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HS Code |
558418 |
| Product Name | Tert-Butyl Chloroacetate |
| Cas Number | 107-59-5 |
| Molecular Formula | C6H11ClO2 |
| Molecular Weight | 150.60 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 142-144°C |
| Density | 1.057 g/mL at 25°C |
| Refractive Index | 1.415-1.418 |
| Melting Point | -36°C |
| Flash Point | 46°C |
| Purity | Typically ≥98% |
| Solubility | Insoluble in water, soluble in organic solvents |
| Smiles | CC(C)(C)OC(=O)CCl |
| Inchi | InChI=1S/C6H11ClO2/c1-6(2,3)9-5(8)4-7/h4H2,1-3H3 |
| Storage Temperature | Store at room temperature, keep container tightly closed |
As an accredited Tert-Butyl Chloroacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Tert-Butyl Chloroacetate, 500g, supplied in a sealed amber glass bottle with a child-resistant screw cap and labeled hazard symbols. |
| Shipping | Tert-Butyl Chloroacetate should be shipped in tightly sealed containers, away from sources of ignition and incompatible materials such as strong bases or oxidizers. It must be transported according to regulations for hazardous chemicals, preferably under cool, dry conditions, and clearly labeled to indicate its corrosive and harmful nature. |
| Storage | Tert-Butyl Chloroacetate should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and moisture. It should be kept away from strong oxidizing agents, acids, and bases. Proper chemical storage cabinets designed for flammable liquids are recommended. Use secondary containment to prevent spills and label the container clearly. |
Applications of Tert-Butyl Chloroacetate in Industrial ManufacturingTert-Butyl Chloroacetate serves as a key intermediate in several advanced chemical manufacturing routes. Our expertise in its production ensures consistent purity and specification, supporting leading customers in specialty synthesis. The following application scenarios demonstrate established downstream integrations and finished goods in the pharmaceutical, agrochemical, and specialty chemical sectors. 1. Synthesis of Pharmaceutical Intermediates for β-Lactam AntibioticsLeading pharmaceutical manufacturers incorporate this material in multi-step synthesis routes to protect carboxyl functional groups during β-lactam antibiotic intermediate production. Its use enables selective reactivity management, particularly during the formation of penem and carbapenem skeletons in pilot-to-commercial batch and continuous processes. The tert-butyl ester moiety improves purification yields and facilitates downstream deprotection under mild, controlled acidic conditions. Industry compliance standards
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2. Agrochemical Intermediate for Herbicide SynthesisAgrochemical synthesis routes utilize tert-butyl chloroacetate as an alkoxycarbonylation agent for constructing key intermediates in selective herbicide actives. Its use in the protection of glycine and related amino acid derivatives enables subsequent steps requiring base stability and allows high-yield isolations, reducing side reactions. The controlled deprotection sequence supports efficient process scale-up for both early and late-stage pipeline compounds. Industry compliance standards
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3. Fine Chemical Synthesis for Specialty MonomersProducers of specialty acrylate, methacrylate, and related polymer monomers employ this raw material as a precursor for esterification, leading to high-purity tert-butyl ester monomers. Its attributes allow consistent batch scale control and reliable downstream polymerization, especially where controlled hydrolysis or ester group removal is required for the targeted polymer backbone. The application streamlines purification steps, maintaining narrow molecular weight distributions essential for specialty coatings and adhesives. Industry compliance standards
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4. Custom Synthesis for Active Ingredient Contract ManufacturingContract manufacturing organizations (CMOs) and custom synthesis labs use this intermediate for temporary ester protection during the preparation of complex small molecules, especially where selective cleavage is essential to preserve other functional groups. Its role is critical in processes requiring multi-stage purifications and late-stage deprotection. Custom projects may tailor the stoichiometry and deprotection strategy specifically to project goals, enhancing both yield and purity benchmarks in highly regulated production environments. Industry compliance standards
Typical usage ratio
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As a chemical manufacturer with decades of experience in halogenated esters, we have worked extensively with Tert-Butyl Chloroacetate. Watching the demands in fine chemicals evolve each year, we see the role of this compound grow steadily in both pharmaceuticals and organic synthesis. Chemists value it for its unique balance of reactivity and selectivity, which doesn’t always show up in other chloroacetate esters.
Manufacturing Tert-Butyl Chloroacetate requires tight process control from chlorination of acetic acid derivatives through strict distillation, and our processes support high-purity output in bulk. Our standard model typically exceeds 98% purity by gas chromatography. Water content remains low, keeping hydrolysis in check, and trace metal analyses help meet international regulatory needs, especially for active pharmaceutical ingredient (API) and agrochemical production. Each batch passes assays for color, acidity, and residual solvents. Fine-tuning these specifications didn’t happen overnight. Decades of practical troubleshooting in production lines led to the most reliable setpoints.
Industry standards keep shifting, both from regulatory bodies and customers. Most pharma customers demand a level of product documentation and batch certification that’s backed by traceability through every step of the synthesis and workup. We see requests for detailed impurity profiles and photostability data. Generics companies lean on us for data on extractables and leachables, as we serve manufacturers of both intermediates and finished drug substances. Throughout, the persistent focus is tight batch-to-batch reproducibility and clean analytical traces that avoid unknown peaks. Our technical teams work with customers to resolve issues on both the lab scale and in commercial downstream reactions.
Not all chloroacetate esters suit all applications. Tert-Butyl Chloroacetate offers several distinct advantages in the esterification and alkylation fields. Lab and pilot plant teams tell us that the tert-butyl group introduces sterics that slow down undesired transesterification or hydrolysis side reactions. This attribute matters in multi-step synthesis, especially during the preparation of β-amino acids and other building blocks where selectivity is critical. Methyl or ethyl chloroacetate, by contrast, often show up as competitive substrates, but they lead to mixtures of products under similar conditions. Our customers have moved away from those lighter analogues when cleaner conversions or more stable intermediates are required.
Handling and storage offer some clear contrasts too. Methyl and ethyl derivatives often display higher volatility and require additional safety precautions if used at scale. Tert-Butyl Chloroacetate, once properly sealed and stored away from light, shows reduced tendencies toward decomposition. Every so often, we troubleshoot storage or shipment conditions for buyers in climates with extreme humidity. Moisture pick-up leads to hydrolysis of the chloroacetate group, forming tert-butyl glycolate and hydrochloric acid. Our technical teams address these problems at the packaging stage by recommending high-density polyethylene drums and desiccant packs for extended transit.
Synthesis of pharmaceutical intermediates stands out as the leading use for Tert-Butyl Chloroacetate. We have watched its adoption increase as global manufacturing shifts toward more sophisticated small-molecule APIs. The reactivity of the chloroacetate group allows for selective transformation into β-haloamides and related scaffolds, which form the backbone for many antiviral and oncology drug candidates. In our experience collaborating with custom synthesis houses and CDMOs, robust lot traceability and impurity data enable Tert-Butyl Chloroacetate to fit smoothly into regulated production lines.
Agrochemicals and specialty chemicals companies put this intermediate to work for producing herbicide and insecticide actives, often via routes where other esters would lead to less stable intermediates or where slower hydrolytic cleavage gives better separation from co-products. In academic research, we see Tert-Butyl Chloroacetate pop up in developing blocking groups, linker synthesis for glycoconjugates, and as a winsome building block in new reaction pathway exploration. Chemists continue to discover innovative ways to use its favorable physical and chemical properties.
Polymer chemists approach us to produce Tert-Butyl Chloroacetate for reactive monomer synthesis and grafting reactions. Its steric bulk compared with methyl or ethyl variants helps modulate length and branching in specialty copolymers. The same stability under common reaction conditions draws interest from firms producing coatings, adhesives, and high-performance resins, where end-product consistency matters for large-scale customers.
In chemical manufacturing, small improvements in process translate to meaningful differences for end users. Early on, we recognized that standard chlorination approaches using elemental chlorine or sulfuryl chloride could generate colored by-products, introducing cleanup headaches for downstream chemists. By optimizing our chlorinating systems and employing modern continuous-flow reactors, we’ve increased both output and color consistency. Automated in-process monitoring allows us to maintain lower impurity loads, even at higher run rates.
Having in-house glass-lined reactors means we can sidestep corrosion issues that would otherwise throw off product quality or necessitate frequent shutdowns for maintenance. Many competitors who rely on multipurpose equipment struggle with contamination or variability, especially when switching between different chloroacetate esters. An investment in dedicated lines for Tert-Butyl Chloroacetate paid off with reduced cross-contamination—this matters to pharmaceutical customers whose regulatory filings depend on tight control of trace carryovers.
We focus on solvent recovery from the outset. After chlorination and esterification, we reclaim and purify organic solvents, cutting down on both emissions and production costs. This attention to waste management not only tightens margins but also keeps us one step ahead of tightening environmental regulations. Partners appreciate our ability to provide environmental impact data that supports their own sustainability reporting.
Staying proactive on safety keeps our teams incident-free. Tert-Butyl Chloroacetate brings hazards typical of organohalide esters—skin and eye irritation, corrosivity, and a need for controlled ventilation during charge and discharge operations. Regular safety training, local exhaust ventilation, and robust bulk handling protocols keep incident numbers at zero. This focus on hands-on worker protection feeds back into customer trust. They receive materials handled with care and consistency.
We field regular questions about choosing between tert-butyl, methyl, and ethyl chloroacetates for specific transformations. In direct esterifications, tert-butyl provides a step up in hydrolytic stability. Methyl or ethyl esters hydrolyze readily under basic or acidic conditions, sometimes producing unwanted by-products and complicating purification. Tert-butyl’s bulk retards such cleavage until purposely triggered under acidic conditions, providing chemists with another handle on selectivity. This proves invaluable in multi-step sequences where orthogonal protection and deprotection strategies save time, cost, and excessive solvent use.
Storage needs differ markedly. We see best results by keeping tert-butyl derivatives in sealed, light-proof drums at room temperature. The product remains clear and colorless for months, compared to the faster yellowing and degradation experienced with more volatile methyl and ethyl analogues.
Reaction selectivity is another standout feature. Alkylations run with tert-butyl chloroacetate generally display higher yields of the target compound, thanks to the reduced side reactions. This means less time spent re-purifying or adjusting downstream steps—key wins for cost control. Shelf life and stability always arise in pharmaceutical audits, and tert-butyl’s light resistance translates to fewer customer complaints or returned shipments.
Our team remains vigilant to evolving expectations from global regulatory agencies. Tert-Butyl Chloroacetate supplies destined for the pharmaceutical sector require comprehensive documentation, impurity panels, and validated analytical methods that stand up to scrutiny in audits. We work directly with regulatory affairs specialists, supplying stability data, impurity fate studies, and toxicology reports where available.
Interest in sustainable sourcing continues to grow. Over the years, we have adopted greener chemistry principles in the plant, favoring lower-impact reagents and solvents, tighter solvent recycling, and emissions mitigation. Large downstream clients reach out for life cycle analysis support and want reassurance that their supply chains minimize environmental burdens.
Supply chain security draws concern as many countries look for reliable partners that can supply not just product but continuity. Our bulk storage capacities, multi-modal logistics partnerships, and signed long-term supply agreements grant customers greater peace of mind, especially during periods of regulatory upheaval or raw material price swings. We maintain substantial raw material reserves specifically for tert-butyl chloroacetate so that we can buffer market shocks.
Day-to-day, our teams engage directly with formulation chemists, process engineers, and purchasing managers to resolve technical pain points. We support customers in kinetic studies when they scale up, source analytical standards for impurity tracking, and help establish robust cleaning validation for switchovers. We don’t deliver product and walk away—partnerships thrive on continued dialogue, regular site visits, and rapid troubleshooting when side reactions or storage questions arise.
Some customers ask for product tailored to specific needs. We have responded with custom blends or bespoke packaging—smaller lots for high-purity research applications, or bulk deliveries in transport tankers for commercial customers. Alongside, we track feedback through structured post-shipment follow-ups. These hands-on connections drive us to fine-tune every aspect of production and logistics, resulting in fewer complaints and increased customer retention.
Many buyers cite us as the fastest problem-solvers when they encounter a hiccup or have an unplanned change in production needs. We have developed a flexible production planning system that can respond quickly to market signals, drawing on digital twins of our reactors to plan resource needs days in advance. This agility underscores our commitment to mutual success.
We invest heavily in R&D to improve the yield, purity, and cost-effectiveness of Tert-Butyl Chloroacetate. In-house chemists track emerging literature while piloting process improvements with small-scale continuous reactors. Real-world feedback from large- and mid-scale partners informs tweaks in raw material feeds, chiller settings, and workup protocols. Environmental health and safety (EHS) requirements continue to evolve, so we stay alert for greener chlorinating agents and safer, less volatile solvents. Early adoption of digital monitoring and process automation enhances both output and employee safety.
Proactively, we benchmark our product’s performance against competing international suppliers, using round-robin testing in customer labs. Collaborating with academic and industry partners, we sponsor studies on novel uses or improved downstream handling for Tert-Butyl Chloroacetate. This sharpens our responsiveness to changing industry needs, bringing in new business from surprising corners of specialty synthesis.
Within our operations, Six Sigma and lean manufacturing principles guide cost-control and process stability efforts. Metrics such as cycle time, energy use per ton, and rework rates influence management’s approach to daily operations. Cumulative incremental improvements across several years have pushed our defect rate lower, meaning customers spend less time vetting incoming product and less money resolving non-conformances.
Tert-Butyl Chloroacetate’s sensitivity to moisture and light demands robust packaging and disciplined warehouse practices. Leaks or exposure during transit translate into both safety risks and costly product loss. To prevent these problems, we designed sealed drum linings and recommend cool, dark, low-humidity warehouse storage. Over time, we have analyzed retention samples and compared degradation rates among packaging types. High-density polyethylene drums with tamper-evident seals outperform metal containers, particularly in hot, humid regions. This approach cuts out routine problems like hydrolysis by-products and keeps customer workflows uninterrupted.
Shipping regulations on organohalides have only gotten stricter, with increased scrutiny on hazardous materials logistics. Our in-house compliance team follows global dangerous goods regulations and regularly retrains logistics staff. In high-volume orders, we coordinate with carriers familiar with chemical-specific documentation, reducing customs delays or shipment rejections.
On the usage front, customers switching from methyl or ethyl chloroacetate may encounter longer reaction times due to tert-butyl’s steric hindrance. To address this, our application chemists share optimization data and rerun pilot reactions to help chemists tweak conditions, often uncovering benefits in selectivity and yield. Instead of generic technical sheets, this collaboration brings targeted solutions that shorten time to market for new products built on our intermediates.
As active participants in both global and local supply chains, we observe market shifts and work to cushion customers from volatility. Periods of raw material shortage or logistical bottlenecks test the resilience of companies at every tier. By maintaining buffer stocks of key reagents and working with alternate suppliers, we protect both our own output and downstream users against unexpected delays. We review supply chain risks quarterly and initiate scenario planning exercises to keep disruption time to a minimum.
Exchange rates, energy prices, and import-export policies all play roles in the landed cost of intermediates like Tert-Butyl Chloroacetate. We track these influences and keep customers informed of changes that might affect their planning cycles. Partners benefit from transparent communications, advanced warning of potential price shifts, and reliable product availability. These practices foster stronger trust and longer-term relationships than generic, price-driven sales approaches.
New applications continue to emerge as customers advance innovative therapies, new agrochemical actives, and high-value specialty materials. The controlled reactivity, selective hydrolysis, and manageable hazards of Tert-Butyl Chloroacetate ensure its continued relevance in chemical synthesis. Process and regulatory innovations, customer-driven collaborations, and a sharp focus on reliability will shape its path forward. Through a sustained commitment to quality, safety, and transparency, we help chemists and engineers devote energy to building the future—knowing the intermediates they rely on will perform as promised.
