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HS Code |
578345 |
| Chemical Name | N-Isopropyl-N-Phenyl-Chloroacetamide |
| Molecular Formula | C11H14ClNO |
| Molecular Weight | 211.69 g/mol |
| Appearance | White to off-white crystalline solid |
| Melting Point | 65-68°C |
| Density | 1.13 g/cm³ (estimated) |
| Solubility In Water | Slightly soluble |
| Cas Number | 68359-57-5 |
| Pubchem Cid | 352365 |
| Smiles | CC(C)N(C1=CC=CC=C1)C(=O)CCl |
| Inchi | InChI=1S/C11H14ClNO/c1-9(2)13(10-6-4-3-5-7-10)11(14)8-12/h3-7,9H,8H2,1-2H3 |
| Storage Conditions | Store in a cool, dry, well-ventilated area |
As an accredited N-Isopropyl-N-Phenyl-Chloroacetamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 500g of N-Isopropyl-N-Phenyl-Chloroacetamide is supplied in a sealed, amber glass bottle with a tamper-evident cap and hazard labeling. |
| Shipping | N-Isopropyl-N-Phenyl-Chloroacetamide should be shipped in tightly sealed containers, protected from moisture and incompatible substances. Transport under cool, dry conditions in accordance with local, national, and international regulations for hazardous chemicals. Ensure proper labeling and include safety documentation. Handle with appropriate PPE, and avoid exposure to heat and direct sunlight during transit. |
| Storage | N-Isopropyl-N-Phenyl-Chloroacetamide should be stored in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidizing agents. Store the chemical in a tightly sealed, labeled container made of a compatible material, and avoid moisture exposure. Ensure proper secondary containment and access is restricted to trained personnel, following standard laboratory chemical storage protocols. |
Applications of N-Isopropyl-N-Phenyl-Chloroacetamide in Industrial ManufacturingN-Isopropyl-N-Phenyl-Chloroacetamide serves as a critical intermediate and process additive across pharmaceuticals, agrochemicals, polymer synthesis, and dye manufacturing. As an original manufacturer, we ensure compliance and high purity to support demanding industrial customers with clear technical support for every downstream segment. 1. Pharmaceutical Intermediate for Local Anesthetic SynthesisPharmaceutical manufacturers incorporate this compound as a key acylating agent in the synthesis of amide-based local anesthetics, such as phenacetin derivatives and related compounds. The precise acylation step requires stringent control of reaction parameters to meet API production standards. Our product undergoes rigorous QC to match regulatory spectral and impurities profiles for pharmaceutical precursors. The intermediate enters the synthetic route at the stage preceding final coupling or amidation, directly impacting product assay and residual solvent determinations before formulation into injectable and topical forms. Industry compliance standards
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2. Agrochemical Intermediate for Selective Herbicide ProductionSpecialty agrochemical producers use this compound in the synthesis of chloroacetamide-type herbicides. The intermediate plays a vital role in the N-alkylation step for selective herbicide actives, where precise ratio control prevents off-target activity and minimizes environmental residuals. We deliver consistent batch-to-batch specification, focusing on trace solvents and low halide contamination demanded by pesticide registration authorities. The product typically enters as an alkylating agent during the mid-stage condensation, preceding formulation into EC, SC, or WG agrochemical doses intended for broadleaf and cereal crop application. Industry compliance standards
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3. Reactive Additive in Specialty Polymer ManufacturingPolymer compounders employ this chloroacetamide as a chain stoppers and functionalizing agent in the production of specialty polyamides and engineering resins. Its incorporation modulates molecular weight and imparts site-selective halogenation, critical for end-use applications in automotive and electronics. Our material offers consistent reactivity profiles and narrow impurity bands required for high-performance polymer lines. Dosing protocols focus on limiting side reactions that could impact downstream mechanical properties. The introduction occurs at pre-polymerization reactor charging, under nitrogen atmosphere and specific temperature ramps prior to catalyst introduction. Industry compliance standards
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4. Intermediate in Azo and Anthraquinone Dye SynthesisIndustrial dye manufacturers rely on this raw material as an acyl donor in the synthesis of complex azo and anthraquinone dyes. Its structure ensures targeted activation of chromophore coupling reactions, greatly influencing dye bath fastness and color brilliance. Our process control offers ultra-low residual halides and color bodies demanded by international textile dye standards. Dosing levels adjust in response to dye bath yield calculations and end-use coloration intensity targets. Integration occurs during the acylation or N-alkylation phase, prior to workup, filtration, and spray drying for dye standardization. Industry compliance standards
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Our facility has specialized in the production of fine and specialty chemicals for decades, and N-Isopropyl-N-Phenyl-Chloroacetamide stands out by how it combines reliable reactivity with targeted selectivity. The molecular structure, featuring the isopropyl and phenyl groups attached to the chloroacetamide backbone, offers distinct behavior in synthesis compared to more basic chloroacetamides. In each batch, we watch for consistent molecular alignment and purity, measured by strict in-process checks, so researchers and formulators avoid inconsistency during downstream functionalization.
Our standard model, produced to an assay exceeding 99%, appears as a solid crystalline product with a melting point closely aligned with pure reference material. We document trace impurities at each stage, not only meeting regulatory thresholds but also ensuring downstream chemical processes stay reproducible. This commitment pays off for applications involving agrochemical intermediates, custom pharmaceutical synthesis, and specialty materials research.
You can spot the difference between lab-scale batches and full-scale runs of N-Isopropyl-N-Phenyl-Chloroacetamide by handling the product through each scale-up. Lab syntheses deliver a textbook sample, but the real story emerges on the production floor managing reaction kinetics, crystallization rates, and solvent recycling efficiency. Years in the facility have taught our staff how to reduce off-spec material using real-time temperature and pH monitoring—skills not listed in theoretical synthesis handbooks. During drying and milling, we watch closely for particle agglomeration. If clumping creeps in unexpectedly, downstream users notice. In-house, we can intervene immediately with mechanical adjustments and solvent tweaks.
On working days, our hands-on teams track batch records, but they also recognize patterns that lead to better workflow. For some applications, trace water in the final product can hamper subsequent alkylation steps. In our experience, a slow drying phase, with careful control of nitrogene flow, minimizes this risk more effectively than aggressive heat exposure. Customers have reported fewer side-products and improved yields because of this extra oversight, even if it lengthens production time slightly.
Colleagues sometimes ask: “What’s the real difference between this compound and simpler products like N-Phenyl-Chloroacetamide or N,N-Diisopropyl-Chloroacetamide?” We notice it in the field, especially as new synthetic routes become popular. The isopropyl group slows down undesired side reactions in nucleophilic substitution, granting this material greater selectivity where reaction conditions run hot or basic. This difference matters most in pharmaceutical or agrochemical research where formulation costs climb rapidly if purification becomes involved.
Our plant runs both N-Phenyl-Chloroacetamide and N-Isopropyl-N-Phenyl-Chloroacetamide lines, so we’ve contrasted reactivity in practice. With the isopropylphenyl compound, we typically see a higher success rate during challenging N-alkylation reactions, and less chlorinated byproduct. Reagent choice at the manufacturer’s level means end-users spend less time scrubbing byproducts from their reaction mixtures. Scaling up, that saves both solvent expense and labor, a small but steady edge in competitive market sectors.
It’s tempting to frame fine chemical manufacturing as a battle of certificates, but anyone in the sector knows character and reliability go beyond paper. Managers invest heavily in controlling every aspect because even a slight batch deviation can impede performance down the line for a polymer modifier or pharmaceutical intermediate.
Maintaining a reliable supply of N-Isopropyl-N-Phenyl-Chloroacetamide means more than turning raw materials into product. Each incoming shipment of isopropylamine or phenyl chloroacetyl chloride is checked in-house for water and trace amine content, since these often drift above specification if left unchecked by third parties. Our technical teams standardize the process using robust inline IR and chromatography, catching impurities before they enter the reactor. The goal: to protect customers from supply interruptions or unpleasant surprises, especially those working with tightly regulated applications.
Documentation is more than a regulatory box-tick. It’s built straight into how we operate. Full traceability documents accompany every shipment, starting with a unique batch code and ending with a signature after final pre-shipment assay. If there’s a complaint or technical request, it can be chased down to the day, worker, and vessel. This transparency builds confidence for customers bound by local or global quality protocols.
In pharmaceuticals, development teams often choose N-Isopropyl-N-Phenyl-Chloroacetamide for its suitability as a building block in the synthesis of active molecules requiring high regioselectivity in amide formation. The product’s structure lowers the risk of forming regioisomeric contaminants, which can stress later purification. We’ve seen this first-hand via technical feedback, where downstream users shave shifts off their timeline when running specialized condensation reactions with this compound.
Agrochemical companies also pick N-Isopropyl-N-Phenyl-Chloroacetamide as an intermediate for crop protection products or herbicide safeners. One prominent trait—thermal stability—matters here. Unlike more basic amide alternatives, this molecule resists hydrolysis and decomposition under the elevated temperatures common during formulation. That keeps physicochemical profiles stable until final product blending.
There’s growing demand in polymer research as well. Chemists preparing polymers with pendant functional groups notice that side-chain incorporation with N-Isopropyl-N-Phenyl-Chloroacetamide introduces fewer chain defects and delivers consistent performance across repeated batches. As a manufacturer, we track each development by following up with long-time customers, offering formulation advice, or suggesting process modifications to maximize compatibility.
From the factory’s perspective, the real hurdles emerge in scaling up to commercial quantities. Managers see it in the cost of handling hazardous precursors and in safe, closed-system operation. Most facilities design equipment and protocols around these realities. The chlorinating step in the synthesis generates HCl gas—something you can’t ignore in a properly run plant. We’ve adopted scrubbers fed with caustic solution to neutralize emissions, and operators run checks daily to make sure exposure limits stay well below regulatory targets.
Waste management challenges push every producer to innovate. The solvents needed for consistent crystallization become hazardous waste after repeated cycles. Our plant’s recovery team re-treats solvents using fractional distillation and operates under strict local waste regulations. We treat effluent to reduce chemical oxygen demand before discharging water into public treatment systems. Staff stay current on best practices not from manuals but from working with authorities during inspections and audits. Over the years, we reduced disposal costs and minimized impact on the environment, running solvent recovery rates above 90%.
Occupational safety is paramount. Production staff working with acyl chlorides and amines wear chemical-resistant suits and gloves. You see respect for chemicals in how staff move and communicate—shouting if a leak starts or double-checking containment lines before every transfer. The practices seem tedious, but they prevent accidents and product contamination.
The global market for specialty chemical intermediates gets more complicated each year. New rules on contaminant levels, packaging, product tracking, and operator safety shape every aspect of our operation. Customers from North America, Europe, and Asia approach us with a suite of regulatory queries. They want compliance with REACH, TSCA, and local agency rules in every shipment, so we keep documentation ready and train staff on requirements weekly. There’s no way around these expectations. If we detect an issue in a raw material, we pull batches from the line immediately, no matter how busy the schedule becomes.
Inspections and unannounced audits remain a regular part of life in this niche segment. They teach humility. Even small discrepancies—out-of-date labels or missing records—push improvement cycles. As a company rooted in manufacturing, we learned to view audits as a resource, not a hurdle, nudging our processes toward higher repeatability and lower risk of non-conformance.
Not every product ends up in a simple, one-step application. Our clients routinely reach out with questions about how to optimize reaction yields, reduce costs, or adjust particle size for their next trial batch. Support means more than offering a standard product specification—it means sharing lessons learned during routine production or troubleshooting.
Many of these discussions uncover unique applications or unconsidered performance advantages. For instance, several of our long-term research partners reported improved amide coupling performance when pre-milling the material to a finer grade. We worked together to adjust our final comminution step and provided smaller particle grades by request, making it easier for customers to blend into complex formulae. These tweaks arose from mutual trust and ongoing feedback, not from textbook best practices.
Shared experience sharpens our process. In the past, one customer encountered unexpected yellowing in their formulation, traceable to a rare impurity we had not detected at normal sensitivity thresholds. We invested in higher-sensitivity analysis, isolated the cause, tweaked the purification, and shared the new protocol. Both the plant and client learned from the process, developing a collaborative habit that yields higher-quality batches for every user.
N-Isopropyl-N-Phenyl-Chloroacetamide production continues to evolve. Green chemistry trends, supply chain disruptions, and changing end-user requirements push us to find smarter, cleaner ways to operate. Managers spend more time on life-cycle analysis, looking at how raw materials are sourced, and optimizing every step from reagent selection to energy use. Teams now review waste benchmarks not annually, but constantly, hunting for any drop in emissions or waste volume.
Customers want flexibility—smaller lots for R&D, rapid scale-up for pilot runs, and steady high-quality supply for full commercial launches. Our operations now design shift schedules and inventory management around these requirements. We’ve invested in better process control integration, so we respond quickly to special requests or niche synthetic challenges.
Synthetic chemists continue exploring new applications of N-Isopropyl-N-Phenyl-Chloroacetamide beyond older textbooks. Our technical team stays alert to these developments by monitoring literature, attending conferences, and exchanging notes with users directly. Each new application broadens the market but also uncovers additional challenges and needs. Whether it’s inventing a novel process additive, shortening reaction timeframes, or reducing purification steps, the task sits close to home for anyone used to rolling up their sleeves in a chemical production facility.
Experience running a chemical manufacturing plant offers a down-to-earth view of N-Isopropyl-N-Phenyl-Chloroacetamide’s role in industry. The compound’s structure, physical quality, and functional reliability shape how downstream researchers and formulators design their own processes. Day-to-day, it’s a matter of keeping lines running, tracking every variable, and working with users to improve performance. Every bottle shipped embodies thousands of creative, technical, and manual decisions made by real people on the production floor, not just analysts or marketers. With each batch, the goal is the same: deliver chemical building blocks that meet strict criteria and push the boundaries of what researchers and industry can accomplish next.
