|
HS Code |
758458 |
| Chemicalname | N-Butyl Nitrite |
| Casnumber | 544-16-1 |
| Molecularformula | C4H9NO2 |
| Molarmass | 103.12 g/mol |
| Appearance | Yellow liquid |
| Odor | Fruity, sweet |
| Boilingpoint | 78-79 °C |
| Meltingpoint | -115 °C |
| Density | 0.877 g/cm³ |
| Solubilityinwater | Very slightly soluble |
| Vaporpressure | 119 mmHg (at 20 °C) |
| Flashpoint | -12 °C |
| Refractiveindex | 1.406 |
| Unnumber | 2491 |
| Storagetemperature | Store at 2-8 °C |
As an accredited N-Butyl Nitrite factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 100 mL of N-Butyl Nitrite, securely sealed with a tamper-evident cap and chemical hazard labeling. |
| Shipping | N-Butyl Nitrite must be shipped as a hazardous material, following strict regulations. It should be packed in airtight, chemically compatible containers, clearly labeled, and cushioned against breakage. Transportation must comply with DOT, IATA, or IMDG guidelines, including documentation for flammable and toxic substances. Proper ventilation and spill response materials are required during shipping. |
| Storage | N-Butyl Nitrite should be stored in a cool, dry, and well-ventilated area, away from heat sources, open flames, and direct sunlight. Keep the container tightly closed and protected from moisture. Store separately from oxidizing agents, acids, and bases. Use appropriate, clearly labeled, corrosion-resistant containers. Ensure proper grounding and bonding to prevent static discharge, and follow all applicable safety regulations. |
Applications of N-Butyl Nitrite in Industrial ManufacturingN-Butyl Nitrite serves as a niche functional chemical intermediate across select downstream industries due to its reactive nitrosating properties. Our manufacturing expertise enables consistent product quality for high-purity industrial processes. Below, we outline the principal application channels where this material plays a critical role in specialty syntheses. 1. Pharmaceutical Intermediate SynthesisInnovators and generic manufacturers utilize N-Butyl Nitrite in controlled nitrosation reactions to generate key pharmaceutical intermediates, especially where mild nitrosation and selective alkyl nitrite introduction are crucial for API development. Experienced formulators adjust dosing parameters based on reaction substrate sensitivity to optimize yield and minimize impurities according to strict regulatory protocols. Industry compliance standards
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2. Organic Synthesis for Agrochemical ManufacturingProducers in the crop protection sector incorporate N-Butyl Nitrite as a controlled nitrosating agent to functionalize heterocyclic scaffolds and aromatic precursors during the synthesis of certain insecticides and fungicides. Processing technicians monitor addition rates and reaction by-products, as agrochemical formulation requires low residual impurity levels to meet export tolerances and toxicity assessments. Industry compliance standards
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3. Rubber Accelerator ProductionIndustrial rubber additive plants employ N-Butyl Nitrite for the nitrosation of aromatic amines, forming precursor molecules for the synthesis of several vulcanization accelerators. Quality assurance teams confirm residual nitrite removal and control for process safety, as batch purity and reagent conversion directly impact final accelerator strength in tire and technical rubber applications. Industry compliance standards
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4. Specialty Dyes and Pigment Intermediate ManufacturingDye and pigment chemical plants utilize N-Butyl Nitrite to create diazonium salts from aromatic amines in the early synthesis routes of selected azo dyes. Plant engineers control temperature and dosing profiles tightly to maintain desired chromophore formation while complying with effluent nitrite disposal regulations and achieving high selectivity for vibrant color yields. Industry compliance standards
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5. Laboratory-Scale Analytical Reagents ProductionChemical laboratories and diagnostic kit manufacturers employ N-Butyl Nitrite in small-scale preparation of reference reagents, particularly for diazotization and nitrosation analytics. Formulators select concentrations based on tube or flow volumes and validate batch consistency with chromatographic checks to meet reagent specification sheets for laboratory customers. Industry compliance standards
Typical usage ratio
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Most days in our chemical facility, the distinct, sweet scent of N-Butyl Nitrite lingers in the air. Workers recognize it instantly, the same way one recognizes the smell of solvents on a paint shop floor. We blend and fill this yellowish liquid in steady batches, watching for every detail that builds reliability, from raw material intake to sealed drums. N-Butyl Nitrite doesn’t just travel straight from our reactors to tankers. The process demands attention—for quality, safety, and that particular consistency end-users expect.
Chemists in our plant have always kept a close eye on the final product. Over the years, we’ve learned how slight changes in raw butanol purity, reactions temperatures, or nitric acid grades shape not only yield but also stabilizer levels and shelf life. We don’t cut corners on filtration or water removal, because a trace of moisture changes storage requirements and clouds a customer's process. Our product comes with a familiar clarity, a subtle yellow that never turns murky, supporting downstream applications without surprises.
Not all nitrites behave the same in the hands of a user. N-Butyl Nitrite runs clear and fast, both literally and figuratively. Some manufacturers cut costs by using lower-purity butanol or hurrying the distillation, but this shortcut always shows. In our daily work, reliability comes not from marketing words, but from controlling each variable and tracing each lot from storage tank to shipping manifest. Each drum’s paperwork matches what’s inside. Customers ask for specific spec sheets and we supply them, but experience says the performance in real-world tasks matters more than numbers on a page.
Over countless shipments, we’ve taken calls from downstream users. They share frank feedback, whether a formulation runs hot or reacts sluggishly. We listen, take notes, and implement changes. Sometimes that means extra filtering, or switching stabilizers because end-users don’t want trace alkali residues interfering with sensitive reactions. We understand, because we run those same pilot tests before scaling up a batch.
N-Butyl Nitrite stands out compared to shorter alkyl nitrites like methyl or ethyl variants. Short-chain nitrites flash off quickly and don’t tolerate storage as well. Longer ones, like isoamyl or isopropyl nitrite, find use in different fields or meet stricter regulatory hurdles. N-Butyl Nitrite balances volatility, reactivity, and manageable handling. It isn’t so volatile that it evaporates off your bench, nor so persistent that disposal creates extra hoops.
Most chemical manufacturers handle large volumes, so bulk storage conditions matter. We design our tanks for minimal air ingress, keep them cool, and mind every gasket in the line. A few years ago, a batch with a suspect O-ring taught us that lesson. A warehouse operator flagged an odd smell—the sort that signals a leak or polymerization risk. The batch came off line, the gasket was swapped, and the cause of the off-spec odor got traced back to just two drums. We don’t forget those details.
Learning from years spent in bunkered warehouses, we never overlook ventilation protocols or regular calibration of sensors. Nitrites don’t take kindly to heat or sunlight, and our maintenance log makes that clear. Technicians rotate drums and verify venting because any deviation brings headaches, from pressure build-up to nitrogen oxide formation. Plant managers find that using stainless steel or specially lined pumps has paid off; less corrosion, fewer maintenance stops, tighter seals every time.
End users turn to N-Butyl Nitrite for its strong nitrosating properties. Our bulk clients push the chemistry in both laboratory syntheses and full-blown commercial applications. Pharmaceuticals, agrochemicals, metal finishing—each field writes its own rules. In denitrosation reactions, customers want predictable rates; in solvents blends, they care about volatility curves matching their process windows. We help with those benchmarks by tailoring batches, passing along the lessons from our own floor to theirs.
Metal treaters use N-Butyl Nitrite as an anti-corrosion agent, especially in cooling and cleaning cycles. Unlike alternatives, it rarely causes yellowing or residue build-up if used within limits. In some formulations, it serves as a chemical intermediate, especially in azo dye production or as a starting material for more complex nitrite esters. We hear from blenders who struggle with stability; their engineers care about peroxide formation or gas-off rates that disrupt metering.
Our feedback loop features more than just static product specs. Chemists in the field tell us exactly how our material works under their specific temperatures, pressures, and catalyst loads. From this, we've tuned our stabilization approach. Some users operate at the edge of safety margins, dealing with exothermic scenarios where stability isn’t a luxury; it’s a must. Our product’s minimal residual acidity is no accident but a result of months spent calibrating our distillation cut points. We don’t lean on artificial additives to mask underlying problems. Instead, we monitor actual water and impurity content, sticking to a consistent standard batch after batch.
Local authorities and international bodies set strict expectations for materials like N-Butyl Nitrite. Shipping regulations have gotten tighter over time, and not every region accepts a product without full traceability. We’ve always kept proper documentation, batch records, and worked with regulators to pre-clear specifications before dispatch. We regularly update SDS documentation to reflect new research—not only because rules change, but because customer safety teams demand transparency.
In practice, this means auditing our raw materials, certifying handlers, and investing in redundancy measures against spills. We train our staff not just to follow rules, but to recognize subtle cues—a color shift in a tank, unexpected warmth during transfer, or a faint odor change. Most accidents start with a missed warning sign, not an explicit failure. Our focus on daily safety checks is a lesson learned from years in handling fast-reacting organics.
We also engage closely with transporters. Our shipping partners run regular drills, and we provide technical support if a container shows signs of unwanted heat or pressure en route. Emergency response plans don’t sit in a binder gathering dust; we revise them based on close calls and honest feedback from logistics providers. As a chemical manufacturer, we treat the downstream environment with respect, keeping waste in line, emissions tightly regulated, and our impact minimal.
Users ask directly: why not pick cheaper alternatives, such as methyl or propyl nitrites, or switch to other nitrosating agents? Our answer comes from thousands of tests and real field feedback. N-Butyl Nitrite walks the compromise line between safety, speed, and process flexibility. Shorter chains give more reactivity, but bring volatility and storage headaches. Longer chains, while sometimes safer, do not hit the same reaction profiles and may miss crucial regulatory windows.
Unlike sodium nitrite or inorganic nitrosating agents, N-Butyl Nitrite lets organic chemists operate in less aqueous, more controlled conditions. The selectivity matters in pharma synthesis, where purity and side reaction rates mean profits or loss. Nitrosonium salts and other agents introduce solubility and compatibility issues for some process lines. N-Butyl Nitrite brings flexibility for those running mixed-phase or solvent-based systems.
Our competitors sometimes prize output over reputation. We’ve learned that customers don’t forget tank failures, yellowed batches, or process delays. Rework and recalls don’t build loyalty. Our repeat customers tell us that a trusted source saves money even when prices fluctuate, because downtime costs more than a marginal raw material difference. Over the years, we've established backward integration, ensuring our butanol source is traceable, and our waste streams meet local and international safety markers.
Some regulatory regions have considered banning certain alkyl nitrites due to recreational misuse, but N-Butyl Nitrite keeps legitimacy through strict tracking, regular audits, and responsible handling. We keep close ties with local authorities and review changing legal requirements regularly to keep product moving without bottlenecks or legal gray areas.
Chemical manufacturing is never static. Our R&D team pushes to enhance batch stability, develop new stabilization techniques, and lower residual moisture even further. Every new development springs from user input. Painting lines, fertilizer blenders, custom synthesis shops—each group provides critical insight into which pain points need smoothing and which are a fact of the chemistry itself.
In recent years, we have used automated batch monitoring and smart data logging. This technology helps us catch early deviations, sometimes outside human senses, such as micro-level color shifts or tiny exotherms. Our line operators combine deep experience with modern sensors, ensuring quality control isn’t lost in the push for efficiency.
The shift to more sustainable chemistry impacts how we treat waste streams, how we recover solvents, and what stabilizers we select for each batch. Many users ask pointed questions about lifecycle impacts, CO2 footprint, and safe discharge protocols. We don’t shy away from these. Our own internal audits look at energy consumption, emissions, and supply chain impact—knowing that downstream buyers demand not just product performance but ethical responsibility. Some clients want closed-loop shipment or documentation tracing each lot’s full environmental impact. We provide these details because the culture of chemical manufacturing is changing, and staying ahead is not negotiable.
Things rarely flow smoothly in large-scale chemical factories. Unplanned shutdowns, raw material hiccups, or weather impact on logistics can throw off a month of scheduling. Hot days in summer force us to cool storage tanks using external chillers; on cold nights, we worry about condensation sneaking into the loading lines. Filtration fouling is a routine challenge; reacted solids need to be caught or downstream quality suffers.
Another constant concern is waste management. Unreacted acids or side products must be neutralized in closed systems, and vent lines cleaned regularly to prevent dangerous build-up. Years of experience have taught us which coating materials last and which break down under prolonged nitrite exposure. Stainless steel devices see less wear, but even the best alloys show corrosion when minor leaks go unchecked.
Security also ranks high. Nitrites raise unwanted attention, so our site enforces strict access control, periodic audits, and regular external reviews. Background checks for onsite operators, security camera coverage for sensitive areas, and digital batch logging add confidence for auditors and genuine peace of mind for our team.
Interacting with international shippers comes with translation mishaps and varying labeling rules. Packages may get delayed at ports if documentation is out of sync, so we pre-release papers and maintain relationships with customs agents. Traceability matters more each year—and we invest in digital batch codes and chain-of-custody tracking not just for compliance, but to give ourselves and our customers confidence that each drum is exactly what they ordered.
Process safety always stays at the front of our minds. N-Butyl Nitrite reacts strongly to contamination and scale-up hazards. Regular reviews, shared lessons, and continuous training form a safety culture that prevents incidents. We keep detailed records and encourage close communication between operators, supervisors, and R&D staff.
N-Butyl Nitrite will remain in demand as industries evolve. Changes in environmental regulation, market needs, and technology influence how manufacturers adjust practices. We keep an eye on green chemistry trends, specialty demands, and shifts in the global supply chain. Experience tells us the best manufacturing practices come from a mix of tradition and adaptability.
Our years of work with N-Butyl Nitrite have built understanding that goes beyond datasheets. We believe close ties to end users, transparent process management, and patience in the face of challenges lead to the most reliable product. As markets shift and applications grow, we keep learning and improving batch by batch, always focused on user needs and the practical realities of chemical production.
Feedback from those who use N-Butyl Nitrite in the field continues to drive real progress. If problems arise, we solve them together, relying on practical experience and an open pipeline of information sharing. Each improvement, whether a minor tweak in the distillation process or a major shift in logistics, ripples out to support smoother operations for everyone who counts on this vital chemical.
This long-term approach doesn’t just serve the bottom line—it keeps our relationships steady, our operations dependable, and our reputation as a trusted source of N-Butyl Nitrite firm. We stand behind every tank, every drum, and every shipment, putting industry experience to work at every step.