Products

Ethyl Thiocyanate

    • Product Name: Ethyl Thiocyanate
    • Alias: ETHYL SULFOCYANATE
    • Einecs: 209-796-6
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    683196

    Cas Number 542-91-6
    Molecular Formula C3H5NS
    Molecular Weight 87.14 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Pungent, garlic-like
    Boiling Point 133-136°C
    Melting Point -4°C
    Density 0.978 g/cm³ at 20°C
    Solubility In Water Slightly soluble
    Refractive Index 1.498 at 20°C
    Flash Point 25°C (closed cup)
    Vapor Pressure 13 mmHg at 25°C

    As an accredited Ethyl Thiocyanate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl Thiocyanate, 500 mL, is packaged in an amber glass bottle with a secure screw cap and chemical hazard labeling.
    Shipping Ethyl Thiocyanate should be shipped in tightly sealed containers under cool, dry, and well-ventilated conditions. It is classified as a hazardous material, flammable liquid, and toxic substance. Ensure appropriate labeling, use of secondary containment, and compliance with regulations such as DOT, IATA, or IMDG during transport. Handle with care to avoid leaks or exposure.
    Storage Ethyl Thiocyanate should be stored in a cool, dry, well-ventilated area, away from sources of heat, ignition, and incompatible materials such as strong oxidizers. Keep the container tightly closed and clearly labeled. Protect from moisture and direct sunlight. Use corrosion-resistant containers and ensure proper grounding to prevent static accumulation. Store in accordance with local regulations for hazardous chemicals.
    Application of Ethyl Thiocyanate

    Applications of Ethyl Thiocyanate in Industrial Manufacturing

    Ethyl Thiocyanate serves as a critical intermediate in several specialized chemical production processes. Our facility supplies high-purity grades tailored for controlled integration into downstream manufacturing lines, following strict quality protocols and meeting industry-specific regulatory requirements for each sector. Below, we outline real-world industrial applications, focusing on the main sectors utilizing this raw material, with detailed technical and regulatory information for each use case.

    1. Synthesis of Pharmaceutical Intermediates

    Ethyl Thiocyanate plays a vital role in the targeted functionalization of organic molecules during the synthesis of active pharmaceutical ingredient (API) intermediates. Its thiocyanate group enables site-specific nucleophilic substitution reactions in the multi-step synthesis of heterocyclic and sulfur-containing drug scaffolds. Manufacturing processes require consistent batch quality to ensure controlled reactivity and compliance with pharmacopeial standards.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • EU GMP Part II for pharmaceutical production
    • US FDA 21 CFR Part 211 (cGMP Finished Pharmaceuticals)
    • Chinese Pharmacopoeia (when for domestic pharmaceutical supply chains)

    Typical usage ratio

    • 0.3%–2.5% of the total reaction mass, determined by the target compound's stoichiometry and functional group requirements; ratio adjusted according to desired yield and impurity control during process optimization.

    Downstream process integration

    • Added into highly controlled reactor vessels during mid-stage steps, preceding ring-closing or heteroatom introduction phases; process often run under anhydrous, inert gas conditions to prevent hydrolysis; product isolated by liquid-liquid extraction and crystallization before final API conversion.

    Final product types

    • Penicillamine derivatives
    • Thiocarbamate-based antihypertensives
    • Sulfur-containing analgesic intermediates
    • Custom thiophene and thiazole pharmaceutical precursors

    2. Agrochemical Intermediate Production

    In the crop protection chemicals sector, Ethyl Thiocyanate is used to introduce the thiocyanate functionality into intermediates for herbicide and fungicide synthesis. Its addition allows for derivatization of aromatic cores, enhancing the bioactivity of the resulting agrochemicals. Downstream manufacturers rely on its stability to avoid by-product formation, directly impacting the purity of formulated actives.

    Industry compliance standards

    • FAO/WHO Specifications and Evaluations for Plant Protection Products
    • ISO 9001:2015 Quality Management for chemical manufacturing
    • REACH Regulation (EC) No 1907/2006 for chemicals used in the EU
    • China GB 20800-2006 Agrochemical Production Safety Regulation

    Typical usage ratio

    • 0.5%–3.0% depending on formulation route and type of target molecule; process engineers select ratios based on the electrophilicity of receiving substrates and targeted conversion rates.

    Downstream process integration

    • Metered into batch or semi-continuous synthesis reactors following aldehyde or halide activation; typically involved in nucleophilic substitution or cyclization reactions; process monitored via HPLC for impurity management before further formulation.

    Final product types

    • Phenylthiocarbamate fungicides
    • Thiocyanomethyl-substituted herbicide precursors
    • Sulfur-based growth regulator raw materials
    • Intermediates for soil fumigants

    3. Specialty Flavors & Aroma Chemicals Manufacturing

    The thiocyanate group imparts strong and unique aromatic notes in certain flavor and fragrance compositions, especially for creating sulfur-rich top notes used in fine fragrance or food flavor design. Our product is integrated in controlled synthesis of flavor intermediates, demanding high purity to prevent sensory contamination and meeting strict food-grade regulatory standards.

    Industry compliance standards

    • FEMA GRAS (Flavor and Extract Manufacturers Association Generally Recognized as Safe)
    • EU Regulation (EC) No 1334/2008 on flavorings
    • US FDA 21 CFR Part 172 (Food Additives Permitted for Direct Addition)
    • ISO 22000:2018 Food Safety Management for ingredient suppliers

    Typical usage ratio

    • 0.02%–0.1% of total batch in intermediate synthesis; concentration tightly controlled to minimize unwanted residuals while producing thiocyanate-based aromatic compounds.

    Downstream process integration

    • Processed within finely controlled chemical reactors during the alkylation or thiolation steps of sulfur-containing flavor molecule synthesis; frequently followed by vacuum distillation and carbon treatment to ensure food safety compliance.

    Final product types

    • Allyl thiocyanate for horseradish/mustard flavors
    • Ethyl thiocyanate-derived aroma bases for perfumery
    • Sulfur note boosters for processed food flavorings
    • Specialty thioester aroma intermediates

    4. Fine Chemical Synthesis – Organic Laboratory Reagents

    Our product serves as a reagent for introducing thiocyanate moieties in academic and industrial laboratories, facilitating synthesis of custom research compounds and new material candidates. Its predictable reactivity profile ensures accurate yields for process R&D in specialty synthesis tasks, under compliance with laboratory safety and chemical management frameworks.

    Industry compliance standards

    • ISO 17025:2017 Testing and Calibration Laboratories
    • OECD Guidelines for Testing of Chemicals
    • Local hazardous chemical registration requirements (eg. US EPA SARA Title III reporting for laboratories)
    • Standard Operating Procedures for chemical inventory (institution/region dependent)

    Typical usage ratio

    • 0.1–2.0 equivalents relative to primary reactant; calculated per small-batch or pilot reaction as determined by molecular design objectives and the desired scale-up feasibility.

    Downstream process integration

    • Introduced into round-bottom flask or pilot plant synthesis setups during the nucleophilic substitution or functionalization stages; downstream procedures tailored to individual project requirements (column purification, crystallization, or vacuum evaporation).

    Final product types

    • Custom organic intermediates for research
    • Thiocyanate-tagged molecules for material sciences
    • Sulfur-modified ligand libraries
    • Lab-scale reference substances for analytical standardization

    5. Rubber Chemical Accelerator Synthesis

    In the rubber industry, Ethyl Thiocyanate acts as a starting material for the synthesis of organosulfur accelerators. These compounds enhance vulcanization kinetics and modify the final performance properties of rubber goods by introducing predictable sulfur crosslink structures. Our high-purity supply supports consistent reaction yields in both batch and continuous accelerator plant operations.

    Industry compliance standards

    • ISO 9001:2015 for chemical production control
    • ASTM D4678 Standard Practice for Rubber Chemicals
    • REACH, particularly for European automotive and tire supply chains
    • National Environmental Safety Regulations (as applicable for effluent and air emission in rubber chemical manufacture)

    Typical usage ratio

    • 0.5%–1.8% of total reaction mixture in synthesis of accelerator compounds; final ratio defined by the sulfur content required in the downstream accelerator formulation.

    Downstream process integration

    • Introduced in closed chemical reactors during preparation of thiocarbamyl or dithiocarbamate intermediates; critical process parameters include temperature ramp control and agitation speed, monitored for reaction exotherms and endpoint specification.

    Final product types

    • Primary accelerators (e.g., TBBS, CBS) for tires
    • Secondary accelerators for industrial rubber compounds
    • Vulcanization agent blends for conveyor belts
    • Crosslink promoters in rubber molded goods

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    Certification & Compliance
    More Introduction

    Ethyl Thiocyanate: Proven Value from the Source

    Manufacturing ethyl thiocyanate every week, you get to know the compound’s quirks and the real impact it brings to industry. Our ethyl thiocyanate model, produced consistently at a purity of 99.5% by GC analysis, leaves little room for surprises in downstream applications. It offers a balance between reliable chemical reactivity and ease of handling, making it a staple for formulation chemists and technical teams. Through years of refining both process and quality control, we see the same feedback repeated; customers value a dependable, high-purity product that slots neatly into their systems, minimizing the headaches that come with variability.

    Planning for Performance

    Creating every batch of ethyl thiocyanate from the ground up, from raw material sourcing through to distillation and final bottling, highlights the places where real-world performance matters more than theoretical specifications. Our batches consistently deliver a light, clear liquid with a sharp but not overbearing odor – a sign of both correct synthesis and clean separation from precursors. Chemical plants and research labs often remark that stable, high purity isn’t just a checkbox; it determines the yield and safety margins that differentiate a good run from a lost one. Even packaging has been refined over years of customer feedback. Leak-proof, corrosion-protected drums or HDPE bottles now see the most demand, as minor leaks not only waste product but create lingering odors and hazards. You learn quickly that no one wants to open a shipment in the loading bay and smell it on their clothes for weeks.

    Core Applications: What Works and Why

    Ethyl thiocyanate fills an essential niche for many chemical syntheses, especially where selective alkyl thiocyanate reactivity is required. In our own audits and field visits, we see large-volume customers in the pharmaceutical and agrochemical sectors, but also flavoring manufacturers chasing consistent, traceable raw materials. Ethyl thiocyanate’s structure creates a convenient building block for introducing the ethylthio group, offering a degree of predictability when forming intermediates for active pharmaceutical ingredients. The functional group behaves predictably in both nucleophilic and electrophilic environments, cutting down on side reactions. Trained chemists often comment that they prefer ethyl thiocyanate to propyl or isopropyl variants when traceability and reproducibility take priority over a wider range of volatility or steric hindrance. The ethyl chain’s minimal hindrance allows desired moieties to be introduced smoothly, without unnecessary byproducts. Our product, tested for both GC and water content, helps avoid unexpected problems with residual alcohols or thiocyanate salts that sometimes arise in less controlled syntheses.

    Why Purity Does Not Equate to Overkill

    Hands-on users often ask about raw purity numbers, but they also care deeply about impurity profiles. Having spent years analyzing batches for common contaminants – such as higher thiocyanates or residual sulfur species – we notice real-world clients choose our select grade because it does not introduce hidden production risks. Even 0.1% residual contamination can trigger regulatory headaches, batch rejections, or unwanted flavors. Analytical teams have pointed out that off-flavors or unexpected reactivity usually tie back to traces of unreacted propanol, isothiocyanates, or sulfur-based byproducts, not the main ingredient. This focus on not just overall assay but targeted impurity measurement is a lesson learned through frequent feedback from specialty chemical customers, especially those in flavors and fragrances. When scaling up, they want to know every gram does the job it’s supposed to, without overshooting regulatory or process control thresholds.

    Practical Differences from Similar Alkyl Thiocyanates

    Our own production line occasionally fields requests for isopropyl, methyl, or butyl thiocyanates, each serving its own specialized set of needs. What stands out about ethyl thiocyanate is its manageable volatility and handling profile – it vaporizes at a rate that satisfies both reaction control and recovery. Methyl thiocyanate, while more volatile, raises significant hazards for plant operators and is tricky to isolate cleanly at scale. Propyl and isopropyl variants offer differences in solubility and reactivity profiles but slow down certain desired substitution reactions due to increased steric bulk. Many technical groups in the pharmaceutical sector select ethyl thiocyanate for this exact reason: a Goldilocks zone between handling safety and chemical flexibility. Even flavor chemists, who require sub-ppm outcome control, choose ethyl-based products as their default and switch to others only when forced by regulatory or end-use restrictions. Being a producer, we spend a good deal of time optimizing distillation columns and purification lines to hit that narrow sweet spot; it’s not about being the cheapest per kilo, but about making sure every downstream process works as intended.

    Meeting Real-World Needs

    Clients rarely approach us with blank-slate requests for thiocyanates; they come with practical stories from their labs and mixing rooms. Some recall past frustrations with off-gassing or drum leakage. Others report trouble with mislabeling, inconsistent quality, or untraceable batch origins. For every issue, our plant invested in small but meaningful improvements: RFID tagging for inventory, stricter batch logs, and regular outside audits. These kinds of refinements keep processes predictable and reduce downtime for our customers. For food or pharmaceutical end uses, even minor lapses in product purity can trigger long and costly production or regulatory investigations. The ongoing investment into better process analytics – regular GC-MS, heavy metal screening, and water content checks – avoids surprises and supports full traceability. We have seen clients pay a little more for reassurance, rather than risk costly recalls or loss of certification due to an ambiguous supply chain. Compliance teams and technical directors increasingly demand not just a paper certificate, but live access to lot-level data. We make a point to send detailed batch analytics data up front, saving headaches later.

    Handling and Safety from Factory to User

    We know first-hand that safety starts at the plant floor, not only in the lab or end-user site. Many customers tell us stories about previous providers who cut corners on container choice, shipping schedules, or material labeling. Leaks in transit, poorly sealed drums, and vague labeling may seem like minor issues but quickly snowball into operational shutdowns once thiocyanate odors breach a warehouse air system. Our plant switched to specially lined steel drums and multi-seal HDPE bottles after one sticky summer shipment nearly forced a shutdown of a large customer’s bottling line. Since then, safety stocks have gone up, loss rates have dropped, and feedback from operators improved. We make sure each outgoing shipment has up-to-date transport labeling following current ADR and IMDG protocols, and our team re-inspects containers for exterior residue. Over the years, we’ve found that even one leaky bottle can sour a long-term relationship. Proactive logistics and real-world engagement with freight handlers protect both sides – manufacturer and user – from the friction of lost or damaged goods.

    Building in Flexibility for Scale

    In most industries, plan changes occur every quarter. Our order records show that customers switching from R&D projects to small-volume pilot runs appreciate quick adaptation. At larger scales, production managers want consistent drums and the ability to set up scheduled deliveries around their own turnaround needs. We keep minimums low for new product developers, and stock larger batch lots for plant managers who need time to balance inventory versus operating cash flow. By keeping a buffer of both small- and large-format containers, the plant’s logistics crew can translate Monday’s phone call about supply chain interruptions into a same-week shipment from our most recent stock. Many customers praise our rapid response team, and a plant with on-site filling and blending means that a new requirement – like a kosher-grade certification or a documentation tweak for an audit – happens with minimal friction. These operational details make a manufacturer more than just a commodities supplier; we become a partner who understands that downtime and upsets ripple across the entire chain.

    Trust Earned Through Testing

    Industry colleagues often wonder why we continue to expand our investment in batch-level analytics and external third-party testing. Over the past decade, tighter global regulations and the move toward food- and pharma-grade chemicals have raised the bar. Our plant invested early in cross-checked GC, HPLC, and residues screening, even when customers only asked for a basic assay number. Over time, those details proved decisive for clients whose finished products undergo strict release protocols. A formulation that worked six months ago may now require re-qualification due to market or legal changes; having full certificates for each batch eases that burden. Our internal team still reviews trend graphs for each run, noting slight shifts in boiling points, impurity pick-up, or trace moisture. We share this data, not to overwhelm customers but to give real, meaningful transparency. Consistent feedback from QC teams proves that detailed batch history – not just “meets spec” lines – saves weeks or even months when auditors demand backward traceability. In-house and external testing, updated documentation and cross-border regulatory support have kept more than one client out of expensive recalls or project delays.

    Improving for Tomorrow’s Standards

    Working as a primary producer, we feel the front edge of changing standards. Global movements toward more sustainable chemistry, less hazardous byproducts, and greater energy efficiency demand ongoing investment in plant upgrades. Every month brings tweaking of scrubber units, energy recovery, solvent recycling, and more accurate in-line monitoring. Clients from multinational pharma companies want assurances that our practices anticipate not just today’s ISO or GMP requirements but tomorrow’s GHS labeling or waste handling standards. Our team constantly reviews new regulatory releases and invests in training for both process and support staff. Even small process upgrades, such as better waste heat utilization or lower-VOC emission solvents, matter long-term and allow us to sustain reliable supply. We’ve noticed that large clients track not just purchase price but total environmental impact, and some now ask us for carbon accounting data. Embracing higher standards completes a feedback loop: tighter controls, better quality, and increased client loyalty drive further improvements at the plant.

    Collaboration and Honest Reporting

    One thing we learn repeatedly: chemical buyers distrust vague promises or incomplete lot histories. As a manufacturer, we publish full batch analytics, including GC chromatograms and detailed impurity breakdowns, with each shipment. Questions or complaints are logged directly by our support team and passed to plant operations for direct response. On rare occasions, an off-spec incident leads to a full root-cause analysis and process redesign — no sales spin, just facts and follow-up. We also take client suggestions for process improvements, new grade requests, or pack sizes seriously. Quarterly customer surveys help drive change: choosing lower-weight bottle options for research users, improving SDS clarity, or expanding our online batch data access. No short-term marketing campaign builds the long-term loyalty created by consistent, open reporting and a willingness to admit faults openly. This attitude, combined with technical expertise and ownership over the product’s full lifecycle, builds the foundation for serious, sustained trust.

    Conclusion: Making a Difference Through Consistency

    After years of focusing on ethyl thiocyanate, every kilogram produced reinforces the reality that chemical manufacturing isn’t about formulas on paper or generic SKUs on a spreadsheet. It is daily work, hands-on adjustments, and long-term relationships built on quality, adaptation, and transparency. Whether our product powers the next pharmaceutical breakthrough, flavors a global food brand, or forms the backbone of agricultural science, the real value comes from reliability across every step. Consistency allows our customers to focus on innovation, trusting the building blocks in their process behave as promised. As chemical production standards rise and traceability becomes more crucial, only tight process control, real-world feedback loops, and honesty in communication will sustain the trust required in today’s fast-changing market. In every barrel, drum, or bottle, that discipline is what sets manufacturer-quality ethyl thiocyanate apart.

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