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HS Code |
433212 |
| Chemicalname | 3-Bromophenol |
| Casnumber | 591-20-8 |
| Molecularformula | C6H5BrO |
| Molarmass | 173.01 g/mol |
| Appearance | White to off-white crystalline solid |
| Meltingpoint | 32-36 °C |
| Boilingpoint | 220 °C |
| Density | 1.75 g/cm³ |
| Solubilityinwater | Moderately soluble |
| Flashpoint | 104 °C |
| Pubchemcid | 68227 |
| Smiles | C1=CC(=CC(=C1)O)Br |
| Synonyms | m-Bromophenol; Meta-bromophenol |
| Refractiveindex | 1.604 |
As an accredited 3-Bromophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 3-Bromophenol is packaged in a 100g amber glass bottle with a secure cap, labeled with hazard symbols and chemical information. |
| Shipping | 3-Bromophenol is shipped in tightly sealed containers, compliant with safety regulations for hazardous chemicals. It should be stored in a cool, dry, and well-ventilated area, away from incompatible substances. Appropriate hazard labels must be attached, and shipping must follow relevant regulatory guidelines, such as those of IATA and DOT. |
| Storage | 3-Bromophenol should be stored in a tightly closed container, away from incompatible substances such as oxidizing agents and strong bases. Keep it in a cool, dry, and well-ventilated area, protected from light and moisture. Ensure storage in compliance with local regulations and label all containers properly. Avoid sources of ignition, as it is combustible. |
Applications of 3-Bromophenol in Industrial ManufacturingAs a direct manufacturer, we supply 3-Bromophenol for specialized uses in advanced chemical production chains. Downstream industries leverage this intermediate for key syntheses in agrochemicals, pharmaceuticals, dye manufacture, and specialty resins. All applications reflect real industrial practices and compliance requirements. 1. Synthesis of Agrochemical IntermediatesMajor agrochemical plants employ 3-Bromophenol as a halogen source in the synthesis of selective herbicides and fungicide actives. Its reactivity enables coupling and substitution during production of phenoxy-derivative intermediates, crucial for the next-step formulation of effective agro-active molecules. Manufacturers optimize process conditions for yield and purity, ensuring that downstream agrochemical APIs achieve regulatory tox and residue standards. Industry compliance standards
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2. Pharmaceutical Intermediate ManufacturingBulk API synthesis facilities source 3-Bromophenol for non-sterile and GMP-regulated fine chemical manufacturing. Its brominated aromatic ring allows precision substitution and further derivatization towards anti-infective, anti-inflammatory, and CNS-active compound APIs. QC teams verify raw material traceability and batch consistency to support audits and DMF filings. Industry compliance standards
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3. Industrial Dye and Pigment SynthesisDye manufacturers introducing halogenated phenolic derivatives use 3-Bromophenol as a controlled halogen source for azo and anthraquinone dye staple intermediates. Its controlled reactivity helps optimize color fastness and generate specialty shades. Production scaleup pays special attention to waste management and colorant batch reproducibility. Industry compliance standards
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4. High-Performance Resin and Polymer AdditivesProducers of epoxy, phenolic, and polycarbonate resins rely on 3-Bromophenol as a monomer modifier or polymer additive. It serves to modify mechanical and flame-retardant properties by incorporating a brominated aromatic ring during polymerization. Industrial processors maintain strict controls over bromine release and assess additive influence via mechanical and thermal testing. Industry compliance standards
Typical usage ratio
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Working daily in chemical manufacturing, we see the importance of consistent quality and reliability in every drum and bottle leaving our facilities. 3-Bromophenol carries the weight of many years of development and handling experience. This phenolic compound, with a bromine atom bonded at the meta position, brings a distinctive set of characteristics to chemical synthesis, flavor and fragrance production, the pharmaceutical sector, and scientific research.
Decades of expertise tell us that not all halogenated phenols are created equal. Small changes in structure shape how each material behaves. In the case of 3-Bromophenol, shifting the bromine group to the third position creates notable distinctions compared to the ortho and para isomers. These differences define its odor profile, its reactivity in lab work, and its downstream applications.
In pharmaceutical synthesis, 3-Bromophenol gets called on for its reliable reactivity. Researchers turn to this compound for cross-coupling reactions and as an intermediate in building complex molecules. Its predictable profile in Suzuki and Buchwald-Hartwig couplings gives chemists confidence in reproducibility. Industries producing active pharmaceutical ingredients (APIs) often depend on batch-to-batch consistency—a reality we face every day on the production floor, where deviations can halt entire projects.
Outside of pharma, manufacturers in the flavor and fragrance world tap into 3-Bromophenol’s unique sensory profile, characterized by notes of medicinal, phenolic aroma with a subtle smoky undertone. For these sectors, purity translates directly to olfactory clarity. Continuous attention to impurity profiles—honed by years of quality control protocol—means end-users avoid unwanted off-notes and inconsistent experiences.
3-Bromophenol’s utility extends to dye intermediates, agricultural research, and polymer science. Each of these segments draws critical benefit from our expertise in producing material free from color impurities and unwanted halide byproducts. Rigorous purification and in-line monitoring serve as daily proof points that a manufacturing-first perspective helps users trust their supply chain.
We produce 3-Bromophenol in batches that reflect best practice in controlling color, purity, and trace moisture. Our standard offering holds a minimum purity of 99%, tested via HPLC and confirmed by gas chromatography. Slight color differences don’t escape attention—the faint yellow to off-white crystals mark true 3-Bromophenol free from excess tars or side products. Water content, always a concern for those running sensitive reactions, gets kept below stringent thresholds, as determined by Karl Fischer titration. These are not arbitrary points but the result of years of operator vigilance and adjustments made on the fly in response to raw material shifts.
The physical nature of 3-Bromophenol—solid crystals at room temperature, a melting point hovering around 32 to 36°C, and a recognizable odor—shapes standard operating procedures in packaging and transport. Packaging options reflect the realities of scale: small pharmaceutical labs favor sealed glass or HDPE bottles in 100-gram and one-kilogram increments, while larger operations require seamless transfer into 25-kg fiber drums with double liners. These choices stem from countless consultations with end-users, storage trials, and transitions through customs and hazardous freight corridors.
Putting 3-Bromophenol side by side with its closest relatives, the differences are clear in both hands-on usage and technical outcomes. The para isomer, 4-Bromophenol, behaves differently in coupling chemistry and brings a softer, milder aroma for perfumers and flavorists. The ortho variant, 2-Bromophenol, carries a sharper, almost metallic odor and noticeably different solubility in organic solvents. These distinctions are not theoretical—they’re the sum total of thousands of lab notebooks and hours troubleshooting downstream process hiccups.
From a manufacturing perspective, distinct safety and environmental profiles come into play. 3-Bromophenol’s vapor pressure, aquatic toxicity, and stability under ambient conditions all demand proper engineering controls during synthesis and packaging. Learning from decades of scaling up, we have adopted closed-system transfers, real-time emission monitoring, and investments in solvent recovery where possible. Each isomer’s profile influences effluent treatment and worker training protocols.
Another difference emerges in analytical demands from our partners. Analytical chemists often need custom solutions tailored to their own instrumentation calibration. The isomeric distinctions require unique standards, solvent systems, and handling recommendations, which we regularly provide based on years of lab support requests. Our technical team fields questions ranging from chromatographic retention times to storage longevity under varying climate conditions.
Scaling from gram to multi-ton output involves a balancing act between cost, safety, and purity. Fluctuations in raw bromine and phenol price, shipping disruptions, and regulatory updates form part of our daily operating environment. Every new batch brings a fresh opportunity for deviation, but it also creates moments for process adjustment and innovation. We install new purification columns only after live data tells us the benefit, not because a brochure promises it. Environmental authorities expect transparency in waste handling; we work closely with them at every change to ensure compliance and keep environmental impact minimal.
Our operators have learned through practice how temperature control, dosing rates, and agitation affect not just output, but also impurity profiles and physical appearance. Frequent micro-sampling during reaction and downstream work lets us adjust, not just react. We share process data when requested, supporting our partners’ audits and regulatory submissions.
Pharmaceutical intermediates account for a meaningful portion of 3-Bromophenol consumption. Medicinal chemists repeatedly share that reactivity and selectivity kick off multi-step integrations—no minor detail when timelines are tight and every percent yield matters. In the agrochemical space, 3-Bromophenol serves as a block for synthesizing fungicidal and herbicidal compounds, providing a backbone for further halogen substitution or etherification.
In the electronics industry, certain customers synthesize specialty polymers relying on 3-Bromophenol as a monomeric starting material. For these partners, we document trace metals analysis and guarantee freedom from high-volatility organic contaminants, reflecting their process capabilities and end-point electrical properties. Some flavor and fragrance creators focus on the niche, leveraging the compound’s signature smokiness for specialty blends. Our sensory lab regularly hosts panels to track aromatics across lots, a step often missed elsewhere.
Direct engagement with research and scale-up calls for more than shipping high-purity chemicals. Customers consult our technical chemists on solubility optimization for multi-component reactions, stability in mixed-solvent systems, and safe handling of residual vapors during pilot trials. We share practical storage experience—from layered drum lining to temperature logging—so that years of know-how spill into every supply. We have solved spontaneous crystallization in cold chain shipping, and we flag solvent interactions that newer firms only learn about after a product recall.
The cost of subpar material isn’t theoretical to us. We’ve heard from teams sent back to square one due to a slight off-grade batch. Unanticipated reactivity or an undetected trace contaminant can set back months of development work, generate disposal headaches, or lead to regulatory re-inspection. Our work aims to reduce those chances to as close to zero as real life allows. Every kilogram we dispatch reflects testing, documentation, and feedback loops connecting the plant floor to the customer’s bench.
Compliance forms the backbone of modern chemical manufacture. Our 3-Bromophenol production integrates local and international safety guidelines, with regular updates in response to REACH, TSCA, and applicable amendments. Safety Data Sheets reflect actual lot analysis, not theoretical composition. We regularly host safety walkthroughs with both field inspectors and customer audit teams. These exchanges shape how we label, pack, and present information—not as an inconvenience but as a direct contributor to safer, more reliable product stewardship.
Documentation demands have increased steadily, prompted by the evolution of end-market regulations. Our years in the industry have taught us that clear compliance reduces delays, legal risk, and human error on-site. Batch traceability, archival of Certificates of Analysis, and continuous process validation represent ongoing investments in transparency. That way, regulatory questions get answered with evidence, not speculation.
Every kilogram of 3-Bromophenol produced has a footprint on worker health, facility hygiene, and local ecosystems. We handle all raw and finished products in ventilated rooms, using PPE protocols refined over time. Vent scrubbers capture airborne emissions, and effluent lines pass through multiple separation and neutralization steps before any discharge. Safety measures protect our team, but just as crucial is support for end-users with guidance on safe transfer, spill response, and storage. Decades in manufacturing have cemented the principle that operational reliability grows from front-line awareness, not just written policies.
We invest in fire suppression and vapor control, responding to the realities of phenolic material storage. Routine emergency drills, solvent compatibility reviews, and incident investigations form our response to both best practice and lessons learned the hard way. As demand for sustainability deepens across markets, we track and report waste generation per lot, emissions intensity, and solvent recyclability. Lessons learned around wastewater treatment and welding repairs on steel tanks have improved not just our bottom line, but the surrounding environment.
Ongoing research and user feedback drive process improvement. Even as core chemical processes remain stable, minor changes in chlorination or purification protocols add up to safer, more efficient operations. Our teams monitor shifts in catalysis technique, test new solvent systems, and adopt automation where it reduces operator exposure and improves consistency. We spin lessons from failed small-batch runs into new standards for scale-up. This ongoing cycle of technical review and operational change keeps 3-Bromophenol flowing smoothly to industries that rely on precision and dependability.
Direct conversations with formulators and R&D labs have improved our filtration systems and added new analytical checkpoints, ensuring quality before dispatch. Whether the request comes from a multinational research team or a local start-up, we apply decades of experience to ensure complaints become the seeds of next year’s process upgrades.
Producing 3-Bromophenol at scale is a daily challenge and a responsibility. Customers count on the material’s properties—whether they work in tight regulatory environments or create consumer goods that demand traceability and reproducibility. The path from raw phenol and bromine to finished product features hundreds of hands, automated steps, and checkpoint verifications. Our most satisfied partners return for reasons beyond price. They seek assurance that each shipment reflects lessons learned, improvements implemented, and a company culture rooted in hands-on experience.
Discussions on value in the chemical sector too often overlook the role of actual production know-how. The feedback from a chemist struggling with solubility, or an operator noticing a slight color drift, triggers improvements more quickly than any external audit. We listen, adapt, and evolve. 3-Bromophenol’s niche uses depend on these incremental advances—an ethos best learned inside the factory, not from a data sheet.
In a world where sourcing can drift unpredictably and regulatory challenges only increase, working with an actual manufacturer shapes every stage of product life. 3-Bromophenol’s role in so many critical chemical pathways connects innovation in the lab to the reliability of the full-scale plant. Our story continues, built on open doors, routine consultation, and the cycle of improvement that comes from facing the production line. This foundation gives our partners more than a product—it brings peace of mind that every bottle, drum, and truckload arrives crafted with care, rigor, and trusted experience.