3-Nitrophenol

    • Product Name: 3-Nitrophenol
    • Alias: m-nitrophenol
    • Einecs: 203-618-0
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    960971

    Chemicalname 3-Nitrophenol
    Casnumber 554-84-7
    Molecularformula C6H5NO3
    Molarmass 139.11 g/mol
    Appearance Yellow crystalline solid
    Meltingpoint 96-97 °C
    Boilingpoint 279 °C
    Solubilityinwater Moderately soluble
    Density 1.478 g/cm³
    Pka 8.36
    Refractiveindex 1.625
    Flashpoint 138 °C

    As an accredited 3-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 3-Nitrophenol, sealed with a screw cap, labeled with hazard warnings and product details.
    Shipping 3-Nitrophenol is shipped in tightly sealed containers, protected from light, moisture, and incompatible substances. It is classified as a hazardous material and must be labeled appropriately, following all relevant regulations for transport by road, air, or sea. Handle with care and use protective equipment during shipment and handling.
    Storage 3-Nitrophenol should be stored in a tightly closed container in a cool, dry, well-ventilated area, away from sources of ignition and incompatible substances such as strong oxidizing agents or reducing agents. It should be kept out of direct sunlight, and containers must be clearly labeled. Appropriate spill containment and chemical safety protocols should be in place in the storage area.
    Application of 3-Nitrophenol

    Applications of 3-Nitrophenol in Industrial Manufacturing

    3-Nitrophenol plays a critical role as an intermediate material in multiple industrial sectors. As a direct manufacturer, we supply this compound with consistent quality, supporting a range of downstream applications, each with unique regulatory, formulation, and operational requirements.

    1. Agrochemical Synthesis – Herbicide Intermediate

    Producers in the agrochemical industry use 3-nitrophenol to synthesize selective phenolic herbicides through etherification and coupling reactions. It provides the nitro-substituted phenolic backbone required for several modern crop protection agents. Process parameters and product specifications must comply strictly with agricultural regulations to ensure both environmental safety and application effectiveness.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • REACH Regulation (EC) No 1907/2006
    • EPA 40 CFR Part 180 (USA)
    • Globally Harmonized System (GHS) for classification and labelling

    Typical usage ratio

    • 10–25% by weight of final active ingredient precursor batches, adjusted based on targeted molecular structure and reaction yield optimization

    Downstream process integration

    • Charged into the condensation reactor after temperature ramp-up; undergoes etherification with halogenated alkyl reagents
    • Acts as a limiting agent in coupling and subsequent reduction steps

    Final product types

    • Selective cereal herbicides (e.g., nitrophenyl ether-based products)
    • Pre-emergence weed control compounds
    • Active substance intermediates for fungicides

    2. Pharmaceutical Active Ingredient Manufacturing

    Within pharmaceutical synthesis, 3-nitrophenol serves to produce analgesics and antipyretics through controlled nitration and further hydrogenation. Manufacturers must stringently document batch records and maintain traceability throughout the synthesis process, with compliance to pharmacopoeial standards to control impurities and uniformity of API quality.

    Industry compliance standards

    • US Pharmacopeia (USP)
    • European Pharmacopoeia (EP)
    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • FDA CFR Title 21 Part 210/211

    Typical usage ratio

    • 15–30 mol% as a key aromatic intermediate, with real-time adjustment based on the final molecular structure of API and monitored by HPLC analysis

    Downstream process integration

    • Added during the primary nitration step in multi-step aromatic transformations
    • Direct hydrogenation or further substitution yields amine derivatives for API formation

    Final product types

    • Paracetamol and related analgesic drug substances
    • Antipyretic active pharmaceutical ingredients
    • Nitrophenyl-derivative intermediates for antihistamines

    3. Dye and Pigment Production

    3-Nitrophenol enters azo dye and pigment manufacturing as a diazo coupling component, imparting bright chromatic properties to the resulting pigments for paper, textile, and ink industries. Precise dosing and reaction monitoring ensure color consistency and safety for downstream applications. Compliance with colorant legislation and certification of non-toxic byproducts is mandatory for market entry.

    Industry compliance standards

    • EN 71-3 Safety of Toys (migration of certain elements for dye use in products touching skin)
    • EcoLabel criteria for textile dyes (EU Flower)
    • OEKO-TEX Standard 100 chemical restrictions
    • REACH Annex XVII – Restrictions on azo dyes

    Typical usage ratio

    • 5–18% of total dye batch volume, with adjustment according to shade, fastness, and solubility targets

    Downstream process integration

    • Charged after aromatic amine preparation and prior to diazotization
    • Coupled with aromatic amines under controlled pH to form dye linkage compounds

    Final product types

    • Azo textile dyes (direct yellow, acid orange families)
    • Paper brighteners
    • Organic pigments for printing inks

    4. Rubber and Polymer Additives Manufacturing

    Rubber compounders use 3-nitrophenol in synthesizing antidegradant additives and specialty stabilizers. As a phenolic precursor, it ensures long-term durability and oxidative resistance of finished elastomeric materials. Quality control requires precision in both feedstock purity and integration protocol to align with technical standards for automotive and industrial applications.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for manufacturing consistency
    • ASTM D1171 for weatherability of rubber compounds
    • European Directive 2011/65/EU (RoHS) – restriction of hazardous substances
    • FDA 21 CFR Part 177 (for food-contact polymer grades)

    Typical usage ratio

    • 3–6% by weight in antioxidant masterbatch, adjusted for polymer type and performance targets

    Downstream process integration

    • Incorporated during the polymerization or compounding step, then fully dispersed in the matrix before vulcanization
    • Acts as a modifier or antioxidant source within stabilizer packages

    Final product types

    • Rubber antioxidant masterbatches
    • Polymeric stabilizer concentrates
    • Elastomeric technical sheets

    5. Photographic Chemical Manufacturing

    Producers in the imaging chemicals sector employ 3-nitrophenol as a developing agent and photographic reducer. It offers precision control over reduction processes in black-and-white film, paper photographic developers, and certain electronic imaging applications. Traceability is critical to meet manufacturing standards and to prevent batch-to-batch variation in image-quality related chemicals.

    Industry compliance standards

    • ISO 9001:2015 for chemical production consistency
    • ANSI/NAPM IT4.120 for photographic chemical purity
    • Directive 2004/42/EC (EU) on Limiting Volatile Organic Compounds (VOCs)
    • GHS for chemical hazard labelling

    Typical usage ratio

    • 0.2–1.0% of total developer solution; subject to fine tuning per film sensitivity and image density requirements

    Downstream process integration

    • Added to developer concentrate immediately prior to mixing with other agents such as hydroquinone
    • Operates as the main reducer during substrate immersion and image formation phase

    Final product types

    • Black-and-white photographic developers
    • Film processing agents
    • Specialty photographic reduction chemicals for imaging laboratories

    6. Specialty Chemical Synthesis – Corrosion Inhibitor Production

    3-Nitrophenol acts as an intermediate in the manufacturing of phenolic-based corrosion inhibitors used in metalworking fluids and circulating cooling systems. Its chemical structure contributes both to active inhibition and film formation over metal surfaces. Producers ensure the integration process remains consistent with environmental safety and technical performance benchmarks.

    Industry compliance standards

    • EN 12021 & EN ISO 8044 for corrosion inhibition standards
    • REACH Regulation requirements for downstream use notification
    • ASTM D665 for testing rust-preventing characteristics in water
    • ISO 14001 for environmental management

    Typical usage ratio

    • 2–7% of the formulated inhibitor concentrate, with ongoing adjustment according to protection duration and metal type

    Downstream process integration

    • Incorporated in the final blending stage, often prior to emulsifier or surfactant addition
    • Functions as an active phenolic component during product dilution for end-use application

    Final product types

    • Water-soluble metal corrosion inhibitors
    • Concentrated coolant additives
    • Specialty metalworking fluid protectants

    Free Quote

    Competitive 3-Nitrophenol prices that fit your budget—flexible terms and customized quotes for every order.

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    Certification & Compliance
    More Introduction

    Introducing 3-Nitrophenol: A Practical Perspective from the Manufacturing Floor

    3-Nitrophenol at a Glance

    3-Nitrophenol carries a distinct yellow crystalline form and offers a sharp edge of usability in several key chemical industries. With years of hands-on production experience, our focus has always been on meeting the real-world quality standards that our downstream partners demand. Our model covers purity levels above 99%, where trace impurities—such as residual water, metal ions, and related phenolic compounds—are rigorously controlled during synthesis, washing, and drying steps. We set specification limits based on consistently tested, reproducible data, not marketing language or lab-bench assumptions.

    Process Insight: How 3-Nitrophenol Shapes Up in Production

    On our shop floor, batches move through nitration of phenol under closely watched thermal and pressure controls. Precision matters here. Moisture content and temperature during reaction and crystallization stages play a direct role in product consistency. Our staff fine-tunes process parameters based on batch analytics; this ensures reproducibility, especially for customers with critical downstream reactions where contaminants trigger side products or plant downtime. We started offering 3-Nitrophenol several decades ago, and feedback from our long-term partners in pharmaceuticals, dye manufacturing, and pesticide intermediates constantly shapes our approach.

    Where 3-Nitrophenol Proves Its Worth

    Many customers come to us looking for 3-Nitrophenol to anchor specific chemical syntheses. In the pharmaceutical sector, it acts as a necessary intermediate in the synthesis of certain antipyretic and analgesic compounds. Some dye houses select our 3-Nitrophenol because of its solubility and stability profile when reacting with aromatic amines. Agricultural chemical plants value our product for its role in fine-tuning pesticide formulations; their quality assurance teams often report minimal residue and consistent reactivity, thanks to our controlled nitro and hydroxyl group placement and impurity profile. Our team knows that an unexpected impurity level—even below standard detection—can push a batch out of acceptance, potentially wasting weeks of labor on the customer’s end. That feedback drives tighter batch-to-batch control, regular outside lab verification, and full lot history transparency.

    Differences That Matter: 3-Nitrophenol vs. Alternatives

    Out in the marketplace, you find multiple nitrophenol isomers—2-Nitrophenol and 4-Nitrophenol being the main competitors. Chemically, all three deliver a nitro group grafted onto the phenol ring, but the position shifts both their reactivity and toxicity. In preparative organic synthesis, 3-Nitrophenol stands out for its balance of steric and electronic effects: nucleophilic substitution takes a different pathway compared with the ortho or para compounds. Some customers ask if they can swap 3-Nitrophenol for one of the isomers when faced with supply shortages, only to run into solubility issues or unexpected color changes in their final product. After dozens of plant consultations over the years, our technical support team learned to map each customer’s process limits before sending even a test lot. No two applications are identical, so we prefer a direct conversation rather than sending generic advice.

    From an environmental handling standpoint, we also see regulatory and waste treatment profiles shift depending on the isomer. Our wastewater treatment technicians collaborated with downstream users to configure in-house protocols that keep effluent levels within local standards, with 3-Nitrophenol generally showing a more predictable breakdown compared with some other phenolic nitro compounds. Every year, hazardous waste regulations grow stricter, so product selection impacts cost far beyond the purchase price.

    Daily Realities: Handling, Packaging, and Consistency

    Practicality governs our approach to packaging and shipping. Bulk users in dye or pesticide synthesis might need material in drums or customized intermediate bulk containers, which we prep in controlled environments to minimize cross-contamination. Some of our pharmaceutical partners require smaller, double-lined bags sealed inside clean drums, all nitrogen-flushed and barcoded back to the originating batch. We stand behind full traceability: every label connects back to raw material receipts, process logs, and final QC results. If an issue ever arises, we trace, analyze, and correct—sometimes even sharing our investigation results with the user community so that lessons aren’t wasted.

    Early on, we learned that transportation and longer-term storage can influence the chemical profile. Temperature shifts sometimes cause slight color darkening or absorbance drift. To anticipate this, we built a program of stability testing and retain sample tracking—so the product in your process mirrors what we tested on our own floor. By sending regular feedback to end-users, we aim to minimize the guesswork that often creeps in with chemical sourcing. Shelf life, storage conditions, and reactivity retention aren’t just regulatory talking points for us—they’re business realities, learned through years of batch reviews and user feedback cycles.

    Why End-Users Keep Coming Back

    What matters more to customers than a certificate of analysis is the question: will your material work like last time? Hundreds of times each year, our technical service team fields calls from customers tracing performance hiccups in their own plants, chasing root causes down to minor variations in 3-Nitrophenol supply, moisture pickup, or trace iron content. Sharing our batch histories and process logs allows us to help rather than hide. In decades past, we learned the hard way that opacity about process drift or post-shipment handling can backfire—so now, we err on the side of full disclosure, even if it means exposing a missed metric or an outlier test result.

    We also share application knowledge across our customer base, under strict confidentiality. When a dye maker reports a bottleneck due to solubility slowdowns, we relay our findings to other firms experiencing similar effects. Transition metal contamination, especially from older reaction vessels or storage drums, has tripped up more than one client’s synthesis; we document these experiences, update our maintenance protocols, and offer technical notes reflecting real output, not just theoretical claims.

    Supporting Innovation and Process Efficiency

    New entrants in pharmaceutical or specialty chemicals often notice commercial 3-Nitrophenol doesn’t behave exactly as textbooks suggest. Each plant brings subtle differences: water activity in the workspace, ambient air quality, and handling temperatures all influence yield and selectivity when 3-Nitrophenol forms part of a larger synthetic chain. By offering pre-shipment samples, technical validation reports, and experienced process consultation, we help customers avoid the pain of lost batches, reprocessing, or regulatory non-compliance. Sometimes a tweak in drying protocol—switching from hot-air to vacuum, for example—solves a months-long productivity bottleneck. We draw on our internal R&D team as well as insights from customers worldwide, piecing together best practices and sharing them openly.

    Over the years, we’ve seen a trend toward greener processes. Several customers approached us aiming to replace less selective or less environmentally friendly nitrophenol sources. Working together, we trialed routes that recover or reuse solvents, cut down NOx emissions, and substitute cleaner nitration agents. Our ability to manufacture at different scales, from pilot to commercial, means we support these transitions with real data—not just promises. This hands-on collaboration acts as a two-way street: our own production efficiency jumps alongside our customers’ process upgrades.

    Quality, Regulatory Acceptance, and the Path Forward

    We treat regulatory acceptance as a benchmark, not a ceiling. Our standard batches run through rigorous impurity profiling before release. Residual solvents, unreacted phenols, and heavy metals fall below pharmaceutical and food industry limits—even for batches headed toward industrial dye or pesticide use. Our audit trail includes both in-house and independent lab verification, ensuring cross-checks on all specifications. Many customers work in highly regulated fields and value the fact that our documentation includes everything they need for batch tracking and product registration audits.

    As regulations shift, particularly in the EU and North America, we stay on top of evolving standards for workplace exposure, downstream waste, and environmental release. Changes in permitted impurity limits or workplace handling guidelines don’t catch us by surprise; we flag those in our technical bulletins, often giving customers time to adjust procedures or file amendments. The dialogue between manufacturer and user matters as much as any written guideline. Sharing what works—and what fails—puts both us and our clients ahead of the regulatory curve.

    Cost and Supply: Navigating the Realities of 3-Nitrophenol Sourcing

    Any frequent buyer knows supply chain disruptions can derail even well-designed manufacturing plans. From sudden feedstock cost hikes to logistics bottlenecks, we’ve managed them all over decades, usually with workable contingency plans. We hold buffer stocks of both key precursors and finished 3-Nitrophenol. Just-in-time scheduling means nothing without a failsafe system for spikes in demand or port slowdowns. Recent years showed how market stress—whether geopolitical or pandemic-driven—can throw off the balance; our response is open communication with customers and flexible shipping arrangements to keep lines running.

    Cost rises as a frequent concern. As a direct producer, we see raw material, labor, and compliance costs at the granular level. We try to keep price swings transparent by breaking down the main drivers for customers. Sourcing phenol or nitric acid locally protects against currency shifts, while in-house waste handling shrinks disposal overhead. Sometimes we help long-standing partners set up their own intermediate warehousing or optimize batch sizes so that transportation and storage costs stay manageable. Small, everyday tweaks stack up to real budget relief once procurement and logistics are fully aligned.

    Future Trends: Meeting New Challenges Together

    As applications for 3-Nitrophenol evolve, so do requirements for purity, traceability, and environmental impact. Automation and real-time analytics now inform our process adjustments; statistical controls flag even the minor batch deviations before they reach the customer. Some partners have moved toward continuous manufacturing or demand near-zero waste from intermediates. These shifts drive us to review our own manufacturing footprint, invest in cleaner technologies, and experiment with alternative solvents or milder reaction conditions.

    In the years ahead, synthetic chemistry moves toward higher efficiency and wider digital integration. Electronic batch records, blockchain traceability, and even machine learning models that predict process drift—all these tools add new layers of reliability. We embrace these changes with the understanding that no technology replaces experience built on real-world manufacturing challenges. Our legacy in 3-Nitrophenol production offers a foundation, but our mindset stays adaptable.

    Bridging Experience With Customer Needs

    What brings customers back isn’t just a technical edge or a polished certificate—it’s results. We built our business on the knowledge that behind every order sits someone relying on our consistency. We know the stakes: a failed synthesis ripples through supply chains, stalls product launches, or triggers costly recalls. Experience, direct feedback, and enduring relationships with users keep the standards honest. Every batch release, every technical call, every troubleshooting session—each interaction shapes the next order.

    We believe that sharing experience, approaching challenges openly, and aiming for authentic partnership make the biggest difference in the real-world application of 3-Nitrophenol. The modern market will always chase cost and regulatory demands. Strong, reliable manufacturing roots—tempered by years of face-to-face troubleshooting—remain the most valuable asset in delivering 3-Nitrophenol that exceeds expectations.

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