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HS Code |
173388 |
| Chemical Name | Butyronitrile |
| Iupac Name | Butanenitrile |
| Molecular Formula | C4H7N |
| Molar Mass | 69.11 g/mol |
| Cas Number | 109-74-0 |
| Appearance | Colorless liquid |
| Boiling Point | 116°C |
| Melting Point | -112°C |
| Density | 0.803 g/cm3 at 20°C |
| Flash Point | 28°C (closed cup) |
| Solubility In Water | 6.3 g/L at 20°C |
| Odor | Sweet, ether-like odor |
| Refractive Index | 1.397 at 20°C |
| Vapor Pressure | 16 mmHg at 25°C |
As an accredited Butyronitrile factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Butyronitrile is packaged in a 500 mL amber glass bottle, featuring a secure screw cap and a clear hazard label. |
| Shipping | Butyronitrile should be shipped in tightly sealed containers, protected from light, heat, and sources of ignition. It is classified as a flammable liquid (UN 1126) and must be transported according to hazardous materials regulations. Handle with proper labeling and ensure compatibility with other chemicals to avoid dangerous reactions during transit. |
| Storage | Butyronitrile should be stored in a cool, dry, well-ventilated area away from sources of heat, ignition, and direct sunlight. Keep containers tightly closed and properly labeled. Store separately from oxidizing agents, acids, and bases. Use corrosion-resistant shelving. Ensure proper grounding and bonding to prevent static discharge. Store in compliance with all relevant chemical safety regulations and guidelines. |
Applications of Butyronitrile in Industrial ManufacturingButyronitrile is used as a critical intermediate in varied chemical manufacturing processes, delivering essential functionality for polymer and specialty solvent production, as well as pharmaceutical and agrochemical synthesis. Based on our direct experience as a manufacturer, below are key application scenarios with relevant compliance, process, and end-product details. 1. Intermediate in Pyridine and Specialty Amines SynthesisOur clients in agrochemical and pharmaceutical industries use butyronitrile as a vital building block for synthesizing heterocyclic compounds such as pyridine and substituted pyridines, which are essential in active ingredient synthesis. The nitrile group in butyronitrile participates in cyclization reactions under controlled catalytic conditions, and downstream processes require precise feedstock ratios for safe conversion. We ensure our product complies with stringent requirements for low water and impurity content to support high-yield manufacturing and minimize unwanted byproducts. Industry compliance standards
Typical usage ratio
Downstream process integration
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2. Precursor in Solvent Manufacturing for Industrial ExtractionButyronitrile serves as a precursor in the synthesis of specialty solvents required for metal extraction, hydrocarbon purification, and cleaning formulations. Producers employ hydrogenation and alkylation reactions where butyronitrile provides both the nitrile functionality and controlled volatility needed for downstream solvent quality optimization. Our high-purity grades meet industry-specified water and color specifications for solvent manufacturers requiring consistent extraction performance. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
3. Monomer Precursor for Polymeric MaterialsDownstream polymer manufacturers rely on butyronitrile in the synthesis of acrylonitrile derivatives, which are essential monomers for various specialty polymers and resins. The controlled reaction of butyronitrile with acrylate functionalities under modified conditions yields customized macromolecular structures, supporting the technical requirements of coatings, adhesives, and specialty molded components. Our stringent attention to impurity profiles enables consistent downstream polymerization performance. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
4. Intermediate in Pharmaceutical API ManufacturingButyronitrile acts as a key nitrile intermediate in active pharmaceutical ingredient (API) synthesis for select antihypertensive and anticonvulsant agents. Pharma manufacturers deploy it in substitution, addition, and functional group transformation steps under validated GMP conditions. Feed purity and microcontaminant levels are crucial to ensure final API meets pharmacopoeial standards, and our materials supply full traceability to support regulatory filings. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
5. Starting Material for Agrochemical ManufacturingMany large-scale agrochemical producers use butyronitrile in the synthesis of active agents for herbicides and insecticides. It enables selective introduction of nitrile groups during complex molecule assembly. Batch records demand strict source documentation and analytically verified purity, particularly when agrochemical products must comply with export regulations or pesticide safety registration dossiers. Our technical team supports process scale-up with real-time analytical support. Industry compliance standards
Typical usage ratio
Downstream process integration
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In our plant, we handle a portfolio of specialty chemicals, and butyronitrile holds a practical yet distinctive place on our production line. This colorless liquid, known for a sharp, somewhat sweet odour, doesn’t just pass through our reactors as a commodity—it drives several critical value chains. Each drum and tanker that leaves our facility reflects our direct oversight for purity, process safety, and understanding of industrial demand.
Butyronitrile’s chemical model, C4H7N, tells you part of the story, but its real importance emerges on our shop floor. The production uses beginning with acrylonitrile or n-butanol ensure that quality factors trace back through properly monitored reactions and precise distillation steps. In our process, we target technical specifications tailored mainly for pharmaceutical synthesis, rubber accelerators, and fine agrochemical formulations. Assuring low water content and keeping impurities below 0.05% means our downstream partners—those making products like sulfa drugs or elastomer additives—avoid costly purification reruns. The purity doesn’t just sit on a spec sheet; it reduces equipment fouling, minimizes off-gassing in closed systems, and cuts down on paperwork for root cause analyses.
Our butyronitrile most often ships with assays above 99.5%, typically reaching benchmarks of less than 100ppm acidity and under 200ppm moisture. These are not arbitrary targets plucked from textbooks—they’re rooted in decades of feedback from technicians and plant managers who operate synthesis reactors for pharmaceuticals, specialty rubbers, and certain textile intermediates. If water content slips above specs in a batch, a sulfonamide manufacturer will get clogged filters and delayed campaigns. Acid levels higher than the agreed trace amounts trigger degradation that amplifies cleaning cycles, undermines storage stability, and can even lead to critical yield losses in specialty chemical synthesis.
Running butyronitrile through our in-house analytics instead of depending on third-party data gives us tight reins on what moves out of the plant. Every drum bears our direct quality assurance, and our teams learn more each year from honest post-mortem reviews of customer batch failures. Real-world scrutiny hones our specifications in a way lab theorizing never could.
Butyronitrile flows into some widely separated segments: pharmaceuticals, agrochemicals, rubber chemicals, and a handful of specialty intermediates. In pharmaceuticals, batch consistency sits at a premium. Our direct input arrives at API facilities, where the margin for error in alkylation or condensation routes remains slim. End-use examples, like the synthesis of pyridine derivatives or sulfonamides, demand consistent reaction kinetics. If batches vary, loss of time and upsets in work-up mount rapidly.
Our rubber chemical customers harness butyronitrile to create accelerants and modifiers. From the plant operator’s perspective, using high-assay material simplifies the formulation, makes catalyst selection more predictable, and prevents small molecular changes from cascading through a reactor charge. Even small amounts of acetone or water enter as contaminants, and their effect becomes pronounced at scale—causing everything from yield decline to undesired side products. It’s not chemistry in the abstract; it’s about keeping the next rubber compounding run smooth, safe, and within cost.
Some customers use our output in synthesizing pesticides or herbicide precursors. The difference it makes in these applications comes down to hydrolytic stability and clarity—you can’t afford haze, discoloration, or breakdown products when the next stage could amplify even trace contamination.
Operators new to the nitrile family sometimes view butyronitrile alongside acetonitrile, propionitrile, or even valeronitrile. The real experience of handling these chemicals demonstrates their unique strengths and roles. Acetonitrile, lighter and more volatile, shines in HPLC and solvent extraction, but lacks butyronitrile’s cusp between hydrophobic and reactive behavior. Propionitrile finds use for flavor and fragrance applications but seldom supports the heavier molecular structures our clients build. Butyronitrile’s four-carbon chain drives balance: it dissolves, reacts, and builds without the volatility of shorter nitriles or the cumbersome viscosity of longer chains.
This balance turns practical at the filling station. With butyronitrile, we avoid some of the losses to evaporation you see with acetonitrile drums left for even a short while in an open air transfer bay. The flash point, roughly around 30°C, falls close to propionitrile, but our operators and tanker crews know to take the extra precautions due to the heavier vapors and mild toxicity. Customers choosing higher chain nitriles often mention pumpability or mixing issues—not common feedback with our butyronitrile, where a readily handled viscosity range maintains process reliability from transfer to blending.
Colleagues sometimes ask why not substitute butyronitrile with similar chain length solvents, such as butanol or butyl acetate, especially when handling closed-loop reactor setups. The difference remains in chemical reactivity and extraction selectivity: butyronitrile supports nitrile-based synthesis routes and downstream isolations that simply collapse with an alcohol or ester. A few agricultural chemical makers tried to swap butyronitrile for other solvents in pilot runs—every time, product yields dropped, or impurity profiles shifted dramatically. That underscores why knowing precisely what chemical sits in a storage tank is not a mere technicality, it is a matter of operational reliability.
In over twenty years of producing butyronitrile, we have watched procurement trends upturn assumptions. Five years ago, modest water or acid levels raised few eyebrows. Now, our major accounts demand proof at every transaction—batch reports, independent GC analysis, and certificates referencing each shipment’s timestamp. This pivots on heightened regulatory oversight and rising precision in downstream uses, but it also comes from accumulated experience. When a pharmaceutical contract hangs on an API synthesis, a wayward impurity in nitrile feedstock forces risk assessments and possible regulatory filings. Half a percent off-target impurity can push a whole batch outside registration criteria.
Responding to these real-world pressures, we have invested both in plant-scale upgrades—spinners, fractionators, moisture-controlled storage— and in training our operators to treat deviations as learning opportunities. Every part per million off in a final COA traces straight back to reactor conditions, solvent recycling, or even how tank cars are washed between campaigns. Direct manufacturing oversight, rather than arm’s length trading, brings these variables into our daily practice, and customers notice.
The most pressing demands today revolve around traceability and documentation. Gone are the days when a simple spec sheet satisfied partners—now, customers want full digital audit trails, which tie each tote or ISO tank to a batch number, operator log, and third-party analytical report. As a direct manufacturer, we have real-time access to every stage of batch processing, and this visibility functions as a form of quality insurance for both us and our buyers.
Butyronitrile arrives with its own set of hazards, chiefly flammability and human toxicity. Our shop floor procedures bake these factors into every shift. Unlike trading houses that ship sealed barrels assembled well upstream, we work hands-on through each step—maintaining positive pressure, vapor abatement, and evacuation protocols. Our operating staff don’t just follow scripts; their feedback keeps incremental improvements constant. When transferring butyronitrile between process skids late at night or loading drums on a humid morning, small changes in ventilation, static control, or PPE matter.
Waste minimization and environmental discharge form part of every manager’s morning brief. Even as our butyronitrile order book expands, we focus on closed-loop loading, condenser upgrades for vapor capture, and recirculation practices, not just as regulatory responses, but as cost-saving and community-responsible moves. Every improvement lowers on-site emissions and keeps local waterways free from accidental discharge. As with all mid-size chemical operations, we balance throughput and stewardship, recognizing that waste always equals margin lost, and a single incident can cost months of trust with local regulators.
Customer audits prompt a clear-eyed look at every safety and handling protocol we’ve ever drafted. Cohorts from pharma and agrichemical makers ask to walk our drum yard and filling lines—trust builds when they see written SOPs manifest in lived practice. Seeing our labeling, sealed sample vials, and chain of custody logs in person makes a stronger impression than endless digital paperwork.
Everything from batch uniformity to order traceability comes down to granular control. On the production line, temperature holds, distillation rate tweaks, and solvent-wash protocols drive improvement. These steps move beyond specification sheets—they represent plant engineers’ and operators’ accumulated experience, especially as small deviations can trigger snowballing disruption downstream.
For instance, we once encountered a scaling challenge when a minor variance in distillation column temperature led to increased carryover of butylene impurities—an issue that caused a polymer manufacturer’s polymerization step to fail. Rectifying the process called not just for stricter controls on our end, but direct communication with the affected customer. Collaborating through raw data, material tracebacks, and joint lab analysis brought the process into tighter control for future runs. Such events shape our operational discipline and clarify that hands-on oversight trumps any level of desk-bound quality assurance.
Our operators do not simply clock in for shiftwork—they become stewards of material health from reactor startup to bulk tanker fill. They spot emerging inconsistencies before they escalate, leveraging cross-team knowledge built from regular post-campaign reviews. Rotating crew schedules inside the plant help maintain this vigilance, breaking out complacency that sometimes creeps into established runs.
Nearly every production manager faces the pressure of cost containment, but the full value calculation for butyronitrile never stops at price per kilo. The risk of lower-grade imports, often sourced by resellers eager to shave margin pennies, has led several of our longtime clients to return to direct sourcing. Batch failures tied to hidden impurities or ambiguous COAs cost exponentially more in lost output and wasted manhours than any short-term savings.
Direct communication lines, not just stamped certificates, separate us from dealers who simply move material through warehouses. If a customer’s plant manager rings us two days before a vial qualification run, our production scheduler can trace the actual tank, shift, and analytical results for every kilogram in their lot. Technical input goes both ways: when a downstream operator encounters an upset, we listen, adjust, and help troubleshoot—because we built the product, and know which variables to hunt. Such relationships may not always appear in public trade statistics, but they build the long-term stability that markets crave.
Source traceability also supports tighter margin management. While traders sometimes focus only on moving stock, we see every rejected batch or transport failure as wasted opportunity. Keeping transport times tight, offering flexible containerization, and staying tuned to global logistics delays keeps disruptions low. It’s the only way to defend customer uptime and safeguard our own production reliability.
Not every batch ships out perfect. We face choke points when raw material purity varies or when maintenance windows force in-process holds. As direct manufacturers, we adapt fast—rerouting reactors, scheduling re-distillation campaigns, or bringing mobile vacuum pumps to shift column cut points. In every case, the knowledge our operators bring into batch review meetings makes all the difference. Recurring process deviations become teaching moments instead of costly mysteries.
Supply chain shocks, such as sudden regulatory changes on feedstock transport or regional plant shutdowns, reshape planning every quarter. Close supplier relationships—built on years of mutual audits and transparency, not just price haggling—help us secure the consistent feedstocks essential for uninterrupted production. Our residue handling, wastewater controls, and emission abatement evolve right alongside. External audits no longer strike panic because we work upstream of regulation, tracking and documentation ready from day one.
Far from the glossy marketing perspectives sometimes found online, our perspective as a manufacturer centers on daily, practical realities: plant reliability, product trust, and best-in-class transparency. Those qualities win long-term, even as market headwinds and cost pressures come and go.
As new customer demands surface—tighter specs, greener synthesis routes, real-time quality dashboards—we invest directly back into our plant and workforce. Upgrading sensor arrays, digitalizing process logs, automating QC integration, and offering transparent data access bolster our promise that every shipment represents not just a product, but proven accountability up the chain of custody. Our field reps spend time at customer sites, share insights on safe handling and end-use optimization, and bring feedback to our R&D cycles with the voice of real users—not just sales metrics.
Butyronitrile endures as a robust intermediate because those who manufacture, not merely distribute, carry the burden and opportunity to improve every link in the chain. Each improvement springs from a direct conversation—between our plant staff, our customers, and the partners relying on us in their next campaign. The true difference emerges batch by batch, not just in product, but in the reliability and certainty that come from working directly with a producer rooted in the practical, daily business of chemical manufacturing.