| HS Code | 344477 |
| Chemical Name | Dl-Pyroglutamic Acid |
| Other Names | DL-2-Pyrrolidone-5-carboxylic acid |
| Molecular Formula | C5H7NO3 |
| Molecular Weight | 129.11 g/mol |
| Cas Number | 98-79-3 |
| Appearance | White crystalline powder |
| Melting Point | 184-186°C |
| Solubility | Soluble in water |
| Ph 1 Solution | 2.4 - 2.6 |
| Purity | ≥98% |
| Boiling Point | 322.6°C at 760 mmHg |
| Storage Conditions | Store in a cool, dry place |
As an accredited Dl- Pyroglutamic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The packaging for Dl-Pyroglutamic Acid features a tightly sealed 500g white HDPE bottle with clear labeling, safety information, and batch details. |
| Shipping | **Dl-Pyroglutamic Acid** is shipped in tightly sealed containers to prevent moisture absorption and degradation. It is typically packaged in amber glass bottles or HDPE containers. Shipping complies with standard chemical transport regulations, including labeling and documentation. The product is handled as non-hazardous and is shipped at ambient temperature unless otherwise specified. |
| Storage | DL-Pyroglutamic Acid should be stored in a tightly sealed container, protected from moisture, heat, and direct sunlight. Keep it in a cool, dry, and well-ventilated area, ideally at room temperature (15–25°C). Avoid storing near incompatible substances such as strong oxidizers. Label the container clearly, and follow all relevant safety and regulatory guidelines for chemical storage. |
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Over many years in chemical manufacturing, few intermediates have shown the adaptability and practical value that DL-Pyroglutamic Acid offers. Produced at our facility from L-glutamic acid by cyclization, DL-Pyroglutamic Acid emerges as a fine, crystalline powder, white or off-white in appearance, with a molecular formula of C5H7NO3. Chemists often call it 5-oxoproline. Its structure and chiral nature—since it contains both D- and L- forms—set it apart from the single-isomer alternatives that exist in the market.
Conversations among manufacturers about batch stability, yield, and quality testing often circle back to experiences with raw materials. We have seen that even a minor deviation in purity or moisture impacts reactions downstream, especially in active pharmaceutical ingredient synthesis or in creating precise peptide sequences. Our standard material, supplied at greater than 99% purity and framed by a moisture content below 0.5%, has helped customers keep their yields on target across dozens of projects. These specifications did not appear by chance; they grew out of trial, error, process refinement, and what we learned from client feedback and our in-house R&D.
DL-Pyroglutamic Acid plays a pivotal role as a building block in pharmaceuticals, food additives, and research applications. In peptide synthesis, practitioners depend on its cyclic structure, which contributes to peptide stability and aids in the formation of complex molecular arrangements. Many APIs (active pharmaceutical ingredients) rely on its presence in the intermediate stages. Customers working in nutraceuticals look for its steady integration into formulations targeting cognitive wellness, while specialty food vendors add it for its flavor-enhancing properties—especially where umami or savory profiles are required.
Working directly with downstream users, we’ve witnessed how batch-to-batch variability can stall production timelines. Our process keeps particle size consistent, typically below 100 microns, to ensure solubility and handling remain efficient whether material is moved from sacks by hand or with automated lines. Regardless of scale, technicians want to avoid clumping and ensure uniform distribution. In our experience, the small particle distribution helps reactors run smoothly, limits the time spent on manual agitation, and encourages more reliable product performance.
The main practical distinction between DL-Pyroglutamic Acid and its single-isomer relatives, L- and D-, centers on versatility and cost. Single-isomer preparations often require additional separation steps and more stringent inputs, which raises price and challenges availability in larger quantities. Many industrial and laboratory processes do not require the biological specificity of pure L- or D- forms; they instead value reproducibility, ease of handling, and compatibility with existing formulations.
Pharmaceutical producers investigating chirality-dependent reactions may specify single-isomer acids—L-Pyroglutamic Acid often for its biocompatibility or D- for specific enantioselective syntheses. Most users in flavors, food research, and technical chemistry achieve their goals with DL-grade, which brings both enantiomers together in a racemic mixture. By offering both forms in a single, cost-saving product, companies shorten procurement cycles and reduce storage headaches without the possibility of cross-contamination between isomer types.
In manufacturing, quality assurance steps beyond periodic checks; it defines a core part of our identity. Each lot of DL-Pyroglutamic Acid goes through multiple control stages—starting from raw material inspection, through crystallization, drying, and finished goods testing. Spectroscopic analysis, chromatography, and moisture determination form part of our daily routine. We have noticed that the closer we stick to measured controls at each stage—rather than only final sampling—the fewer surprises arise, either during our in-house use or further down the line with clients.
Traceability stands as more than a regulatory box to tick. Too often, customers share stories of losing origin details on intermediate materials, especially after repackaging or internal transfers. We provide full origin documentation, alongside certificates of analysis, for each shipment. The manufacturing team keeps digital records accessible for years. This effort gives end users peace of mind; if an audit or investigation calls for supply chain transparency, records can be produced within hours, not weeks.
Sustainability weighs on every conversation about new chemical processes. In DL-Pyroglutamic Acid production, water usage and waste stream management represent the largest sources of environmental impact. From early pilot batches onward, we optimized our crystallization and purification to reclaim as much solution as possible, recycling solvents and minimizing effluent load. The adoption of closed-loop systems and the pursuit of better yield per energy input drive tangible reductions in both cost and environmental footprint.
Handling practices matter because they influence both sustainability and personal safety. DL-Pyroglutamic Acid produces little dust and rarely presents acute toxicity, yet inhalation precautions and protective gear make up standard procedure on our floors. Experienced workers understand that open drums attract moisture from the air, which can affect solubility and hinder downstream processing. Double-sealing and desiccated storage conditions work better than constant monitoring by instruments alone. We keep humidity-controlled storage for all inventory, large or small.
No two clients use DL-Pyroglutamic Acid quite the same way: some dissolve it at scale in jacketed vessels, others dose it by hand for pilot runs in university labs. By talking directly with production techs and R&D teams at customer sites, we see recurring themes—such as reactivity concerns in high-temperature synthesis and the importance of syrup-like solutions to control reaction speed.
Our recommendations come from years working with a product line, not just from reading technical notes. For food-grade clients, cross-contamination concerns dominate, so we dedicated sealed lines and batch separation to protect allergen control. Pharmaceutical and research buyers press us for finer particles and higher purity, so we adapted a supplementary filtration and drying step. Reports of “floaters” or undissolved solids in reactions led to updated QC checks for insoluble matter before packing. Each adaptation grew from actual problems flagged by real users, not from speculation or marketing research.
Purchasing directly from the source means consistent product, technical documentation that reflects real process conditions, and access to engineers who actually oversee the batches. We have seen how indirect supply routes, through traders or repackers, often break the chain of communication. When issues arise—be it mismatched size distribution, purity dips, or labeling discrepancies—direct access to the people who made the product gives a faster path to resolution.
Feedback from longtime customers reveals that support from a manufacturer often speeds solution development. When a client in medical polymers ran headlong into gelling problems related to minor metal contaminants, an open discussion allowed our technical team to pinpoint the issue and tweak a single crystallization parameter. Over time, this direct line of problem solving cuts uncertainty, shortens development cycles, and breeds trust both ways.
Looking to the next decade, growth in peptide therapeutics, cognitive health products, and flavor science will place more scrutiny on DL-Pyroglutamic Acid and how manufacturers ensure its reliability. Automation, tighter in-line controls, and real-time batch tracking raise quality thresholds. Digitized process control and predictive maintenance spot and correct drift in process variables early, limiting off-spec material before it hits the market.
We intend to continue investing in in-process analytics, expanded purification technologies, and more efficient energy recovery from heat-intensive steps. Conversation with leading scientists and procurement officers makes clear that demand will rise for materials meeting both traditional benchmarks—high purity, traceability, cost control—and new expectations: reduced carbon impact, renewable feedstocks, and transparency all along the chain.
Industry-wide sharing of best practices, as well as honest dialogue between manufacturers and end users, continues to shape how DL-Pyroglutamic Acid is made, tested, and delivered. Experience in this business has taught us that innovation rarely emerges from isolated research or generic recommendations; real progress comes from listening to the exact needs of the people using our materials, adapting those lessons back into our process, and repeating the cycle.
The story of DL-Pyroglutamic Acid at our facility evolves with each year, shaped by industry shifts, regulatory changes, and the unforgiving realities of chemical process management. We have learned, through direct experience, that controlling small process details results in bigger, more dependable gains in performance for our users. Clear communication with buyers, rigorous quality steps, and a willingness to adapt manufacturing to new challenges have made this product line a reliable pillar, whether destined for food science, fine chemicals, or advanced pharmaceuticals. As the environment for chemical manufacturing transforms, practical experience and close customer engagement will continue to guide how DL-Pyroglutamic Acid—and every batch that follows—supports downstream innovation and success.
