Products

Butyl Chloroacetate

    • Product Name: Butyl Chloroacetate
    • Alias: Chloroacetic acid butyl ester
    • Einecs: 203-302-7
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    146294

    Chemical Name Butyl Chloroacetate
    Cas Number 4478-83-5
    Molecular Formula C6H11ClO2
    Molecular Weight 150.60 g/mol
    Appearance Colorless to pale yellow liquid
    Odor Sharp, pungent
    Boiling Point 192-194°C
    Melting Point -43°C
    Density 1.099 g/cm3 at 25°C
    Solubility Insoluble in water, soluble in most organic solvents
    Flash Point 74°C (closed cup)
    Refractive Index 1.421 at 20°C
    Vapor Pressure 0.37 mm Hg at 25°C

    As an accredited Butyl Chloroacetate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Butyl Chloroacetate is packaged in a 25 kg blue HDPE drum, sealed securely with a tamper-evident cap and hazard labeling.
    Shipping **Butyl Chloroacetate** is shipped in tightly sealed containers made of steel or glass, protected from heat, moisture, and direct sunlight. It is classified as a hazardous material (UN 2810), requiring proper labeling and compliance with international transport regulations for toxic liquids. Handle with protective equipment to avoid spills and exposure.
    Storage Butyl Chloroacetate should be stored in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizers, bases, and acids. Keep the chemical in a tightly sealed container made of compatible material, and protect it from moisture and direct sunlight. Ensure proper labeling, and keep it away from heat and ignition sources to minimize the risk of hazardous reactions.
    Application of Butyl Chloroacetate

    Applications of Butyl Chloroacetate in Industrial Manufacturing

    Butyl Chloroacetate functions as a key intermediate in specialized synthesis, with established use in limited but high-value downstream sectors. Below, we detail its industrial roles, focusing on the chemical, pharmaceutical, agrochemical, and specialty material fields, covering compliance, composition, integration, and resulting products.

    1. Active Pharmaceutical Ingredient (API) Synthesis for Local Anesthetics

    Butyl Chloroacetate acts as a critical alkylating agent in the manufacturing pathway of certain ester-type anesthetic APIs, such as Butamben. Its direct use as a substrate in condensation reactions with para-aminobenzoic acid (PABA) enables control over purity, reaction speed, and final yield. Accurate measurement of input concentration and monitoring of residual impurities remain essential to meet regulatory standards for injectables and topical APIs.

    Industry compliance standards

    • ICH Q7 GMP for APIs
    • United States Pharmacopeia (USP)
    • European Pharmacopoeia (EP)
    • 21 CFR Part 210/211 (FDA)

    Typical usage ratio

    • 1.05—1.15 molar equivalents relative to PABA, adjusted based on in-process GC-MS purity analysis to minimize excess reagent and downstream impurity load

    Downstream process integration

    • Added in the esterification stage following PABA preparation and base neutralization, typically under nitrogen with controlled addition rate to limit hydrolysis

    Final product types

    • Butamben (local anesthetic API)
    • Intermediates for other ester-based APIs

    2. Herbicide Intermediate Production in Crop Protection Chemicals

    Butyl Chloroacetate finds targeted use as a reaction intermediate for the synthesis of selective chloroacetate herbicides. Conversion via nucleophilic substitution yields core herbicide molecules, with quality management focusing on residual halide content and absence of unreacted esters. Specifications are driven by agrochemical regulatory norms as residues in field-use products must remain within published limits.

    Industry compliance standards

    • Food and Agriculture Organization (FAO) pesticide specifications
    • ISO 9001:2015 for chemical manufacturing
    • China National Standard GB 20656 for agrochemical intermediates
    • REACH registration (EU)

    Typical usage ratio

    • 0.95—1.1 molar ratio to nucleophile (e.g., substituted phenol compound), with fine-tuning based on LC analysis to achieve target conversion without build-up of unreacted chloroester

    Downstream process integration

    • Charged after the completion of initial coupling and hydrolysis stages, entering the functionalization reactor under alkaline or basic catalysis

    Final product types

    • Phenoxyacetate herbicide actives (e.g., MCPA esters, 2,4-D derivatives)
    • Crop protection intermediates for broadleaf weed control

    3. Synthesis of Plasticizer Raw Materials

    Within specialty plasticizer manufacturing, Butyl Chloroacetate serves as an intermediate to produce custom dialkyl esters targeting niche polymer formulations, especially for medical device and cable insulation applications. Controlled esterification and transesterification enable end-use manufacturers to reach precise flexibility, migration resistance, and processability parameters required by the polymer processing sector. Extensive batch traceability and impurity profiling ensure downstream compliance for medical and electrical standards.

    Industry compliance standards

    • UL 94 and RoHS Directive (2011/65/EU) for electrical insulation
    • USP Class VI for medical-grade plastics
    • EN 71-3 for plasticizer migration
    • ISO 9001:2015 for batch consistency

    Typical usage ratio

    • 1.0—1.2 molar equivalents to alcohol feedstock, with variation according to specified final ester composition and copolymer compatibility

    Downstream process integration

    • Inserted in the primary esterification reactor, combined with alcohols under acid catalyst and followed by vacuum stripping of unreacted materials for purity

    Final product types

    • Plasticizer esters for PVC compounds
    • Medical device polymer modifiers
    • Specialty cable sheath insulation grades

    4. Fine Chemical Intermediate for Aroma Chemical Synthesis

    Leading fragrance and flavor houses utilize Butyl Chloroacetate as a building block in the synthesis of unique ester and lactone molecules, which contribute characteristic fruity or sweet notes to high-value perfumery blends and food fragrances. The compound enters precise alkylation reactions, where process engineers optimize solvent choice, temperature profiles, and reaction order to isolate highly volatile, low-residue components free of banned impurities in line with international perfumery legislation.

    Industry compliance standards

    • International Fragrance Association (IFRA) Standards
    • FEMA GRAS (Generally Recognized as Safe) status for flavor intermediates
    • ISO 9001:2015 and FSSC 22000 for flavor ingredient production
    • EU Regulation (EC) No 1334/2008 for food flavorings

    Typical usage ratio

    • 0.8—1.1 molar equivalents as per target molecule, customized per downstream formulation and volatility/losses during distillation

    Downstream process integration

    • Used in core alkylation or esterification steps, added post-purification of initial alcohol or acid feed, with continuous in-line GC analysis to verify product profile

    Final product types

    • Raspberry, pineapple and apple-type aroma chemicals
    • Creamy-lactonic esters used in premium fragrances
    • Specialty perfumery intermediates for fine and functional fragrances

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    Certification & Compliance
    More Introduction

    Butyl Chloroacetate: Value and Craftsmanship in Industrial Chemistry

    Our Experience with Butyl Chloroacetate

    Every batch of Butyl Chloroacetate in our inventory reflects thousands of hours refining the process and listening to what industries want from this molecule. As a chemical manufacturer with a long history working closely with fine chemicals, we've learned the real-world value of purity, stability, and yield for this product. From pharmaceuticals to agrochemicals, formulators demand tight control over impurity profiles and consistent physical properties. In the plant, differences in raw material quality and reaction conditions leave a direct stamp on the outcome. We make adjustments and monitor everything closely so end users see results they can count on, not surprises.

    The Role of Butyl Chloroacetate in Synthesis

    Standard butyl chloroacetate starts with chloroacetic acid and butanol, catalyzed under acid. As simple as that might sound, a lot happens in each reaction run: minor byproduct formation, water removal, temperature shifts, and catalyst carryover can affect not only the product yield, but its purity and downstream usability. These things directly matter. Chemists seeking crisp ester bonds or minimal residual acidity find such differences play out in their own product quality, yields, and purification times.

    Our own customers have shown us how small technical details create challenges later on—impurities raise side-reaction risks, off-odor batches can foul sensitive syntheses, and variable boiling points translate into erratic column performance. At the plant, we dedicate time to process validation and maintenance because we know how essential a reliable supply is to every supply chain built around this intermediate.

    Model, Specifications, and Quality Details

    We manufacture butyl chloroacetate under controlled, documented conditions. Each lot delivers on expected purity, typically above 99.5% by GC, with water content and acidity checked at tight specifications. Density and color are kept consistent, minimizing the risk of inter-batch variation. We never let shipments leave the warehouse until results for each batch clear the standards needed for specialty chemical and regulated applications. Long-term customers trust the reliability because we share not only certificates, but real insights into how minor properties influence downstream chemistry. That kind of transparency, forged through years of technical exchange and troubleshooting, distinguishes production labs from basic bulk blenders and resellers.

    Solubility, volatility, and hydrolytic stability serve as key properties for butyl chloroacetate. Its molecular formula, C6H11ClO2, places it among the alkyl chloroacetates, but regular users recognize that batch-to-batch consistency in these properties has practical significance beyond a mere theoretical formula or CAS number. Product purity, hydrolysis resistance, and odor profile change the performance profile in actual synthesis, not just on paper.

    Practical Applications: Industry Knowledge

    Over the years, formulators and process chemists have turned to butyl chloroacetate for its unique reactivity. In pharmaceuticals, it's used to create active esters or as a critical building block when protecting or modifying molecules. In agrochemicals—herbicides, plant growth regulators, and specialty actives—its predictable reactivity and limited side reaction profile make it valuable well beyond what's achievable with less controlled esters or bulk chloroacetates. Consistent purity means less downstream purification time, which reduces costs and boosts throughput for everyone involved.

    Other uses show the versatility: in performance polymers, specialty coatings, and as intermediates for fragrance and flavor manufacture. We've seen its popularity grow among startups in specialty synthesis who require consistent reactivity, minimal off-odors, and a trusted source. In laboratory routines, minor differences in impurity profiles or solvent residue can scramble a week’s worth of work if the chemical doesn't hold to specification, or if it absorbs too much water en route. Because our operations focus on full-lot traceability and rapid feedback, clients can plan production timelines with fewer surprises.

    The Differences Compared to Other Alkyl Chloroacetates

    Industrial users quickly spot the differences between butyl chloroacetate and its cousins like methyl or ethyl chloroacetate. Size of the alkyl group changes not just volatility and boiling point, but the rate at which the ester participates in transesterifications, substitutions, or hydrolysis. Butyl’s higher boiling point gives it more shelf-life and stability under ambient conditions, while methyl or ethyl varieties flash off or decompose faster in less robust storage facilities. During production, these distinctions have real economic consequences: butyl chloroacetate’s lower vapor pressure can translate into reduced emissions and easier containment, especially in warm climates or processes without specialized ventilation.

    Some users only notice these contrasts after a failed scale-up or plant trial, where a substituted ester behaves so differently that downstream equipment fouls or extra washing is needed. Our regular feedback from process engineers highlights these details. Extended storage tests show butyl’s improved shelf-life under common warehouse conditions. In processes that require controlled dosing or gradual addition, its higher boiling point and slower volatility often provide a more forgiving processing window, reducing the risks of procedural mishaps compared to lighter esters.

    Sourcing Matters: Impact of Production Practices

    We do not believe in one-size-fits-all production. Many alkyl chloroacetate products from the open market display high variability in water content, acid residues, or mixed esters. This can cause sudden batch failures or regulatory compliance issues. Our processes center on careful batch selection, raw material traceability, and close attention to final purification. Our staff runs both routine and abnormality checks for every batch, from residual solvent analysis to organoleptic tests. This is routine not just for pharmaceutical clients but every end user, because a single anomalous batch can disrupt downstream schedules and burn through project budgets.

    Quality means more than passing COAs. Multiple clients rely on integrated real-time feedback about changes in supply chain, storage recommendations, and transport considerations, not generic paperwork. In our role as manufacturer, sharing operational intelligence—like thermal storage advice and real-world test outcomes—minimizes the gap between bench-scale promise and plant-scale outcome. Adjustments in production scale can introduce new impurity sets or alter yields, and we set aside production slots to manage these transitions carefully, without risking quality in routine batches.

    Working Around Technical and Regulatory Challenges

    Experience as a manufacturer highlights real bottlenecks: managing raw material purity, handling plant shutdowns, and aligning batch releases with client deadlines. The global chemicals trade increasingly faces scrutiny on environmental credentials and impurity control. Clients in the EU and North America need proof of origin, impurity studies, and regulatory clearances to pass audits. The best documentation starts with modern production records and responsible sourcing, not stock answers or re-badged resale.

    Production facts show a trend toward more hands-on cooperation between supplier and client, particularly for specialty applications. User feedback routinely shapes our production priorities: requests for tailored impurity control, more detailed breakdowns of minor components, or real evidence that a batch performs as needed in a specific process.

    Insights on Technical Limitations and Solutions

    Practical problems crop up year-round: hydrolysis in humid warehouses, pump seal failures from corrosive byproducts, off-odor complaints where storage atmosphere wasn’t inert. Our team responds by tweaking dehydration steps, adding nitrogen blankets for some shipments, and upgrading seals in our own lines. We discuss these choices openly because production floor decisions have a direct line to end-user reality.

    We provide butyl chloroacetate in both drum and bulk tank formats, depending on client need, and have repeatedly adapted packaging to respond to changing environmental regulations on secondary containment, drum re-use, and labeling practices. Some clients ask for special package sizes for just-in-time delivery—so they avoid stock degradation or extra labs tests.

    Chemical compatibility in the laboratory and factory matters more than ever as process intensification increases. We've been tasked to advise on long-term storage, troubleshoot failed reactions after summer heat spikes, and walk through client plant shutdown protocols. By sharing trends we see—such as seasonal volatility increases or increased breakdown risk during monsoon—users get a genuine, not just theoretical, sense of chemical stability and process margins.

    Reducing Industry Waste, Supporting Sustainability Goals

    Not every product release occupies a smooth path from plant to user. Regulatory requirements and customer feedback push us to minimize impact wherever possible. Over the years, we've made moves to fine-tune distillation columns for solvent recovery, reduce vented emissions during esterification runs, and recycle solvent and water wherever practical. Every percent of improved yield or reduced environmental footprint counts for a lot over large production runs.

    Clients working toward ISO or environmental certification rely on us providing batch documentation on recycling inputs, actual waste handling, and even on-site audits. Our technical team supports these requests because they produce a net benefit for the industry. We know the chain only runs as strong as its least reliable or transparent link. As manufacturers, not just traders, we have the full picture from raw material gate to finished product, with every opportunity to improve and pass those benefits along.

    Building Trust Through Real-World Application

    Manufacturers should not restrict themselves to what appears in MSDS sheets or stock chemical catalog descriptions. Real-world insight comes from batch-by-batch troubleshooting and from engaging closely with users as they work through pilot plant upscaling, new reaction presentations, and equipment commissioning. One long-standing pharmaceutical partner once faced repeated batch crystallization failures due to low-level moisture—a seemingly minor issue, but one quickly solved through improved drying and controlled-atmosphere packaging.

    In another case, a specialty polymer client approached with a storage tank fouling issue triggered by small but consistent increases in acid number in certain shipments. Backtracking through plant documentation and comparing old versus new reactor cleaning routines made the difference; small production tweaks resolved a downstream headache that wasn’t visible on a basic COA.

    These experiences underscore the importance of keeping eye-level communication and understanding how every lot of chemicals translates into final product reliability, worker safety, and business reputation. We update clients on batch transitions, share test deviations before they snowball, and follow up after every unconventional use—not just out of duty, but because experience teaches it is the only way to sustain partnership.

    Why Butyl Chloroacetate Remains Essential to Specialty Synthesis

    Butyl chloroacetate delivers a balance of reactivity, processability, and storage stability unmatched by lighter alkyl variants or more specialized esters. Process chemists depend on its robust ester group and controlled halide content for sensitive substitutions, esterifications, and as a versatile bridge-builder in multi-step synthetic schemes. Over time, we’ve learned that users care about predictable boiling points, a sharp onset of volatility, and freedom from byproduct accelerants—none of which stay stable without careful process control all the way from raw incoming material to finished product storage.

    In both scale and lab settings, downstream users have told us repeatedly that quality-of-life improvements come not from transformative technologies, but from unbroken reliability, batch-to-batch familiarity, and an honest exchange about what is in each shipment. By controlling crucial properties—moisture, acid value, purity, residual solvents—we deliver more than a molecule: we enable better project timelines, easier regulatory transitions, and stronger product reputations for every client using this intermediate in their supply chains.

    Looking Ahead: Meeting Future Industry Demands

    Every chemical user faces increasing regulatory oversight, supply chain interruptions, and tighter margins on waste and emissions. The industry trend shifts toward closer partnerships between manufacturer and user, based on data sharing, real-life performance, and an honest dialogue about what works and why.

    For butyl chloroacetate, the difference between a routine product and a truly reliable intermediate lies in those details only visible to manufacturers and direct users: moisture pickup on the filling line, subtle changes in odor indicating incipient hydrolysis, or trace impurities with a habit of interfering with downstream chemistry. We remain focused on sharing this view not only to supply a product, but to contribute know-how and support every client's own technical reputation.

    As production demands change, and as new applications develop, we stay close at every step, adapting specifications and production routines to make sure continued suitability even for rapidly evolving processes. Our development team tracks new trends and shares outcomes so the entire chain, not just the end user, makes progress together.

    Conclusion: The Manufacturer’s Perspective on Supplying Real-World Chemistry

    Supplying butyl chloroacetate extends beyond regular shipments or COA numbers. As direct manufacturers, our responsibility begins at raw material approval and stretches all the way to supporting the end user's technical, regulatory, and environmental goals. Product quality takes shape from rigorous procedural discipline and close client dialogue, not from relying on generic standards alone.

    Years of focus on process improvement and day-to-day troubleshooting have taught us the difference between a standard chemical and a reliable partner product. That difference—reflected in product consistency, timely support, and collaborative development—shapes the real value in every batch of butyl chloroacetate we ship.

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