|
HS Code |
429574 |
| Chemical Name | 4-Bromobenzoyl Chloride |
| Cas Number | 5138-18-1 |
| Molecular Formula | C7H4BrClO |
| Molecular Weight | 219.46 |
| Appearance | White to off-white crystalline powder |
| Melting Point | 59-62°C |
| Boiling Point | 274°C (at 760 mmHg) |
| Density | 1.64 g/cm³ |
| Solubility | Reacts with water, soluble in organic solvents like ether and chloroform |
| Purity | Typically ≥98% |
| Refractive Index | 1.608 |
| Smiles | C1=CC(=CC=C1C(=O)Cl)Br |
| Inchi | InChI=1S/C7H4BrClO/c8-6-3-1-5(2-4-6)7(9)10/h1-4H |
| Synonyms | p-Bromobenzoyl chloride, 4-Bromobenzoylchloride |
| Storage | Store in a cool, dry place, tightly closed container under inert atmosphere |
As an accredited 4-Bromobenzoyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The 4-Bromobenzoyl Chloride is packaged in a 25g amber glass bottle with a secure screw cap and warning label. |
| Shipping | 4-Bromobenzoyl chloride is shipped in tightly sealed containers, under cool, dry, and well-ventilated conditions. It is classified as a corrosive and hazardous material. Transport must comply with relevant regulations (such as DOT, IATA, IMDG) and include proper labeling and documentation. Avoid contact with moisture and incompatible substances during transit. |
| Storage | 4-Bromobenzoyl chloride should be stored in a cool, dry, well-ventilated area, tightly sealed in a corrosion-resistant container, and protected from moisture and light. Keep it away from incompatible substances such as water, alcohols, amines, and strong bases. Store under inert gas if possible, and clearly label the container. Use secondary containment to prevent leaks or spills. |
Applications of 4-Bromobenzoyl Chloride in Industrial ManufacturingAs a direct manufacturer of 4-Bromobenzoyl Chloride, we supply this compound to multiple specialized downstream sectors. Its reactivity and purity enable advanced processing requirements across key chemical industries. The following are primary, verified industrial applications. 1. Pharmaceutical API Synthesis4-Bromobenzoyl Chloride functions as an acylating agent in the development of active pharmaceutical ingredients, especially during the synthesis of benzamide-based drug intermediates, local anesthetics, and certain antipsychotic pharmaceutical actives. Our product undergoes strict analytical verification to ensure traceability and reaction yield consistency during scale-up and validation, which are critical for GMP-compliant production. Bulk pharmaceutical companies most frequently introduce the compound at the early-stage formation of benzoylated intermediates, forming part of multistep synthesis for finished APIs intended for regulated markets. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
2. Agrochemical Intermediate ProductionCrop protection and agrochemical producers depend on 4-Bromobenzoyl Chloride to generate key aryl amide and urea derivatives. These intermediates serve as backbone structures for selective herbicides and fungicides. Formulators require stable supply under controlled impurity levels, as this reactant directly affects downstream conversion efficiency and eventual product toxicology profiles. Manufacturers adjust ratios based on the functionalization degree of their base molecules, typically integrating the material at the early or middle stages of their synthetic route. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
3. Liquid Crystal Monomer ManufacturingProducers of LCD and OLED materials incorporate 4-Bromobenzoyl Chloride to synthesize rigid-rod monomer families that act as orientation-determining units in display technologies. Tight specification on halogen content, trace metal residues, and color key the compound's suitability for precision polymerization and subsequent assembly of advanced optical-grade liquid crystals. The material typically enters at the initial monomer acylation stage, affecting optical clearing points, viscosity, and dielectric properties of the final crystal mixture. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
4. Specialty Dye Intermediate SynthesisDye and pigment manufacturers use 4-Bromobenzoyl Chloride to create halogenated aromatic intermediates for high-performance azo and anthraquinone colorants. The material's selectivity enables custom functionalization vital for textile, plastic, and inkjet dye houses. Its purity ensures consistent chromophore coupling and minimizes batch-to-batch color shift. The compound typically becomes part of the synthetic chain at the acyl group introduction, which determines the final dye’s fastness and solubility. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
5. Photoinitiator Synthesis for PolymerizationThe compound plays a critical role in the synthesis of aromatic ketone and benzoin photoinitiator molecules used in UV-curable coatings, adhesives, and 3D printing resins. Optical and electronics industry manufacturers require precise acyl chloride input to maximize product response to UV activation. 4-Bromobenzoyl Chloride integrates at the key benzoin condensation stage, where stringent handling limits contaminant introduction that could affect UV absorption and polymer initiation rates. Industry compliance standards
Typical usage ratio
Downstream process integration
Final product types
|
Competitive 4-Bromobenzoyl Chloride prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please contact us at +8615365186327 or mail to admin@ascent-chem.com.
We will respond to you as soon as possible.
Tel: +8615365186327
Email: admin@ascent-chem.com
Flexible payment, competitive price, premium service - Inquire now!
Many users enter the market for 4-Bromobenzoyl chloride without direct experience of how the product takes shape from concept to finished batch. As a company grounded in chemical manufacturing for decades, we have seen a constant evolution in expectations for quality, purity, and adaptability. 4-Bromobenzoyl chloride serves as a crucial intermediate in the development of pharmaceuticals, agrochemicals, and specialty chemicals, and its unique reactivity profile calls for precision at every step.
A process engineer working at the reactor side knows every kilogram of 4-Bromobenzoyl chloride comes about through carefully controlled reactions. We start with 4-bromobenzoic acid, working in conditions that consistently demand tight temperature control and close monitoring of hydrogen chloride gas release. Safety isn’t just about ticking boxes—our workforce wears the results on their shirts when dealing with the pungent fumes and corrosive byproducts. Modern reactors with rigorous seals, active scrubbers, and automated dosing systems keep exposure minimal and quality high.
The produced acid chloride batch rarely comes out perfect right off the line. Each lot gets sampled directly at the outflow, and we see from real-world experience that minute temperature fluctuations can swing condensation rates and introduce color bodies—unwanted impurities that show up as faint yellow tints. Years ago, the manual approach left room for considerable variability, but real-time sensors coupled with computer oversight have tightened purity, increasing consistency to levels that only a high-capacity manufacturer witnesses over hundreds of tons a year.
From a production standpoint, purity demands in the pharmaceutical sector drive most technical upgrades. While smaller traders might promise spec sheets filled with “99%+” notations, scaling up past 100 kg exposes the difficulty of reaching those benchmarks batch after batch. We maintain GC purity above 99.5% and limit acid content below 0.2% because post-reaction contaminants directly block downstream reactivity, leading customers to lose whole days of synthesis. Longer chain impurities, even below visible thresholds, cause inconsistent yields for anyone using 4-Bromobenzoyl chloride to introduce acyl groups into active pharmaceutical ingredients or pesticide scaffolds.
Handled lacking fresh production, acid chloride quickly hydrolyzes, sending free HCl vapor through air-tight drums. In summer, higher ambient humidity pulls the hydrolysis rate higher still, making immediate packaging under inert gas critical. Each drum—whether destined for custom synthesis in Europe or generic APIs in India—meets detailed stability checks on arrival at dispatch. Our decades filling thousands of orders have led to robust drum lining practices. We use polytetrafluoroethylene seals grafted onto steel, which outlast commercial rubber closures that degrade against HCl emissions.
Looking past the factory gates, the end uses of 4-Bromobenzoyl chloride trace the arc of fine chemical innovation. Laboratories rely on this acid chloride for Friedel–Crafts acylation, drawing on the reactivity of the benzoyl chloride group and the bromine atom to insert into complex molecular frameworks. Reliance on stable and reactive acid chloride supplies translates to fewer failed runs and more reliable scale-up.
Pharmaceutical developers targeting next-generation drugs reach for 4-Bromobenzoyl chloride when they need to introduce a bromo-benzoyl functionality onto amines or phenols. The resulting amide or ester intermediates find new life in cancer therapeutics and anti-inflammatory candidates. The sensitivity of downstream reactions makes any deviation from chloride purity more than a technicality; yield drops, and impurity profiles multiply, turning post-synthesis cleanup into a multi-day task.
Agriculture sees a similar trend. Custom pesticide manufacturers who modify their lead molecules with bromo-substituted benzoyl groups turn to freshly produced batches. Any misstep or long transit storage time leads to a marked loss in reactivity, due not only to hydrolysis but also to micro-contamination. Our supply streams to agrochemical clients often require us to coordinate just-in-time delivery, with re-certification on arrival—no minor achievement considering global shipping volatility.
Chemists often compare 4-Bromobenzoyl chloride to other acid chlorides. From the perspective of large-scale production, three differences stand out clearly. The presence of the bromo substituent increases molecular weight and confers a distinct reactivity. Reactivity differences between 4-Bromobenzoyl chloride and simple benzoyl chloride trace to electronic effects. The para-bromo group pulls electron density, raising the activation barrier for nucleophilic attack. As a result, reacting with amines or alcohols calls for slightly longer times or increased temperature, compared to unsubstituted benzoyl chloride. Seasoned process chemists adapt conditions in real time, a reality that cannot be captured by textbook comparison.
Structural differences also change physical handling. 4-Bromobenzoyl chloride is more hygroscopic and fumes more on exposure to air than its non-brominated equivalent. From the perspective of the worker on the drum line, even tiny leaks leave a recognizable scent in the warehouse, and the corrosion risk to metal fittings rises, driving us to reinforce fittings and cycle through more exhaustive preventive maintenance. In production, this means more robust ventilation and quality-driven packaging.
In the end, its elevated molecular weight creates a solid—whereas some lower-mass acyl chlorides can appear faintly oily, 4-Bromobenzoyl chloride forms off-white crystalline solid. Seeing this texture and color day after day, any deviation alerts us to process drift or batch contamination. Technicians use sight and scent before even sending samples to GC, a level of contact that separates manufacturer from reseller.
The days of local production serving only regional clients faded as global collaboration between pharmaceutical labs and chemical manufacturers expanded. Our batches of 4-Bromobenzoyl chloride travel thousands of kilometers, crossing climate zones and customs checkpoints. Each step exposes the acid chloride to fresh risks—moisture ingress, temperature swings, and mechanical vibration all wear at integrity.
To preserve product value, we insist on multi-layer drum barriers, vacuum sealing and dry inert flushing at fill. Any batch left to sit without nitrogen headspace—even for a few days—forms unwanted byproducts. Such degradation escapes notice in low-volume sales, but shows up fast on the production scale, where even a single leaking container can sour an entire shipment. Our experience with logistics leads us to partner only with carriers who provide customs inspection with minimal container opening, and who maintain climate controls between warehouse transfer points.
Tracking and tracing do not remain the sole province of paperwork. We built bespoke barcoding systems for every drum or container leaving our site. We link each barcode with full batch data, so when a client calls with an analytics report, we check real-time in-house records of moisture contact, packaging timestamp, and storage environment. This matters most when tailored batches for high-sensitivity applications head into market. The real cost of a lost or contaminated acid chloride delivery remains far higher than notes on a balance sheet; it can mean project delays or recalls down the chain.
No manufacturer achieves the right profile for 4-Bromobenzoyl chloride by ignoring environmental and regulatory requirements. Decades ago, emissions from acid chloride production would have meant significant HCl gas release into the surroundings. We retrofit old plants with advanced scrubber systems and invest in neutralizing exhaust streams, seeing firsthand the change in worker health reports and local air monitoring feedback.
Our audit teams regularly walk through production, spotting lags in response times, corrosion on lesser valves, and changes in the telltale smell profile of production areas. They know from experience where corrosion or vapor transfer can introduce contamination—risking not just the integrity of the product but also long-term facility health.
Waste management forms a central pillar of ongoing production. We collect aqueous and organic streams, monitor for residual bromo-organics, and treat by multiple stages before release. In response to tightening chemical control norms, we keep our analytics up to date, not just for compliance, but because residual discharge from acid chloride plants also draws scrutiny from advocacy groups. Facing these demands, we design protocols that balance productivity, safety, and stewardship.
As direct producers utilized to fielding calls from global clients, the technical requests we receive cover everything from material compatibility to synthetic route troubleshooting. Our chemists, many who spent years on batch analytics and pilot plant development, speak directly to client teams about potential incompatibilities or purification challenges unique to 4-Bromobenzoyl chloride. We listen for concerns over solvent selection, unwanted acylation byproducts, or discrepancies between lot-to-lot reactivity.
The stories behind these requests reveal gaps in generalized supplier knowledge. Unless someone has watched a distillation pot foam up or seen a faulty seal’s corrosion, abstract warnings about “handle under dry conditions” lose meaning. Years turning out 4-Bromobenzoyl chloride mean we saw oxidized batches, frozen pipelines, and HCl cloud formation. This experience feeds into aftersales support. Instead of reciting generic precautions, our team walks clients through practical fixes and shares what works, not just what sounds plausible in theory.
Our product’s role never ends at the warehouse door. We follow through until the downstream chemistry shows successful conversion and clean products. Whether a client needs advice on optimizing acylation temperature or wants a GC-Mass spec of potential impurities, our background enables us to offer practical feedback grounded in process experience.
Custom projects occasionally need modified crystal size or alternate packaging, dictated by the specific methods used downstream. Our flexibility stems from witnessing the cost of overly rigid batch design—small tweaks at our end sometimes save months of wasted time at formulation labs or kilo-scale pilot plants. Hundreds of conversations with academic and industry partners show that open communication tightens the gap between factory batch and successful product candidate.
Some in the market opt for sporadic purchasing, treating 4-Bromobenzoyl chloride as a commodity—whoever offers the best price wins. Our decades watching client projects grow and evolve reveals the limits of that approach. Long-term reliability matters far more than one-off discounts; supply interruptions in specialty intermediates erase hard-earned process gains. Continual feedback cycles with repeat customers let us anticipate changing regulations, shifting process specs, and the inevitable new reaction schemes that arise as research progresses.
Our R&D teams, informed by regular production scale-up problems, adjust purification and processing routes months before regulatory or process bottlenecks force an emergency redesign. In practice, the only way to hold purity and performance over time is to keep every team, from quality control to packaging, connected directly with clients’ needs. This exchange doesn’t just create better acid chloride; it supports entire supply chains bound by trust and shared technical language.
The meaning behind every drum of 4-Bromobenzoyl chloride comes down to a mix of chemistry, process awareness, and respect for downstream challenges. Years of seeing both successful and failed reactions, knowing what it feels like to trouble-shoot a process on a holiday weekend, push us to deliver product batches that genuinely perform. We learned that purity, freshness, packaging, and technical support intertwine in ways only witnessed by manufacturing teams held accountable for each crate that leaves the premises.
A careful approach, shaped by direct experience with production realities, quality standards, and a commitment to problem-solving, sets commercial acid chloride apart from the theoretical or commodity-grade variety. For those seeking more than just a supply of 4-Bromobenzoyl chloride—looking for a partner whose priority remains product integrity and real-world technical backup—our doors remain open, guided by the lessons learned with every batch turned and every challenge met.
