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HS Code |
943439 |
| Chemical Name | 4-Nitrobenzyl Bromide |
| Cas Number | 100-11-8 |
| Molecular Formula | C7H6BrNO2 |
| Molar Mass | 216.03 g/mol |
| Appearance | Light yellow to beige crystalline solid |
| Melting Point | 74-78 °C |
| Density | 1.67 g/cm3 |
| Solubility In Water | Slightly soluble |
| Flash Point | 146 °C |
| Pubchem Cid | 7405 |
| Smiles | C1=CC(=CC=C1CBr)[N+](=O)[O-] |
| Inchi | InChI=1S/C7H6BrNO2/c8-5-6-1-3-7(4-2-6)9(10)11/h1-4H,5H2 |
As an accredited 4-Nitrobenzyl Bromide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 4-Nitrobenzyl Bromide, 25g: Supplied in an amber glass bottle with safety-sealed cap and hazard labeling, packed in protective cushioning. |
| Shipping | 4-Nitrobenzyl Bromide is shipped in tightly sealed containers to prevent moisture and light exposure. It is classified as a hazardous material and should be transported according to local, national, and international regulations, ensuring chemical-resistant packaging. Proper labeling and documentation are required for safe handling during transit. |
| Storage | 4-Nitrobenzyl bromide should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from heat sources, direct sunlight, and incompatible substances such as strong bases and oxidizing agents. The storage area should be equipped to avoid moisture absorption, and the compound must be kept away from ignition sources. Properly label the container and handle with protective equipment. |
Applications of 4-Nitrobenzyl Bromide in Industrial Manufacturing4-Nitrobenzyl Bromide serves as a crucial alkylating agent and protected group precursor in multiple industrial value chains. Our material allows for precision control in complex molecule synthesis, enabling efficient downstream manufacturing across several specialized chemical sectors.
Many pharmaceutical manufacturers employ this compound to introduce the 4-nitrobenzyl group during the synthesis of protected amines and alcohols, which is essential in advanced multi-step API production. The compound facilitates selective alkylation and deprotection reactions, with precise dosing required to avoid over-alkylation or by-product formation. The clean conversion and high yield of protected intermediates prove critical for antibiotic and central nervous system (CNS) drugs, particularly in the synthesis of key building blocks that undergo later reduction, hydrolysis, or coupling steps within GMP processes. Industry compliance standards
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2. Photolabile Protecting Groups in Life Science ReagentsManufacturers of biochemical assay kits and DNA/RNA synthesis reagents utilize this material as a photoremovable protecting group. The compound integrates into oligonucleotide or peptide backbone structures, allowing controlled deprotection by UV irradiation. The selectivity and removal efficiency ensure accuracy in sequencing and real-time biosensing applications, supporting automated synthesis protocols and high-throughput screening demands in genomics and proteomics laboratories. Industry compliance standards
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Producers in the agrochemical sector employ this compound as an intermediate for constructing nitrobenzyl-containing herbicide and pesticide actives. Its reactivity in nucleophilic substitutions enables precise installation of the nitrobenzyl moiety onto aromatic or heterocyclic cores. Strict process parameters maintain batch-to-batch consistency and minimize impurity carryover, with compliance to crop protection quality benchmarks and environmental residue regulations. Industry compliance standards
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In specialty polymer manufacturing, this compound provides a highly effective route to embed photoreactive groups into main chain or side chain structures. Used extensively in the preparation of UV-crosslinkable adhesives and coatings, its benzyl bromide functionality reacts with polymer backbones to allow for post-curing or photolithography. Strict process control governs the amount introduced, as excess can lead to unwanted crosslink density or degradation. Industry compliance standards
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In the fine chemical sector, colorant manufacturers select this compound as a C-alkylation reagent in the synthesis of nitrobenzyl-containing dye molecules. Its bromide group participates in nucleophilic aromatic substitutions, forming complex intermediates which deliver high stability and desirable optical properties. Process engineers tightly manage stoichiometry and temperature to produce uniform batches and prevent color shifts caused by side reactions, conforming to international pigment standards. Industry compliance standards
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Contract and custom manufacturing partners leverage this input for developing proprietary molecules, particularly during medicinal and material science research. It enables the preparation of complex scaffolds or the introduction of photolabile tags required in structure–activity relationship studies. Flexible dosing and reaction route optimization are paramount as project teams transfer synthesis from laboratory scale to pilot and commercial levels. Industry compliance standards
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Over the years in chemical manufacturing, the importance of meticulous attention to process control and purity has been beaten into every batch, every drum, every gram that reaches a research bench or pilot reactor. 4-Nitrobenzyl bromide often appears on requests from advanced chemical labs and specialty material companies. Our own experience, working through the challenges of scaling up from kilo-lab to commercial volume, has taught us what these customers really care about – not just a CAS number, but a chemical with the reliability, consistency, and transparency that only comes from a vertically integrated production pathway.
The practical chemist sees value in this compound because it’s more than just a lab curiosity. 4-Nitrobenzyl bromide participates in a range of well-established synthetic transformations – alkylations, nucleophilic substitutions, and protection-deprotection protocols. What sets it apart is the electron-withdrawing nitro group, sitting ortho to the benzylic bromide. This feature significantly activates the molecule, supercharging its reactivity toward nucleophiles.
We’ve observed how this behavior streamlines selective benzylation reactions in nucleoside chemistry, peptide modification, and specialty dye synthesis. Academics and industrial R&D teams, squeezing value from every reaction step, have recognized how it offers crisper selectivity and milder reaction conditions compared to related benzyl halides.
I remember a batch from several years ago that taught us not all 4-nitrobenzyl bromide is created equal. We received a sample of technical grade from an “importer with an address but no synthesis shop.” It was a clear example: even trace impurities—unreacted 4-nitrotoluene, isomeric bromides, or oxidized byproducts—could halt downstream chemistry dead in its tracks. There’s a real cost, in wasted labor and lost development time, to shortcuts in purification.
Manufacturing from raw feedstock under vertical control means the team tunes each step and reviews every analytical trace. Success isn’t about producing the most product. It’s about delivering a genuine reagent standard that reacts as intended from vial to flask—no silent failures, no unexplained stalling, and no time lost tracing strange peaks on the HPLC.
Our 4-nitrobenzyl bromide production starts from high-purity 4-nitrotoluene, which many commodity suppliers overlook in their hurry for output. Careful, measured bromination using elemental bromine—not mechanical blends of stabilized bromine salts—drives high selectivity toward mono-bromination at the benzylic position. Quality checkpoints at every unit operation weed out side products before they accumulate. Constant vigilance fights overbromination at the aromatic ring, which lowers yield and spawns persistent impurities.
Vacuum distillation—rather than basic atmospheric processing—further cleans the product before it ever reaches our crystalline isolation tanks. These choices are the result of years of hands-on troubleshooting and repeated internal audits. Beyond visual inspection, comprehensive GC-MS and NMR verification settle purity content. Product batches above 99% by both chromatographic and spectroscopic analysis leave our plant. Data for each lot back every delivery.
A lot of buyers think operational cost savings can be drawn from the bottom shelf by choosing “off grade” or unlabeled sources. The reality, learned from direct experience, is starker. Inconsistent compound, contaminated with retro-brominated isomers or polymeric materials, will clog instrument lines, foul catalysts, and waste more than just money. In custom synthesis and process development labs, false savings create weeks of repeated QC and mitigate failed runs that eat into entire quarterly project cycles.
We ship 4-nitrobenzyl bromide in a crystalline form—stable at ambient storage, but handled in inert atmosphere under scaled production to prevent hydrolysis and minimize airborne exposure for plant personnel. Moisture uptake triggers hydrolytic loss and formation of 4-nitrobenzyl alcohol, so careful packaging in airtight drums with desiccant ensures long-term shelf life and usability. Standard drum sizes accommodate both high-throughput process chemistry and boutique, one-off screenings.
Hard lessons in synthesis shine a light on real distinctions between similar-sounding chemicals. Compare 4-nitrobenzyl bromide to simple benzyl bromide or the 2-, 3-nitrobenzylic analogues. The position and electron intensity of the nitro group at the para location fundamentally changes reactivity and safe handling requirements. The electron-withdrawing effect heightens the susceptibility of the benzyl group to nucleophilic displacement. Reactions that stall or require elevated temperatures with unsubstituted benzyl bromide proceed cleanly with the nitro analog, reducing byproduct formation and hazardous overreaction.
Customers ask about cross-compatibility, only to discover that isomeric or low-grade suppliers have sold them an inferior 2-nitro or di-nitro compound. These differences are not academic; even minor impurity can confound kinetic profiles or lead to unreliable assay results, especially in pharmaceutical precursors or sensitive materials. Our process tracks not just identity, but isomeric purity, eliminating cross-contamination with off-pattern aromatic bromides.
The manufacturing mindset extends past each production run. We link every batch of 4-nitrobenzyl bromide to a full provenance file—not just for regulatory filings, but to support customer traceability and troubleshooting. Inclusion of full spectroscopic datasets for each lot aligns to both Western and Asian market compliance standards. Technical support is ready to walk through specific reactivity profiles, impurity challenges, or compatibility with uncommon solvents and reagents, based on direct factory experience.
A common pain point: uncontrolled supply chains introduce product that lacks audit trails. Teams lose precious hours tracing “mystery failures” in flagged syntheses, often discovering the culprit traceable right back to a batch lacking basic documentation. Lessons like these cement the value of buying directly from the source.
Our customers span medchem, functional dye manufacturing, and advanced polymer research. Contract research organizations want material that meets strict impurity profiles for GMP pathway work. R&D labs push for milder, more selective benzylations in complex heterocyclic syntheses. Diagnostic kit manufacturers demand assurance that their building blocks perform consistently, lot to lot—since even intermittent wobble in reactivity invalidates long-term comparative studies. That’s why our internal QC standards are set higher than what low-cost brokers claim as “acceptable.”
Over the decades, feedback cycles from user labs have forced continuous improvement. One partner in nucleoside analog synthesis found that uncontrolled peroxide byproducts from poor stabilization caused degradation in their sensitive APIs. By analyzing and updating our production quench and packaging protocols, we eliminated these false signals at the origin, providing consistent results downstream.
Real chemical manufacturing finds its success not just in pristine synthesis but in rigorous packaging. Our team never shortcuts package testing or shipment stability studies. We ship 4-nitrobenzyl bromide in sealed, tamper-evident drums with package inserts listing individual container trace numbers. These choices, hammered out over years of root-cause investigations, prevent subtle contamination and allow for precise recall or investigation, should the need ever arise.
Our plant design separates final drying and handling from upstream operations, so the material that customers receive never picks up cross-contaminants or activators from unrelated batch flows. Dedicated storage restricts temperature cycling, which matters on such an active benzylic system. All handling instructions come drawn from direct batch experience, with clear do’s and don’ts for dilution, solution preparation, and disposal routes, enabling customers to work practical safety into their SOPs.
The shift in global markets toward responsible manufacturing brings new expectations. We’ve seen that simply meeting baseline environmental and personnel safety thresholds is inadequate. As a chemical manufacturer in a tightly regulated market, we integrate updates in local and global hazardous waste policies—focusing not just on waste minimization but solvent recovery and real-time environmental monitoring around our plant boundaries.
Worker exposure to active benzylic compounds is managed through regular monitoring, ergonomic handling tools, and practical engineering controls. Pragmatic safety protocols learn from real accidents, which unfortunately remain all too common at loosely regulated sites. Transparent incident reporting and honest communication with all levels of production staff have lowered our own incident rate. These approaches have been refined through participation in industry consortia sharing best practices.
One lesson taken to heart from customer feedback is that every link in the supply chain introduces not just margin but risk. False economy from third-party resellers can lure with an initial discount, but buy-side chemists inevitably pay the difference in failed syntheses, lost time, or untraceable contaminated reagents. Direct purchase means access to the original analytical data, documented handling history, and full process background—all which cannot be guaranteed downstream.
Our practice is to foster direct conversations with user groups, not just procurement offices. This open-door model enables us to learn quickly when field chemists encounter new use cases, or select for alternate particle sizes or bespoke packaging. This responsiveness would remain impossible through indirect resellers or generic trading houses, who lack knowledge of production practices and are unable to troubleshoot product-specific technicalities.
Manufacturing 4-nitrobenzyl bromide to a high standard is not solved with search engine optimization, trade show gloss, or halfway specification sheets. Decades of cumulative failure analysis, hands-on reactor operation, and direct engagement with research leaders shape the product that customers receive. The tight feedback loops between QC, production staff, and frontline users guarantee a level of reliability unknown to loose brokered intermediaries.
We understand the direct connection between manufacturing rigor and reliable scientific progress. Every drum, vial, and data sheet aims to serve chemists who know shortcuts or unknowns derail real work. The long-term trust of both returning and new customers keeps us honest and sharp—this is the work of practical, experience-driven chemistry, not just commodity buying and selling.
As researchers push into emerging chemical spaces—targeted drug delivery, photoresponsive materials, and custom ligand creation—the value of robust, pure intermediates only increases. Feedback from researchers has highlighted the delicate balance between reactivity and storage stability, a challenge solved by fine-tuning both synthetic and physical handling at every step. Some users need larger, reactor-ready quantities; others demand boutique, batch-sized packs with lot-segregated documentation. All benefit from the same tight production protocols and unwavering attention to traceability.
Looking back, the journey from small-scale, hand-stirred syntheses to modern continuous systems has not lessened the craft, but elevated it. Every challenge in scaling or purification led to process improvements not only for 4-nitrobenzyl bromide, but for all active benzylic intermediates. The ability to pivot quickly—whether the request is for lower moisture content, finer particle size, or alternate solvent solubility documentation—stems only from first-hand technical expertise, not from formulaic buying and selling.
We know supply interruptions or unexpected purity gaps sink months of progress in specialty chemical projects. For this reason, we train all staff—from shift operators to lab analysts—to own every step, flag every inconsistency, and treat customer complaints not as tickets to close, but as vital feedback on product performance. Combined with investments in continuous learning and updated analytical tools, these habits ensure that each 4-nitrobenzyl bromide lot matches or outperforms its predecessor.
The knowledge transferred from retiring experts to new technicians preserves institutional wisdom, preventing loss of nuance that shortcuts or purely automated systems never recover. This continuity contributes just as much as pounds shipped or lines read by an HPLC, anchoring our product in tradition as well as technological progress.
Straightforward, unembellished manufacturing meets a scientific world where reliability is everything. We manufacture 4-nitrobenzyl bromide so that scientists and engineers—facing high expectations and tight schedules—can move forward, confident that the core building blocks will not let them down. It’s a matter of pride and professionalism that every lot leaving our plant bears the marks of careful synthesis, attentive purification, and transparent documentation.
No fine print, no last-minute surprises, just a commitment to practical quality forged by real manufacturing experience. This approach outlasts fashion and withstands the pressure of hurried markets. As new discoveries require sharper, smarter intermediates, we’ll still be here, sharpening every process, tuning every drum, and backing up every batch of 4-nitrobenzyl bromide, as we’ve done for years. Every customer, from startup R&D lab to multinational process team, deserves nothing less.
