Products

Fluoroacetic Acid

    • Product Name: Fluoroacetic Acid
    • Alias: Monofluoroacetic acid
    • Einecs: 206-992-3
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    942422

    Chemicalname Fluoroacetic Acid
    Casnumber 144-49-0
    Molecularformula C2H3FO2
    Molecularweight 78.04 g/mol
    Appearance Colorless crystalline solid
    Meltingpoint 35-36 °C
    Boilingpoint 165 °C
    Solubilityinwater Soluble
    Density 1.338 g/cm³
    Pka 2.59
    Odor Odorless
    Hazardclass Highly toxic
    Flashpoint 104.4 °C (closed cup)
    Synonyms Fluoroethanoic acid

    As an accredited Fluoroacetic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Fluoroacetic acid, 100 g: Supplied in a sealed amber glass bottle with tamper-evident cap and hazard labeling, within secondary protective packaging.
    Shipping Fluoroacetic acid must be shipped as a highly toxic, hazardous material under strict regulations. Use corrosion-resistant, tightly sealed containers, clearly labeled with appropriate hazard symbols. Transport must comply with UN 2922, Class 6.1 (toxic), and all local, national, and international guidelines. Only trained personnel should handle and ship this compound.
    Storage Fluoroacetic acid should be stored in a tightly sealed container, away from incompatible materials such as oxidizers and bases. Store it in a cool, dry, well-ventilated area, preferably in a corrosion-resistant cabinet. Keep it away from sources of heat, ignition, and moisture. Clearly label storage containers, and restrict access to trained personnel due to its extreme toxicity.
    Application of Fluoroacetic Acid

    Applications of Fluoroacetic Acid in Industrial Manufacturing

    As a direct manufacturer of fluoroacetic acid, we supply material strictly for regulated industrial sectors with real market demand. Below we detail validated downstream applications with essential process and compliance references.

    1. Synthesis of Organofluorine Agrochemical Intermediates

    Major agrochemical formulation producers incorporate fluoroacetic acid as a building block to manufacture key intermediates for herbicides and rodenticides, especially fluoroacetate-based actives. The compound is typically introduced at early-stage esterification or amidation steps within a controlled reaction environment. Industrial protocols strictly regulate dosage, with batch-tuned adjustment to minimize byproduct formation and ensure consistent yield for downstream synthesis. Final intermediates are isolated, purified, and subjected to multiple analytical quality controls before conversion to commercial agrochemicals.

    Industry compliance standards

    • REACH (EC) No 1907/2006
    • US EPA FIFRA 40 CFR
    • China GB 2763 - Maximum Residue Limits for Pesticides
    • ISO 9001 Quality Management for Registered Plants

    Typical usage ratio

    • Active conversion steps: 0.1–0.8 molar equivalents depending on target molecule complexity; chemists adjust based on stoichiometry for ester or amide formation.

    Downstream process integration

    • Integrated at pre-chlorination or amidation phase, either in batch reactors or continuous flow units, with post-reaction neutralization for safe handling.

    Final product types

    • Ethyl fluoroacetate intermediates
    • Sodium fluoroacetate technicals
    • Registered rodenticide actives
    • Off-patent herbicide precursors

    2. Pharmaceutical Intermediate Production for Fine Chemicals

    Leading pharmaceutical and specialty fine chemical producers utilize fluoroacetic acid as a fluorinated moiety donor during multi-step syntheses of drug intermediates. It is often used in the preparation of reference molecules for medicinal chemistry programs, where regioselective introduction of a fluoroacetyl group is needed to modify biological activity. Stringent control over input quantity, reaction temperature, and containment is enforced to manage safety and achieve reproducible purity at intermediate and final stages.

    Industry compliance standards

    • ICH Q7 GMP Guide for Active Pharmaceutical Ingredients
    • USP/NF Monographs for Fluorinated APIs
    • WHO GMP Guidelines
    • European Pharmacopoeia (Ph. Eur.)

    Typical usage ratio

    • 0.05–0.2 molar equivalents relative to amine or alcohol substrate; exact proportion determined by stoichiometry and analytical yield targets in R&D or scale-up batches.

    Downstream process integration

    • Fed as a coupling reagent during acylation or as a direct introducing agent at key fluorination stage; temperature-controlled addition under inert atmosphere in GMP-compliant reactors.

    Final product types

    • Fluoroacetyl-protected amino acid intermediates
    • Synthetic reference materials for screening
    • Specialty pharmaceutical fluorinated building blocks
    • Custom research compounds

    3. Reference Standard and Analytical Reagent Preparation

    ISO-accredited laboratories and analytical chemistry manufacturers process fluoroacetic acid to generate traceable reference standards and working solutions, essential for environmental and residue monitoring. The raw material undergoes controlled neutralization or derivatization, with batch-specific documentation to ensure reference traceability. Exact concentration is achieved via precision dilution and quantitative analysis, conforming to laboratory QA protocols for use in robust HPLC, GC-MS, or immunoassay calibration routines.

    Industry compliance standards

    • ISO 17025 Laboratory Accreditation
    • USP Reference Standard Requirements
    • OECD Good Laboratory Practice (GLP)
    • EPA SW-846 Methods for Hazardous Waste Analysis

    Typical usage ratio

    • Standard preparation: 10–500 mg/L solution concentration; varied based on detection sensitivity and instrument linearity requirements.

    Downstream process integration

    • Processed in cleanroom environments; neutralized or derivatized in micro-batches, followed by calibration and filling; documentation provides material traceability and chain of custody for analytical standards.

    Final product types

    • Primary and secondary analytical standards
    • Residue analysis control samples
    • Calibration solutions for chromatographic systems
    • Certified spiking solutions for proficiency testing

    4. Synthesis of Specialty Fluorinated Monomers for Polymer Research

    Polymer research divisions and materials science companies deploy fluoroacetic acid within the custom synthesis of monomers possessing fluorinated side chains. Precise addition during esterification or transesterification enables crafting of batch-series materials with tailored chemical resistance or unique dielectric properties. Usage parameters vary by the targeted end-property, and process engineers closely monitor conversion rates, solvent compatibility, and polymerization kinetics to meet both R&D and pilot-scale documentation demands.

    Industry compliance standards

    • ISO 9001 Quality Management (R&D laboratories)
    • RoHS Directive (2011/65/EU) for downstream electronic polymers
    • TSCA Inventory (for US polymer research)

    Typical usage ratio

    • 0.2–2.0 molar equivalents according to monomer batch, with the loading adjusted to optimize fluorine incorporation into the polymer backbone or side group.

    Downstream process integration

    • Added at monomer functionalization step; followed by polymerization under controlled temperature and vacuum conditions suitable for open or closed reactor systems.

    Final product types

    • Custom fluorinated monomers
    • Experimental high-performance polymers
    • Dielectric polymer resins for electronics
    • Functional coatings for laboratory research
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    Certification & Compliance
    More Introduction

    Fluoroacetic Acid: Dedicated Production for Specialist Needs

    Decades of Practice, One Familiar Chemistry

    We have been producing fluoroacetic acid for many years, always with careful respect for its properties and hazards. The chemistry is straightforward, but the consequences of shortcuts are well known to anyone with real experience in handling toxic organic acids. Every step in our batch process, from raw material selection to distillation and packing, sticks to clear, established safety controls and traceability checks. This ensures our acid arrives at consistent purity and meets the strictest analytical benchmarks. Unlike a casual handler, our focus remains steady: predictable results for labs and manufacturers who know that margin for error is slim.

    No Place for Guesswork: What Matters Most in Fluoroacetic Acid

    Fluoroacetic acid may seem simple on paper—a clear, colorless solution with a sharp odor, notorious for its high toxicity. Anyone turning this compound out at scale learns quickly that each batch brings unique challenges. Small differences in temperature control or trace moisture levels during synthesis can change outcomes. We monitor every stage with reliable titration and chromatography methods, never relying on theoretical yields alone. Even with modern automation, skilled operators double-check sample results and reagent additions. Routine solvent exchange and container compatibility checks limit corrosion risks and storage losses. Our plant records confirm the same: stabilizing all these variables directly affects the acid’s reactivity, shelf life, and ease of downstream use.

    Modeling What Matters: Forms and Packaging from the Source

    Fluoroacetic acid leaves our site in liquid form, stabilized to maintain potency and purity through just-in-time filling. We produce it at industry-standard concentrations, mainly at 80 to 98 percent by weight. This range covers the analytic and synthesis needs for fine chemical and specialty reactions, while also keeping transport in compliance with local and international rules. Every drum or flask receives tamper-proof seals and full batch records—never generic packaging or reused drums. Direct shipment means we control every detail, eliminating unknown storage conditions or extended shelf times. We have handled regulatory spot checks over the years. Proper labeling with clear hazard and purity information is routine here, and builds trust with our repeat customers.

    What Use Looks Like in the Real World

    We know precisely where most of our fluoroacetic acid ends up: in research labs, synthesis routes for select pharmaceuticals, and specialized agricultural projects. Its role as a reagent comes down to the unique fluorine atom attached to its carbon skeleton. That simple change delivers tremendous chemical leverage. Researchers employ it to build fluorinated building blocks, test new drug candidates, and explore enzyme inhibition. Plant pathologists and toxicologists rely on it for tightly controlled field trials and laboratory reference standards. We cannot speak to applications that lie outside strict regulatory oversight, and we do not ship to parties without documented end uses. Stringent supply chain vetting keeps our product exactly where it’s supposed to be.

    What Sets Ours Apart from Lower-Grade Acid

    There are technical differences between fluoroacetic acid from an established chemical manufacturer and material from uncertain sources. We achieve contaminants less than 0.1 percent across major analytes and never allow heavy metal or organic byproduct contamination above analytical detection limits. We operate our reactors with real-time monitoring—color changes, pressure spikes, and temperature deviations all trigger investigation hours, not days, after a batch is closed. Our acid ships in acid-resistant, tested containers—not glass or unsuitable plastics that leach impurities. We have replaced aging infrastructure with stainless steel lines and scrupulously maintain gaskets to prevent unseen leaks or cross-contamination. Each improvement came from root-cause analysis of actual field issues, not generic upgrades.

    Shelf Life and Storage: Beyond Just Sealing and Labeling

    Fluoroacetic acid isn’t shelf-stable in the way solvents or inert reagents can be. We stamp production dates prominently and advise on maximum storage periods based on analytical stability data, not guesswork. Our warehousing stays cool and dry, and we keep stocks moving—no product gathers dust for months awaiting sale. An open or improperly resealed drum provokes immediate investigation. Occasionally, we’ve helped customers retrace events leading to frozen or decomposed acid. Each incident, and our internal data trends, have tightened our handling, training, and response times. Maintaining this chain of custody reduces loss, waste, and above all, user risk.

    Why Fluoroacetic Acid Demands Specialized Knowledge

    Fluoroacetic acid is not a routine organic acid; its inherent toxicity sets it apart. Only skilled technicians should handle it. Our experience shows that unfamiliar users, or those borrowing lab procedures from acetic acid or chloroacetic acid handling, quickly run into trouble. Proper local exhaust, full PPE—including double gloves, face shields, and chemically resistant aprons—and reliable spill kits remain non-negotiable. We notify all partners of changes to our safety data sheets and regularly field calls on proper neutralization and waste disposal. Over the years, our technical consultations have helped avert more than one near-miss accident where unapproved storage or incompatible neutralizer handling could have had fatal outcomes.

    Comparison with Similar Compounds: Hard Boundaries

    The temptation to substitute fluoroacetic acid for less regulated acids like acetic acid or chloroacetic acid exists, but only for those who miss the dramatic leap in biological activity and physico-chemical properties. Fluoroacetic acid’s acute toxicity stems from its close structural mimicry to biological compounds—a similarity exploited in biochemical research but demanding strict containment elsewhere. Chloroacetic acid, while corrosive and dangerous in its own right, doesn’t present the same risks for enzyme inhibition and secondary poisoning. Researchers and manufacturers ask us about direct substitutions. Our response always draws on case histories and regulatory discussions: handling thresholds, exposure limits, and required process controls diverge for good reason.

    Consistency and Scale: Learning Through Production

    Repeated, scaled production cycles of fluoroacetic acid start to tell their own story. Early on, we lost material from vapor phase loss and unexpected side reactions with incompatible cleaning agents, driving revisions to valve design and plant cleaning schedules. Process improvements came from tracking each loss incident; column trades, heating jacket swaps, and raw material supplier adjustments all left their mark on the final product. Unlike a laboratory preparation, scaled production introduces batch-to-batch differences—opacity, odor variations, subtle color shifts. Our internal standards, developed from thousands of data points, flag anything abnormal. A clean batch passes not just basic purity, but matches historical density, refractive index, and even normal boiling point within a narrow range.

    The Role of Documentation and Traceability

    Proper traceability stands as one of our main bulwarks against error. We have absorbed the lessons of other manufacturers’ missteps, from mislabeling to inventory losses. Every outgoing shipment comes with not only a certificate of analysis from our own lab but enough retained sample and production records to reconstruct the entire process upstream. Any question from a regulatory audit receives documentation that ties back lot, supplier, and operator. This reduces recall risks and means questions about batch characteristics get answered without delay. We have never encountered a case where going light on paperwork led to long-term gains. Instead, paperwork anchors every other safety and quality system.

    Distribution: Controlled, Direct, and Verified

    Selling directly to end users limits the unknowns in our supply chain. Every recipient goes through qualification, including background checks on intended application, facilities review, and confirmation of proper handling procedures. We have refused orders that didn’t meet our thresholds. The volume of fluoroacetic acid we move is modest by mass-market chemical standards, but deliberate. It avoids stockpiling and ensures only competent hands use the material. Distributors and brokers often ask about resale, but we hold to our policy and manage only direct accounts, with full transparency in shipment and usage logs. This model keeps us accountable, the customers safe, and regulatory relationships sound.

    Training and In-House Protocols

    In our own facility, training goes beyond generic chemical safety. Every technician working on a fluoroacetic acid line completes recurring competency checks and must demonstrate understanding of exposure symptoms, emergency first aid, and full-scale containment and decontamination routines. Open communication during shift changes and production log updates minimizes uncertainty. We learn from near-miss reports and feed those lessons back into training, refining protocols in light of even minor deviations. Our written procedures are living documents, verified by internal audits and external review. Over time, the combined knowledge of operators forms a resource stronger than any manual alone.

    Unpacking Regulatory Compliance: Lessons from Practice

    No regulatory framework for hazardous chemicals remains static. National and international policies tighten around fluoroacetic acid with every passing year. Staying compliant means more than filling out paperwork or ticking boxes during inspections. Inspections can happen with little warning and always expect supporting evidence for every claim. We have invested significant time in updating classifications, hazard statements, and transport documentation. The most telling indicator of compliance comes from customer return rates—low incidents of improper paperwork or rejected cargos underline our attention to detail. Our regular dialogue with authorities clarifies interpretations and keeps us ahead of changes, not scrambling behind them.

    Innovation and Improvements: Incremental and Practical

    Major breakthroughs in fluoroacetic acid production are rare, but continual refinement fuels progress. Through our process engineers’ initiative, we have improved yield by adjusting reaction timing and monitoring minor byproduct formation. It took multiple iterations before finding that optimizing reactor agitation could reduce acid decomposition on hot spots. We switched to more robust, corrosion-resistant linings after analyzing pressure test failures in old tubing. These investments rarely draw public accolades, but they mean consistent outturn and smoother scale-up, and fewer scrapped batches on the floor. Our regular internal reviews examine pilot plant data alongside customer feedback, shaping investment in infrastructure and staff skills.

    Handling Incidents: Learning from Real-World Events

    Over the years, accidents involving fluoroacetic acid shape a facility’s culture more deeply than any routine run does. One incident involving improper venting drove us to refit all fume extraction with automatic monitoring. In another, a shipping issue revealed a shortfall in external transporter's awareness of acid hazards, prompting a training and certification requirement for all of our logistics partners. Each incident creates a teaching opportunity, resulting in updated procedures and closer supervision. Our commitment to open reporting and in-house investigations builds a culture of prevention, not blame. Patterns across the sector reveal that the best long-term safety record comes from open, honest incident analysis and actionable follow-no matter the cost or inconvenience.

    Waste Minimization and Environmental Responsibility

    Disposal of unwanted fluoroacetic acid, contaminated drums, or byproducts never falls into the category of routine waste. Our protocols for neutralization and destruction rely on established chemical routes, always double-checked by our engineers for completeness. Discharge to the environment remains off-limits under all circumstances. We maintain partnerships with licensed waste processors whose facilities meet or exceed our own standards for accountability and transparency. On-site, any spillage triggers immediate containment and clean-up, with data logged for trend analysis and reporting. Regular environmental audits challenge our assumptions and reveal opportunities for better source control or material recovery.

    Customer Support: Drawing on Hard-Won Insight

    Providing fluoroacetic acid means standing behind what we ship, not just in quality but in support. Over decades, chemists and safety officers from partner laboratories have sought advice on atypical syntheses, dosage adjustments, or emergency responses to exposure. Our technical staff draw on firsthand knowledge, not just datasheets. If support is warranted, we share methods, recommend contractors for waste treatment, or refer callers to the most current regulatory guidance. Some of our most valued customer relationships began following complex troubleshooting calls, where we were able to help recover product or fine-tune usage procedures. Consistent feedback sharpens our protocols, narrows the risk envelope, and deepens trust among experienced users.

    Summary: Why Responsible Production Matters

    Producing fluoroacetic acid poses constant reminders of the boundary between innovation and caution. Customers depend on precise chemistry and documented reliability, but above all, on a supplier who knows and respects the material’s power. Our practices, shaped by years of hands-on production and field experience, reflect the real demands and risks of fluoroacetic acid. By insisting on robust safety, traceable supply, and informed technical support, we meet both scientific and regulatory expectations—and protect the broader community from harm. This approach has sustained us through market cycles and allowed us to contribute to the advancement of safe, transparent, and high-integrity specialty chemical production.

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