|
HS Code |
740280 |
| Chemical Name | N-Acetyl-p-Phenylenediamine |
| Synonyms | 4-Acetamidophenylenediamine |
| Molecular Formula | C8H10N2O |
| Molar Mass | 150.18 g/mol |
| Cas Number | 101-80-4 |
| Appearance | White to off-white crystalline powder |
| Solubility In Water | Slightly soluble |
| Melting Point | 164-168°C |
| Density | 1.26 g/cm³ |
| Purity | Typically ≥98% |
| Storage Conditions | Store in a cool, dry place, tightly closed |
| Stability | Stable under normal conditions |
| Pka | 4.2 (for amino group) |
| Odor | Odorless |
As an accredited N-Acetyl-P-Phenylenediamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle labeled "N-Acetyl-P-Phenylenediamine, 25g" with hazard symbols, tightly sealed, packed in protective cushioning. |
| Shipping | N-Acetyl-P-Phenylenediamine is shipped in tightly sealed containers to prevent contamination and moisture exposure. The packaging complies with chemical safety regulations, and typically includes hazard labelling. It is transported at ambient temperature, protected from direct sunlight and incompatible substances. Shipping documentation includes Material Safety Data Sheets (MSDS) for safe handling and regulatory compliance. |
| Storage | N-Acetyl-P-Phenylenediamine should be stored in a tightly sealed container in a cool, dry, and well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizers. Protect from moisture, direct sunlight, and heat. Ensure proper labeling and keep it away from food and drink. Use secondary containment to prevent spills and exposure. |
Applications of N-Acetyl-P-Phenylenediamine in Industrial ManufacturingAs an established manufacturer, we supply N-Acetyl-P-Phenylenediamine for specialized industrial uses, focusing on regulated sectors where its chemical characteristics deliver manufacturing reliability. Below, we outline selected downstream scenarios, including quality standards, technical formulations, and process details specific to each application area. 1. Oxidative Hair Dye IntermediatesN-Acetyl-P-Phenylenediamine serves as a core intermediate in the formulation of permanent oxidative hair coloring creams. It modifies dye precursor reactivity, enhances color shade stability, and reduces the potential for sensitization relative to non-acetylated analogues. Professional hair dye producers regulate its inclusion according to allowable amine concentrations and finished product safety requirements. Industry compliance standards
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2. Medical Device Colorants (Diagnostic Strips & Indicator Patches)Manufacturers utilize N-Acetyl-P-Phenylenediamine as a chromogenic precursor in medical diagnostic test strips where a stable, hypoallergenic dye source is required for patient-contact indicator layers. Its acetylated structure reduces skin reactivity, addressing clinical requirements for direct patient use in sensitive detection systems. Industry compliance standards
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3. Specialty Textile Dye Synthesis (Permanent Fiber Colors)In the textile industry, N-Acetyl-P-Phenylenediamine is employed for the synthesis of para-phenylenediamine-based fiber-reactive dyes used in high-value textile applications. Its acetyl group influences dye fixation rates and final shade reproducibility on polyamide and wool substrates while meeting increasingly strict eco-toxicological standards. Industry compliance standards
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4. Photographic Developer Agent ManufacturingN-Acetyl-P-Phenylenediamine has historical and current use as a primary agent in black-and-white photographic developer formulations, where its acetyl derivative provides controlled electron donor behavior during silver halide reduction. Photo chemistry producers select this compound to modulate developing rates and reduce the toxicity profile of the final developer solution. Industry compliance standards
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N-Acetyl-P-Phenylenediamine, also referred to by its model APDA, serves as a practical answer for industries seeking a stable antioxidant and intermediate. Our team at the synthesis plant handles this compound daily, watching raw materials transform under carefully controlled temperatures and clean reactor protocols. Through years of refining our process, we’ve managed to keep impurities at bay and achieve a consistent, high-purity end product, typically appearing as off-white crystals. The melting point and solubility profile support its flexibility for formulation laboratories. Most technical managers and product engineers who visit our plant look for signs that our product sticks to strict physical standards — grain size, dust content, and storage stability — to make scaling up feel smooth. Our crew agrees on what counts: the batches run pure, limits get checked before packing, and our engineers stand behind recorded analysis you can actually cross-verify.
Over several decades, we’ve seen N-Acetyl-P-Phenylenediamine shift its profile from a pharmaceutical ‘lab curiosity’ to an indispensable stabilizer in rubber manufacturing, dyestuffs, cosmetics, and hair colorants. Customers in specialty polymer fields rely on it to counter oxidative degradation in high-performance resins during curing or high-temperature extrusion. Our operators learned early on that the difference between a batch standing up in a UV-exposed application or failing down the line comes down to upstream purity: no metallic residues, no excess moisture. This compound’s acetylated structure allows it to dodge certain regulatory red flags that raw p-phenylenediamine or other aromatic amines may attract, especially in consumer-facing formulations. Environmental teams on both sides — ours and our clients’ — regularly analyze trace byproducts to gauge compliance with evolving REACH and GHS frameworks. Practical experience with international audits drives us to keep our documentation transparent and accessible at any time.
Lab staff who test every lot track melting point consistency and impurity traces by HPLC for a simple reason: downstream users deserve predictable input. The APDA we ship typically meets a purity threshold of 99% plus minor permissible variance, adjusted to customer feedback over years. For users blending solvent-based and water-based systems, our operators check particle flow and consolidation under real mixing conditions — not just in a dry lab. The practical outcome from this approach: dissolving speed, dusting risk, and batch reproducibility meet industry expectations, not just internal projections. Many of our technical partners perform side-by-side trials using our APDA against other common antioxidants and consistently report lower color drift and more predictable QA test results. When you’re running pilot extrusions or colorant batches, that reliability means less downtime and a smoother transition from test runs to full-scale production.
Comparing N-Acetyl-P-Phenylenediamine to non-acetylated p-phenylenediamine, our chemical engineers stress the benefits of extra safety margins during handling and blending. The acetyl group not only tempers reactivity but also cuts down user exposure to free amines, a factor regulatory and occupational health teams appreciate. Toxicological reports and workplace air sampling from our own facilities confirm dramatically reduced vapor and dust readings when handling APDA versus unmodified aromatic diamines. Where cost and chemical compatibility allow, clients increasingly choose the acetylated form for applications that cross over into personal care, given tighter restrictions on aromatic amine content. This acetylation reduces allergenic potential and the tendency to trigger unwanted side reactions in colors, elastomers, and blends with sensitive excipients.
Getting hands-on with multiple antioxidant systems over the years, plant technicians and chemists have cataloged the ways APDA scores against older alternatives like unsubstituted p-phenylenediamine or even certain thiol-based stabilizers. APDA typically yields improved shelf life in color-sensitive polymers, and demonstrates stability across a wider pH and thermal band. While cost per kilo sometimes runs slightly above traditional antioxidants, the economic value shows up in fewer batch failures and easier waste stream management. Wastewater from our APDA-involved operations clears out faster and meets permit guidelines with less downstream adjustment compared to older amine-rich systems. End users who swap in APDA — especially those in high-volume, high-visibility consumer goods — find fewer issues with regulatory agency reviews and less trouble with inconsistent color or performance under end-use stress.
The advantages seen downstream always start upstream. Production staff at our site spend a good deal of time logging batch origin, reactant lots, and environmental readings for each reactor charge. By holding onto sample archives and batch records for years, we’ve supported customer troubleshooting and regulatory audits with traceability that goes beyond typical supplier paperwork. Environmental, Health, and Safety teams review incidents and batch records regularly — not as an afterthought, but as a requirement for keeping customer relationships productive. We keep open channels between technical support and our customer teams. Engineers and synthesis operators share practical advice with clients, covering safe storage to optimal blend timing, guided by feedback from industrial users troubleshooting tough blends, high throughput processes, or fine-tuning hair color formulations to meet performance standards and safety rules.
Clients own the real test bench. Across plants in several countries, QA managers have returned feedback on APDA outcomes in both plastics and colorant formulations. Recent field studies reported cutbacks in color instability during long-haul shipping of heat-cured elastomers, saving downtime and shipment rejections. Makers of specialty resins and advanced coatings credit APDA formulations for resisting yellowing and oxidative fading, even after repeated thermal cycling. In hair color blends, R&D chemists tally APDA’s role in achieving bolder tone precision and lower rates of adverse cutaneous reactions among test panels. By reducing the concentration of allergenic amine species in the final blend, makers open their products to broader market segments and new regulatory zones.
Troubleshooting is hardly theoretical for our process support teams. When a user flagged unplanned color drift in a pressure-sensitive adhesive mixing line, our staff analyzed trace metals and cross-checked mixing protocols, uncovering a raw material cross-contamination. By tweaking our dehydration phase and upgrading in-line dryers, subsequent APDA shipments to that user delivered result stability by the third production run. In another recent scenario, a customer piloting a life science diagnostic substrate found that high-purity APDA cut back false-positive artifact rates, raising throughput and reducing analytical delays. These stories keep our production staff grounded, reminding everyone that every filter, drying phase, and sampling trace impacts end-use experience across fields as diverse as cosmetics, aerospace composites, and elastomeric gaskets.
Feedback from customers, mixed with our own warehouse crew’s experience, refines the way we handle shipping and storage of APDA. The powder’s reactivity profile places it among compounds best managed in dry, airtight bulk bins. Our packers never cut corners on moisture-barrier liners after spotting an uptick in caking and off-odor issues years ago from poorly sealed drums in humid weather. Packing adaptation — not merely meeting a specification — makes day-to-day logistics run smoothly. Operators in our climate-controlled warehouses track batch rotation and enforce FIFO handling, based on shelf-life trials and field returns, with regular product stability spot checks under varied lighting and ambient temperature. In end-user factories, onsite technical audits verify bin-loading practices and the avoidance of cross-contamination, especially in hair color and skin-contact applications.
Staff at our site learn from missteps. Shipping APDA through coastal ports in summer heat forced us to switch container types after batches arrived with clumped material and degraded assay. With feedback from both logistics and QA teams, we moved to triple-layer drum containers with sealed nitrogen flusher units for long-haul orders bound for equatorial or high-humidity clients. In the process, we cut back incident response times, dropped insurance claims, and gained ground with both freight partners and repeat customers who judge us by materials that land in production lines clean, free-flowing, and specification-tight. Each granular adaptation in storage, labeling, and shipment has roots in solving real delivery headaches and end-user complaints.
Our environmental and compliance teams check the latest regulatory bulletins and maintain contact with global compliance officers. Recent years have made REACH and GHS more visible in buyer decisions, especially in sectors facing consumer scrutiny. As a result, we routinely run our APDA batches through extended screening to rule out trace regulated aromatic amines, persistent organic pollutants, and possible N-nitrosamine formation. These checks aren’t just about paperwork — they simplify user certification and speed up customs clearance, especially for buyers needing hassle-free audits and priority green channel import licensing.
Waste from APDA handling and use sparked investment at our site in wastewater neutrals and closed-loop solvent recovery. By building feedback from regulators and cleaning system vendors into our upgrades, we not only met but exceeded most regional limits on aromatic amine releases and solids content. Continuous monitoring and logged data let us address issues the moment they arise, instead of arguing over end-of-line corrective action. In countries upgrading food contact material guidelines, our APDA consistently passes regulatory chromatographic and migration tests, allowing clients to move confidently across markets that once blocked products over trace contaminants or unclear documentation. Compliance for us means investment and daily diligence, not just an annual check-box.
Research and development rarely stand still in chemical operations. Our lab chemists and process engineers continue to gather input from industrial partners and field technicians, guiding improvements to both product and service. This means regular tweaks to purification techniques, operator retraining, and pilot projects with partner users for validating new use cases and tighter regulatory demands. Plant upgrades — often born out of a single sharp-eyed operator’s observation or customer’s critical batch report — roll out into new batchwork, adjusting for fine points others may not see until their product hits a snag. These adjustments ripple across subsequent product lots and guide our internal target specs for physical consistency, blend time, and environmental resilience.
Collaboration with long-term industrial users gives us a practical window into subtle trends: color shift in specialty pigments, packaging failures for high-demand storage conditions, and compatibility tweaks in next-generation elastomers or diagnostic polymers. Through routine on-site visits, phone consults, and field sample exchanges, our support teams log experience across a wide swath of technical needs. As new applications emerge in fields such as flexible electronics and eco-conscious personal care, our process lines and documentation adapt, aiming to back up every ton shipped with technical trust and real-world usability. Ongoing workforce training and an open-door approach with customers give us the benefit of spotting batch weaknesses early — long before they can threaten a user’s process or product claim.
N-Acetyl-P-Phenylenediamine may appear unassuming in drum or bag, but to our plant operators and technical staff, it means dependable, measurable output for demanding industries. Decades of making, testing, and refining this compound have taught us the difference that real craftsmanship, close-field feedback, and strong process discipline make on the material’s downstream reliability. We ship to users who expect not just chemical specs, but clarity, traceability, and a network of technical support able to help diagnose or optimize every new application. As safety rules tighten and performance benchmarks climb higher, reliability from factory floor to finished product keeps our staff focused on refining both the compound and the overall experience of its use.
The story of N-Acetyl-P-Phenylenediamine at our site matches the broader evolution in specialty chemicals. Experience on the floor counts as much as factory automation or certification paperwork. Technicians, plant engineers, and chemists drive the cycle of improvement by handling each stage openly, tracking each procedure, and standing behind results. For us, chemical manufacturing isn’t just about shipping drums. It’s about backing customer innovation, supporting regulatory peace of mind, and building a foundation where performance figures mean real-world results for every team that opens a drum, fills a reactor, or launches a new consumer product.
