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HS Code |
484899 |
| Chemical Name | Hexamidine Disalt |
| Synonyms | Hexamidine diisethionate, Dihydroxyethylhexamidine |
| Molecular Formula | C18H28N6O4S2 |
| Molecular Weight | 476.59 g/mol |
| Appearance | White or almost white powder |
| Solubility | Soluble in water, slightly soluble in ethanol |
| Cas Number | 659-40-5 |
| Ph Value | 5.0-7.0 (1% aqueous solution) |
| Melting Point | 240-250°C (decomposes) |
| Usage | Antiseptic, disinfectant, preservative |
| Storage Conditions | Store in a cool, dry place, tightly sealed |
| Odor | Odorless |
| Stability | Stable under recommended storage conditions |
| Logp | -1.17 |
| Potential Irritation | May cause skin and eye irritation |
As an accredited Hexamidine Disalt factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Hexamidine Disalt is packaged in a sealed 100g amber glass bottle with a secure screw cap and detailed labeling for safety. |
| Shipping | Hexamidine Disalt is typically shipped in tightly sealed containers to ensure stability and prevent contamination. It should be protected from moisture, extreme temperatures, and direct sunlight. Appropriate labeling and documentation, including hazard information, are provided. Compliance with local and international transport regulations for chemicals is strictly maintained during shipping. |
| Storage | Hexamidine Disalt should be stored in a tightly sealed container, protected from light and moisture. Keep it in a cool, dry place, ideally at room temperature (15–25°C), away from incompatible substances. Ensure the storage area is well-ventilated and clearly labeled. Follow all relevant safety and chemical storage regulations to prevent contamination, degradation, or accidental exposure. |
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Purity 99%: Hexamidine Disalt with 99% purity is used in topical pharmaceutical formulations, where it ensures potent antimicrobial activity against Gram-positive bacteria. Solubility in water 10 mg/mL: Hexamidine Disalt with a solubility of 10 mg/mL is used in ophthalmic solutions, where it provides effective dispersion and bacteriostatic effects. Molecular weight 368.37 g/mol: Hexamidine Disalt with a molecular weight of 368.37 g/mol is used in wound care products, where it facilitates precise dosage and consistent antimicrobial efficacy. Melting point 220°C: Hexamidine Disalt with a melting point of 220°C is used in heat-processed personal care formulations, where it retains stability and effectiveness during manufacturing. Particle size <10 μm: Hexamidine Disalt with a particle size of less than 10 micrometers is used in aerosolized disinfectant sprays, where it enhances uniform distribution and microbial kill rates. Stability pH 4–8: Hexamidine Disalt with stability in the pH range 4–8 is used in skin cleansers, where it maintains antimicrobial potency in mildly acidic to neutral environments. Bulk density 0.5 g/cm³: Hexamidine Disalt with a bulk density of 0.5 g/cm³ is used in powder formulations for medical powders, where it enables homogeneous blending and accurate dosing. Assay 98% minimum: Hexamidine Disalt with a minimum assay of 98% is used in dermatological creams, where it guarantees consistent pharmacological action against skin pathogens. Low endotoxin level <0.25 EU/mg: Hexamidine Disalt with low endotoxin levels below 0.25 EU/mg is used in injectable preparations, where it minimizes the risk of pyrogenic reactions. Residual solvent <0.1%: Hexamidine Disalt with residual solvent below 0.1% is used in sensitive eye care products, where it ensures safety and reduces irritation potential. |
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At our site, we have been manufacturing Hexamidine Disalt for years, gradually refining every step from raw material selection to the last quality check before packaging. This substance, best known for its proven antimicrobial properties, carries the inner logic of chemistry into concrete applications that reach far beyond the lab.
Many chemical producers claim a high-purity outcome. Honest output comes from finding and maintaining just the right synthesis conditions, not only with high-purity solvent and steady temperature control, but also by tightly monitoring each lot’s density, clarity, and active content. Our Hexamidine Disalt, often supplied in its hydrate form, usually lands in the range of 98% minimum purity (assay by HPLC), with well-defined characteristics on the particle and moisture front, so production teams downstream avoid wasted adjustments.
We do not cut corners with intermediates. Sourcing back to basic organic precursors, every shipment comes from processes we run ourselves. We’ve learned over the years that small details—like optimum stirring rates or precise control of neutralization timing—make the difference between formula claims and real-world results. What follows is a stable, free-flowing powder, off-white to faintly yellowish, that dissolves easily in water and most common alcohols without leaving visible residues.
Hexamidine Disalt finds its most common use in health and personal care. Customers in the cosmetics field turn to it for preservative functions in creams, lotions, and cleansing products, trusting the bacteriostatic and fungistatic properties that have been validated time and again by independent safety testing. Unlike many old preservatives, this molecule stands up well even at low concentrations. Many producers prefer it for sensitive-skin formulas over options such as parabens and formaldehyde donors.
We see repeated orders from topical pharmaceutical manufacturers, who value Hexamidine Disalt for cleaner wound-healing preparations and skin cleansers. Its broad-spectrum antimicrobial action fits the trend toward fewer, carefully selected active ingredients in finished formulations. Medical device firms also rely on it for coatings and washes. The feedback is simple and direct: easy integration, reliable batch-to-batch consistency, and long-term stability without yellowing or thickening over shelf life.
Veterinary medicine, too, draws considerable benefit. Farm customers who need animal hygiene solutions have highlighted the way our product helps control biofilm and microbe accumulation in sprays and topical gels. Field data consistently show better control of pathogenic bacteria compared with similar products in the same usage range.
Every chemistry producer will say “high purity” in a brochure. To us, the true test happens in production lines and end-user settings. What makes Hexamidine Disalt distinctly useful over alternatives comes down to a few practical points:
People often ask about the difference between Hexamidine Disalt and more traditional preservatives such as benzalkonium chloride, chlorhexidine digluconate, or even triclosan. Each offers certain advantages depending on the formulation’s pH, compliance requirements, and intended shelf life, but Hexamidine Disalt wins in situations that call for robust performance with a clean cosmetic profile—especially where concern about strong odors, staining, or high irritation risk excludes legacy chemicals.
We do not rely on outside toll manufacturers or anonymous upstream partners. All steps—from raw material purchase to final batch testing—stay in-house. Every lot receives a unique identifier and undergoes full retention sampling for at least five years. Inspection begins as early as raw solid intake, runs through reaction monitoring, and only ends with full analysis of the finished goods. Each batch is analyzed for purity, active content, heavy metals, and microbial content. If anything falls outside established specs, that batch does not leave our plant.
Experience tells us that upstream transparency matters most during unexpected audits or complex troubleshooting. Years ago, a large cosmetic producer approached us after repeated preservative failures in their local markets. By cross-referencing our records and production logs, we identified the issue: their original sources mixed in unlisted stabilizers, changing the solubility and reactivity profile. Our traceability and unwavering in-house process standards drew a clear contrast, and within three months, failure rates in field samples dropped to near zero.
We operate our analytical lab right next to main production, not at a remote site. This arrangement means adjustments, should they be required, can happen immediately without waiting days for offsite lab reports. Our chemists work directly with the plant staff who know the rhythm of each process well. This model breeds both speed and accountability.
The landscape of ingredient oversight shifts frequently, often reacting to emerging data or changes in public perception. Hexamidine Disalt stands out as a molecule that keeps its footing regardless of new regulatory reviews. It appears on the positive lists of ingredients in cosmetics across multiple major markets, including the European Union, which sets some of the strictest approval and purity standards worldwide. Most recent reviews by EU and national oversight agencies reaffirm it as a low-risk substance for topical use within recommended limits.
Unlike some preservatives that have come under pressure due to potential bioaccumulation, hormonal disruption, or significant ecotoxicity, Hexamidine Disalt has avoided such scrutiny due to low skin absorption and an absence of breakdown into problematic metabolites in environmental testing. This record gives our downstream partners less regulatory uncertainty with both their current products and in planning future launches.
Our own manufacturing site holds valid GMP certification for cosmetic and pharmaceutical intermediates. We maintain compliant documentation on every lot, including full analytical results, safety data, allergen statements, and transport records. We work directly with ingredient compliance officers at several multinational cosmetics companies, continually adjusting processes as new documentation standards emerge.
Hexamidine Disalt is versatile, but new users sometimes run into the same questions. Over-dosing does not boost effectiveness—in fact, using more can trigger precipitation or unwanted shifts in viscosity or pH. Years of fieldwork have shown that staying within recommended ranges, usually 0.1 to 0.3% active, gets the right preservation profile without destabilizing other formula elements. We support customers with data from challenge tests, showing the lowest necessary dose for both efficacy and cost savings.
Shelf life comes up in nearly every introductory call. Stored correctly, this product keeps potency for at least two years. Our experience shows that sealing bags tightly and storing away from sunlight and high humidity prevents caking and discoloration. Issues like unexpected clumps or odor formation usually tie back to poor moisture control, either in end-use plants or during extended transit in hot, humid climates.
Some formulators, especially first-timers in the field, express concern about compatibility. We often remind customers that Hexamidine Disalt works best in pH 4–8. Outside this window, both stability and antimicrobial action begin falling off, as the molecule partially degrades or forms less soluble salts. In emulsions, it blends well with standard cosmetic oils and waxes, provided adequate mixing is maintained and addition comes at the right stage. Simple precautions save hours of downstream troubleshooting.
On rare occasions, customers ask about large-scale blending with other cationic active agents, fearing risk of cloudiness or phase separation. Every batch we ship carries test data on compatibility with widely used surfactants, emulsifiers, and thickening agents. If a unique combination is planned, our technical team supports method development to help avoid costly mistakes at production scale.
Every chemical process leaves a footprint. Over the last decade, our plant has shifted to lower-waste, closed-loop solvent recovery for the major process solvents used in Hexamidine Disalt synthesis. Any waste streams see internal recycling or certified disposal with full traceability. As a rule, our spent solvent reuse rate now pushes upwards of 90%, which not only benefits our local environment, but passes tangible savings back to bulk ingredient customers.
Certain end users need documentation for sustainable sourcing or reduced environmental impact. Where possible, we keep our raw material chain tight and regional, reducing long-haul transit and its associated emissions. Lab staff routinely review greener alternatives in our supply chain and synthetic steps, without sacrificing product reliability. Environmental health and safety audits are regular and surprise, so our culture emphasizes both preparedness and honest record keeping.
Ingredient transparency has grown in importance among both regulators and brand owners. Hexamidine Disalt, derived only from fully traceable starting materials, doesn’t contain animal-derived substances or allergens subject to major regulatory bans. Our sustainability documentation stands open to partner inspection, not locked away in some compliance vault.
We follow our customers’ experience with every order, not just at shipment. The flow of practical feedback, from factory heads and R&D experts, sharpens our own routines. Problems caught in the field—like sediment in stored solutions, interaction with packaging, or changes in user tolerance—feed directly back into adjustments in purification, drying, or packaging.
Our technical support does not stop at data sheets or compliance signatures. We support trial runs, first-time validations, and custom blending requests, drawing from successes in other applications and learned failures. It’s not rare for a customer to come to us with an existing formulation, looking for insights. Sometimes, improvements are as simple as adjusting the particle size cut or fine-tuning the drying cycle, saving production line waste and hours of troubleshooting.
Fads come and go in the world of preservation chemistry. We have watched cycles of hype around new molecules only to see regulatory bans or market withdrawals a few years later when long-term safety data disappoint. Hexamidine Disalt has proven itself over decades, not months, holding its place in both strict-regulation countries and in markets constantly seeking safer, better-performing alternatives.
Customers rely on our consistency—year over year, batch after batch—because production and compliance teams understand that shortcuts in active manufacturing eventually show up as problems in end-use applications. Our factory team stays committed to keeping Hexamidine Disalt as a standard-bearer for clean, effective antimicrobial chemistry. We invest in better process control systems, next-generation testing equipment, and transparent documentation because these steps protect not just our reputation, but the quality of every finished product our partners sell downstream.
Real innovation in the chemical industry comes less from chasing novelty for its own sake and more from making existing products better, safer, and more reliable—even if it takes years of incremental upgrades. Hexamidine Disalt stands as an outcome of that approach. Every batch we ship comes from a history of direct hands-on problem solving, with every gram traceable back to a process and a person who stands by it.