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HS Code |
319587 |
| Cas Number | 98-16-8 |
| Molecular Formula | C7H6F3N |
| Molecular Weight | 161.13 g/mol |
| Iupac Name | 3-(Trifluoromethyl)aniline |
| Synonyms | m-Trifluoromethylaniline, 3-Aminobenzotrifluoride |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 174-176 °C |
| Melting Point | -2 °C |
| Density | 1.289 g/cm³ at 25 °C |
| Solubility In Water | Slightly soluble |
| Flash Point | 77 °C |
| Refractive Index | 1.492 |
| Smiles | CC1=CC(=CC=C1)N |
| Inchi | InChI=1S/C7H6F3N/c8-7(9,10)5-2-1-3-6(11)4-5/h1-4H,11H2 |
As an accredited 3-Trifluoromethylaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | A 100g amber glass bottle with a secure screw cap, labeled "3-Trifluoromethylaniline," includes hazard warnings and handling instructions. |
| Shipping | 3-Trifluoromethylaniline should be shipped in tightly sealed containers, compatible with aromatic amines, and clearly labeled. It must be protected from moisture, heat, and ignition sources. Ship according to local, national, and international regulations for hazardous chemicals, often under UN number 2735. Use appropriate cushioning and leak-proof secondary packaging when necessary. |
| Storage | **3-Trifluoromethylaniline** should be stored in a tightly sealed container in a cool, dry, and well-ventilated area away from sources of ignition and incompatibles such as strong oxidizers and acids. Protect from moisture and direct sunlight. Store at room temperature. Ensure appropriate labeling and keep away from food, beverages, and incompatible materials to prevent contamination and hazardous reactions. |
Applications of 3-Trifluoromethylaniline in Industrial Manufacturing3-Trifluoromethylaniline serves as a specialized intermediate in multiple chemical synthesis routes across regulated sectors. Its strong electron-withdrawing properties and aromatic structure support advancements in active compound production, high-performance coatings, and material science. Below, our experts detail the key downstream applications built on real industrial demand and compliance.
Our industrial clients in the crop science sector incorporate 3-Trifluoromethylaniline as a key intermediate during the synthesis of sulfonamide and pyridine-based herbicides. The compound's profile enhances biological selectivity, supports regioselective substitutions, and aligns with multi-step custom synthesis. Chemical engineers favor it for enabling rapid integration into aromatic substitution pipelines, especially where receptor binding affinity and metabolite stability matter. In regulated manufacture, the input material undergoes lot-wise tracking and impurity screening to fulfill downstream registration standards. Industry compliance standards
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API manufacturers rely on 3-Trifluoromethylaniline to introduce trifluoromethyl-phenyl moieties into antihypertensive, anticancer, and antifungal drugs. The raw material participates in Buchwald-Hartwig couplings and nucleophilic substitutions for sartan and kinase-targeted molecular backbones. Since trace impurities and residual solvents affect pharmaceutical compliance, all batches undergo IOQC as per ICH Q7 guidelines. The integration process supports tailored pharmacophore assembly, critical for activity and regulatory filing. Industry compliance standards
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Specialty coatings manufacturers select 3-Trifluoromethylaniline to boost fluorine content and hydrophobicity in OEM and electronic coatings. It functions as a crosslinking monomer during co-polymerization with acrylic or epoxy resins, directly influencing moisture, chemical, and UV resistance of the applied films. Regulatory controls necessitate pre-registration of the starting material and routine VOC/solvent analysis in finished batches. R&D teams achieve fine-tuned gloss and dielectric properties by varying the aromatic amine dosage at the pre-polymer feed stage. Industry compliance standards
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Colorant producers utilize 3-Trifluoromethylaniline as a diazo component in the production of high weather-fastness azobenzene dyes and pigments. The material's fluorinated structure imparts increased heat and UV light stability, making it preferable for automotive, industrial textile, and high-value plastic coloration. Downstream pigment plants maintain closed-loop handling to minimize occupational hazards and perform analytical verification (HPLC, GC-MS) for batch uniformity. The incorporation level depends on the desired tinctorial strength and target base substrate. Industry compliance standards
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3-Trifluoromethylaniline stands out in the family of substituted anilines for its unique structure and robust properties. As a manufacturer, we produce 3-Trifluoromethylaniline with careful attention to both purity and consistency. Chemists often look for a compound that brings something extra to reaction profiles without introducing unnecessary complications downstream. The addition of a trifluoromethyl group at the third position of the aniline ring gives this compound not only improved stability but also different electronic and steric effects compared to its unsubstituted or differently substituted cousins.
Our production process aims for a purity level typically exceeding 99%, as verified by both gas chromatography and NMR. Each batch receives thorough testing from our in-house quality control laboratory. The result: materials you can rely on to show true batch-to-batch reliability. That consistency does not come by luck. It’s earned through careful process control, modern manufacturing infrastructure, and experienced teams who know these molecules well.
From our experience, a big part of 3-Trifluoromethylaniline’s value comes from its influence on molecular electronic character. Introducing three fluorine atoms to the aromatic ring pulls electron density away, which can make a real difference in both reactivity and performance. Chemists working in agrochemicals or pharmaceuticals can exploit these traits, using the compound either as a core building block, an intermediate, or an end-group modifier.
It’s important to look past catalog numbers and see what these attributes mean on the bench and in the plant. For example, 3-Trifluoromethylaniline’s higher chemical stability under harsh reaction conditions often gives it an edge over other anilines. In our own pilot plant trials and scale-ups, this stability translates to cleaner reactions with fewer side products. The trifluoromethyl group doesn’t just tweak reactivity. It can also improve hydrophobicity, decrease metabolic degradation, and alter biological activity — key points for anybody working with life science applications.
Using 3-Trifluoromethylaniline, teams in our own labs have developed building blocks for next-generation crop protection agents and advanced pharmaceuticals. Its distinct reactivity profile supports selective transformations, be it for amide coupling, N-arylation, or even palladium-catalyzed transformations. We’ve seen a clear decrease in by-product formation in several standard organic transformations compared to the methyl- or chloro- analogs. Ultimately, this translates to less time in purification steps and more productive use of resources.
Feedback from large-scale chemical producers and specialized R&D labs matches our own results: materials based on 3-Trifluoromethylaniline display marked improvements in both stability and traceability. For the process chemist, reliable performance means fewer headaches. Nobody appreciates dealing with batch-dependent impurities or unexpected color formation during synthesis, and over time, small improvements in reliability lead to meaningful gains in throughput.
We watch the details closely. We produce 3-Trifluoromethylaniline as a colorless to pale-yellow liquid, which helps with work-up and downstream handling. Strong batch-to-batch color consistency is often underappreciated, yet helps end users by providing visual confirmation of chemical quality. Certain other isomeric trifluoromethylanilines may show slightly darker color profiles or evidence of oxidative degradation over time. By fine-tuning the process and keeping oxygen away during storage and shipping, we help our customers avoid discoloration and shelf-life concerns.
The compound itself holds up well at standard temperature and pressure. Still, just like other aniline derivatives, storing it in airtight containers out of direct sunlight keeps it at its best. Our logistics routines include temperature controls and vapor-barrier packaging, reducing the odds of loss or contamination. We don’t simply ship a chemical. We track every batch and maintain sample reserves for any necessary follow-up. Looking at the data, the overwhelming majority of concerns relate not to the molecule but to issues like operator error or poorly maintained storage environments.
Compared to regular aniline or mono-substituted analogs like 4-Trifluoromethylaniline, the 3-position substitution changes both reactivity and product profile. The ortho and para analogs can sometimes take you in a different direction, both in terms of reactivity and in final product stability. In pharmaceutical research, 3-Trifluoromethylaniline’s meta-position substitution tends to favor certain binding profiles in structure-activity relationship studies.
In our facilities, we have compared production runs using both 3- and 4-Trifluoromethylaniline as coupling partners. The 3-substituted version often provides more precise reactivity in electrophilic aromatic substitution and N-alkylation reactions, while also leading to less poly-substitution and fewer tars. Our analytical team has confirmed this through both HPLC and final product purity tests. R&D partners in Japan and Germany using the same product line have cited similar improvements in process yields.
From an environmental perspective, the trifluoromethyl group offers better oxidative resistance. This becomes especially clear during storage trials under elevated humidity or acid-catalyzed conditions. In contrast, other electron-donating analogs, like 3-methylaniline, show greater sensitivity to such factors. This isn’t just an academic point. It means fewer stability failures, easier handling, and reduced risk of hazardous off-gassing, which matters not just for plant safety but also for regulatory compliance in multiple jurisdictions.
Reactors don’t make allowances for poorly defined intermediates. That’s why we consistently hear from chemical engineers who appreciate strong product documentation, reliable CoA support, and clear technical backup during scale-up. We document trace impurities to below 0.1%. On the manufacturing floor, fewer surprises translate to a much smoother operation, whether the project runs at kilo, hundred kilo, or multi-ton scale.
Beyond the main product, we invest in waste stream management and in recovery systems to minimize both operational downtime and environmental footprint. Fluorinated aromatics, including 3-Trifluoromethylaniline, can pose special handling challenges. Years back, we re-engineered a section of our plant to install extra scrubbers after a period of inconsistent pH in wastewater. Since then, our compliance metrics have steadily improved, reducing costs in both water treatment and hazardous waste disposal.
We offer technical guidance for teams transitioning from small-scale or research synthesis to production-scale implementation. Toxicology teams in life science companies regularly ask for full impurity profiles and stability data. Our QC and regulatory support personnel provide this upon request, using our in-house library of historic batch data. Several regulatory submissions have drawn on our analytical profiles for 3-Trifluoromethylaniline, and we know how valuable preexisting risk assessment data can be, especially when timelines are tight or supply chain pressures run high.
In drug development, the meta-trifluoromethyl group occupies an important niche. The third position typically avoids metabolic hot spots common to para- or ortho- analogs. Our collaborations with pharma firms often focus on robust API manufacture and process chemistry optimization involving 3-Trifluoromethylaniline as a starting material, especially when building advanced intermediates. Feedback has shown that carefully managed trace impurity levels contribute to streamlined regulatory submissions.
Agrochemical researchers working on advanced herbicide and fungicide candidates report similar results. The electron-withdrawing effect of the CF3 group at the 3-position not only improves environmental persistence but can also help tune biological activity in key crop species. This delicate balance between stability and bioactivity underlies recent product launches in both Europe and South America, for which our team supplied specialty grades of 3-Trifluoromethylaniline.
Both sectors value transparency. Clients appreciate not just the purity or GC trace but also batch consistency, reproducibility in multi-step syntheses, and clear technical support. In our experience, reliability forms the core of a strong supplier relationship, and we build that by sharing process data when needed and listening carefully to evolving customer requirements.
Chemistry keeps changing. Over the past decade, we’ve worked with academic partners and industrial R&D labs pushing for greener, more efficient transformations involving trifluoromethyl anilines. One area of growing interest involves selective catalysis using palladium and copper systems, where the 3-positioned CF3 group offers distinct reactivity benefits. We routinely test our product in such reaction systems, checking for catalyst compatibility, side product formation, and extended reaction profiles.
Building a sustainable future means looking for smarter ways to produce and use molecules. That’s why we continue investing in closed-loop recovery systems and solvent recapture wherever possible. Handling fluorinated compounds demands more attention than standard anilines; we take this seriously both in our labs and production-scale operations. Internal investment in process improvement pays lasting returns, especially as more customers demand lower environmental impact and improved safety profiles.
While specialized applications may call for custom-engineered intermediates, a well-made batch of 3-Trifluoromethylaniline still solves many process challenges. In one notable scale-up, we worked closely with a development partner to reduce total waste output by 15% through improvements in both reaction solvent choice and on-site recovery. Small efficiency gains add up, especially in large-scale plants running continuously.
Sourcing and logistics always bring their own set of obstacles. In periods of tight raw material supply, we keep extra buffer stock of key input chemicals to avoid interruptions. Longstanding relationships with trusted upstream suppliers mean greater resilience to sudden price shifts or geopolitical uncertainty. We also maintain direct lines of communication with logistics providers to ensure clear customs documentation and temperature control through transit.
Contamination control also poses persistent challenges. Fluorinated organics can be unforgiving, sticking to equipment or leading to trace carryover even after flushing cycles. By investing in dedicated production lines and frequent operator training, we minimize contamination risks. We’ve learned that attention to cleaning protocols, periodic line validation, and frequent equipment checks pay undeniable dividends in product quality.
Worker safety always ranks highest. Training sessions for handling amines and fluorinated compounds take place before every major production run. Even one incident in a decade is too many. We keep all procedures updated and enforce PPE use rigorously, informed by real world incidents reported both in our own facilities and across the industry.
3-Trifluoromethylaniline has earned its place in the toolkits of both innovators and production chemists. Its electronic profile, stability advantages, and reliable supply chain support make it a central player in the evolving landscape of advanced chemical manufacture. As markets grow more demanding and new regulations take shape, we stay committed to maintaining the high standards that our customers demand.
R&D never stops. Every year brings new questions about reactivity, impurity control, scale-up challenges, and application potential. We answer these by investing in both technical infrastructure and in specialists who actually know and care about each batch we produce. From process optimization to technical documentation, every part of our operation aims to support high quality science and safe, reliable industrial chemistry.
In sum, 3-Trifluoromethylaniline continues to unlock opportunities for creative synthesis, safer manufacturing, and advanced applications. The lessons we gain from every customer challenge, plant trial, and R&D project guide our ongoing improvements. For those looking beyond simple catalog chemistry, that’s where the real value emerges — in meeting real-world needs with a product that delivers, year after year.
