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HS Code |
465872 |
| Cas Number | 402-24-6 |
| Molecular Formula | C7H4F3NO2 |
| Molar Mass | 191.11 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Density | 1.393 g/cm³ |
| Melting Point | -5 °C |
| Boiling Point | 174-176 °C |
| Solubility In Water | Insoluble |
| Flash Point | 62 °C |
| Refractive Index | 1.509 |
| Vapor Pressure | 0.6 mmHg (25 °C) |
| Synonyms | 4-Nitrobenzotrifluoride, p-Nitrobenzotrifluoride |
As an accredited Nitrobenzotrifluoride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Nitrobenzotrifluoride is packaged in a 500 mL amber glass bottle with a secure screw cap and chemical hazard labeling. |
| Shipping | Nitrobenzotrifluoride should be shipped in tightly sealed, chemical-resistant containers, clearly labeled, and compliant with relevant transport regulations (such as DOT or IATA). It must be protected from heat, moisture, and incompatible materials, and transported by authorized carriers trained in handling hazardous chemicals. Ensure all documentation accompanies the shipment. |
| Storage | Nitrobenzotrifluoride should be stored in a cool, dry, and well-ventilated area, away from sources of heat, ignition, and incompatible materials such as strong oxidizers or acids. Keep the container tightly closed and properly labeled. Use appropriate chemical-resistant containers, and protect from physical damage. Store in accordance with local, regional, and national regulations for hazardous chemicals. |
Applications of Nitrobenzotrifluoride in Industrial ManufacturingNitrobenzotrifluoride is an essential intermediate across multiple industrial sectors, especially in high-value agrochemical, pharmaceutical, pigment, and polymer applications. As a chemical manufacturer, we address advanced downstream requirements by supporting compliance, usability, and process continuity in each industry-specific context. 1. Agrochemical Intermediate SynthesisIn crop protection production, manufacturers use nitrobenzotrifluoride as a key building block for selective herbicides and insecticides. Its strong electron-withdrawing and fluorinated properties allow downstream processes to fine-tune bioactivity profiles and improve thermal and UV stability of active ingredients. Process teams typically introduce this chemical during the acylation or halogenation steps to create advanced intermediates for sulfonylureas, triazines, and fluoro-substituted aromatic pesticides. Industry compliance standards
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2. Pharmaceutical Intermediate for Active Ingredient SynthesisLeading pharmaceutical companies employ nitrobenzotrifluoride to introduce fluorinated aromatic rings in advanced API synthesis, particularly within CNS drug candidates and anticancer molecules. Downstream chemists leverage this compound to enhance metabolic stability, boost bioavailability, and optimize pharmacokinetic characteristics. The substance enters synthesis before the reduction or cyclization steps and undergoes further substitution to generate key heterocyclic intermediates. Industry compliance standards
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3. High-Performance Pigment and Dye ManufactureNitrobenzotrifluoride serves as a foundation in the synthesis of specialty dyes and pigments, particularly azo and anthraquinone systems for demanding applications. Colorant producers utilize its electron-deficient ring structure to achieve desired colorfastness, chemical resistance, and light stability—critical attributes in plastics, fiber, and coatings coloration. Integration typically occurs during diazotization, coupling, or further reduction to amine intermediates. Industry compliance standards
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4. Specialty Polymer Modification and Fluoropolymer AdditivePolymer manufacturers use nitrobenzotrifluoride derivatives to introduce fluorinated and nitroaromatic functionalities in specialty engineering polymers, such as polyimides and liquid crystal polymers. Its chemical structure enables downstream teams to adjust dielectric, flame retardant, and weathering properties of finished materials. Manufacturers typically introduce the material during monomer synthesis or copolymerization steps. Industry compliance standards
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5. Electronic Chemicals and Liquid Crystal PrecursorsDownstream electronic chemical producers employ nitrobenzotrifluoride as a precursor in synthesizing fluorinated aromatic compounds, essential for advanced display technologies and high-frequency printed circuit substrates. Its unique structure enables precise control over phase transition temperatures and permittivity properties. Integration happens primarily during precursor halogenation, reduction, and subsequent condensation reactions for specialty liquid crystal materials. Industry compliance standards
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6. Fine Chemical and Custom Synthesis ApplicationsContract manufacturing organizations and fine chemical houses select nitrobenzotrifluoride for its ease of functionalization in building advanced intermediates for perfumery, specialty additives, and laboratory reagents. Chemists systematically modify its nitrated and trifluoromethyl aromatic core to access niches where high purity, controlled reactivity, and strong electron-withdrawing effects are required for downstream derivatization or scale-up. Industry compliance standards
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Working on the factory floor and in the labs, we’ve handled Nitrobenzotrifluoride—also known as NBTF or 4-Nitrobenzotrifluoride—daily for years. 4-Nitrobenzotrifluoride (CAS 402-43-7) stands out in our line due to its para-positioned nitro group on a benzene ring, attached to a trifluoromethyl moiety. Its structure brings unique reactivity and functionality. Over time, we’ve optimized our processes to deliver NBTF with high purity, reliability, and consistency, because chemists and engineers depend on repeatable results batch after batch. Our exposure to multiple customer needs taught us why NBTF continues to gain interest across both large-scale and small-batch operations.
NBTF is an aromatic compound, C7H4F3NO2, with a molecular weight of about 191.1 g/mol. The trifluoromethyl group brings both stability and uncommon reactivity patterns. Colleagues in synthesis tell us that this group influences electron density, pushing the molecule to behave differently compared to simple nitrobenzenes or other halogenated aromatics. This has a crucial impact whenever selectivity or resistance to harsh conditions matter. When making intermediates or exploring new APIs, these kinds of differences shape the choices a professional makes.
In our experience, NBTF appears as a pale yellow liquid at room temperature. Its boiling point sits around 175-177°C at 20 mmHg, and it shows a melting point near -1°C. NBTF’s density measures approximately 1.47 g/cm3 at 25°C. The compound dissolves well in common organic solvents such as ethanol, ether, and dichloromethane, which simplifies handling for organic synthesis professionals. Unlike some related compounds that solidify quickly or require specific temperatures for storage, NBTF remains manageable in typical factory and laboratory conditions.
During decades of manufacturing, the difference between NBTF and close relatives like nitrobenzene or trifluoromethylbenzene becomes clear. The presence of both electron-withdrawing nitro and trifluoromethyl groups creates a molecule distinctly less reactive toward electrophilic aromatic substitution but more resilient in situations involving nucleophilic displacement. In dark rooms filled with the chatter of glass reactors and the hum of pumps, these subtle shifts change everything—especially for downstream chemistry.
NBTF’s robust nature gives chemists a starting material where unwanted side reactions diminish. It holds up in both acidic and basic media far better than old-school nitroaromatics or less substituted benzenes. This reliability is particularly important in scale-up environments, where inconsistent behavior leads to wasted lots and headaches for production workers and QC managers alike.
The people who buy from us rarely need an introduction to the core applications—and as manufacturers, we have an up-close view of the possibilities. In pharmaceutical and agrochemical synthesis, NBTF shines as a core intermediate. We see customers using it to craft advanced molecules for new drugs or crop protection agents. Its fluorinated nature influences pharmacokinetics, bioavailability, and metabolic stability—factors no research team can afford to ignore.
In dye and pigment production, teams take advantage of NBTF’s ability to introduce both color and chemical resistance. Some of our oldest clients send feedback on improved persistence in their finished products. NBTF-derived compounds resist fading and breakdown better than materials based on simpler precursors, thanks to the presence of the trifluoromethyl group. In specialty polymer work, NBTF imparts unique characteristics, allowing downstream manufacturers to meet specific thermal or chemical demands.
Over the years, we’ve shipped NBTF to research labs and pilot plants tackling new synthetic routes: Whether as a raw material for nucleophilic aromatic substitution or as a strategic functional group installer, we make sure each drum meets strict impurity control and moisture standards. Once, a partner in the pharmaceutical development field highlighted reduced side product formation compared to traditional nitrobenzene: They could push reactions harder, shorten purification steps, and cut batch failures. That made a difference not only in lab time, but real-world bottom lines.
In dye chemistry, teams report that starting from NBTF allows easier modification and downstream processing. We’ve adjusted our distillation process to supply large, low-impurity batches for these customers. Their feedback drives us to refine our standards and support their success. Our collective experience across hundreds of shipments means that both routine and challenging projects rely on the same quality every time.
Colleagues often ask us: How does NBTF measure up against regular nitrobenzene, or even trifluoromethyl-substituted benzenes without a nitro group? We see three major differences. First, the electron-withdrawing effect is much stronger in NBTF, bringing a noticeable suppression of unwanted side reactions in many aromatic substitution processes. Many users come back to report reproducibly higher yields in those transformations.
Second, the presence of fluorine improves product stability—an observation echoed by process development specialists. In a side-by-side run, chemists have told us they get cleaner HPLC traces using NBTF-derived intermediates. Third, as opposed to ortho- or meta-nitro analogues, the para configuration of NBTF opens up more targeted downstream modifications. That means more predictability and less risk during API, dye, or agrochemical synthesis.
Our equipment operators spend hours piping and transferring NBTF around the plant, and we have learned plenty about its physical behavior that books rarely mention. Despite its significant vapor pressure at room temperature, proper containment and routine ventilation handle any odors or vapors without special issues. The liquid nature at room temperature also allows straightforward pumping, metering, and loading for processes on scales ranging from lab flasks up to full tankers.
We keep an eye on direct skin contact or long-term inhalation—so proper gloves, goggles, and vapor extraction are in place throughout our production lines. Our internal guidelines reflect not just regulation but hard-won experience from years on site. Strict loading and QC routines prevent contamination both inbound and outbound, something critical in regulated environments like drug manufacture.
Molecular purity affects every reaction NBTF appears in, and as manufacturers we feel the responsibility more than anyone down the chain. We use in-line and batchwise HPLC, GC, and NMR to ensure each drum and container meets strict control on isomers, water content, and trace metals. Every reactor run gets tracked, with samples archived for future reference. Lab teams run multiple purity checks on random outlots, and the feedback loops between QA and operations stay tight.
We’ve learned that small impurities—sometimes invisible to the usual analysis—can make or break a downstream reaction. That’s why we sample at every mixing point and enforce documented calibration routines. If issues ever crop up in the QC lab, we trace the source and respond quickly. Our years of feedback from research and production partners allow us to improve, batch after batch.
As end-to-end manufacturers of NBTF, we hear the pressure every time procurement teams call after a shipment delay, elsewhere, causes missed project milestones. By managing our process from raw material sourcing through final drum filling, we control timing and availability in ways brokers simply can’t match. Safety stocks of key inputs and tested process flexibility let us handle periodic swings in customer demand. It’s not just a matter of running reactors—regular plant maintenance, robust operator training, and rigorous audit routines make the difference between routine fulfillment and last-minute headaches for customers.
Our logistics crew works closely with documentation experts, so regulatory shipments travel on time—even with increased attention on dangerous goods. We’re not perfect, but years of direct trade with regional and global partners tells us what to prepare for, what to double-check, and where to invest in redundancy.
We’ve watched the regulatory landscape for NBTF and related fluorinated aromatics grow more complex. In our experience, this pushes manufacturers to step up environmental controls, minimize waste, and invest in safe handling practices. Our plant runs advanced scrubbers and distillation residue treatment systems to keep emissions and effluents within permitted limits.
We track developing regulations in all our destination markets, and have invested to meet Reach, TSCA, and other major compliance regimes. Audits and customer inspections happen regularly—our direct involvement from raw material to final packaging means we retain the knowledge, paperwork, and practical insight needed to respond quickly. Customers developing regulated end-products often reach out for support with technical files, traceability, and regulatory queries. Decades in this industry taught us responsiveness here can mean the difference between a smooth project launch and costly delays.
NBTF’s role stretches far beyond any one application—on the ground, we observe both established and emerging industries increasing their demand. In the years since fluorinated aromatic intermediates began replacing more traditional building blocks, research and production teams have pushed the limits of performance in nearly every organic synthesis field. New methodologies, which we follow closely through industry seminars and customer collaboration, now hinge on reproducible, high-purity NBTF inputs to reduce time to result and enhance yield.
We regularly receive technical questions about customizing the impurity profile or scaling up to pilot or production scale. R&D chemists sometimes need tighter control on metallic ion content, while polymer specialists want assurance about trace water or specific byproduct absence. We tailor our process in response, often developing custom purification or analytical procedures guided by our own QC staff.
Customers’ biggest challenges often come down to batch variability, contamination, or logistics breakdowns from overseas suppliers. As the original producer, we solve these problems by keeping the entire process in-house. Whenever a research group needs a small tweak on color or impurity, we work directly with them, running split batch samples and adjusting purification steps until the grade fits. In cases where lead times or export paperwork cause slowdowns, we leverage our in-house regulatory team to keep shipments timely and avoid surprises at the port.
We learned in the trenches that communication with the chemists using our product matters just as much as the material itself. Whether it’s an unexpected result on a pilot run or a request for documentation, our ability to answer quickly—across language and time zones—forms lasting partnerships. Routine reporting, regular feedback loops, and open access to lab data keep misunderstandings low and results consistent.
The trends point to increased demand for NBTF and related molecules, especially as regulatory approval drives up the need for predictable, reliable intermediates. Our own investment focuses on keeping quality high, availability consistent, and the product profile stable. We anticipate shifting customer requirements and adjust our processes, whether for tighter impurity control or improved transport security.
We’ve added extra analytical methods to our quality arsenal and upgraded storage and drum-filling infrastructure to keep pace with greater scrutiny from both regulators and supply chain auditors. Direct lines to the chemists and engineers using NBTF keep us grounded—so we never invest in features or claim advantages that don’t translate to real value in the lab or production hall.
Nitrobenzotrifluoride’s niche grows every year. Its distinct chemical structure, coupled with insights from decades of direct manufacture, allows us to deliver an intermediate trusted by innovators in pharmaceuticals, agrochemicals, dye manufacture, and specialty polymers. We know from experience that consistency, reliability, and a willingness to adapt to unique challenges separate an ordinary supplier from a real manufacturing partner. By controlling every step, and learning from every customer outcome, we ensure each batch offers a foundation—not a liability—for the next breakthrough.
