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HS Code |
341505 |
| Cas Number | 616-44-4 |
| Iupac Name | 3-Methylthiophene |
| Molecular Formula | C5H6S |
| Molar Mass | 98.17 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Density | 1.029 g/cm³ |
| Boiling Point | 115-117 °C |
| Melting Point | -37 °C |
| Flash Point | 24 °C |
| Refractive Index | 1.529-1.531 |
| Solubility In Water | Slightly soluble |
| Canonical Smiles | CC1=CSC=C1 |
As an accredited 3-Methylthiophene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle with a secure cap, labeled "3-Methylthiophene, 99%, 100 mL." Features hazard pictograms, safety information, and batch details. |
| Shipping | 3-Methylthiophene is shipped in tightly sealed containers, typically glass or high-density polyethylene bottles, to prevent leakage and exposure. It should be stored and transported in a cool, well-ventilated area, away from sources of ignition. As a flammable liquid, it must comply with relevant hazardous materials shipping regulations. |
| Storage | 3-Methylthiophene should be stored in a tightly sealed container, in a cool, dry, and well-ventilated area away from sources of ignition. The storage area should be free from strong oxidizers, acids, and bases. Protect the chemical from direct sunlight and moisture. Properly label the container, and store it in compliance with local chemical storage regulations. |
Applications of 3-Methylthiophene in Industrial Manufacturing3-Methylthiophene serves as a key intermediate in specialized chemical industries, contributing unique structural features needed for targeted synthesis in pharmaceuticals, advanced materials, agrochemicals, and electronic components. Below are application areas where direct incorporation and technical handling of 3-Methylthiophene drive commercial production at scale. 1. Pharmaceutical Intermediate SynthesisPharmaceutical manufacturers incorporate 3-Methylthiophene as a building block in the synthesis of complex active pharmaceutical ingredients, particularly within anti-infectives and central nervous system (CNS) compounds. Its methyl-substituted heterocyclic ring enables high regioselectivity in catalyzed cross-coupling reactions. Operators typically use it in Suzuki, Stille, and Buchwald-Hartwig coupling steps to construct active cores of thienopyridine derivatives and certain anti-epileptic drugs. Material handling, solvent compatibility, and trace metal control remain critical from charging to downstream purification, ensuring product qualification under stringent regulation. Industry compliance standards
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2. Organic Electronic MaterialsProducers of organic semiconductors and conductive polymers use 3-Methylthiophene as a vital monomer in the fabrication of polythiophene-based materials. The compound’s electronic donation characteristics and its defined methyl position support improved hole-transport and thermal behavior in functional polymer chains. Manufacturing integration involves oxidative polymerization, with material specification tightly managed for oligomer distribution and precursor purity. Downstream process design involves strict environmental and occupational controls to ensure thin-film quality for display and sensor technologies. Industry compliance standards
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3. Agrochemical SynthesisLeading pesticide and herbicide manufacturers apply 3-Methylthiophene into targeted fungicide and insecticide molecule synthesis. Its five-membered sulfur ring serves as a reactive core for selective functionalization steps through sulfonation, halogenation, and nitration. Consistent material purity and isomer ratio are essential for downstream bioactivity. Most integration occurs within multipurpose chemical reactors outfitted for hazardous process monitoring, as the final active ingredients often require highly controlled conversion yields for registration and efficacy. Industry compliance standards
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4. Specialty Chemical Manufacturing for Flavors and FragrancesProducers of advanced aroma chemicals incorporate 3-Methylthiophene for synthesizing sulfur-containing flavor and fragrance molecules. Its structure allows preparation of key synthetic analogues contributing roasted, burnt, and umami notes in food and perfumery applications. Precision in process parameters is crucial to maintain organoleptic quality and to avoid the formation of undesired by-products. Production involves tight compliance with batch traceability and food safety management from raw material to final distillation or blending. Industry compliance standards
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Down in the gut of every chemical plant, choices about sourcing mean the difference between a truly controlled process and rolling the dice with every batch. Whenever our team talks about 3-Methylthiophene, we know the value sits not just in the purity of the drum but in the years it took to get that drum right—without hidden contaminants and with a spec the next stage can really count on. As a chemical manufacturer, every person here shares the drive to deliver 3-Methylthiophene that behaves predictably on the line, so every reaction moves forward without headaches.
3-Methylthiophene lives up to its reputation when synthesized and purified using practices honed by steady hands. We keep a close eye on every variable. We take pride in reactors and columns built to last—pipelines without blind spots, vessels that resist fouling, and procedures that catch off-odors early on. We have encountered runaway thiophene byproducts in less-polished systems before, so we do not settle for shortcuts. Each stage, from methylation through distillation, gets hands-on attention, and every drum leaving our yard needs to pass rigorous GC and MS analysis—not just for the numbers, but for batch-to-batch consistency that cuts out trouble at your end.
Our product routinely achieves a purity that lets it jump right into demanding syntheses, whether you are heading toward pharmaceuticals, agrochemicals, or electronic intermediates. This is not the type of feedstock that surprises you with off-color spots in the chromatogram. Our technology holds the 3-methyl group strictly at the ring’s third position, with impurity profiles that stay far below the 0.5% marker even on large lots. Stability during storage matters, so containers ship dry and sealed, because moisture or light exposure can nudge the sulfur chemistry into places you do not want.
Other grades of thiophenes float through the market, and some outfits cut corners for cheap volume. As a producer, we see what these shortcuts cost in downstream headaches: polymer yellowing, catalyst deactivation, or unclear mass balances. We have spent years tracing the roots of those problems, which often come back to a few overlooked ppm of a wrong contaminant. Our methods put special care into sulfur residue removal and unwanted C4-C6 byproduct stripping. These are not afterthoughts on a spec sheet; they mean less rework and higher yields for folks handling tough coupling reactions or HPLC processes down the line.
Whenever a new lab comes to us describing erratic performance, we usually find they had been fed a recycled-grade or an off-brand batch of 3-Methylthiophene. The difference in final product clarity or intermediate conversion can be dramatic—sometimes within a few runs. We do not gamble with those variables. As a manufacturer, our commitment extends beyond raw analytical data. We maintain logbooks on every reactor run, right down to the shift, lot, and parameter set. This record-keeping culture comes from seeing ordinary supply chains buckle under stress when no one recalls exactly what went in the kettle last week.
Chemical processes are built on predictability, and our 3-Methylthiophene gives chemists that bedrock. Once received, the product finds workhorse duties in synthesis routes for advanced building blocks. Many customers rely on it as a skeletal precursor in API sidechains, where one odd impurity could mean extra days of work or cascade into regulatory issues. Polymer labs value its role in semiconducting material production—the sulfur heterocycle brings electron-rich character, which translates into better performance metrics for organic field-effect transistors and solar cell layers.
Agricultural chemistry depends on getting the functional group precisely at the third position, not elsewhere on the ring. Crop science teams say trace contamination from competing positional isomers can tank efficacy in new formulations. Our product owes its reputation to consistently holding this selectivity. Batteries and advanced materials labs turn to us when they need starter molecules for high-spec support films and membrane tech. We’ve learned from their feedback and adapted our purification flows. The result: a reproducible and documented product lifecycle, from synthesis to application scale-up.
The tough part about working with sulfur aromatic intermediates comes from their tendency to pick up traces of moisture, air, or metals once they leave the controlled boundaries of manufacturing. After seeing batches oxidize or discolor during extended shipping, we began overhauling our logistics and repack operations. Now every container is filled and sealed under inert gas. We train our storage technicians not just for compliance but for root-cause awareness—catching vent leaks or packaging flaws before they snowball into recalls.
Every so often a customer will call, describing a sudden batch anomaly, and all eyes turn to traceability. We digitized our batch records so the entire synthesis—temperatures, reagent grades, operator changes—can be called up in minutes. This transparency becomes insurance for chemists relying on 3-Methylthiophene in tomorrow’s campaign. More than once, we have supplied parallel reference samples from different lots to help partners root out secondary process variables unrelated to the starting material. Clean supply builds confidence, which unlocks faster development cycles and fewer delays.
The way 3-Methylthiophene handles—its volatility, odor, and purity demands—means it cannot be viewed like a commodity solvent or a bulk hydrocarbon. Lab teams and plant operators look for quick, predictable phase behavior. Our customers routinely report that our lots pour and vaporize with less residue. Viscosity and boiling range might seem like technical footnotes, but one glassware foul-up or a distillation column clog means downtime and frustration. Sometimes the unheralded aspect of a product, like how well it stays free of polymeric surface fouling or the way it doesn’t cloud up on the shelf, tells a deeper story about manufacturing culture. These details do not make spec sheets; they get baked into everyday workflow once you notice the improvement.
On shipping days, operators compare notes with the QC team to spot trends or slips, treating each outgoing lot less like anonymous product and more like a trusted tool passed from one craftsperson to the next. It’s a habit built from years of feedback—not just from high-volume buyers, but from small batch researchers who run into unexpected snags that only show up in practice, not in lab-scale tests. In that way, we have learned to listen, adapting not only specs but handling recommendations so that unexpected bottlenecks at the user’s site get solved by design, not by chance.
The expectations for chemical purity and documentation keep tightening, especially for companies working in pharma and electronics. Regulatory compliance doesn’t come from a box-ticking culture; it grows from shared responsibility at every level—purchasing, production, QA, logistics. We constantly tune our synthesis flows to cut byproduct emissions and lower residual solvent levels. Recycling streams used to be a cost-only issue, but now sustainability reviews by major customers push us toward more efficient scheduling, closed-transfer equipment upgrades, and tailored waste capture.
It’s no secret that producing organosulfur compounds brings challenges. Wastewater and odor management become critical, especially for facilities close to residential zones. We invested in atmospheric scrubbers to keep incidental releases under controls that meet and often exceed local guidelines. Partnering with waste processors who specialize in sulfur chemistry gives us added peace of mind—no runarounds over legal compliance, and no risk of downwind complaints. This attention to environment, health, and safety does not stop at the fence line. It translates into respected standing with local regulators and builds long-term trust with customers who prioritize sustainability in their supply chain reviews.
One of the challenges that comes with 3-Methylthiophene is adapting logistics and package size to real-world customer needs. Bulk buyers often want full tankers or ISO containers, but we also supply specialized lots for research and pilot projects in smaller drums or custom sealed ampules. We welcome dialogue about particular needs—temperature-controlled shipping, rush fulfillment for development trials, or extra documentation for regulatory filings. Our operations team responds quickly; engineers who actually design our packaging listen to downstream teams and can make adjustments when bottlenecks crop up mid-project.
Over the years, we have handled emergency orders when unexpected runouts or R&D surprises hit. Supplying high-purity intermediates demands more than just shipping a box; it means walking alongside customers when their own deadlines tighten. Our tech support is run by people who actually understand the molecule—chemists and engineers who made the product, not call-center agents reading from a queue. Customers get answers rooted in chemical reality, not templated scripts.
As more markets look toward flexible, fast-response manufacturing, the future belongs to chemical partners who can scale quality consistently. For us, that has meant investing in both continuous and batch-based synthesis lines, so we can keep pace with changing demand without shaking up product identity. Data from new production runs gets folded back into process improvements. We host review sessions every quarter to match operational tweaks to actual user feedback—and we do not wait for complaints to fix what isn’t working. Learning loops close faster, and each year our product sees incremental gains in both purity and ease of handling.
A few years back, we noticed an uptick in specialist requests for highly deuterated or isotopically labeled 3-Methylthiophene, mostly for tracing studies in environmental and pharmacological settings. While these are custom orders and demand extra tooling, this sort of responsiveness lets us stay ahead of the curve in specialty intermediates. Our core product underwrites those innovations by maintaining a steady supply chain backbone, never letting the uncommon requests eat into regular reliability.
At first glance, the small size and volatility of 3-Methylthiophene resemble basic thiophenes or other methylated aromatics. The difference becomes clear once you look at how downstream reactions unfold. Positioning the methyl group on the third carbon not only shapes the electronic distribution but tunes the reactivity in coupling, cyclization, and substitution steps. Compared to 2-methylthiophene, the third-position isomer fits templates where steric hindrance or selectivity dictate the outcome—and for certain pharmacophores, only one isomer will do.
The sulfur ring itself stands apart from oxygen and nitrogen heterocycles widely used in fine chemical synthesis. Sulfur’s polarizability affects how palladium or nickel catalysts interact during C-H activation or cross-coupling steps. In electronic material labs, this translates into better bandgap tuning for organic conductors or photovoltaic layers. We have run dozens of joint trials with customers who benchmarked our material against imported analogs, and time after time, less precise products created roadblocks in scale-up—unwanted isomers, off-odors, or unpredictable side reactions. Our efforts to control all those minute impurities pay off when a customer gets their tech transfer right the first time.
Across the years, every new round of product feedback pushes us to recalibrate assumptions and address details others miss. 3-Methylthiophene’s journey from raw materials to application-ready intermediate demands as much faith in the human side of manufacturing as it does trust in analytical instruments. We have built our workflow around transparency, swift feedback response, and a refusal to compromise on the fine points. Each barrel or drum out of our yard comes stamped with that promise—a chemical backbone ready for your next reaction, built the right way, every time.