent assay and impurity targets. Many in the industry chase larger scale or faster throughput, but we focus on reproducibility—and our repeat customers notice the difference. Each drum and package reflects that effort and the institutional knowledge developed by plant operators who’ve mixed, filtered, and dried countless batches.
People link hydroxyproline closely with collagen, and that’s accurate. It drives applications ranging from nutritional supplements to wound healing formulas. The technical teams we support rely on true-to-label hydroxyproline content: that’s why our focus falls on the L-isomer and tight chiral purity controls, instead of the lower bars accepted in less technical markets. Most regular customers sit in pharmaceutical and life sciences labs, but we also see interest from food, beverage, and cosmetic companies. The trend towards “clean label” collagen ingredients has put pressure on us to maintain history of every batch and deliver material free from non-proteinogenic isomers or unacceptable heavy metal residues.
Hydroxyproline’s most established use stays as a standard in collagen and protein quantitation assays. Laboratories rely on the unique structure to measure animal gelatin or plant hydrolysate content at ppm levels. Here, accuracy of content and lack of by-product peaks make or break a test, so we validate every production lot by both HPLC and specific optical rotation. Field feedback shows that even minor impurities can skew quantitation in critical pathology work or nutraceutical blending, so we invest in analytical calibration that goes well beyond typical commodity amino acid benchmarks.
Our standard model runs as L-Hydroxyproline with assay over 99.5% by HPLC, moisture below 0.5%, and minimal oxidation products. We keep mesh size fine and regular (often 80 mesh or finer) for lab use, with granular lots available for bulk dissolutions and feed-grade requests. Biobased applications often ask for documentation on animal by-products, so we keep every batch traceable back to the individual rendering plant and animal lot. Over the last three years, we’ve fielded more queries about vegan or plant-derived hydroxyproline—at scale, these sources are not yet feasible, but pilot programs for recombinant production are starting to show results, especially as the global regulatory landscape evolves.
Some commercial hydroxyproline on today’s market comes from offsite tolling operations or from traders blending synthetics with animal-derived material. As a direct manufacturer, we see differences show up in color, solubility, and even the crystalline habit under basic microscopy. Customers with high-performance liquid chromatography instrumentation will spot minor peaks from other amino acids or recover traces of endotoxins if the process water or feedstock quality drops. Any supplier who blends from multiple sources risks introducing these variances—and customer complaints invariably come back to trace origins. Running a closed cycle with validated, local raw material keeps us accountable and helps us react quickly to traceability demands from our food and pharma partners.
Matching every run of hydroxyproline to the last isn’t an abstract technical goal. Laboratories and formulation chemists design experiments and build supply chains around predictability. From firsthand experience, we know that small deviations in amino acid profile can frustrate an entire month of analytics at a pharma company, or ruin the solubility in a new protein beverage. We’ve learned over years that even the choice of reactor material or drying temperature can shift product characteristics just enough to throw off blending or tableting runs downstream.
Maintaining a tight window on impurities, both at the organic and trace metals level, means regularly refreshing processing equipment and retraining plant staff. We run weekly stability studies and cross-reference between HPLC, Kjeldahl nitrogen, and IR analyses. Whoever claims perfect record-keeping in this industry probably hasn’t faced a real recall or customer investigation. We log every anomalous batch, push improvement of procedures, and offer batch reserves if our customers see questions down the line. These habits grow out of hard lessons and avoidable problems, and we see trust build up with every year this discipline stays in place.
From a technical manufacturing view, focus lands on the L-isomer content, optical purity, and removal of amorphous by-products. Our typical L-Hydroxyproline features the following values:
These are not marketing claims—they’re rooted in test data and reflect actual observations from our quality team. We do not blend or dilute our hydroxyproline with other amino acids or bulking agents. Each production lot, down to the kilo, runs through at least two independent quality checks before shipping. If a customer puts up their own chromatography, the expected result carries our signature, not just a generic certificate. Years ago, vague or rounded specs led to confusion and delays for both sides, so now we let our records speak clearly, supported by retain samples and full transparency about any deviation.
Over the last decade, hydroxyproline supplies have expanded fast, but not all sources measure up. Factories that bulk up with less pure or mixed isomers can shave cents from costs but often bring headaches to product developers. We hear about finished products with gritty mouthfeel, failed QC tests, or unexplained fading over shelf life. Many times, these issues trace back to the way hydroxyproline was produced: crude purification, subpar gelatin stock, or rushed drying steps that let in colorants and flavor notes not seen on the spec sheet.
As a manufacturer, we’ve countered trends toward commoditization by refining batch control and source documentation. While some competitors repackage amino acids sourced from outside, we stick to local inputs and our own lab controls. Batch-to-batch reliability reduced customer sampling time and kept pilot-scale projects on track. It’s not gold-plated hydroxyproline, but it beats the headaches that come with inferior material. Teams with project deadlines or regulatory filing pressure find peace of mind in unambiguous product traceability and physical consistency.
Some hydroxyproline markets—particularly North America and Europe—demand full compliance with food and pharma-grade GMP requirements. Changing trace elements in the feedstock or process water can shift hydroxyproline’s compliance profile, especially under recent EU food safety regimes. That’s why we run constant traceability, not just batch cataloging. Laboratories or brand owners reach out for more than routine Certificates of Analysis: they want the nuanced explanation behind each measurement, and the comfort that someone on the other end can answer their questions directly. Our own in-house compliance manager keeps up with REACH, US DMF filings, and Kosher/Halal audits, which gives both us and our clients an extra level of oversight.
Vegan and cruelty-free labeling shapes some conversations. Biotechnology routes have yet to match the yield, cost, and purity of animal-based extraction, but companies in nutraceuticals and specialty peptides are testing these alternatives. We’re part of this R&D push and see a strong case for plant-based or microbial hydroxyproline, especially as downstream protein engineering makes inroads. In parallel, trace-level microbial residues or antinutritional factors now receive much more scrutiny—meaning hydroxyproline suppliers must understand cross-contamination risks all the way back to the fermentation or rendering plant.
Our operations have faced raw material shortages, freight delays, and shifting regulatory demands. In tough seasons when porcine or bovine gelatin gets tight, our local supply partnerships keep us running, but require flexible scheduling and at times, running nights or weekends to keep up. We reject the temptation to cut corners or accept substandard suppliers, even if spot prices spike. Instead, we carry heavier inventories and safeguard multi-source contracts, balancing price and quality over the long run. Not all factories have this capacity, but experience proved that a month spent smoothing supply links saves far more in lost sales and customer trust down the road.
Shipping and storage also matter. Hydroxyproline attracts and adsorbs water readily—it absorbs odors from other consignments or even picking up off-notes from container wood. We began using double-lined, food-grade polyethylene bags years ago, and now even our industrial customers request this packaging. Ambient warehouse storage rarely works in humid regions; our plant now runs dehumidified air and direct-dispatch protocols for sensitive lots. These steps, learned from past complaints and spoilage incidents, keep quality steady and bills lower over time.
Synthetic biology and peptide chemistry count on reliable hydroxyproline to design new scaffolds, drugs, and analytical kits. Occasionally a new customer asks about post-translational modifications or other hydroxyproline analogs—our technical staff can walk through each option. Out of dozens of test runs, some products call for custom mesh cuts or tighter moisture controls, depending on downstream handling and automation requirements. We partner directly with biotech research teams because they value open channels with the technical side—not just a mute supplier. On more than a few occasions, subtle variances in IR or MS spectra flagged an issue before it hit a customer’s product development line, giving us the chance to adjust or replace material without extensive downtime or cost.
Direct feedback from formulation teams shapes how we produce, test, and package hydroxyproline. Every specification, from particle size to metal content, started as a field request or problem report. Unlike contract or repack operations, we respond with immediate plant trials and share full QC results so partners can see adjustments in real time. Product development in fast-moving food and pharma sectors can’t always wait weeks for lab tweaks, so our direct manufacturing model builds mutual trust and streamlined troubleshooting.
We’ve earned a reputation not just for tight specs, but for clear communication and honest timelines. Customers who’ve fought with shipment delays or ambiguous origins recognize the value in a supply partner with tangible, in-house control. As new regulatory requirements or research needs emerge, we adapt formulation or testing regimes—keeping both the science and the story clean. Every container of hydroxyproline carries not only a validated assay, but also a record of methodical, tested process improvements stacked up over years of real-world production.
Industry trends move quickly: customers expect greener raw materials, digital traceability, and documentation to satisfy both regulators and conscious consumers. Our plant invests in greener enzyme systems and water-saving protocols—not just to tick boxes, but because local regulations and resource scarcity force us to innovate. Digital tools now let us streamline batch records, making audit trails faster and reducing manual errors that used to cost us weeks in potential investigations.
As plant-based alternatives gather speed, we invest in pilot facilities that test fermentation technologies and synthetic biology methods. Many customers want reassurance that supply won’t dry up or drop in quality if the animal-based market faces another shock, so we maintain clear plans for both continuity and next-generation production platforms. These transitions aren’t just technical—they bring shifts in staff skills, process design, and capital allocation. Having a hands-on team, trained on every line of equipment, positions us to bridge new methods with proven performance.
In summing up, hydroxyproline means more than an item on a spec sheet. It links quality raw material, controlled processes, and earned trust. As real-world manufacturers, we hold each drum and bag to the same standards we would want if we were the end user, because from our factory floor, we see how every small detail reaches far down the value chain—affecting research, health, and the reputation of every brand and lab that depends on us.
