Glutaronitrile

    • Product Name: Glutaronitrile
    • Alias: 1,4-Dicyanobutane
    • Einecs: 203-853-2
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    788136

    Chemicalname Glutaronitrile
    Casnumber 110-61-2
    Molecularformula C5H6N2
    Molecularweight 94.12 g/mol
    Appearance Colorless to pale yellow liquid
    Meltingpoint -30 °C
    Boilingpoint 267 °C
    Density 0.98 g/cm3 at 20 °C
    Solubilityinwater Miscible
    Flashpoint 113 °C
    Odor Faint, characteristic
    Vaporpressure 0.03 mmHg at 25 °C

    As an accredited Glutaronitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Glutaronitrile is packaged in a 500 mL amber glass bottle, sealed with a screw cap and tamper-evident label for safety.
    Shipping Glutaronitrile should be shipped in tightly sealed containers, away from heat and sources of ignition, as it is flammable and toxic. Transport in compliance with local, national, and international regulations (e.g., UN 2810, class 6.1 toxic substance). Use suitable labeling and provide proper documentation, ensuring safe handling and storage during transit.
    Storage Glutaronitrile should be stored in a tightly closed container in a cool, dry, and well-ventilated area, away from heat, sparks, open flames, and incompatible substances such as strong oxidizers and acids. Store under inert atmosphere if possible. It should be protected from moisture and direct sunlight. Label containers clearly and ensure proper secondary containment to prevent leaks or spills.
    Application of Glutaronitrile

    Applications of Glutaronitrile in Industrial Manufacturing

    As a direct manufacturer, we supply Glutaronitrile to industrial customers operating in well-established sectors. Precision control of material quality, process integration, and compliance with relevant regulatory frameworks remain critical for downstream applications. The following sections outline specialized industrial uses of Glutaronitrile with clear specifics for compliance, input ratios, processing, and finished goods.

    1. Intermediate for Hexamethylenediamine (HMDA) Synthesis

    Glutaronitrile is a key intermediate in the chemical conversion pathway to hexamethylenediamine. Producers in the polyamide industry feed this material via catalytic hydrogenation within pressurized reactors. This approach allows stringent control over purity profiles critical for downstream nylon 66 manufacturing. Monitoring of by-products and trace contaminants is essential to meet end-use requirements, especially for polyamide resins in automotive and textile sectors. Glutaronitrile’s specification and introduction must align with established protocols for achieving targeted amine values and minimizing side-reactions.

    Industry compliance standards

    • ISO 9001:2015 (Quality Management Systems for chemical manufacturing)
    • REACH Regulation (EC) No 1907/2006 Annex II (EU chemical handling and safety)
    • GB/T 19589-2017 (China: Polyamide 66 resin materials)
    • ASTM D789 (Test methods for amide content in polyamides)

    Typical usage ratio

    • 1.00–1.05 molar equivalents relative to total intended hexamethylenediamine production
    • Adjustment based on catalytic yield and batch size, generally 800–1000 kg Glutaronitrile per metric ton HMDA output

    Downstream process integration

    • Introduced to the hydrogenation reactor after pre-heating and filtration
    • Conversion to HMDA under controlled temperature and pressure, catalyzed by Raney Nickel or similar systems
    • Effluent purified and separated for polymerization

    Final product types

    • Nylon 66 polymer chips
    • Engineering plastics granules
    • Fiber-grade polyamides
    • Industrial polyamide resins for automotive parts

    2. Precursor for Glutaric Acid Manufacturing

    Chemical plants utilize Glutaronitrile as a direct precursor to synthesize glutaric acid via hydrolysis. This step demands careful reaction control regarding temperature, acidity, and agitation, as incomplete conversion or residual nitrile content can compromise downstream use in polyester and plasticizer production. Trace analysis for cyanide and related impurities is mandatory at this stage. Glutaric acid derived from this route serves high-value manufacturing chains, with strict specification limits on residual organic nitriles ensuring regulatory compliance for end products.

    Industry compliance standards

    • EU Commission Regulation (EC) No 231/2012 (Definition and purity criteria of food additives – when used as food contact material component)
    • US FDA 21 CFR 177.2420 (Polyester polymers for food packaging)
    • ISO 14001:2015 (Environmental Management for chemical synthesis lines)
    • QC/T 1202-2019 (China: Chemical raw materials for plasticizers)

    Typical usage ratio

    • 1.00–1.03 molar equivalents to target glutaric acid yield, translating to 1.1–1.2 kg of Glutaronitrile per kg glutaric acid output after adjusting for water and reagent excess

    Downstream process integration

    • Fed into acid hydrolysis reactors, typically with sulfuric acid under heat
    • Mounted in batch or continuous-flow systems, with multi-stage purification
    • Product slurry filtered and crystallized prior to drying and blending stages

    Final product types

    • Glutaric acid for polyester intermediates
    • Specialty polyesters for electronic encapsulation
    • Plasticizer blends for flexible PVC
    • Thermoplastic modifiers for automotive interiors

    3. Solvent and Synthesis Reagent in Pharmaceutical API Manufacturing

    API manufacturers employ Glutaronitrile as a synthesis reagent or polar aprotic medium for building complex pharmaceutical molecules, especially certain anticonvulsants and CNS drug intermediates. Handling and batch control occur according to cGMP practices, with full traceability of raw and in-process material. Because pharmaceutical applications face intense regulatory scrutiny, each lot must pass rigid QC for purity, isomeric composition, and absence of residual solvents. Processing stability and reaction kinetics depend on precise introduction of Glutaronitrile within the multi-stage synthesis, requiring validated procedures for scale-up.

    Industry compliance standards

    • ICH Q7A (Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients)
    • US FDA 21 CFR Part 210/211 (Current Good Manufacturing Practice in Manufacturing, Processing, Packing, or Holding of Drugs)
    • European Pharmacopoeia 10th Edition Monographs (Purity and impurity thresholds for APIs)
    • Chinese Pharmacopoeia (Volume IV): Residual Solvents in pharmaceutical excipients

    Typical usage ratio

    • Variable 0.2–1.5 molar equivalents, depending on synthetic route and drug candidate
    • Generally 10–50 kg per batch size for specialty CNS compounds

    Downstream process integration

    • Charged as reagent or solvent in specific step of multi-stage syntheses
    • Removed via distillation or aqueous workup in the API isolation phase
    • End-product subjected to final purification and residual solvent analysis

    Final product types

    • Pharmaceutical intermediates for anticonvulsants
    • Advanced CNS-active drugs (e.g., piracetam derivatives)
    • Specialty heteroaromatic building blocks
    • Fine chemicals for custom pharmaceuticals synthesis

    4. Electrolyte Component in Industrial Battery Manufacturing

    Glutaronitrile serves as a specialized additive in high-voltage electrolytes for lithium-ion and lithium-metal industrial batteries. Its high dielectric constant and viscosity-modifying characteristics enable improved ion transport and chemical stability in advanced electrolyte blends. Battery assembler lines require purified, low-moisture grades of this nitrile to prevent side reactions or gassing during operation. Qualification involves precise control at blending stations, supported by regular SPE/NMR testing to confirm the absence of interfering traces, thus assuring performance consistency in finished energy storage devices.

    Industry compliance standards

    • UN 38.3 (Lithium Battery Transport Safety)
    • IEC 62660-2:2018 (Secondary lithium-ion cells for industrial applications)
    • ISO/TS 16949 (Automotive sector battery quality systems)
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances in electrical equipment)

    Typical usage ratio

    • 1–6% by weight as an additive in electrolyte solutions, depending on chemistry and voltage target
    • Adjusted according to target viscosity and ionic conductivity requirements

    Downstream process integration

    • Blended with main carbonate solvents and lithium salts in controlled mixing tanks
    • Direct injection into cell assembly lines through inline filtration units
    • Component tracked by batch for traceability and post-assembly QA release

    Final product types

    • High energy density lithium-ion cells
    • Lithium-metal primary and secondary battery assemblies
    • Automotive and stationary industrial battery packs
    • Specialty batteries for aerospace and defense electronics

    5. Specialty Solvent for Agrochemical Synthesis

    Agrochemical producers leverage Glutaronitrile as a process solvent and reaction medium in targeted synthesis of fine chemicals and herbicide intermediates. Its polarity and stability under controlled conditions enable efficient transformation of precursors in nitrilation or amination reactions necessary for modern crop protection molecule manufacturing. Raw material handling and emissions control are closely monitored under EHS protocols. Extensive final batch testing for residual nitriles and heavy metals supports product stewardship and compliance within food-chain-sensitive sectors.

    Industry compliance standards

    • FAO/WHO: JMPR Guidelines for pesticide active ingredients (Residue limits in active ingredients)
    • ISO 9001:2015 (Agrochemical production quality management)
    • China National Standards GB 2763 (Maximum residue limits for pesticides in food)
    • REACH (Annex XVII: Restrictions on nitrile use in plant protection)

    Typical usage ratio

    • 0.5–2.5% by weight of total reactor charge on process step basis
    • Volume adjusted based on substrate solubility and target reaction time

    Downstream process integration

    • Dosage into jacketed reactors before precursor loading for main synthesis step
    • Application as co-solvent during key nitrilation or amidation reactions
    • Recovered and purified by distillation after batch completion

    Final product types

    • Pyridine-based herbicide active ingredients
    • Selective fungicide intermediates
    • Insecticidal fine chemicals
    • Formulated crop protection end-products

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    Certification & Compliance
    More Introduction

    Glutaronitrile: A Closer Look from the Manufacturer’s Floor

    Understanding Glutaronitrile from the Ground Up

    Making chemicals means spending plenty of time with the raw materials, troubles, and demands of industry. We put our hands on every batch, and with glutaronitrile, it pays to know what you’re handling and what makes it valuable. Glutaronitrile sits among the niche chemicals, but once you start working with it, you see the finer points that put it in demand.

    With the formula C3H6(CN)2, glutaronitrile stands out for its two nitrile groups tightly bonded to a five-carbon backbone. You see the application of this specific chemistry the moment you follow it through the plant—its combination of reactivity and stability gives it a distinct edge, one that persists even as other dinitriles or solvents crowd the market.

    Product Purity and Industrial Value

    We set our sights on high-purity glutaronitrile because anything less means more downstream issues and inconsistencies. In our plant, purification isn’t left to chance or wishful thinking. Every batch of glutaronitrile gets tested for water content, residual ammonia, and trace by-products. We keep water content low—under 0.1%—not just for show, but because excess moisture twists the results in downstream synthesis and invites corrosion across the feed pipes and line joints.

    Typical industrial-grade solutions rarely match this level of care. When lower-grade material rolls off basic systems, it might suit rough-and-tumble tasks, but for real chemical transformations, impurities spell trouble. Nitrile chemistry isn’t forgiving, and experience tells you that frustration from unintended side reactions wastes both time and money. We avoid this by holding to tight purity standards.

    What Sets Glutaronitrile Apart in Practice

    To understand why glutaronitrile finds its place on production lines, you can’t look at it the same way you look at acetonitrile, adiponitrile, or succinonitrile. Glutaronitrile's five-carbon chain and dual nitrile functionality give it just the right flex for specialty syntheses—especially where longer alkylene chains matter. Succinonitrile, with a shorter backbone, limits your options. Adiponitrile adds a carbon and shifts physical properties, changing reactivity and solubility in key processes. Put side by side, glutaronitrile gives you a workable midpoint and suits unique applications.

    Each year, the specs matter—colorless liquid with a faint but sharp odor, boiling above 200°C, density right around 0.97 g/cm³, and a flash point upwards of 90°C. These numbers frame what handling this compound means to production managers, especially when planning plant upgrades or switching bulk flows between syntheses. The manageable volatility reduces risk compared to shorter-chain nitriles, while the higher boiling point lets you push the limits in closed system reactions.

    Many chemical routes seek the balance glutaronitrile brings. For example, specialty polymers need longer chain linkers that avoid crystallinity—glutaronitrile delivers the right flexibility, while shorter nitriles like malononitrile make for rigid, brittle results. End users can see a difference in final texture and resiliency just by switching the core chain length. That’s something that gets tested not in theory but under actual workloads when customers demand better performance.

    From Synthesis to Special Use Cases

    Every part of the manufacturing chain draws on hands-on knowledge. Most glutaronitrile on the market today comes through the hydrogenation of glutardiamide or the dehydration of glutaric acid derivatives—both routes demand precise temperature and pressure control. Our production staff adjust parameters based on real-time analytics, because a slight drift in reactor temperature can leave unconverted starting material or side products behind.

    On-site, we monitor exotherms and flow rates with care, using robust feedback loops to ensure product consistency. Waste minimization sits at the forefront—nitrile chemistry brings environmental stakes, and we recycle waste streams through catalytic treatment to limit ammonia, nitriles, and trace cyanides in effluent. Local rules drive a stricter approach than many overseas producers take, but we tie compliance to plant safety and our own peace of mind.

    Real Application Stories from the Industry Floor

    End users value glutaronitrile for its adaptability in fine chemicals and polymer manufacturing. We work with producers who manufacture specialty polyamides using glutaronitrile as a precursor. These polyamides, when you study the microstructure, display superior flexibility and thermal resistance—traits linked directly to the five-carbon backbone. Lab staff analyze the changes, running comparative melt flow and tensile strength tests between products made from glutaronitrile and those using alternative chain extenders.

    Intermediate manufacturers count on the chemical stability of glutaronitrile during multi-step reactions. Nitrile groups retain their integrity after exposure to acidic or basic conditions, which lets chemists push synthesis further before needing to introduce protective groups. Teams report that reduction and hydrolysis steps yield more predictable results with glutaronitrile, especially when compared to adiponitrile, which can lead to over-reduction and unwanted by-products.

    In pharmaceutical synthesis, staff rely on glutaronitrile for constructing five- and six-membered heterocycles. The dinitrile structure supplies multiple points of attack for ring closure and substitution. Research staff at contract manufacturing organizations tell us that using high-purity glutaronitrile streamlines isolating intermediates since side reactions with impurities consume excess solvent and time. Fluctuations in starting material purity directly echo in batch reproducibility—that real-world consistency matters at scale.

    Some clients use glutaronitrile to build non-standard ligands for catalysts and to synthesize chelating agents for water treatment. Researchers often push us for technical data beyond the usual certificate of analysis. We run additional stability and solubility tests in their preferred solvents and provide hands-on advice from our in-house chemists—a foundation that goes beyond generic technical support.

    Battery and electronics developers look at specialty nitriles for their dielectric and electrochemical properties. We field questions about glutaronitrile’s breakdown potential and dielectric constant, since these properties influence performance in high-voltage and specialty capacitor applications. Our technical team works with start-ups and well-established manufacturers, running iterative blends to test compatibility, thermal drift, and resistance to hydrolysis under load.

    Model, Packaging, and Storage as Understood by Manufacturers

    We categorize glutaronitrile both by standard grade and high-purity options. Most customers working fine chemicals or polymers need a material with purity above 99.5%. For these, we use lined drums or ISO tanks tested for nitrile compatibility, as simple steel containers might degrade or impart trace metals that ruin the finished polymer. We designed our warehouse with controlled temperature and ventilation systems—most issues we've seen in the past involved aged stock that picked up off-odors from poor seals or humidity incursion during shipment.

    Pure glutaronitrile remains stable in cool, dry conditions for years. Contamination from unintended co-storage has ruined mixed shipments in the past, so we always segregate it from acids, oxidizers, and strong bases. Each product is tallied and checked—the extra effort keeps stock usable and prevents inventory disputes that could slow deliveries.

    Our logistics team manages both rail and direct truck shipments, monitoring for leaks and offloading issues. All staff receive hands-on training to handle nitrile exposure safely. Every season, the procedures get revised with worker feedback to tighten standards. That real experience—not just what the regulations ask for—cuts accident rates and avoids downtime.

    Safety Lessons and Risk Management from Experience

    Working with nitriles, we’ve learned the value of treating them with respect, not fear. Glutaronitrile demands close ventilation and reliable protective gear. Gloves, goggles, and local capture devices form part of the minimum—because even minor exposure causes irritation or more serious health risks. We cycle safety training to new hires and experienced technicians, updating everyone when science and regulation move forward.

    Our safety team doesn’t just tick boxes for audits. They walk the plant, watch loading and unloading, and enforce spill protocols. Long experience with nitriles shows that the most common issues come from rushed transfers or poor connections at valves. Extra checklists and pre-transfer inspections add a few minutes to shift changes but prevent equipment loss and shutdowns that nobody wants.

    Waste management includes not just on-site neutralization but documented incineration or hydrolysis. We’ve upgraded our plant infrastructure over the years to recover and treat vapors, putting time into engineering rather than sending problems down the line. Every operator knows their spill containment routes and keeps both small and large-scale kits on hand.

    We coordinate with local hazmat teams and periodically run joint drills; that’s the reality of chemical manufacturing—preparing for issues you hope never arise, learning from small incidents before a larger one has a chance to develop.

    Choosing Glutaronitrile: Beyond the Brochure

    End users seek out glutaronitrile when they require a dinitrile that balances performance, processability, and manageable hazards. We see orders coming from polymer plants building next-generation resins, pharmaceutical firms scaling up pilot syntheses, and electronics manufacturers pursuing specialty solvents. Their choice reflects not only the properties of the chemical but the level of transparency and technical support we embed into every shipment.

    Other dinitriles each have their moment in the spotlight, but glutaronitrile’s versatility stems from its optimal chain length and robust functional groups. In our operation, it stands as the preferred choice for balancing chemical reactivity with physical safety. Chemists looking to make plasticizers, hardeners, or polyamide intermediates choose glutaronitrile when they want fewer surprises during the downstream reactions—consistency that develops from years of careful control at the manufacturing stage.

    Every batch carries the marks of where it came from—how the line operators kept moisture out, how QC chemists double-checked for amine or acid contaminants, and how shippers ensured the drum arrived clean and in good shape. Our customers often return with new requests or custom spec sheets, challenges that we accept because we approach each production run not as a commodity but as a precise, technical task building on long-standing know-how.

    Industry Trends and Customer-Driven Innovation

    Markets for specialty nitriles evolve quickly. We regularly get inquiries about custom modifications or the potential for lower-odor versions, and we study what can be done starting with raw material sourcing. Supply chain disruptions or regulatory changes push us to anticipate future constraints and look for novel ways to recycle or reclaim side-streams—a real reality in today’s market as environmental and corporate governance climb to new expectations.

    Some innovation arises from direct customer feedback: a client may notice trace color formation in a batch, and we build extra purification or testing steps to eliminate causes. Others look for greener routes or more sustainable processes, prompting us to consider renewable feedstock or alternative solvents in production. Our R&D chemists work directly on the plant floor and in the lab, ensuring change isn’t just about paperwork but about test results and consistent material output.

    We maintain relationships with universities, joint development ventures, and industry consortia that open new windows into process analytics and product validation. Collaborations with industrial partners on pilot plants show how real-world operation often diverges from textbook chemistry, so we draw on both types of expertise to sharpen the route from idea to scalable product.

    The Importance of Consistent, Reliable Glutaronitrile

    Few industries value reliability as much as chemical processing. Inconsistent supply or variable purity doesn’t just slow down individual users—it paralyzes entire product lines. Our operations crew knows that every call from a downstream manager about an unexplained batch failure echoes through the supply chain, and it pays to track every drum by batch, check, and archive.

    Having the right analytical information is as important as the actual shipment. We routinely field requests for older batch samples to track performance drift or supply certificates well beyond what basic regulations demand. It’s this kind of careful, informed traceability that builds long-term relationships and sets real manufacturers apart from brokers or resellers.

    Ceaseless attention to detail allows us to say no contaminated drum ever makes it out the door, and our storage and rotation schedules reflect this commitment. We keep reserves aside for emergencies and allocate specialist shipments for critical users where purity demands extra scrutiny. Years of experience teach us that these unseen safeguards build the reputation and trust needed to remain competitive in a field evolving technically and logistically.

    Looking Forward—Continuous Improvement in Glutaronitrile Manufacturing

    Every chemical plant faces new challenges each year—new regulations, new customer requests, and new technical hurdles. With glutaronitrile, as the demands on downstream products become tighter, we invest further in analytics, process control, and waste reduction. Our team constantly refines both the synthesis pathway and the purification steps so that bottlenecks and rework drop.

    We tap into digital monitoring, adding sensors, cameras, and cloud-based batch tracking so that feedback from one shift can speed the learning for those that follow. Investments in bulk storage and improved drum logistics help us move with the seasonality of demand, smoothing out peaks and valleys so neither the plant nor customer stockrooms run dry.

    Improvements don’t end at the plant gates. We work with shippers, forwarders, and end-user labs to make sure the journey from production floor to warehouse shelf happens with predictable quality. If an issue arises, we retrace every step and adjust our process—not just for the next drum, but for the next shipment and the next year’s business.

    Why Glutaronitrile Still Matters in Developing Applications

    Despite the competition from other dinitriles and new synthetic techniques, the reliability and balance of glutaronitrile keep it in the conversation for both legacy and emerging production lines. We watch its use expand into advanced polymers, energy storage, high-performance elastomers, and specialty reagents. The real story isn’t just about the molecule—it’s about how a stable, traceable, and responsive supply chain can help new chemistries move from the bench to the market.

    For manufacturers, each iteration of process improvement, technical support, and customer partnership reflects accumulated knowledge. The driving force comes not from the datasheet but from the actual running of the plant, problem-solving in real time, and understanding how material quality influences outcomes for thousands of end users.

    Glutaronitrile takes its real value where application, purity, and performance intersect. We see our daily responsibility as not just making chemicals but delivering consistency and reliability to a market that depends on both. Each drum that leaves our facility carries with it the lessons of every shift, every test, and every customer who stakes their next batch on what we create.

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