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HS Code |
519254 |
| Cas Number | 112-16-3 |
| Molecular Formula | C12H23ClO |
| Molar Mass | 218.77 g/mol |
| Iupac Name | dodecanoyl chloride |
| Appearance | Colorless to yellowish liquid |
| Boiling Point | 277 °C (530.6 °F) |
| Density | 0.934 g/cm³ at 20 °C |
| Melting Point | -6 °C (21.2 °F) |
| Solubility In Water | Reacts with water |
| Synonyms | Lauryl chloride |
As an accredited Dodecanoyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Dodecanoyl Chloride, 500 mL, is sealed in an amber glass bottle with a tightly screw-capped lid, labeled with hazard warnings. |
| Shipping | Dodecanoyl chloride must be shipped in tightly sealed containers under inert gas, away from moisture and incompatible substances. It is classified as a hazardous material (Corrosive, UN 3265) and requires labeling and documentation in accordance with international shipping regulations. Appropriate personal protective equipment and emergency procedures must be in place during handling and transport. |
| Storage | Dodecanoyl chloride should be stored in a cool, dry, well-ventilated area, away from moisture and incompatible substances such as bases, alcohols, and strong oxidizers. It must be kept tightly sealed in a corrosion-resistant container, preferably under inert gas. Protect from light and heat. Proper safety labeling and secondary containment are recommended to prevent leaks and accidental exposure. |
Applications of Dodecanoyl Chloride in Industrial ManufacturingDodecanoyl chloride serves as a crucial intermediate in multiple industrial sectors. Our manufacturing expertise ensures strict batch consistency and traceability for all downstream applications. Below we outline real-world manufacturing uses and related process insights. 1. Pharmaceutical Intermediate SynthesisPharmaceutical formulation teams use dodecanoyl chloride to synthesize a range of active pharmaceutical ingredients (APIs), particularly within the development of prodrugs, local anesthetics, and antimicrobial agents. The compound enables precise acylation of amino and hydroxyl functions under controlled conditions, yielding high-purity intermediates for regulatory submissions. Reliable reagent quality, validated release parameters, and secure full-scale supply underpin commercial drug launching and upscaling projects. Industry compliance standards
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2. Surfactant Manufacturing for Detergent IndustryDodecanoyl chloride is essential in the industrial-scale synthesis of acylated surfactants such as dodecanoyl amides and esters, where it aids in the production of high-purity nonionic and cationic surfactants. These compounds exhibit superior emulsifying, foaming, and cleaning capabilities required in concentrated laundry liquids, hard-surface cleaners, and detergents for institutional use. Process engineers directly monitor conversion rates to ensure batch-to-batch reproducibility and low residual chloride content. Industry compliance standards
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3. Synthesis of Specialty Lubricant AdditivesManufacturers of high-performance lubricants and metalworking fluids rely on dodecanoyl chloride to produce esters and amides that provide tailored friction-reducing and anti-wear properties. The raw material supports precise introduction of lauroyl chains into proprietary additive molecules, improving film stability and thermal resistance in demanding applications. All usage must address volatility and color stability in accordance with automotive and industrial lubricant standards. Industry compliance standards
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4. Polymer Modification in Advanced Material ManufacturingProducers of specialty polymers and engineered plastics utilize dodecanoyl chloride for surface modification, grafting, and chain-end functionalization. Its use enables the introduction of hydrophobic lauroyl groups to tune polymer solubility, flexibility, and chemical resistance. This approach finds widespread adoption in medical devices, advanced coatings, and plastic film industries requiring custom polymer architecture for unique end-use conditions. Industry compliance standards
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5. Fragrance and Flavor Ester ProductionAromachemical manufacturers use dodecanoyl chloride for the synthesis of long-chain esters crucial to fragrance and flavor profiles. By reacting with select alcohols under catalyst control, it yields high-purity lauric esters used in premium perfumery bases, fine soaps, and food-grade flavors. Producers monitor purity, sensory thresholds, and trace residuals to comply with global supply chain and end-user regulatory requirements. Industry compliance standards
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Dodecanoyl chloride stands out among acid chlorides for its balanced chain length, presenting an attractive all-rounder to those of us who’ve spent decades in chlorination chemistry. We produce this molecule because its C12 structure delivers a combination of reactivity and workability that fits applications from high-performance polymers to specialty surfactants. On the factory floor, we call it a sweet spot product—long enough to be robust, short enough to remain manageable in a day-to-day production process.
At the plant, we run dodecanoyl chloride in dedicated reactors using refined lauric acid and thionyl chloride. The product rolls out clear to slightly yellow, with a recognizable pungency that makes any seasoned chemist’s nose twitch. We do not run mixed-feedstock; consistency in the chain length brings predictable yields, reproducible downstream results, and fewer surprises in storage stability. This is the kind of feedstock you want if you value straightforward reactions and minimal fuss with post-treatment.
We keep the acid chloride content above 98 percent by weight, measured right at the line. Features like moisture and color are just as tightly watched. We fight atmospheric hydrolysis fiercely—moisture control becomes a top priority, or you end up with stubborn acid build-up over time. This is not just lab chat; trusting that incoming batches deliver high assay keeps blending runs smooth and waste low. Color matters as well. High-purity cuts keep yellows at bay, showing polymer chemists and fine chemicals formulators that they can work without constant purification headaches.
Customers reach out for our dodecanoyl chloride (sometimes labeled as lauroyl chloride) when they want to build into amides, esters, and specialty surfactants. Its neat reactivity streamlines one-pot syntheses in personal care, lubricants, antibacterial agents, and polymer additives. Amidation stands tallest among uses: the C12 backbone lands powerful results in cationic surfactants—a central ingredient in conditioners for both hair and textiles. Esterification follows closely, with the reliable chain length affording controlled hydrophobicity in oil phase raw materials.
Anyone formulating for medical or agrochemical purposes demands clarity and spec control, and the direct-from-manufacturer approach gives the traceability and consistency research labs ask for. When we’re approached for scale-up projects—say, a new biocide, or a trial for a greener solvent—direct input from production saves both sides weeks of iteration by understanding real batch variances rather than relying on hypothetical property tables.
We’ve handled everything from acetyl to stearoyl chloride in bulk. Where dodecanoyl shines: it’s long enough to contribute meaningful hydrophobicity in formulations, but not so long that it turns waxy or non-pourable at ambient conditions. Contrast with octanoyl or decanoyl—you hit volatility and odor issues with shorter chains. Push up to palmitoyl, and you’re wrestling with solidification in tanks and clogged lines unless every inlet is heat-traced. Dodecanoyl chloride lands in the practical zone, pumping well and reacting at a controllable rate, letting process engineers focus on throughput without adding heaters or excessive ventilation.
In terms of synthesis outcomes, our years of output show that dodecanoyl chloride reacts efficiently with both primary and secondary amines, far more smoothly than with bulkier, less-mobile acid chlorides. The shelf stability in a proper drum—under nitrogen, out of the sun—means customers can buy in volume and not fear rapid degradation. By avoiding excessive volatility, it also makes working conditions a little less harsh—fewer escaping fumes, less rework.
Polymers built with dodecanoyl chloride as a functional modifier display higher lubricity and tailored melting points compared to those using shorter acid chlorides. We’ve assisted customers optimizing PE and nylon additives, where adding the C12 chain ensures softness in the finished material—noticeable in cable insulation or film coatings. By contrast, shorter acid chlorides tend to limit mechanical flexibility or fail to deliver adequate hydrophobic protection in coatings exposed to moisture.
We keep meticulous logs—from the earliest days on analog charts to electronically archived runs—documenting how our dodecanoyl chloride travels from reaction vessel to final packout. The trust in our product gets built batch by batch, demonstrated in feedback loops with R&D partners and manufacturing clients. A product manager at a multinational surfactant producer once told us that only by switching to direct supply could they shave a week off their production timeline. The responsibility weighs on us: sound customer relationships aren’t abstract. They are forged in meeting the promised assay, honoring agreed freshness, and reacting proactively when rare logistics snags occur.
Custom packaging is a well-discussed benefit, but what really matters is closed transfers, compatible liners, and guidance for first-time handlers on managing acid chloride—these details often come only from manufacturers with boots on the ground. If you’ve ever tried to empty a welded drum of a waxy acid chloride with a hand pump, you’ll know how much difference smooth, compliant packaging makes.
Hydrolysis remains the biggest day-to-day threat to quality. Atmospheric humidity slips in with every crack in the seal, so filling is done under dry nitrogen, and we prompt users to unseal drums only right before use. We’ve invested in real-time monitoring and airlocks for this very reason, learning hard lessons from a few early batches in the rainy season.
Another challenge is occupational safety during transfer and blending. Acid chlorides demand respect; we run regular refresher courses on PPE, spill protocols, and proper neutralization. By working directly with clients’ EH&S teams, we have helped them reduce minor exposure incidents and avoid regulatory citations. Practical tips—such as vented bung caps or acid-scavenging wipes—only come up after hundreds of routine transfers and feedback. Handling expertise makes or breaks a chemical program; this is seldom appreciated until a drum is mishandled.
In analytics, in-house gas chromatography and Karl Fischer titration make up our front line. There’s a temptation sometimes to over-rely on third-party certificates, but direct, real-time verification lets us adjust upstream process parameters instantly rather than batch-by-batch. Customer complaints from several years ago about off-odors helped kick off a two-year upgrade of our drying and venting systems. The sharpest learning comes from hands-on problem solving, not peer-reviewed papers.
Regulations around acid chlorides have steadily increased, with new requirements on labeling, track-and-trace, and safe transportation. Having teams who understand not just the letter, but the intent, of chemical safety laws keeps downstream handlers out of trouble. Together with customers, we review handling documentation every quarter, taking enforcement actions as a real-world signal for where improvements matter. We’ve worked with European and Asian inspectors, and experience tells us direct provision of batch traceability and immediate access to product records keep audits painless.
Waste disposal is another shared concern. Hydrolysis byproducts can’t go straight down the drain. Local and international norms require neutralization and control; we coach users on simple calcium carbonate treatments and ensure they have proper MSDS and guides tailored for their jurisdiction. A product made with responsibility lets clients sleep easier, not just procurement officers but plant workers too.
Not all acid chlorides are created, handled, or stored the same. Taking lauric acid as a base brings purity up from the very first step—by avoiding triglyceride- or palm-oil-based sources, we produce a consistent C12 stream with tight impurity profiles. Mixing plant-derived starter materials introduces wide assay swings and contaminant traces—this might pass muster in non-critical uses, but any deviation spells trouble in active pharmaceutical or agrochemical intermediates. We safeguard batch inputs with controlled, supplier-certified input chains, ensuring every lot performs the same batch after batch, year after year.
The way a product is filled also brings real-life impact. Pre-dried drums and fill stations keep ambient moisture away, avoiding the chalky precipitate or corrosive vapor that can come from sloppy post-market repacking. Direct shipment from our facility means no intermediate breaks in seal, giving buyers the freshest cut. Re-bottled or repacked acid chlorides can lose the edge in purity and freshness before they even reach a user’s dock. With our process, users find opening a drum, pulling a sample, or running a QC HPLC yields tight, repeatable answers—for anyone building fine chemicals, days saved on rework or, worse, troubleshooting, make the whole difference between success and headaches.
On the manufacturing side, innovation grows directly from real production needs instead of abstract blueprints. Years ago, as surfactant users began looking for more biodegradable and skin-friendly compounds, we saw direct requests for better traceability and purity in acid chlorides like dodecanoyl chloride. Routine feedback sparked investments in reactor upgrades, scrubber integration for improved byproduct management, and even changes in our packaging partners for better idiot-proof handling. We now see food packaging and new-generation plastics blending dodecanoyl-derived monomers for improved flexibility, taking cues not from theoretical models, but from real machinery and end-customer requirements.
Technical partnerships thrive on direct access to our production knowledge. Whether it’s troubleshooting a polyamide stuck in a pilot plant, or re-tuning a surfactant blend for foaming optimization, close relationships accelerate practical innovation. If a polymer chemist calls up on a Friday afternoon, talking through the last two years of inconsistent melting points, a seasoned process engineer at the plant can often trace the root to a subtle specification creep in the acid chloride. Cutting through the fog of supply chain data, live connections short-circuit countless research dead-ends.
Demand for structured, mid-length acid chlorides shows no sign of slowing. As customers move towards specialized, higher-function products—especially where non-petroleum sources matter—direct relationships with the actual manufacturer become a competitive edge instead of an afterthought. Investments in digital tracking, hands-on logistics feedback, and practical safety support are shaping this market. Not all trends start in the boardroom: many of our best improvements have grown out of frank conversations over a noisy filling line or on the sidelines of a maintenance shutdown.
Making dodecanoyl chloride well is not just measuring purity, but riding the full loop from sourcing to scale-up, giving honest warnings about hazards, and making sure every batch works as intended out in the real world. For us, it’s the combination of chemistry done right, operational discipline, and the lived-in feel of working with people who’ve sent out thousands of drums—not just data sheets. Direct experience doesn’t just inform—it shapes the way we build and share chemical products.
