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HS Code |
899198 |
| Cas Number | 106-49-0 |
| Molecular Formula | C7H9N |
| Molar Mass | 107.15 g/mol |
| Appearance | Colorless to pale yellow liquid or crystals |
| Melting Point | −1 °C |
| Boiling Point | 200 °C |
| Density | 1.008 g/cm³ |
| Solubility In Water | 1.5 g/L (20 °C) |
| Flash Point | 82 °C |
| Vapor Pressure | 0.29 mmHg (25 °C) |
As an accredited 4-Methylaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 500 mL amber glass bottle labeled "4-Methylaniline, CAS 106-49-0," tightly sealed with a chemical-resistant cap, hazard warnings displayed. |
| Shipping | 4-Methylaniline should be shipped in tightly sealed containers, clearly labeled, and compliant with local, national, and international hazardous material regulations. It requires storage away from oxidizers and sources of ignition, at cool, well-ventilated conditions. Appropriate protective packaging and safety documentation (SDS) must accompany the shipment to ensure safe handling and transport. |
| Storage | 4-Methylaniline should be stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as oxidizers and acids. Keep the container tightly closed and clearly labeled. Protect from light and moisture. Use appropriate chemical-resistant containers and avoid storing near food or drink. Ensure proper safety measures and spill control systems are in place. |
Applications of 4-Methylaniline in Industrial Manufacturing4-Methylaniline plays a critical role as an intermediate in several specialized downstream sectors, where its chemical characteristics, batch consistency, and compliance with industry regulations directly affect the quality and performance of finished goods. We serve manufacturers who require precise control in their formulations and processing, ensuring reliable integration and full traceability from raw material to end application. 1. Synthesis of Azo Dyes for Textile IndustryMajor textile dye producers use 4-Methylaniline as a core intermediate in the formation of azo dyes, especially in the production of yellow and orange shades. Its reactivity ensures targeted chromophore development, and QC labs validate each batch against color fastness and purity requirements. Quality-controlled material reduces batch rejections from shade deviations, directly impacting operational yield in continuous dye production lines. Industry compliance standards
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2. Manufacture of Agricultural Crop Protection AgentsChemical process engineers select 4-Methylaniline as a functional amine intermediate in the synthesis routes of several herbicide and fungicide actives. Precise molar additions ensure molecular integrity and optimize yields during key transformations such as alkylation and acylation, backed by regular QC to minimize residual impurities that might compromise registration dossiers or product renewals. Industry compliance standards
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3. Production of Rubber Processing ChemicalsManufacturers of rubber additives incorporate 4-Methylaniline as a reaction substrate for producing accelerator compounds essential for controlled vulcanization. The specific amine structure enables targeted development of compounds like sulfenamides, which impart precise cure rates for synthetic and natural rubber processing. In-process verification of purity and residuals is vital to comply with safety and migration standards for downstream automotive or consumer applications. Industry compliance standards
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4. Synthesis of Pharmaceutical IntermediatesGMP-compliant pharmaceutical ingredient manufacturers employ 4-Methylaniline as a functional group carrier during small molecule API synthesis, notably in analgesic and anti-inflammatory drug pathways. The purity profile directly affects reaction yield and impurity clearance. Tightly controlled addition rates and analytic tracking through HPLC/GC ensure conformity with DMF and regulatory submission requirements. Industry compliance standards
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5. Development of Specialty Organic PigmentsProducers of high-performance organic pigments select 4-Methylaniline for its ability to introduce methyl substituents in chromophore systems, particularly in yellow pigment classes. Its addition impacts solubility, particle size distribution, and final pigment shade, which requires thorough full batch documentation for color consistency in plastics, inks, or coatings. Pigment manufacturers conduct real-time QA testing throughout synthesis to meet end user standards in demanding application sectors. Industry compliance standards
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6. Production of Corrosion Inhibitors for Industrial FluidsFluid systems suppliers utilize 4-Methylaniline as a building block in the manufacture of specific aromatic amine-based corrosion inhibitors. These inhibitors are deployed in engine coolants, boiler feed water, and closed-loop fluid systems, where the methyl group provides tailored hydrophobic/lipophilic balance and improves metal surface adsorption performance. Production teams track addition rates to align inhibitor loading with system performance specifications and regulatory caps on amine content. Industry compliance standards
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Competitive 4-Methylaniline prices that fit your budget—flexible terms and customized quotes for every order.
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Working at the production level, I’ve come to appreciate how materials like 4-Methylaniline shape entire chemical value chains. Its core structure—a methyl group bonded to the para position of aniline—brings about distinctive reactivity, which translates directly into how chemists and manufacturers exploit its properties. The para-methyl isomer, often referred to as p-toluidine, differentiates itself from the meta and ortho isomers, not just on paper, but in behavior during some of the most crucial stages of synthesis. Factories processing dyes, agrochemical intermediates, and pharmaceuticals regularly lean towards 4-Methylaniline, because its defined structure means higher yield during certain substitutions, nitrosations, and acylations.
From my experience guiding batches from raw materials to finished product, I see greenhouse-grade purity—and the repeatable consistency our distillation columns permit—has a bigger impact on downstream results than many appreciate. Precision in the boiling range and water content influences syntheses in a way that’s impossible to ignore at scale. Off-grade aromatic amines, or those containing excess isomers or water, actually reduce efficiency and jack up reprocessing costs.
We manufacture 4-Methylaniline with an acute focus on assay and impurity control. 99% purity, analyzed by GC, acts as a basic threshold because lower grades introduce issues in subsequent catalytic reactions, especially hydrogenations or oxidations. The substance appears as a clear to slightly yellow liquid, settling with a faint amine odor. Our inspections place water content by Karl Fischer method below 0.3%, as higher moisture interferes with several catalyst systems and can hydrolyze activated reagents. When our operators describe lot consistency, that’s not just marketing. Batch reproducibility affects safety margins on end-user reactors when dealing with pressure and heat.
Some industries will stretch tolerances, prioritizing volume or price. That tends to backfire when impurities trigger side products or clog multi-stage syntheses. Aniline content—kept well below 0.2%—protects against unwanted amination in dye preps. Any detectable metallic contamination (from our reactors or transfer lines) prompts immediate intervention. Additives have no place here, which gives process chemists predictable results and saves hours during troubleshooting.
Unlike traders viewing material as commodity, as a producer, our sight stays on the end result: how smoothly a batch runs, the actual purity seen at the application interface, and long-term reliability. Processors in dye houses, pesticide tech, or high-end resins rarely forget a shipment that failed because of a cross-contaminated drum or mishandled tanker. One operator once described how an off-spec lot gummed up filters across four days, burning hundreds of man-hours. We don’t ignore lessons like those, so we reinforce the importance of rigorous lot checks, sampling, and historical tracking.
There’s a myth that all 4-Methylaniline sources yield the same performance. From firsthand conversation with plant chemists, I know how slight variation in boiling point, color, or trace metals shows up in HPLC curves or final colorimetry for reactive dyes. The tiniest bit of residual nitro compounds or cross-haloamines in feedstock can change a batch’s outcome, sometimes pushing yields down by 3-5%. Large buyers take the time to sit with production staff to review the full impurity fingerprint—not just assay numbers—before approving a supplier. This isn’t bureaucratic box-ticking. Behind every quality cert, there’s an operator, a shift leader, and a supply chain under real pressure to maintain standards with as few exceptions as possible.
Improvements in our output usually start from end-user feedback. A plant producing azo dyes might call about a new visual impurity or inconsistent melting point in the intermediate stage. That prompts us to revisit every step—from solvent recovery tanks, to feed pump calibration, to storage tank cleaning cycles. Once, a minor tweak in our filtration step removed particulate levels that, on paper, fell well below any industry threshold. The benefit was clearer: cleaner metering pumps on our customer’s equipment, and less downtime in their shift schedules. We log these outcomes and fold them back into our SOPs and operator training.
Here’s a truth some buyers miss: technical support from a manufacturing partner trumps any surface-level price negotiation. It’s easy to find a cheaper quote, but when a run fails and a batch must be traced from drum serial number backward, the relationship—or lack of it—between manufacturer and processor comes into full focus.
Within the aromatic amines family, 4-Methylaniline can look similar to its ortho (2-methylaniline) and meta (3-methylaniline) analogs, but there are distinctions that play out in day-to-day operations. The para isomer, 4-Methylaniline, gives superior control in making dyes where symmetry reduces shade variation, while ortho- and meta-isomers often show up as minor side-products or trace residues. The position of the methyl group affects not just the boiling point but selectivity in diazotization reactions—a common step for coupling with phenol or naphthol derivatives. This selectivity minimizes side reactions, trims waste and reduces byproduct formation, which is why many formulators won’t accept an isomeric mixture.
Some generic suppliers will offer mixed-methylaniline cuts, which may sound cost-effective but don’t measure up during process audits. We’ve seen process yield swing from 84% to over 92% just by tightening the isomer spec. It’s not lab theory—these numbers shape margins and site productivity. For agrochemical intermediates built on toluidine scaffolds, using pure 4-Methylaniline feeds gives much cleaner conversion with acid chlorides or sulfonating agents, meaning faster reactions and fewer purification cycles.
From a handling perspective, while all isomers fall into the same regulatory hazard classes, experienced operators treat the para isomer with extra care given its lower melting point and volatility, adjusting transfer protocols to avoid volatilization losses. These minor choices, repeated day by day, build into real cost-saving and compliance advantages by year’s end.
Production trends for 4-Methylaniline have shifted markedly. Environmental scrutiny now frames almost every step. Old methods using direct methylation of aniline under harsh acid conditions generated high levels of unwanted byproducts and required intensive neutralization cycles. We transitioned to using selective catalytic hydrogenation with recovered methyl-substituted nitrobenzenes sourced from carefully managed supply lines. This cuts down overall waste and improves atom economy in our workflow.
On the shop floor, solvent recovery and re-use make a significant impact. Each batch run is charted not just for main product yield, but for how much off-gas and liquid byproduct heads to our on-site treatment plant. Closed-loop vent systems and in-process distillation reduce fugitive emissions. Newer columns introduced recently drop the overall E-factor for this route, giving greener numbers on our audits. There’s a continuous loop between plant operators, laboratory staff, and waste management to pin down inefficiencies. Our workers’ hands-on ingenuity—modifying valve cycles, adjusting reflux ratios—lowers both utility costs and carbon footprint. Most of these changes trace back to direct feedback from those running the reactors, more than any distant policy memo.
Stringent documentation ties every batch to raw material lots, operator logs, and in-line instrument output. It’s the only way to build trust over years, not just individual shipments. Buyers request full chromatogram packs, not just summary pages, to verify our process really holds at the extremes of the spec range. Consignment samples ride with each bulk shipment, and we retain split lots on site for any future retesting.
Traceability in the context of 4-Methylaniline isn’t an abstract promise. We’re routinely called to trace deviations back to the exact tank or drum. Every time a plant manager discovers an issue—say, a minor increase in trace impurities or a performance drop during coupling steps—immediate access to screening logs and historical QA samples drives the post-mortem process. Missed notes or overlooked operator entries tie directly to lost time and revenue, a lesson you only need to learn once on a busy line.
Workers interact closely with aromatic amines. Long before regulatory bodies raised alarms, experienced crews knew to limit vapor exposure during transfers, ensure exhaust fans were running, and double-check PPE. While the package label lists toxicity and GHS codes, those in the plant recognize subtler risks. The amine odor cuts through any complacency, reminding even the greenest operator to keep procedures tight.
Spill response goes beyond the MSDS sheet. Quick powder absorbents, spill berms, and immediate area cordons run on practiced habit, not memo. Senior staff teach these skills alongside the technical steps because factory pace leaves little time for textbooks. Both technical and safety upgrades land fastest when voiced by the crew itself—especially when troubleshooting the recurring problem of drum sealing integrity or vapor emission on hot days.
With tightening global regulation, raw materials face more scrutiny. In our segment, 4-Methylaniline’s production no longer stops with local compliance. Legislation from buyers’ end markets now shapes how we audit raw sources, document every trace impurity, and invest in emission controls. European and North American buyers have become more engaged with process transparency. Auditors now walk our lines, question our storage protocols, and ask for decades-old run logs. These aren’t hurdles but reality—the market only rewards teams posting real evidence, not abstract assurances.
Our jobs have evolved to navigate both chemical synthesis and environmental documentation. Periodic upgrades, such as real-time online analyzers at release points and rigorous retention of process data, are not technical luxuries. They’re survival moves. Teams work closely with certification officials and internal HAZMAT experts, sometimes looping in external consultants for third-party checks. This has fostered a culture shift that values team-wide vigilance, not just process speed.
Process improvements rarely start from isolated lab experiments. Most fresh ideas come straight off the line—from an engineer seeing recurring distillation drift or a supervisor noting how a cleaning cycle jams with certain off-gas mixtures. Operators often spot tweaks that reduce batch cycle time without sacrificing spec adherence. One adjustment allowed us to switch heat exchangers mid-run, preserving reaction temperature and reducing solvent carryover. Over quarters, these routine adjustments can drive a 2–3% increase in reactor utilization, a figure well worth the effort.
Materials science teams spend part of each week working alongside production, not just reviewing printouts. They walk the floor, listen to maintenance concerns, and test tweaks that may shave minutes off batch turnarounds or drop energy draw on reflux cycles. Actual product improvement owes as much to operational know-how as to upstream laboratory analysis.
Customers who buy at scale expect measurable outcomes: consistent reaction yields, minimal batch-to-batch adjustment, and zero runaway impurities. We tailor shipping schedules to tight production calendars, working directly with partners to avoid downtime. Experienced processors know to call us over the smallest anomaly—like a haze in the storage tank or a fractionally different odor—because they understand how small signals can lead to major issues downstream.
One example remains etched in our records: a dye manufacturer running continuous process needed a rush shipment due to a blocked feed line from another supplier’s product. Within a day, our team organized an expedited batch with full trace analysis and technical support. Direct teamwork cut a potentially week-long outage down to hours. This wasn’t an isolated event—repeat buyers stick with producers that stand behind every lot, even when those calls arrive after midnight.
What keeps producers like us competitive isn’t price alone, but the depth of real partnership, technical response, and proven integrity. Sourcing quality 4-Methylaniline means more than hitting assay marks. It requires an ongoing commitment to sustainable chemistry, actionable technical support, and steady hands across every link of the supply chain. We live in a world where reputation is tested in every batch, shipment, and support call.
Manufacturing isn’t a distant process. From the noisy floor to the paperwork trail, the journey of 4-Methylaniline runs through real people, troubleshooting real tasks, and showing up when things get complex. True value is earned every day—not only in the purity lab but at that point where product performance, customer trust, and process innovation lock together.
