4-Chlorophenol

    • Product Name: 4-Chlorophenol
    • Alias: p-Chlorophenol
    • Einecs: 200-293-7
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    169620

    Cas Number 106-48-9
    Molecular Formula C6H5ClO
    Molar Mass 128.56 g/mol
    Appearance White to light beige crystalline solid
    Melting Point 42-44°C
    Boiling Point 213°C
    Density 1.31 g/cm³
    Solubility In Water 2.7 g/L (20°C)
    Odor Phenolic
    Pka 9.38
    Flash Point 82°C (closed cup)
    Vapor Pressure 0.24 mmHg (25°C)

    As an accredited 4-Chlorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle labeled "4-Chlorophenol, 99%, 500 g"; features hazard symbols, batch number, barcode, and tightly sealed cap.
    Shipping 4-Chlorophenol is shipped in tightly sealed containers made of compatible materials, typically plastic or glass, and cushioned to prevent breakage. It must be labeled with hazard warnings and handled according to regulations for toxic and flammable substances. During transport, it should be kept away from heat, sparks, and incompatible chemicals.
    Storage 4-Chlorophenol should be stored in a cool, dry, well-ventilated area away from heat, sparks, and incompatible substances such as oxidizers and strong bases. The container must be tightly closed and made of materials compatible with phenolic compounds. Store away from direct sunlight and sources of ignition, and ensure proper labeling to prevent accidental exposure or misuse.
    Application of 4-Chlorophenol

    Applications of 4-Chlorophenol in Industrial Manufacturing

    4-Chlorophenol serves as a key chemical intermediate across various industrial sectors. We supply this material to established manufacturers requiring strict product consistency, high purity, and full documentation for regulated downstream applications. Below, we outline specific end-use industries, detail application parameters, compliance requirements, formulation ratios, process integration stages, and final product outcomes.

    1. Synthesis of Agricultural Pesticides

    Agrochemical facilities utilize 4-Chlorophenol as an essential building block in manufacturing selective herbicides and fungicides. It functions as a precursor for synthesizing chlorinated phenolic compounds, critical for biocidal action in crop protection products. Strict control during catalytic chlorination and condensation steps ensures target active ingredients meet residue and ecotoxicity standards before formulation into market-ready pesticides.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) Regulation (EC) No 1907/2006
    • EPA 40 CFR Part 180: Tolerances for Pesticide Chemicals in Food
    • ISO 9001:2015 Quality Management for consistent batches

    Typical usage ratio

    • Applied at 10–30% w/w relative to total raw material input in synthesis of chlorinated herbicide and fungicide actives. Ratio adjusts according to targeted molecular structure and active ingredient concentration requirements in downstream formulation.

    Downstream process integration

    • Charged as main aromatic phenolic nucleus in chlorination, etherification, or oxidative coupling steps
    • Direct coupling with haloalkanes or carboxylic acids to produce registered pesticide actives in multi-stage reactors

    Final product types

    • Selective post-emergence herbicides (e.g., phenoxy herbicides)
    • Fungicide active ingredients (e.g., chlorinated phenol derivatives)
    • Formulated suspension concentrates and emulsifiable concentrates for agricultural use

    2. Manufacture of Pharmaceutical Intermediates

    Pharmaceutical ingredient manufacturers apply 4-Chlorophenol in API intermediate synthesis, particularly for anti-infective and antiseptic ingredients. Its defined reactivity profile supports controlled aromatic substitution, ensuring final pharmaceutical intermediates meet tight impurity and traceability requirements demanded by regulatory authorities.

    Industry compliance standards

    • Good Manufacturing Practice (GMP) as per ICH Q7 and EU GMP (Part II)
    • United States Pharmacopeia (USP) standards for process intermediates
    • EU Pharmacopoeia (Ph. Eur.) reference guidelines
    • Drug Master File (DMF) documentation for regulated supply chain

    Typical usage ratio

    • Incorporated at 5–15% w/w based on reaction pathway and targeted API yield. Adjustment is determined by stoichiometric demands and process impurity thresholds in the production of phenolic-based intermediates.

    Downstream process integration

    • Reacted via aromatic nucleophilic substitution as the phenol donor in key pharmaceutical syntheses
    • Introduced in initial batch processes for preparation of antiseptic, bactericidal, or anti-malarial intermediate compounds

    Final product types

    • Antimicrobial API intermediates (e.g., chlorinated derivatives for topical antiseptics)
    • Starting materials for synthesis of active bulk pharmaceuticals
    • Disinfectant ingredient precursor compounds

    3. Production of Dyes and Pigments

    Specialty dye and pigment producers incorporate 4-Chlorophenol as a functional group donor in modern azo and triarylmethane coloring agents. The phenolic structure is essential for electrophilic substitution steps, granting targeted color fastness and resistance properties while supporting batch-to-batch color uniformity under ISO-controlled processes.

    Industry compliance standards

    • ISO 9001:2015 for colorant manufacturing
    • EN 71-3:2019 Safety of toys (migration of certain elements) for pigments
    • REACH Annex XVII regulations for dye substances
    • Oeko-Tex Standard 100 for textile applications

    Typical usage ratio

    • Input level: 3–10% by mass as a core aromatic unit, tailored to substitution pattern required in azo coupling or for achieving the desired chromophore stability. Usage refined by chromatographic analysis of finished dye.

    Downstream process integration

    • Acts as the base aromatic feed in diazotization and azo coupling steps
    • Introduced during sulfonation to enable water solubility and improve fastness

    Final product types

    • Reactive dyes for cellulosic textiles
    • Organic pigments for plastics and inks
    • Fiber-reactive coloring agents

    4. Formulation of Wood Preservatives

    Wood protection chemical plants use 4-Chlorophenol as a biocidal ingredient to inhibit fungal decay and termite attack in lumber, utility poles, and railway sleepers. With controlled addition in micro-emulsions and oil-borne preservative formulations, manufacturers achieve long-term protection, conforming to regional safety and leaching standards for treated wood.

    Industry compliance standards

    • AWPA P8 (American Wood Protection Association) for biocidal wood preservatives
    • EN 599-1:2013 for effectiveness of wood preservatives
    • BPR (Biocidal Products Regulation) EU 528/2012
    • EPA Pesticide Registration for treated wood products

    Typical usage ratio

    • Used at 2–6% w/w in finished preservative formulations. The amount adjusts according to the class of timber, required protection level, and method of application (pressure treatment or surface spray).

    Downstream process integration

    • Combined with carrier oils during formulation blending
    • Dissolved at controlled temperature and added prior to batch emulsion or oil-phase homogenization

    Final product types

    • Oil-based wood preservatives for outdoor and structural applications
    • Micro-emulsions for timber treatment plants
    • Ready-to-use surface coatings for building materials

    5. Synthesis of Specialty Polymers and Resins

    Chemical resin and polymer manufacturers integrate 4-Chlorophenol in the synthesis of high-performance thermosetting resins, such as epoxy and phenolic systems, especially where controlled reactivity and heat resistance are required. The structure allows for precise chain termination or branching, critical for electrical laminates and engineered composite parts.

    Industry compliance standards

    • UL 94: Standard for Safety of Flammability of Plastic Materials
    • IEC 61249-2-7 for base materials in electrical printed boards
    • ISO 14001:2015 for environmental management in chemical manufacturing
    • RoHS Directive 2011/65/EU for use in electronics encapsulants

    Typical usage ratio

    • Incorporated at 1–5% mass ratio for cross-linking or modification steps in resin backbones. The dosage depends on desired electrical insulation properties, heat stability, and mechanical strength of composite products.

    Downstream process integration

    • Added during monomer charge or as a reactive modifier in prepolymer stage
    • Participates in condensation or polyaddition reactions, influencing polymer chain structure

    Final product types

    • Electrically resistant composite laminates
    • Industrial adhesive resins for automotive and aerospace
    • Heat-resistant molded components

    6. Intermediate for Fine Chemicals Synthesis

    Specialty chemical manufacturers rely on 4-Chlorophenol to prepare tailored organochlorine intermediates used in flavors, fragrances, and customized catalysts. Its reactivity profile supports targeted chlorination, alkylation, and etherification, producing high-purity linkers and boosters for formulations requiring precise aromatic substitution.

    Industry compliance standards

    • ISO 9001:2015 for specialty chemical production
    • REACH Regulation (EC) No 1907/2006 for fine chemicals
    • IFRA (International Fragrance Association) Code of Practice for fragrance ingredients, if used in fragrance intermediates
    • Hazard Communication Standard (OSHA HCS)

    Typical usage ratio

    • Used at 2–12% of batch, tailored to molecular structure design and the specific end-use requirements for downstream fine chemical or fragrance/catalyst synthesis.

    Downstream process integration

    • Serves as the starting phenolic unit in custom alkylation reactions or as a halogenated aromatic in ether linkage synthesis
    • Introduced early in multi-step syntheses to preserve aromatic ring integrity

    Final product types

    • Organochlorine intermediates for chemical manufacturing
    • Synthetic boosters for fragrance bases
    • Specialty catalysts for organic reactions

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    Certification & Compliance
    More Introduction

    4-Chlorophenol: Practical Insights From Direct Production

    Direct Experience Shaping Every Batch

    Inside any plant, experience matters more than theory, especially with a specialty intermediate like 4-Chlorophenol. Working every day with this compound, you get a real sense of its challenges and benefits—a knowledge gained from stirring reactors and fine-tuning purification columns, not pulling files from an office shelf. In production, details make the difference, so this isn’t a generic chemical for us. Its crisp, sharp phenolic aroma and the faint greenish tinge tell you the process is on track before analysis even starts.

    4-Chlorophenol, under the CAS number 106-48-9, comes off our lines in crystalline form, clear and pale in color, usually boasting a purity over 99%. This level is not an afterthought. Precise control of chlorination, purification, and controlled cooling in our reactors means the finished product meets analytical standards and practical industry needs—because those impurities can throw off downstream chemistry. Over the years, you learn not to take shortcuts with phenols; trace contamination or off-the-mark moisture content leads to trouble for the next processor, so consistency always matters.

    Production Nuances and Application Realities

    A trained worker recognizes how much care chlorinated phenols demand during manufacture. Before the drums make it past our gates, each batch undergoes GC and titration, confirming the 4-chloro substitution pattern holds true and that side products fall below practical thresholds. The specifications are not just about numbers: lower iron levels prevent discoloration in resin curing and polymer production, where color stability is critical for end-use.

    With so many steps hinging on quality, small changes at our level carry real consequences further down the supply chain. Pharmaceutical and agrochemical manufacturers rely on this intermediate to kickstart complex syntheses. For them, our batch’s trace impurities or moisture level determine if their next step succeeds or fails. Our ongoing dialogue with downstream chemists keeps specifications grounded in what they really need—optimizing crystalline structure for ease of handling, controlling volatility to reduce exposure risk, and managing dust to minimize plant-level losses during transfer.

    Comparing 4-Chlorophenol to its close relatives, subtle differences shape function and safety considerations. By producing it in-house, these differences aren’t just theoretical. For instance, compared to 4-bromophenol, the chlorinated version volatilizes less aggressively and presents a more manageable profile for storage and shipping. Or contrast 4-Chlorophenol’s behavior with 2-chlorophenol: 4-chloro is less prone to form hard-to-remove tars and gums in certain condensation reactions, which is why several resin manufacturers insist on the para-substituted product after costly failures with the ortho isomer.

    Processing, Handling, and Worker Knowledge

    From a manufacturer’s point of view, handling sets 4-Chlorophenol apart from similar chemicals. Production and packaging follow strict routines that experience, not manuals, have honed. For example, packing this material in high-density polyethylene drums with tamper-evident seals keeps product dryness high—something every maintenance technician knows to double-check, especially after rainy weeks when ambient plant moisture climbs. Our operators insist on using closed transfer lines to counteract volatility issues, and personal protective equipment becomes second nature to anyone on the shift, given the irritant nature of the compound at trace vapor levels.

    Storage counts, too. Daily monitoring limits temperature swings that could drive sublimation or condensation, preserving both safety and integrity. Chemical plant life brings constant reminders that failing to respect a product’s physical quirks leads to real downtime. Dust control and containment have encouraged us to refine in-line system designs, and the lesson always sticks that efficiency in handling aligns with worker safety.

    Longevity in manufacturing also reveals which interventions pay off. Early on, we learned to prevent cross-contamination through rigorous equipment decontamination protocols—switching from caustic rinses to softer, product-friendly cleaning methods. These steps cut down on product losses and translate into batches pharmaceutical engineers can count on for syntheses where even minor contaminants halt an entire operation.

    Market Shifts and Application Growth

    At scale, the market’s demands shape production rhythms. Over time, as demand for specialty phenolic resins or new active pharmaceutical ingredients has shifted, we’ve adjusted batch sizes and scheduling to maintain supply chain reliability. More than a few times, our team has fielded urgent requests from longtime customers whose own plants faced line shutdowns due to late deliveries from less reliable sources. Our lesson from these moments is always practical—reserving flexible reactor capacity and maintaining high-purity stocks somewhere on-site for emergencies.

    The scope of use for 4-Chlorophenol spreads wide. As a manufacturer, seeing the compound ship out for applications as different as dye manufacturing, weed control, and antiseptics gives perspective on formulation priorities. Some buyers want the mildest odor profile, others demand a granule form for blending, and many need specific melting point ranges. We’ve learned over decades that there’s little substitute for a vertically integrated plant with its own analytical lab when industry needs keep evolving. It’s how we can respond quickly—adjusting crystal size, fine-tuning filtration steps, or even revising retention samples to suit emerging customer requests.

    Occasionally, a conversation with a customer’s R&D chemist points us to subtle but important tweaks: reducing trace dioxin precursors, lowering heavy metal content to meet tightening EU compliance, or meeting stricter batch-to-batch homogeneity. It’s a partnership based on what we experience in the plant—not a remote process driven by distant management. Our teams walk the floor; every change gets validated by our own hands. Trust is literal, built on the drum’s clean break when unsealing, the easy pour, and the predictable response in a bench reaction.

    Distinctions: Not All Chlorophenols Are Created Equal

    There’s a common misconception outside manufacturing that all chlorophenols serve similar roles or can be swapped without much impact. Years in chemical production dispel that idea quickly. For example, the para substitution pattern in 4-Chlorophenol impacts its reactivity in etherification much differently than 2-chloro or mixed isomers. Customers in the antioxidant and fragrance precursor sectors emphasize this point constantly. Switching from a resorcinol pathway to a 4-chloro-based process often solves color instability or residual odor problems in finished products—something raw data seldom captures, but repeated plant trials confirm.

    In terms of environmental profile, 4-Chlorophenol’s biodegradation pathways and toxicity load differ from its ortho counterpart. The greater plant tenders care deeply about those distinctions since they affect downstream water treatment and discharge compliance. While regulatory pressure has pushed the whole industry to keep emissions and releases tightly managed, knowing exactly what ends up in waste streams starts with a tight grip on variance in the input material. Our in-house lab keeps analytical windows open not just for product quality, but for identifying any byproducts or trace contaminants with environmental implications.

    Another practical difference surfaces in how the compound responds to common industrial processes like neutralization or solvent extraction. Over time, we saw the benefits in recommending storage under nitrogen atmosphere where feasible, averting slow oxidative discoloration—a tip that only surfaces after encountering the frustration of off-color returns from a careless storage facility abroad.

    Regulatory and Quality Pressures: Production Realities Not Seen on Paper

    Regulation doesn’t happen in a vacuum; it shapes manufacturing decisions every week. Meeting environmental health and safety standards is not about box-ticking. For each new REACH update or EPA advisory, we review plant-scale inventories, tweak procedures, and track each batch’s journey from raw feedstock through to shipment. For a producer, facing raw scrutiny—especially on phenolic intermediates—fosters discipline: we regularly monitor airborne dust, maintain audited logs for each lot, and keep personal exposure as low as possible across all shifts.

    Quality assurance reflects what real usage looks like. For every customer complaint about moisture-sensitive blending or a suspicious off-note, we retrace every step—from raw material chlorination rates right down to drum lining quality. Over time, this has led to greater internal transparency and training, where every operator knows not only the ‘how’ but the ‘why’ of a safe, steady product output. Plant managers develop a sixth sense for spotting anomalies, and continuous investment in operator education backs up documentary compliance with real expertise.

    Future Directions and Improving Sustainability

    Market expectations never stand still. Recent years saw a surge in inquiries from life sciences and electronics sectors. Here, demand for lower trace metal and impurity profiles pushes us beyond standard technical grade boundaries. We respond by tightening process control, investing in advanced purification, and linking batch records to advanced digital tracking. The path from chlorination to purified end product is under sharper scrutiny, and the teams directly controlling those pipelines absorb fast-changing requirements as part of the work culture.

    Sustainability is no longer a buzzword, but a direct challenge. With phenolic compounds, environmental stewardship comes right down to manufacturing’s basics—managing cooling water responsibly, reusing solvents, and tracking all release points for both compliance and conscience. Our switch to low-emission technologies and reconfigured distillation networks did not come easy or cheap, but the benefits have shown up in fewer regulatory interventions and tangible goodwill from municipal partners. Our operators contribute suggestions from hands-on experience, flagging inefficiencies or unsafe bottlenecks in real-time and shaping improvement initiatives.

    We have open engagement with research teams looking into greener production routes—like direct hydroxylation alternatives or selective catalytic chlorination. These partnerships speed up adoption of less wasteful methods and widen the practical toolbox available both to us and the broader industry. Real productivity comes from continual experiment, careful documentation, and readiness to improve. For 4-Chlorophenol, tightening environmental and market standards are an ongoing evolution, with customer-driven specifications nudging us toward cleaner, safer, and more consistent supplies year after year.

    Economic and Social Implications of Reliable Supply

    Supply chain reliability depends on production discipline. These last few years, disruptions reminded everyone how fragile logistics can be. As a direct manufacturer, our challenge grows: to maintain both safety stock and adaptability, especially as regulations grow tighter and customers demand steadier year-round supply. We keep our intake flows diversified, and production lines always have backup material on hand for the inevitable hiccup—a habit learned the hard way during pandemic supply squeezes and shipping gridlocks.

    Our teams have learned that consistent manufacturing quality translates into more than just customer retention. It shapes workplace stability. Smooth, properly controlled production runs keep workers safe and plant morale high. Training new hires in the details of 4-Chlorophenol handling turns into an exercise in pride, as senior operators pass down workflow nuances no automation can replace. These traditions mean fewer accidents, higher retention, and a workplace that takes real ownership of health and safety outcomes.

    On the economic side, direct engagement with end-users draws a sharp line against speculative market spikes or dubious-quality intermediates from secondary traders. By holding to higher analytical standards and real batch traceability, our plant walls keep the unpredictable out—customers downstream run more efficient operations with fewer stops and reworks. Sector-wide, this reliability lowers industry costs and keeps innovation cycles moving, especially in pharmaceuticals and specialty polymers, where every change brings new challenges for raw materials.

    Continual Learning and Building Industry Trust

    Manufacturing teaches you humility and vigilance. With every new synthesis route or customer feedback loop, new lessons surface about the practicalities of handling, storage, or regulatory alignment. Being close to the actual chemistry means learning from mistakes faster and fixing them where they matter—in the next batch, not just in a spreadsheet. Over time, these lessons add up to real trust for buyers who need more than a product—who want an actual partner dedicated to solving technical, regulatory, or supply chain problems, not just filling orders.

    We keep direct feedback lines open with formulation labs and production sites using our 4-Chlorophenol. Yearly site visits, remote troubleshooting, and on-call technical support are not perks, but survival strategies for everyone in the supply chain. In several cases, our operators have provided not just material, but technical advice for safe blending or optimal solvent use, helping customer plants avoid frustration and reduce rework costs. These exchanges repay themselves through long-term loyalty and mutual learning.

    Final Thoughts from a Direct Producer’s Standpoint

    Working hands-on with 4-Chlorophenol reveals more every year—about chemistry, people, and the importance of direct production knowledge. Behind every crystalline drum stand dozens of choices, shaped by daily plant realities and an ongoing conversation with customers. Rather than aiming for empty claims of quality or universal suitability, the real value lies in shared experience, a responsive outlook, and a readiness to confront new challenges in safety, sustainability, and supply reliability.

    If there’s a core lesson from direct manufacturing, it’s that success grows from hands-on care, rigorous technical routines, and honest, clear communication. Chemists, plant workers, and users alike benefit most from this approach. Our commitment to thoughtful, precise production of 4-Chlorophenol reflects both the responsibility we carry and the trust customers place in each batch we ship. Experience in the field pushes us to keep improving, listening, and adapting—ensuring that every order not only meets standards, but supports the broader goals of progress, safety, and partnership across the chemical industry.

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