N-Butyric Acid

    • Product Name: N-Butyric Acid
    • Alias: Butyric Acid
    • Einecs: 202-480-9
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    720509

    Cas Number 107-92-6
    Molecular Formula C4H8O2
    Molecular Weight 88.11 g/mol
    Appearance Colorless liquid
    Odor Unpleasant, rancid butter odor
    Melting Point -7.9°C
    Boiling Point 163.5°C
    Density 0.96 g/cm³ at 20°C
    Solubility In Water Miscible
    Flash Point 72°C (closed cup)
    Pka 4.82
    Refractive Index 1.397 at 20°C

    As an accredited N-Butyric Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing N-Butyric Acid is supplied in a 500 mL amber glass bottle with a secure screw cap and detailed hazard labeling.
    Shipping N-Butyric Acid should be shipped in tightly sealed containers, away from sources of ignition and incompatible substances. It must be clearly labeled and transported according to hazardous material regulations, typically under UN Number 2820, Class 8 (Corrosive). Ensure ventilation, secondary containment, and use appropriate protective equipment during handling and transit.
    Storage N-Butyric Acid should be stored in a cool, well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as oxidizers and strong bases. Store in tightly closed, corrosion-resistant containers to prevent leaks and minimize odor. Ensure storage area has spill containment measures in place and access is restricted to trained personnel. Avoid exposure to moisture and ignition sources.
    Application of N-Butyric Acid

    Applications of N-Butyric Acid in Industrial Manufacturing

    N-Butyric acid serves as a key intermediate in several industrial sectors, thanks to its well-defined chemical reactivity and regulatory acceptance. As a direct manufacturer, we supply our customers with high-purity material suitable for stringent production requirements. Below, we share the foundational application scenarios with technical detail on compliance, formulation, processing, and finished products.

    1. Animal Feed Additive Production

    In modern livestock and poultry nutrition, N-Butyric acid functions as a precursor in the manufacture of sodium butyrate and coated butyrate supplements. These products support gut health and growth performance, especially in antibiotic-free and starter diets. Producers strictly monitor inclusion rates and physical form to ensure safety and palatability within industrial pelleting lines.

    Industry compliance standards

    • EU Regulation (EC) No 1831/2003 on feed additives
    • AAFCO (USA) Feed Ingredient Definitions
    • ISO 22000 Feed Safety Management
    • China Feed Additives Catalogue (MOA Decree No. 168)

    Typical usage ratio

    • Feed additive formulations: 0.2%–0.4% N-Butyric acid equivalent by feed weight
    • Adjust rates according to animal species, life stage, and targeted delivery system

    Downstream process integration

    • Direct neutralization to form sodium or calcium butyrate salts
    • Microencapsulation with vegetable oil or starch for controlled release
    • Blending with premixes before extrusion or pelleting

    Final product types

    • Coated sodium butyrate premixes
    • Water-soluble butyrate powders
    • Poultry, swine, and ruminant feed additives

    2. Pharmaceutical Intermediate for APIs

    Chemical synthesis of certain active pharmaceutical ingredients (APIs) incorporates N-Butyric acid as an acylating agent, especially for small-molecule drugs and prodrugs. Manufacturers apply strict GMP controls, tracing from batch-level raw material handling through to reaction stoichiometry and post-reaction purification under validated protocols.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • USP/NF and Ph. Eur monographs for related compounds
    • FDA 21 CFR Part 210/211
    • China Pharmacopoeia (ChP) for API synthesis

    Typical usage ratio

    • Reactant amount ranges from 1 to 1.2 molar equivalents versus target intermediate
    • Stoichiometry depends on side-reaction controls and target yield

    Downstream process integration

    • Acylation reaction step under monitored temperature and pH
    • Solvent-based purification
    • Final GMP-grade purification and QC release

    Final product types

    • Butyrate ester APIs (e.g., corticosteroid butyrates)
    • Prodrug intermediates (e.g., butyryl groups improving bioavailability)
    • Bulk pharmaceutical chemical intermediates

    3. Food Flavor Ester Synthesis

    Food-grade N-Butyric acid participates in esterification processes that yield artificial fruit flavors and creamy notes for beverages, bakery, and confectionery producers. The acid’s controlled reactivity enables consistent flavor molecule profiles, subject to food safety and purity regulations. Processing plants employ monitored batch and continuous reactors to meet international flavoring quality markers.

    Industry compliance standards

    • FCC (Food Chemicals Codex) specification
    • EU Regulation (EC) No 1334/2008 on flavorings
    • GB 2760-2014 (China National Standard for Food Additives)
    • US FDA 21 CFR §172.515 (Synthetic flavoring substances and adjuvants)

    Typical usage ratio

    • 0.5–2.5 kg N-Butyric acid per 100 kg total ester batch, adjusted for ester type and regulatory maxima
    • Final flavor concentrate: 10–300 ppm in end-use food product

    Downstream process integration

    • Esterification with primary alcohols (e.g., butanol, propanol) under acid catalysis
    • Post-reaction neutralization and distillation for food-grade certification
    • Flavor blend assembly after GC-MS purity verification

    Final product types

    • Butyric acid esters (e.g., ethyl butyrate for pineapple and mango notes)
    • Concentration for soft drinks and juice flavoring
    • Bakery and dairy flavoring bases

    4. Chemical Synthesis of Plasticizers

    In the polymer and flexible PVC industry, downstream plants utilize N-Butyric acid to manufacture butyrate-based plasticizers, which impart flexibility and processing stability to specialty films, coatings, and adhesives. Manufacturers deploy solvent-free synthesis pathways or in-line neutralization, tailored for compatibility with food packaging or medical-grade polymers.

    Industry compliance standards

    • REACH Regulation (EC) No 1907/2006 Annex XVII for plasticizer use
    • US FDA 21 CFR §177.2600 for rubber articles intended for repeated use
    • China GB 9685 Hygienic Standard for the Use of Additives in Food Containers
    • ISO 9001/ISO 14001 for quality and environmental management

    Typical usage ratio

    • 5%–15% by weight of total plasticizer blend in formulation
    • Exact ratio based on target tensile properties and migration testing

    Downstream process integration

    • Esterification with polyols (e.g., glycerol, isobutanol) for butyrate esters
    • Blending into PVC resin before melt compounding or extrusion
    • Compatibility testing with target polymer matrix

    Final product types

    • Flexible PVC films
    • Medical-grade polymer tubing
    • Adhesive dispersions containing butyrate esters

    5. Fragrance and Perfume Formulation

    Fragrance oil manufacturers employ N-Butyric acid in controlled esterification processes to develop aromatic butyrates, which deliver creamy, fruity, and buttery notes in personal care, household, and fine fragrance products. Strict formulation control ensures compliance with allergen, purity, and toxicology requirements set by global standards.

    Industry compliance standards

    • IFRA Standards (International Fragrance Association)
    • EU Cosmetics Regulation (EC) No 1223/2009
    • US TSCA and FDA 21 CFR §700.13 for cosmetic ingredients
    • China Hygienic Standard for Cosmetics Safety

    Typical usage ratio

    • 0.05%–0.5% of fragrance compound weight, depending on target olfactory effect
    • Higher end use in fine fragrances, lower in cosmetics and detergents

    Downstream process integration

    • Esterification to form butyrate esters (e.g., methyl, ethyl butyrate)
    • Fractional distillation and purification to IFRA standard
    • Blending with essential oil or solvent base to final application strength

    Final product types

    • Perfume oils
    • Shampoo and body wash fragrances
    • Detergent and fabric softener scent additives
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    Certification & Compliance
    More Introduction

    N-Butyric Acid: A Closer Look from the Manufacturer

    A Century of Change: N-Butyric Acid on the Production Floor

    The world of organic acids covers a lot of ground, but N-Butyric Acid always gets a strong reaction—literally and figuratively. At our plant, the unmistakable, pungent odor greets every delivery. Anyone who has spent time on a butyric line will know: this is not your run-of-the-mill commodity. N-Butyric Acid, or butanoic acid, brings a signature sharpness both in its scent and performance. Our senior operators know that handling it right requires vigilance and respect for both the chemistry and the people on shift. The model that defines our focus is food and pharmaceutical grade, since those sectors demand high purity, low water content, and careful control of trace metals. Most of the acid we ship meets or exceeds 99% purity, leaving very little room for off-notes or contamination.

    Several grades of N-Butyric Acid move through our storage. Industrial applications, such as the production of plastics and polymers, tolerate broader specs. We generate these with less rigorous distillation, ensuring the acid can act as an effective intermediate for butyrate esters and surface-active agents. On the other hand, customers in flavors, fragrances, and silage additives often call for a refined, colorless liquid with minimal iso-butyric acid isomer—a byproduct that can skew reaction profiles and sensory notes. Every batch report lists not just the assay number, but also the water, color (APHA scale), and iron content, since these can influence both function and compliance. From a manufacturing perspective, this means distillation columns must run tight columns, chilling and condensing fractions with very fine temperature control to avoid both loss and cross-contamination.

    Years on the Line: Experience Shapes Our Perspective

    Decades of work on the plant floor have taught us that few chemicals stir up such strong feelings. The obvious odor is only the start. The properties of N-Butyric Acid—boiling point, volatility, ability to blend with alcohols—demand careful selection of equipment. Stainless steel makes a difference; cheaper metals corrode, leading to off-flavors and stability problems. With each new run, attention shifts to the way acid flows—at 163.7°C boiling point, butyric’s vapors affect condenser efficiency and control systems. Valves and gaskets need regular checks, as leaks never go unnoticed for long.

    In our experience, customers remember bad product more than good. Off-colored or contaminated acid stands out in the feed additive sector, where small traces of metals or foreign odorants cause big problems for manufacturers of animal nutrition blends. Reprocessors, looking to recover contaminated stock, find excessive impurities nearly impossible to remove without redistillation. In contrast, producers running flavor or fragrance lines demand clarity—no cloudiness or organic residues—and consistency from drum to drum. Where our plant shines is in achieving that repeatability in the face of shifting raw material supplies and the occasional power hiccup.

    The Functional Edge: What N-Butyric Acid Does Best

    Direct use as a souring, masking, and flavor-modifying agent keeps demand steady. Our most frequent repeat customers formulate silage additives, seeking butyric’s role in preserving feed and curbing unwanted microbial growth. In ruminant nutrition, butyric compounds contribute to gut health and feed conversion. Several research groups have shown that supplementing silage with correct butyric levels slows down spoilage and improves palatability for livestock, especially dairy cattle. Those who process animal protein hydrolysates or specialty pet food ingredients say that butyric derivatives play a key role in both palatability and digestive function.

    On the flavors and fragrances side, butyric acid acts as a backbone for esterification. Mixed with various alcohols, the acid gives rise to butyrate esters—a sharp pineapple top-note in iso-butyl butyrate or the sweet, buttery undertones in ethyl butyrate. Our strict fraction control reduces unwanted cross-esterification, which can muddy aroma profiles and introduce legal labeling headaches for finished products. As demand for naturals grows, synthetic N-Butyric Acid keeps a cost-competitive edge due to purity and traceability.

    Pharmaceutical users take a different approach. Here, butyric’s properties as a precursor for drug intermediates put an emphasis on ultra-low impurity specifications, consistent documentation, and validated traceability. Plant managers know that cross-contamination risks ruin batches, so changeover protocols run long and detailed. Labs test for not just the major impurities, but also environmental and allergenic risks, following guidelines laid down by pharmacopeias in the US, Europe, and China. Maintaining these standards—especially through scale-up and campaign switching—keeps our QC team busy.

    Looking at Other Acids: How Butyric Sets Itself Apart

    Every acid has strengths and liabilities. We often get questions from technical buyers about the practical differences between butyric and other short-chain fatty acids like acetic or propionic acid. Chemically, butyric stands out for its greater lipophilicity, higher boiling point, and stronger odor threshold. Acetic acid remains basically the chemical backbone of vinegar; it's less odorous and blends more easily into solvent systems. Propionic acid, popular in mold-inhibition for baked goods and animal feed, beats butyric in terms of user-friendliness but falls short in certain preservation and palatability applications. Each comes in multiple grades, but only butyric achieves the blend of volatility, sharpness, and reactivity that pet food formulators and specialty ester producers require.

    From a process engineer’s perspective, handling butyric acid means implementing extra ventilation, special containment, and regular training for the crew. Its volatility at warm-room conditions is noticeable and makes drum selection more critical. Even the fastest plastic linings, which work for weaker acids, eventually degrade here. Metalwork and piping with the right alloys—stainless 316 over 304—cut down maintenance costs in the long run. Over the years, we’ve learned that skimping on these upfront investments impacts both safety and product quality.

    Quality Control: Trust Built on Consistency

    A chemical plant earns its reputation batch by batch. We face this every day in the butyric acid lines. The finished product moves through GC, Karl Fischer titration for water, and color check for visible impurities. Historically, butyric acid earned a reputation for variability, often caused by older production technology that left behind esters, aldehydes, or trace metals. In our shop, updated distillation trains, rebuilt after years of tough service, enable tighter process windows and more predictable output. Labs run every lot for residual volatile acids—usually acetic, propionic, and isovaleric—and post results so the whole crew can see. This goes a long way when bad product means a day’s lost output, extra cleaning, and sometimes the dreaded tanker truck return.

    Feedback from customers keeps us honest. Animal feed blenders notice even slight shifts in odor; aroma houses bounce back drums that fail clarity tests. The lessons have stuck: don’t rush the tails cut at the end of a distillation run, monitor condenser fouling, and check drum seals every time. In the heat of summer, a half-hour delay in cooling can tip product out of spec. Experience drives our priorities—pre-emptive maintenance, clean transitions, and robust safety drills mean less downtime and lower risk of customer complaints.

    Storage and Logistics: Lessons Learned from the Warehouse

    Butyric acid storage isn’t forgiving. Over years, incidents underscore the need for careful management. Standard high-density polyethylene drums can work, but regular checks identify early signs of stress cracking and vapor seepage due to the acid’s persistent fumes. Metal IBCs with acid-rated linings stand up better for longer-term warehouse storage, especially in fluctuating climates. Pallets don’t simply stack—weight distribution and leak containment practices matter, as minor spills travel fast and the vapor reaches every crevice, annoying neighbors or nearby production lines.

    Shipping presents its own demands. N-Butyric Acid, with its UN hazard classification and corrosivity, requires correct documentation and trained handling from pickup through to delivery. Over the years, we’ve seen inbound trucks rejected due to cross-contamination or inadequate venting, with replacement shipments chewing through margin. Good carriers know to avoid mixed loads with flavor-sensitive products. Our shipping coordinators also keep a close eye on containment, stacking, and temperature, particularly in the hotter parts of the year, since uncontrolled heat increases pressure buildup and evaporative losses. Older tankers sometimes need replacement valves or gaskets—overlooking these details risks entire shipments.

    Industry Demand: Cycles, Competition, and Shifting Requirements

    N-Butyric Acid finds itself in the crosshairs of both global trends and regional tastes. Animal nutrition, especially in emerging markets, boosts base demand, as dieticians and nutritionists seek fermentation acids that improve health and livestock yields. In North America and Europe, specialty chemicals and flavors remain important markets, but new pressure comes as customers demand both clean-label ingredients and detailed traceability. No week goes by without at least one major client asking about traceability down to raw material lot, including bio-based content verification.

    On the regulatory front, we need to keep up. Butyric acid tolerances in feed formulations face increased scrutiny by food safety authorities. Documentation demands have jumped, particularly in the EU and North Asia. We’ve responded by improving our document chain, regularly auditing QC records, and upgrading our batch tracking systems. Experience shows that skipping even one link in this documentation chain risks shipment rejections, delayed customs releases, or forced rework on incoming supply.

    Competitive pressures have accelerated improvements in both our process and the acid itself. Synthetic routes, especially those based on biobased fermentation, now supplement traditional petrochemical synthesis. Each process brings a different impurity profile, which needs regular reassessment and, sometimes, an overhaul of analytical protocols. Fermentation-derived acid enjoys a market push in flavors and feed due to perceived sustainability, but requires even tighter controls on byproduct content and sterility. Over the past five years, the pace of process innovation has stepped up—it’s now as much about keeping pace with green chemistry as meeting traditional specs.

    Sustainability: Meeting Expectations from the Market and Our Own Team

    Over the past decade, sustainability has become more than a buzzword. It shapes decisions on both customer and supplier sides. Customers increasingly ask for life-cycle data, renewable sourcing, and lower carbon output per kilogram. The truth is, demands force us to scrutinize every corner of production—from the way we source raw materials to the treatment technologies for controlling emissions. Our move to energy-efficient distillation and solvent recovery reduces waste and cost, but also lets us meet the reporting standards required by multinational customers.

    Reducing odor emissions and waste acid has required real investment. We use closed-system transfer lines, fume scrubbers, and sealed storage, along with periodic audits of emission points. These steps lower not only community complaints, but also regulatory risk, with authorities quick to respond to neighbor feedback in industrial zones. Recovery systems for solvents and waste acids now turn what was once landfill fodder back into the feedstock stream, squeezing more value out of every kilogram.

    Changing attitudes within the plant reinforce these moves. Our employees ask pointed questions about where waste ends up, how energy usage stacks up, and what more can be done to shrink the plant’s environmental impact. Their attention makes a difference—spills get reported faster, leaks get patched promptly, and the sense of accountability rises with each year. Sustainability departments have moved from corporate headquarters into the plant itself, driving improvement projects and holding everyone to measurable standards.

    Innovation and Looking Ahead

    N-Butyric Acid will keep evolving, just like the industries that use it. Bioprocessing technology keeps taking a larger share of global production, especially for markets that lean on “natural” or “bio-based” sourcing. These new sources enter the market with different physical properties and impurity profiles, challenging both the lab and production crews to adapt recipes, monitoring, and batch release criteria.

    Market needs also evolve. Regulatory authorities in animal nutrition and food are starting to ask for lower impurity levels and more transparency, pushing even experienced plants to update their approach. Software now plays a larger role—tracking tanks, flagging outgoing shipments, and keeping quality data accessible. Changes on the ground—emerging pathogens in animal feed, shifting commodity prices—require constant plant adjustment to stay flexible and competitive.

    Every shift brings new lessons. We learn from each missed spec, each customer rejection, and each successful turnaround. As manufacturing staff, not traders, we see the full scope—from raw material storage, through process, to finished drums leaving the dock. The market will keep changing, but hard-earned experience, work ethic, and our commitment to improving each batch keep N-Butyric Acid at the center of our daily effort.

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