|
HS Code |
557983 |
| Cas Number | 59-50-7 |
| Molecular Formula | C7H7ClO |
| Molecular Weight | 142.58 g/mol |
| Iupac Name | 4-chloro-3-methylphenol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 66-68°C |
| Boiling Point | 243°C |
| Solubility In Water | 1.5 g/L at 20°C |
| Density | 1.29 g/cm³ |
| Flash Point | 128°C |
As an accredited 4-Chloro-M-Cresol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 4-Chloro-M-Cresol comes in a 500g amber glass bottle, sealed with a screw cap and labeled with safety and hazard information. |
| Shipping | 4-Chloro-M-Cresol is shipped in tightly sealed, corrosion-resistant containers to prevent contamination and moisture absorption. It is typically transported as a hazardous material, adhering to relevant regulations. Proper labeling, documentation, and protective measures are ensured during shipping, with controlled temperature and ventilation to maintain chemical stability and ensure safe handling. |
| Storage | 4-Chloro-M-Cresol should be stored in a tightly closed container in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizers. Protect it from light and moisture. Ensure that storage areas are clearly labeled and that appropriate spill containment is in place. Personal protective equipment (PPE) should be readily available in case of accidental release. |
Applications of 4-Chloro-M-Cresol in Industrial ManufacturingAs a direct manufacturer, we supply 4-Chloro-M-Cresol to key industrial sectors with demanding quality and regulatory requirements. Our material supports precise formulation, reliable performance, and proven compliance throughout the following application fields. 1. Pharmaceutical Preservatives ProductionLeading pharmaceutical manufacturers use our 4-Chloro-M-Cresol as a bacteriostatic and fungistatic preservative for multi-dose parenteral formulations and topical preparations. The antimicrobial profile addresses a wide spectrum of Gram-positive and Gram-negative organisms. It allows stable blending during aseptic compounding and bulk preservative manufacturing, with full traceability and validated microbial reduction. Strict regulatory controls on residual level, identification, and purity analysis govern the incorporation of this material in finished medicines. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
2. Antiseptic Formulations Manufacturing4-Chloro-M-Cresol serves as an active biocidal ingredient in antimicrobial personal hygiene and surface disinfection products. Formulators blend it into concentrated and ready-to-use liquids, gels, and wipes targeting healthcare-associated pathogens. Consistency in particle sizing and dissolution behavior ensures reliable kill rates across production batches. Compliance with technical dossiers and safety data requirements forms the foundation for downstream product registration in medical and institutional hygiene markets. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
3. Industrial Water Treatment BiocidesOur 4-Chloro-M-Cresol is incorporated by water treatment companies as an active control agent against bacteria, fungi, and algae in industrial process water systems. It is mostly used in closed-circuit cooling towers, recirculating systems, and industrial washing water to minimize biofilm build-up and maintain system efficiency. Safe handling protocols and reliable supply chain documentation are required for compliance with industrial biocide usage regulations. Dosing systems precisely meter the material based on microbial load measurements and system volume. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
4. Agrochemical Formulation PreservativesAgricultural chemical producers employ 4-Chloro-M-Cresol to stabilize high-value crop protection solutions susceptible to microbial spoilage. It enhances shelf life and storage stability for emulsifiable concentrates and water-dispersible granules. Close quality assurance oversight enables compliance with regulatory limits on preservative residues in crop protection agents. Integration takes place during dispersant phase blending, followed by finished product QC testing for active content and preservative stability. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
5. Leather Tanning Fungicidal AgentsTanneries and specialty chemical firms employ 4-Chloro-M-Cresol to prevent mold and fungal growth on wet blue and finished leathers during storage and shipment. It is dosed into soaking, pickling, or post-tanning wash baths under temperature-controlled environments to retain leather softness while ensuring worker safety. Manufacturers monitor residue migration to finished articles to comply with consumer safety and export requirements, particularly in high-end automotive and luxury leather sectors. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
6. Personal Care and Cosmetic PreservativesMajor manufacturers select 4-Chloro-M-Cresol for preservation of cosmetic creams, lotions, and hair care products susceptible to microbial contamination. It offers compatibility with diverse emulsion systems and remains stable through hot and cold processing steps. The concentration and identity of the preservative appear on product ingredient lists as regulated by international cosmetic safety laws. Detailed safety assessments and preservative challenge tests support commercial release of new personal care formulations containing this material. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
|
Competitive 4-Chloro-M-Cresol prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8615365186327 or mail to admin@ascent-chem.com.
We will respond to you as soon as possible.
Tel: +8615365186327
Email: admin@ascent-chem.com
Flexible payment, competitive price, premium service - Inquire now!
Every batch of 4-Chloro-M-Cresol that leaves our plant represents decades of discipline refining phenolic chemistry. Years ago, we noticed how often industries rely on precise standards for sanitizers, disinfectants, and raw materials for synthesis. Consistency remains the most critical promise a manufacturer can make. Across our operations, we hold 4-Chloro-M-Cresol to tight specification: purity above 99 percent, single-digit ppm moisture, and a white to light beige crystalline solid that signals well-controlled chlorination using food-grade catalysts.
4-Chloro-M-Cresol (chemical formula C7H7ClO, CAS 59-50-7) offers a unique substitution pattern: a phenolic ring with a methyl group at the meta position and a chlorine atom at the para position relative to the hydroxyl. This specific molecular structure imparts powerful antimicrobial activity without carrying the toxicity associated with some more heavily chlorinated phenols.
Our crystalline grade exhibits a melting point between 66 and 68°C, a clear fingerprint on gas chromatography, and nearly trace levels of 2,4-dichlorophenol and other unwanted contaminants. Clients sometimes request a finer mesh, so we manage particle size during our drying and milling steps to suit both solution blending and powder mixing. Each lot undergoes analysis by UV-Vis spectroscopy and validated by liquid chromatography to confirm identity and monitor trace byproducts.
Any upstream impurity drifts into the finished product, making high-grade input essential. Lower-grade 4-Chloro-M-Cresol can burden disinfectant formulations with off-odors, dark color, or unpredictable reactivity. Years back, our customers in the personal care sector flagged that uncontrolled batches often led to skin irritation in mild soap products, which we traced directly to inconsistent purity and unchecked byproducts migrating through the process.
By targeting over 99 percent active assay, we help formulators avoid these headaches. We run every batch through a multi-stage distillation to remove volatile organics, and we avoid heavy metal catalysis that can shed unwanted persistent residues downstream. Avoiding shortcuts in synthesis translates to fewer recalled lots, less troubleshooting on customer lines, and peace of mind in each application. We know how quickly a small impurity can balloon into a compliance risk in regulated sectors.
Demand for this compound comes strongest from hygiene and household product makers. Unlike generic cresols or commodity chlorophenols, 4-Chloro-M-Cresol resists natural microbial breakdown and supports long-term product stability. Handwash and antiseptic concentrate producers value this property, since recalls tied to preservative breakdown cost dearly both in reputation and lost revenue.
The pharmaceutical sector turns to 4-Chloro-M-Cresol for preserving multidose vials and creams, especially if a formula will see broad geographic shipping and prolonged shelf times. Our analytical team verifies every shipment to confirm it meets regulatory thresholds for microbiological activity, supporting claims for bacteriostatic action or antisepsis.
Veterinary formulations and animal husbandry also leverage this molecule’s reliability. We once traced a customer’s batchwise infection control problem to a competitor’s inconsistent cresol blend. After switching to our pure 4-Chloro-M-Cresol, their end-use disinfectants met efficacy benchmarks in independent laboratory reviews, affirming that our pooled analytical controls really do pay dividends beyond the lab.
We see smaller but rising volumes in wood protection applications and water treatment, where the balance of biocidal efficiency and dispersibility sets this grade apart from bulkier chlorinated phenols or industrial-grade cresols known for aggressive odor and persistent soil contamination.
Traditional cresols and phenols carry a potent mix of benefits and liabilities. 2,4-Dichlorophenol and phenol itself, for instance, have histories of unwanted odor, skin compatibility problems, and tougher environmental persistence profiles. Some older products, once hailed for broad-spectrum antimicrobial effects, now face restrictions due to chronic toxicity in aquatic ecosystems and bioaccumulation in soil. Our synthetic approach avoids excess transformation products that have proven problematic once released.
4-Chloro-M-Cresol holds a reasonable middle ground. It provides strong anti-bacterial and anti-fungal action without the high toxicity and disposal headaches linked to higher-chlorinated phenols or the offensive, lingering smell common to crude cresol mixtures. In manufacturing, we recognized years ago that clients in the cosmeceutical and personal hygiene field avoid 2,6-xylene derivatives for these very sensory reasons.
Handling safety matters, too. Bulk cresol and phenol carriers are known for corrosive, fuming tendencies at even moderate temperatures. 4-Chloro-M-Cresol offers a lower vapor pressure, lessened volatility, and reduced fume release under standard mixing and blending conditions. Operators appreciate the drop in PPE-intensive steps, and engineering controls can shift from aggressive exhaust to more routine air monitoring, reducing both capital outlay and maintenance.
We draw all feedstock from domestic sources, using methylphenol as a base and importing only medical-grade chlorine for the electrophilic substitution. Every run monitors waste streams for organochlorine content, since halogenated runoff presents real hardship to local wastewater treatment. The mother liquor and wash water coming off the crystallization train contain no free phenol or unreacted chlorine, out of respect for both regulatory and ethical responsibilities.
Earlier technology relied on tin or mercury-based catalysts, but we phased those out to minimize heavy metal residues. Our staff trained up a generation ago to optimize reaction temperature and stirring rates, which allowed us to coax higher yield and less exotherm—this improves not just throughput but also lowers the profile of side products.
Finished lots sit through a 48-hour stabilization and visual inspection step before packaging. Our operators prefer clear, dust-tight drums with moisture barriers to keep shipment quality stable from our dock to the customer’s facility. We only confirm release after three independent analyses match the global assay standards. We learned the hard way that even a few tenths of a percent drift can spell big trouble once a customer relies on an input for regulated disinfectant or pharmaceutical use.
Ambient storage at moderate temperature (20–30°C), good air circulation, and a dry environment are enough to keep 4-Chloro-M-Cresol in top condition. We fill every drum under nitrogen headspace to prevent trace oxidation, since even barely visible pink discoloration at the surface can trigger a rejected lot for our most stringent customers. Blending errors and overdosing often pose greater risk than gradual degradation—our technical team spends much of its troubleshooting effort on dosage audits and process simulations, making sure downstream mixing steps don’t overshoot safe and effective concentration.
Some customers have keyed-in to the importance of correctly sequencing addition: blending directly with anionic surfactants sometimes leads to loss of preservative action, so we emphasize the benefits of staggered addition at slightly elevated temperatures. Through joint projects, we’ve tested competing strategies—tacking the addition to the pre-mix, or slow-feed into heated recirculating tanks. Over time, this labor builds institutional knowledge that we share back with formulator teams.
A few years ago, a batch sent to a major wound-care ointment producer led to skin sensitivity complaints. We collaborated to research root causes and pinpointed a trace impurity from the upstream supplier’s raw phenol. To avoid a repeat, we implemented tighter supplier controls and started running full LC-MS impurity profiles on both feedstock and finished product. Since then, we cut customer quality complaints for this product by more than half. Field experience counts—our team tracks real-world performance closely, picking up insights on how formula tweaks and storage practices translate into customer satisfaction.
Another line of feedback arrived from wood treatment clients who struggled with variable leaching rates from off-the-shelf products. Our batches offered stable dispersion and a cleaner interface with common wood binders, which lowered application waste and supported longer-lasting protective action on treated lumber. Consistent, clean product wins loyalty one pail at a time.
Regulatory scrutiny of halogenated organics only intensifies. Producers and end-users alike expect their upstream suppliers to stay ahead of the compliance curve, and we see value in eliminating legacy contaminants before they become a legal or perception risk.
Several regions tightened standards on effluent discharge, so tracking the full lifecycle and breakdown of 4-Chloro-M-Cresol matters more than ever. We work with accredited labs to test for any long-term persistence and to validate aerobic and anaerobic breakdown in soil and water. This information supports both internal risk assessments and third-party audits, which inevitably ask about worst-case scenarios for product release or accidental spills.
Sector change sometimes comes from market-based pressure, not just regulation. End users lean toward products that combine potent antimicrobial effect and a lower “chemical profile.” Formulators in the household space want fewer label caution statements while keeping long-term protection intact. Being attuned to these shifts allowed us to invest early in synthesis and purification methods tailored for this fine balance—ahead of regulatory mandates.
Demand surges hit from time to time, especially during global health events or after a competitor’s product recall. We scale up only after confirming that core process controls can maintain quality at greater throughput. The temptation always exists to run equipment hotter or skip quality checks to meet deadlines. In our experience, short-term production wins build long-term customer risk. Years ago, one such rushed batch led to a wave of returned product and lost reputation—not only for us, but for the entire domestic industry. Since then, investment in capacity aligns only with raw material availability, operator readiness, and proven logistics partners on both inbound and outbound sides.
Global supply chains remain fragile. Shipments of feedstock take longer to clear customs, and sudden regulatory landscape changes can delay tankers at port. By keeping diverse sourcing relationships and transparency upstream, we avoid unplanned shutdowns and keep customers informed instead of surprised. We published several case studies for clients, detailing how supply interruptions ripple through their own operations. This transparency improves planning on both ends.
Downstream partners continue demanding cleaner, safer, and more sustainable chemical inputs. To deliver, we built dedicated lines for non-cross-contaminating phenolic production. Operators have real incentives for zero contamination and can flag deviations instantly, correcting issues before they propagate into the final product.
Green chemistry principles guide process improvements. Our R&D team tracks routes to minimize waste, capture solvent for reuse, and digitalize batch traceability. Quarterly, customer technical teams join our process engineers to compare analytical findings and field performance, digging deep into subtle shifts that can hint at bigger improvement opportunities. Collaborative troubleshooting, rather than finger pointing, keeps the supply chain strong.
Each season, we test application blends under realistic field conditions, from consumer-grade hand soap to bulk surface disinfectants and medical preservatives. Customers rely on direct feedback from our trials to reduce formulation trial and error. We report both successful outcomes and all anomalies, giving a real-world view of performance to technical buyers who make critical decisions under pressure.
Chemicals like 4-Chloro-M-Cresol sometimes seem like raw materials in a spreadsheet, but real value lies in reliable access and technical accountability. Our clients tell us they want more than a commodity—they want a partner who remembers past challenges and uses that institutional knowledge to anticipate the next one.
Long-term contracts, onsite audits, and traceability through each handoff mean problems are solved quickly. If a complaint ever emerges, our quality team responds with full transparency—detailed batch records, sampling data, and honest assessments on root cause and corrective action. This keeps buyers’ operations running without distraction and supports their credibility with their own downstream users, regulators, and investors.
Every lot of 4-Chloro-M-Cresol is more than a chemical—it’s the result of years of steady improvement, hard-won know-how, and collaborative partnerships built on shared goals. By valuing deep expertise, real data, and ongoing investment in safer, cleaner, and more reliable chemical solutions, we help build a stronger supply chain for all. This approach doesn’t just set a higher standard for us. It makes downstream products safer, compliance more straightforward, and business outcomes more predictable for all our customers, large and small.
