|
HS Code |
333846 |
| Chemical Name | Ethyl 2-Bromo-2-Methylpropionate |
| Cas Number | 5445-17-0 |
| Molecular Formula | C6H11BrO2 |
| Molecular Weight | 195.06 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 64-66°C at 14 mmHg |
| Density | 1.297 g/mL at 25°C |
| Refractive Index | 1.432-1.436 |
| Flash Point | 95°C |
| Solubility | Insoluble in water; soluble in organic solvents |
| Smiles | CCOC(=O)C(C)(C)Br |
As an accredited Ethyl 2-Bromo-2-Methylpropionate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 250g amber glass bottle with secure screw cap, labeled with chemical name, concentration, hazard warnings, and manufacturer information. |
| Shipping | Ethyl 2-Bromo-2-Methylpropionate is shipped in tightly sealed, chemical-resistant containers to prevent leaks and contamination. It is transported according to relevant hazardous material regulations, typically as a flammable liquid with bromo compounds. Proper labeling, documentation, and protective packaging ensure safe handling during transit. Store and ship at room temperature, away from heat sources. |
| Storage | Ethyl 2-Bromo-2-Methylpropionate should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from heat sources, direct sunlight, and incompatible substances such as strong oxidizers and bases. Keep the container upright and clearly labeled. Store at room temperature or as recommended by the supplier. Avoid moisture and ignition sources. |
Applications of Ethyl 2-Bromo-2-Methylpropionate in Industrial ManufacturingOur manufacturing experience with Ethyl 2-Bromo-2-Methylpropionate supports multiple precise applications across advanced chemical industries. Below we detail tested integration pathways, compliance requirements, and practical technical parameters for several focused downstream sectors. 1. Synthesis of Active Pharmaceutical Ingredients (APIs)Ethyl 2-Bromo-2-Methylpropionate serves as a key alkylating agent in the formation of pharmaceutical intermediates, especially in the synthesis of statins and certain oncology drugs. Its reactivity facilitates selective molecular modifications required at critical steps under GMP-controlled environments. Pharmaceutical chemists leverage its bromine atom for targeted introduction of side chains, supporting complex multi-step synthesis with consistent lot-to-lot purity, as verified by analytical QA measures. The starting material is subjected to validated cleaning and containment protocols to meet stringent residual solvent and impurity thresholds, minimizing risk in large-scale commercial API output. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
2. Production of Specialty Agrochemical IntermediatesCrop protection manufacturers incorporate Ethyl 2-Bromo-2-Methylpropionate for bromoisobutyryl functionality in the synthesis of advanced herbicide and insecticide intermediates. It is typically utilized in the generation of activated aliphatic building blocks, improving synthetic efficiency and product shelf-stability. Chemistries are validated to ensure the raw material complies with maximum allowable residual halogens and meets country-specific environmental regulations. Manufacturing teams control batchwise addition and monitor temperature to prevent exothermic runaways during scale-up, especially in closed-loop systems with solvent recovery integration to support clean production mandates. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
3. Initiator Synthesis for Atom Transfer Radical Polymerization (ATRP)Advanced polymer producers employ Ethyl 2-Bromo-2-Methylpropionate as a highly effective initiator for controlled/living radical polymerizations such as ATRP. Its structure provides precise activation and deactivation required for producing block copolymers and functional polymers with narrow molecular weight distribution. Stringent control of residuals and absence of free bromine is essential to meet polymer-grade specifications. Process chemists regularly customize initiator loading to control chain length and branching, employing in-line analytical verification to optimize reaction kinetics and ensure batch reproducibility at scale. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
4. Manufacture of Photopolymer Precursors for UV Curing SystemsThe electronics and printing sectors utilize Ethyl 2-Bromo-2-Methylpropionate in the tailored synthesis of photoinitiator intermediates and functional resins. It enables introduction of well-defined functional groups that enhance polymer crosslinking under UV exposure. Strict documentation of raw material purity, trace residual content, and overall process validation is necessary due to the end-use in packaging inks and photoresists. Manufacturing teams closely monitor reaction completeness and employ filtration and stripping operations to remove trace brominated byproducts, complying with sector-specific migration limits and performance testing for polymerized films. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
|
Competitive Ethyl 2-Bromo-2-Methylpropionate prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8615365186327 or mail to admin@ascent-chem.com.
We will respond to you as soon as possible.
Tel: +8615365186327
Email: admin@ascent-chem.com
Flexible payment, competitive price, premium service - Inquire now!
Ethyl 2-bromo-2-methylpropionate occupies a unique position in our production line, not only because it serves as an increasingly sought-after building block for diverse organic syntheses, but also due to the strict process controls required to maintain high purity. Our experience comes from direct involvement every day with producing this compound at scale, handling everything from raw material selection to the intricacies of packaging and final shipment. We consistently target a minimum purity of 98% for general applications; tighter specifications, such as 99% by GC, remain routinely achievable in tailored production lines where downstream sensitivity demands it.
On our shop floor, rigorous traceability and proven batch records speak louder than product codes. We work with ethyl 2-bromo-2-methylpropionate at scales starting from the multi-kilogram pilot runs through to tonnage per month, maintaining the same commitment to analytical follow-up at every stage. Each step of the process, from methylpropionate esterification to the controlled bromination, has been fine-tuned over years of experience to limit byproduct contaminants—especially halo-substituted side products and residual solvents—which often raise questions for users in pharma and advanced materials development.
In actual synthesis labs and pilot reactors, no one benefits from vague promises or empty phrases. We have learned that our customers, whether working on pharmaceutical actives, agricultural intermediates, or specialty polymers, demand specific performance. The benefit of ethyl 2-bromo-2-methylpropionate starts with its branched structure, which brings increased reactivity compared to linear bromoesters. Alkylation reactions using this molecule tend to proceed rapidly and with precise control over regioselectivity, as demonstrated repeatedly in our clients’ medicinal chemistry campaigns. The ester group affords convenient handling—its solubility in most organic solvents makes formulation and workup straightforward.
Our technical support team spends a considerable amount of time on process consulting, not just supplying material. In process optimization discussions, details matter. Because ethyl 2-bromo-2-methylpropionate displays strong reactivity even under mild basic conditions, side reactions become a non-issue at standard temperatures, which means scale-up translates reliably from bench to plant. We have supported customers migrating from classic alpha-bromopropionates to ethyl 2-bromo-2-methylpropionate, often achieving increased yield or reduced process time as a direct result of the compound’s physical and chemical profile.
Compared with simpler bromoesters such as ethyl bromoacetate or ethyl α-bromopropionate, the methyl substitution on the alpha carbon in ethyl 2-bromo-2-methylpropionate changes both reactivity and downstream chemistry. The methyl group introduces steric effects that slow undesired side reactions, which chemists leveraging route scouting and fragment coupling genuinely value for selectivity. In our conversations with agrochemical developers, for instance, the higher selectivity and predictable branching pattern produced in heterocycle formation helps reduce purification costs and scrap rates downstream.
Resellers often miss a critical fact: true differentiation comes from the day-to-day experience of manufacturing and supporting process development, not simply listing a product in a catalogue. From chlorinated byproduct risk to variability in batch crystallinity, issues abound in unrefined, secondary-sourced material. By controlling both bromination temperature and feed rates, we ensure that the final product meets the needs of demanding applications such as organocatalysts, specialty surfactants, and reactive intermediates in synthesis chains for API and fine chemical output.
Customers with global responsibilities, especially in pharmaceutical and crop protection arenas, expect clear analytical data and regulatory support. Audits, pre-registration reviews, and customer visits have become common parts of our business. Our batch records have passed scrutiny routinely, and years of direct feedback from compliance officers have helped us anticipate issues in data integrity, solvent residues, and impurity fingerprinting.
The documentation we provide goes beyond the basic Certificate of Analysis. We share experience-based insights into impurity control, especially in circumstances requiring multi-ton shipments or repeat campaigns. Our team can pull up analytical chromatograms from decades of archived data, offering reassurance for clients facing major regulatory milestones.
Few discussions around bromoesters escape the topics of waste minimization and safe handling. Experience taught us that with ethyl 2-bromo-2-methylpropionate, bromine management is paramount. Our bromination unit employs state-of-the-art containment, automated dosing, and closed-loop recycling to minimize exposure and environmental load. Spill drills, operator safety training, and emergency procedures have become routine, not just for our site management but as guidance routinely requested by downstream users.
In talking directly with customers’ EHS teams, the recurring focus centers on safe storage, vapor containment, and responsible effluent treatment. We share what works—vapor-reduction equipment, selective neutralization, and efficient scrubber designs—always based on real-life implementation rather than textbook recommendations. This approach reduces the risk of incidents and helps customers feel more confident when scaling their own handling or waste management processes.
For ethyl 2-bromo-2-methylpropionate, temperature control during storage and transport often becomes a discussion point. The boiling point, around 146-148°C, gives it moderate volatility, but extended exposure above 30°C in storage can lead to hydrolysis or slow decomposition. Little practical advantage comes from freezing, but maintaining a closed, well-ventilated and cool storage area reduces operator exposure and preserves stability.
In mass production scenarios, crystallization can occur during tanker loading in cold weather. Rapid warming and recirculation dissolve any precipitate, but we have learned not to rush this process; improper handling can lead to uneven dissolving, which in turn affects dosing accuracy in continuous reactors. We regularly advise clients to use sight glasses and slow agitation during transfer. Experience-based troubleshooting saves both time and material waste, especially critical when operating at scale.
Quality assurance rests on reliable, transparent specification management. Instead of adhering blindly to traditional product standards, we engage with end users to set practical, application-driven specifications. For most pharmaceutical and crop protection applications, we keep water content below 0.1% by Karl Fischer and set GC-purity at a minimum of 98%. For highly sensitive syntheses—especially where even minor oxidation products could impact downstream reaction profiles—custom specifications are negotiated in advance. Requests for particle size, color grade, and trace metals occasionally arise; our QC laboratory provides rapid turnaround data.
We do not rely on external traders for final analysis. Every batch gets tracked and signed off by our in-house QC chemists, who have direct feedback channels with plant operators and maintenance personnel. This integration has led to steady reductions in out-of-spec product returns and streamlined regulatory submissions, directly benefitting users who rely on consistent, timely delivery.
Feedback loops built with research and process chemists have shaped our understanding of real-world applications. Ethyl 2-bromo-2-methylpropionate performs reliably as an alkylating agent, particularly in the preparation of α-branched esters and corresponding acids. Complex heterocyclic frameworks formed via nucleophilic substitution or addition reactions see improvements in overall yield due to the steric hindrance provided by the methyl group. In active pharmaceutical ingredient (API) development, conversion routes using this compound often run cleaner than with unsubstituted analogues, reducing downstream chromatography burden.
We have supported teams upgrading their manufacturing routes by offering application notes based on trials with our material—documenting not just reaction condition details, but pitfalls to avoid. A project team once shaved weeks off validation work by leveraging our shared data on side-product suppression and preferred reaction conditions. In another instance, a materials lab reduced the frequency of maintenance shutdowns after optimizing cleaning protocols based on our observations regarding solubility profiles in different solvents.
Scaling up production or transitioning to continuous flow brings challenges. Many users experience bromine-related residues, batch-to-batch variability, or unexpected off-gassing during product transfer. Years of in-house experience told us that careful feedstock quality management and pre-reaction filtering reduces these headaches. We prioritize full transparency about minor impurity forms and offer proven degassing procedures. Tank venting and precise temperature control smooth the way for uninterrupted delivery down the supply chain.
Waste management and sustainability are rapidly moving targets for us and our customers alike. Our on-site bromine recovery system captures process vapors and liquid residues for reuse, reducing off-site transport and associated risk. In addition, incremental upgrades in reactor heat management continue to shrink energy consumption. For end-users, simple actions such as improved inventory rotation, closed transfer, and investing in small-scale scrubbers have produced strong environmental outcomes—initiatives we actively encourage and help implement.
Over the years, many users transitioned away from multi-stage supply chains, seeking more reliable outcomes and supply security. We have heard repeatedly that direct partnerships streamline communication, reduce delays in technical support, and improve batch-to-batch consistency. Whether the challenge involves urgent turnaround for a process interruption or demand forecasting for new product lines, direct sourcing with experienced manufacturers prevents costly miscommunication and avoids hidden costs often buried in the fine print of distribution contracts.
For customers in tight-margin industries, every saved hour in documentation, every percentage improvement in yield, and every avoided quality incident directly contributes to project success. Our team invests the time not just to produce high-quality ethyl 2-bromo-2-methylpropionate, but also to share the lessons learned in scaling, regulatory compliance, and process improvement. Open lines of communication with production chemists, plant managers, and EHS professionals foster long-term mutual trust and innovation.
Manufacturing ethyl 2-bromo-2-methylpropionate is more than routine—it involves ongoing reassessment of process safety, batch analytics, and customer support. We conduct regular process audits, benchmarking outcomes against both domestic and international producers. Input gathered from end users informs ongoing capital investment, be it in new reactor lines, emission controls, or advanced chromatography systems. Practical improvements, such as streamlined drying systems and optimized purification columns, come not from theory but from day-to-day troubleshooting and feedback.
Some of our best improvements have come from simple observations: fixing a seal leak that reduced moisture ingress, or reevaluating a heating protocol that trimmed several hours off a reaction step. These details, repeated across hundreds of batches, compound into tangible advantages over time. We remain committed to continuous learning, acknowledging that every inquiry or observation from a user carries the possibility of sparking another cycle of improvement.
The chemistry landscape continues to evolve. Our own learning curve is shaped by direct conversations with research teams, production engineers, and regulatory consultants working at the cutting edge of molecular construction. Increasing demand for robust, high-purity alkylating agents reflects the need for both reliability and creativity in organic synthesis. The future lies in compounds like ethyl 2-bromo-2-methylpropionate, which combine stability, reactivity, and safety into a single, versatile package.
We maintain a strong relationship with our clients by going beyond the transactional—offering insight grounded in daily experience and real results. For those looking to improve yield, simplify work-up, or reduce compliance risks, a direct connection to manufacturing expertise ensures that problems get solved. Ethyl 2-bromo-2-methylpropionate stands as more than a commodity; it represents the outcome of sustained, hands-on effort, technical skill, and customer partnership over many years.
Feedback and new challenges only sharpen our focus. Each new requirement, whether regulatory, logistical, or technical, feeds directly into our next iteration of process innovation. For users who value consistent results, transparent interaction, and real insight into supply chain challenges, working with a dedicated manufacturer of ethyl 2-bromo-2-methylpropionate means investing in solutions that go beyond the molecule itself.
