2-Nitrophenol

    • Product Name: 2-Nitrophenol
    • Alias: ortho-Nitrophenol
    • Einecs: 202-030-5
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    830406

    Chemical Name 2-Nitrophenol
    Cas Number 88-75-5
    Molecular Formula C6H5NO3
    Molecular Weight 139.11 g/mol
    Appearance Yellow crystalline solid
    Melting Point 45-47 °C
    Boiling Point 218 °C
    Solubility In Water Moderately soluble
    Density 1.48 g/cm³
    Flash Point 122 °C
    Iupac Name 2-nitrophenol
    Pubchem Cid 980
    Smiles C1=CC=C(C(=C1)O)[N+](=O)[O-]

    As an accredited 2-Nitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle, 100 grams, with hazard labels, tightly sealed cap, chemical name and CAS number clearly marked on the label.
    Shipping 2-Nitrophenol is shipped as a hazardous chemical due to its toxic and potentially harmful nature. It is transported in tightly sealed, clearly labeled containers designed to prevent leakage or contamination. Shipping must comply with local and international regulations, including proper documentation, material safety data, and use of appropriate protective packaging.
    Storage 2-Nitrophenol should be stored in a tightly closed container in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and bases. Protect it from light and moisture. Keep it away from heat or open flame. Properly label the container and ensure it is stored in a designated chemical storage cabinet, preferably one suitable for corrosive or toxic chemicals.
    Application of 2-Nitrophenol

    Applications of 2-Nitrophenol in Industrial Manufacturing

    2-Nitrophenol serves as a crucial intermediate in a number of chemical industries. Its primary value lies in specialized downstream syntheses where precise purity and functional group performance directly affect processing reliability and final product quality. As a manufacturer, we support strict regulatory compliance and application-tailored supply in multiple sectors, each outlined below based on actual market use.

    1. Synthesis of Dye Intermediates

    Manufacturers in the dye industry use 2-Nitrophenol to prepare azo and anthraquinone dye intermediates. The material typically enters the diazotization or coupling stages due to its reactivity as a nitroaromatic compound. Technical teams closely monitor the degree of substitution and purity, since side reactions can lead to inconsistent dye hues and reduced tinctorial strength. Process optimization frequently centers on controlling pH, temperature, and catalyst levels to maximize yield across continuous or batch operations.

    Industry compliance standards

    • Oeko-Tex Standard 100 (for human-ecological safety in textiles)
    • REACH Regulation (EC No 1907/2006) for imported and manufactured chemicals
    • ISO 9001:2015 quality management system requirements
    • ZDHC Manufacturing Restricted Substances List—dye industry version

    Typical usage ratio

    • 5%–12% by weight relative to total batch input substance; adjusted based on chromophore target and downstream reduction requirements

    Downstream process integration

    • Enters after initial aromatic amine preparation; directly feeds into coupling or reduction stage for intermediate synthesis
    • May undergo pre-dissolution or activation sequence before main reaction step
    • Used in both batch dye reactors and automated flow systems

    Final product types

    • Azo dyes used in polyester, cotton, and wool coloring
    • Anthraquinone dyes for high-performance synthetic fibers
    • Reactive and disperse dye intermediates for printing inks
    • Pigment precursor compounds for plastic and paint coloration

    2. Pharmaceutical Intermediate Manufacturing

    Pharma synthesis operations select 2-Nitrophenol as a core building block for certain active pharmaceutical ingredients (APIs) and side-chain extended intermediates. Medicinal chemists employ it during etherification, condensation, or reduction steps to introduce controlled nitro or hydroxy functionalities. Extensive in-process QC safeguards against batch-to-batch variation. Accurate molar ratios and reaction timing are essential for optimizing downstream yield, especially in multi-step API synthesis where residual impurities may affect pharmacopurity and regulatory filings.

    Industry compliance standards

    • Good Manufacturing Practice (GMP; ICH Q7)
    • United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.) for intermediates
    • 21 CFR Part 211 (FDA regulations on drug manufacturing)
    • ICH Q3A/B—Impurity guidelines for new drug substances and products

    Typical usage ratio

    • 0.2–2.5 molar equivalents per synthetic step—based on structure of end pharmaceutical agent and reaction yield curves

    Downstream process integration

    • Feeds into nucleophilic substitution or etherification after initial raw purification
    • May require prior dissolution in polar solvents for reaction uniformity
    • Enters in protected or unprotected form according to desired API structure

    Final product types

    • Intermediates for paracetamol and related analgesics
    • Benzoxazole derivatives used in antifungal and antimicrobial agents
    • Building blocks for cardiovascular and CNS drug research
    • Intermediates for veterinary pharmaceuticals

    3. Agrochemical Synthesis

    In modern crop protection chemistry, 2-Nitrophenol serves as a tailored intermediate for selective herbicides, fungicides, and soil treatment agents. Downstream producers utilize it during ether linkage formation or ring modification steps, capitalizing on its electronic and steric properties. Production processes must balance reactivity and selectivity, while environmental, health, and safety management drives batch characterization and waste stream controls. Flexible tank and inline reactor systems dominate to minimize cross-contamination with other agrochemicals.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS) guidelines
    • EPA Pesticide Chemical Code requirements (United States)
    • ISO 9001:2015 for agrochemical manufacturing QA
    • REACH Annex II for environmental impact

    Typical usage ratio

    • 2%–8% weight-to-weight compared to total active ingredient base; tuned by formulation efficacy and desired application spectrum

    Downstream process integration

    • Introduced during key condensation or coupling stages of herbicide and fungicide synthesis
    • May undergo in situ reduction or alkylation prior to core activity derivatization
    • Used in both multipurpose batch reactors and continuous flow setups

    Final product types

    • Nitroether-based herbicidal compounds
    • Fungicide precursors for broadleaf and cereal crops
    • Soil sterilant intermediates for pre-sowing application
    • Pyridine and benzoxazine derivatives used in pest management

    4. Rubber Chemical Additives Production

    Producers of rubber processing chemicals add 2-Nitrophenol as a reactant in the synthesis of antioxidants and antiozonants. Its phenolic structure anchors subsequent alkylation and sulfonation reactions, delivering high-performance additives that protect finished rubber goods from oxidative and thermal degradation. Plant managers focus on accurate feeding and consistent purity, as off-ratios or impurities can significantly reduce antioxidant effectiveness or alter vulcanization characteristics in the final rubber matrix.

    Industry compliance standards

    • ISO 14001:2015 (environmental management in chemical processing)
    • ASTM D4678 (testing for rubber antioxidant effectiveness)
    • RoHS (Restriction of Hazardous Substances Directive; for rubber in electronics)
    • UL Yellow Card certification (for flame retardant additives in plastics and rubber)

    Typical usage ratio

    • 3%–9% by mass relative to antioxidant base solution; determined by additive solubility and target lifespan of the end product

    Downstream process integration

    • Introduced after rubber polymerization phase as part of additive powder or dispersion blending
    • May react in situ with alkylating or sulfonating agents
    • Feeds into both continuous mixing and masterbatch processes

    Final product types

    • P-phenylenediamine-based antiozonants for tires and conveyor belts
    • Multipurpose antioxidants for industrial and consumer rubber goods
    • Vulcanization retarders for heat-cured elastomers
    • Specialty rubber compounds for automotive and aerospace sealing

    5. Photographic Chemical Manufacturing

    In the production of photographic developers and image stabilizers, 2-Nitrophenol acts as a reducing agent precursor and auxiliary stabilizer. Manufacturers precisely meter its addition to maintain optimal production of phenolate ions, which participate in color formation or silver halide stabilization. Analytical labs track impurities at low ppm levels to prevent fogging, image distortion, or accelerated degradation in processed films and photo papers.

    Industry compliance standards

    • ANSI/NAPM IT9.11 (stability of processed photographic images)
    • ISO 18902 (storage of processed photographic materials)
    • ISO 9001:2015 (documented QC in photochemical production)
    • RoHS (where photo paper intended for electronics)

    Typical usage ratio

    • 0.1%–1.5% by total solution volume; varies depending on desired reduction strength and developer shelf life

    Downstream process integration

    • Dispersed in aqueous or mixed solvent developer formulations following pH adjustment
    • Can be pre-mixed into developer concentrates for end-user dilution
    • May act in conjunction with hydroquinone or metol systems in batch processes

    Final product types

    • Black-and-white film and paper developers
    • Image stabilization solutions for archival photographic products
    • Color paper developer additives for professional photo labs
    • Concentrated developer kits for commercial photo processing centers

    6. Corrosion Inhibitor Formulation

    Some specialty manufacturers incorporate 2-Nitrophenol as a functional additive in corrosion inhibitors for industrial water systems and metalworking fluids. Due to its aromatic nitro structure, it forms chelating complexes with metal ions and slows oxidation at the surface interface. Production lines prioritize monitoring for contaminant ions and particle sizing to avoid downstream filter clogging and ensure stable dispersions in storage and use.

    Industry compliance standards

    • ASTM G31/G50 (standard corrosion testing methods)
    • ISO 12944 (corrosion protection for industrial metals)
    • REACH compliance regarding discharge water and handling
    • EN 60943 (industrial inhibitor classification—Europe)

    Typical usage ratio

    • 0.05%–0.4% by mass in metalworking or recirculating water; dependent on exposure duration and water chemistry

    Downstream process integration

    • Added during water treatment formulation blending before final pH balancing
    • Dispersed in standard and custom metalworking lubricant concentrates
    • Compatible with other organic corrosion inhibitors and anti-scale agents

    Final product types

    • Engine coolant system corrosion inhibitors
    • Metalworking fluid formulations for machining and finishing
    • Industrial boiler water treatment concentrates
    • Protective coatings for storage tanks and heat exchangers

    Free Quote

    Competitive 2-Nitrophenol prices that fit your budget—flexible terms and customized quotes for every order.

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    Tel: +8615365186327

    Email: admin@ascent-chem.com

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    Certification & Compliance
    More Introduction

    2-Nitrophenol: A Closer Look from the Manufacturer’s Perspective

    Direct From the Source: The Reality Behind 2-Nitrophenol Production

    In our world, chemicals don’t just fall out of the sky ready to use. Each batch, each kilogram, comes from hands-on work, real investments, and choices that affect everything from cost to reliability. 2-Nitrophenol has been a staple both for research and industrial synthesis for decades. We make it in bulk and at small scales, depending on the demand—open to working with a chemist looking for a few grams for a project, as well as a plant manager sourcing tons for downstream chemistry. What makes 2-Nitrophenol valuable isn’t just its chemical formula or the yellow tint known by lab technicians worldwide. It plays a specific role in real processes and that’s why we invest time, equipment, and care in getting it right.

    Understanding the Substance: What Sets Our 2-Nitrophenol Apart

    Let’s be up front: Not all 2-Nitrophenol comes out equal. The quality depends on starting materials, reaction control, purification steps, and how it’s handled every step of the way. We’ve tuned each part of our process, aiming for a material free from excess water, isomeric contamination, and leftover acidity. Our 2-Nitrophenol comes as a yellow crystalline powder. Depending on specification requests, we offer material with purity above 99.5%, and always document heavy metal content, moisture, and trace byproducts. What sometimes gets overlooked is the reality that small changes—say, too much moisture, or higher ortho/para isomer content—can disrupt lab reactions and industrial runs. Our quality checks involve not only HPLC, but also methods developed in-house with repeated feedback from customer labs. Every step aims for consistency, not just to chase technical standards, but because our own teams use these chemicals in daily research and production.

    How 2-Nitrophenol Is Applied: Real Uses, Real Results

    Every chemist recognizes the role of 2-Nitrophenol as a building block. It doesn’t make headlines, but it sits behind dozens of actual products found on the market—from dyes to pharmaceuticals. In dye synthesis, 2-Nitrophenol adds not only function but also stability to colorants that endure tough environments. We’ve watched pigment teams rely on its reactivity to create specific shades that hold up to sunlight, solvents, and heat. In pharma, it’s not just a starting material. It’s a step toward more complicated molecules, and every impurity can travel through the route, multiplying problems later. Manufacturing antifungal ingredients, for example, requires confidence that each intermediate meets rigorous controls. It’s not just about what’s present, but what’s not present—no excess ortho- or para-nitrophenol, very low metal traces, and absence of unexpected byproducts. Research labs use our 2-Nitrophenol in enzyme assays, where even scent contamination can throw off results. There’s no substitute for reliability here, and we take those standards personally, having had enough of our own failed experiments early on to appreciate what matters to the people ordering from us today.

    Specifications: Built on Experience, Not Just Paper

    Our technical staff has logged thousands of hours not just in making 2-Nitrophenol, but in troubleshooting problem batches. We know where shortcuts lead―off-flavors, odd melting points, hard-to-filter slurries, you name it. We produce several models tailored to actual customers, not imaginary use cases. For dye manufacturers, we offer a grade with purity certified above 99.5%, less than 0.1% moisture, and metal content below 10 ppm. Labs working on analytical chemistry value our ultra-pure grade, which we double-check for possible isomeric overlap. For bulk users, we make a standard-grade 2-Nitrophenol fitting broader industrial processes, where batch-to-batch reliability means the equipment runs without surprises rather than achieving marginally higher purity. Sometimes, projects need a custom solution—specific particle sizes, specialized purity, or unique documentation. Our team has developed custom isolations and purification protocols over the years exactly for these moments, and we’re never shy about learning from customers when their feedback spots something routine testing missed.

    Comparisons That Matter: Not All Nitrophenols Are the Same

    Plenty of newcomers ask why not just use 4-Nitrophenol or a technical mixture of nitrophenols if the price looks lower. Here’s the inside reality: The isomer matters in both chemical reactivity and practical outcomes. In color chemistry, ortho- and para-nitrophenol deliver different hue strengths and stabilities, so a “mixed” grade means a finished product that’s unpredictable. 2-Nitrophenol, the ortho variant, features hydrogen bonding that sets it apart in both reactivity and physical properties like the melting point and solubility. In pharmaceutical intermediates, regulators inspect both the content and trace presence of isomers because even slight cross-contamination changes downstream pharmacokinetics. Our facilities separate 2-Nitrophenol fraction by fraction. We’ve optimized distillation and monitored chromatography for each lot—tried, failed, and refined testing over years rather than weeks. It’s why when a customer describes a failed lab run with off-spec p-nitrophenol, we can often pinpoint the cause from experience on the ground, not just theoretical knowledge. This is what “manufacturer expertise” actually offers—the ability to tell where the line between acceptable and exceptional falls, with skin in the game.

    Challenges in the Real World: What We’ve Faced and How We Solve It

    We’ve seen supply chain shocks, swings in raw material prices, and even regulatory shifts that change what can or can’t go into processes. Each time, adaptation is our way forward. Take raw material availability. Phenol pricing spikes, and suddenly the entire cost structure for nitrophenols gets pushed upward. We started multi-vendor sourcing long ago and invested in local capacity for basic upstream chemicals. Instead of waiting for market prices to return to “normal,” we put effort into steady supply and showcased this to customers. Unexpectedly, this paid off again during export bottlenecks when others struggled to fulfill contracts. Another issue—shipping hazardous materials in changing regulatory environments. We keep compliance records up to date and maintain our own packaging station, rather than outsourcing. This way, packaging fits requirements for safe transport, reduces breakage, and passes inspections without delay. We also run recurrent in-house training for our warehouse and logistics teams on handling nitrophenol safely—grounded in daily practice, not just clipboard checklists.

    Why Purity and Quality Assurance Set the Foundation

    There’s a difference between technical paperwork and practical, on-the-ground assurance. You can list purity on a certificate, but unless the production system actually delivers milligram-level consistency, that paper means little in the hands of a working chemist. Over years, we designed batch tracking, run double-verification on analytical data, and keep retained samples from each lot for at least two years. We view complaints and returns as part of the business, not an inconvenience. Often, a returned batch leads to process improvements that benefit every future customer. Sometimes, this means shutting down a production run mid-way after seeing unexpected behavior in a reactor or a slight deviation in color or smell. Cutting corners for “one bad lot” gets noticed in the community—many buyers remember who solved their problem and who ignored it. In the end, the trust built through these hard-won lessons underpins long-term relationships. More than a decade in, some of our oldest clients still call directly, knowing we’ll give a straight answer—for better or worse—based on what we know from making the stuff ourselves.

    Behind the Scenes: Environmental and Safety Considerations

    Every chemist knows the hazards built into nitrophenol production. Leaks, spills, and emissions don’t just hurt the plant—they can cause headaches with regulators, neighbors, and our own staff. For 2-Nitrophenol, we engineered zero-discharge waste management into our processes. Waste acids are neutralized and scrubbed. Workers suit up in protective gear, and we monitor air and water quality at every working station. None of this happens because of external pressure alone; the people running our reactors have friends and families nearby, so “acceptable” exposures on paper rarely cut it in real life. We switch out old process lines, run regular safety drills, and keep visible documentation for every major modification. Years ago, a mistake on the night shift led to a minor leak. Rather than issuing a memo and hoping for the best, we invited all line workers to help redesign that part of the system. The result: Fewer incidents, higher throughput, and direct buy-in from every operator. Anyone who claims safety can be left up to management has not spent time inside a functioning chemical plant.

    Intellectual Property and Industry Evolution

    We don’t hold back knowledge from the teams who rely on it daily. Years ago, we ran headlong into patent disputes when big players began shaking up the market with new application routes for 2-Nitrophenol. We’ve learned to adapt our process where necessary and keep updated on both local and international regulations. That involvement in patent landscape isn’t just legal housekeeping; it gives our technical and sales staff an edge in advising customers about what they're really buying and where risks may exist. We join industry working groups, share data with academic partners, and continually refine our protocol for purity based on peer-reviewed findings. Every time a research paper surfaces describing a failed 2-Nitrophenol synthesis from a questionable source, we compare our data. Openness about strengths and weaknesses stands us in better stead for long-term partnerships than keeping everything locked down. If a customer wants a walk-through of our quality controls, we invite them. Trust builds one candid conversation at a time, not through glossy brochures or generic safety statements.

    The Human Stories Behind Manufacturing

    Real people power these operations. Our chemical engineers and operators come from a range of backgrounds—some learned on the job, others honed skills at universities or in small local companies before joining us. Skill transfer happens over lunches, hands-on training, and sometimes through necessary mistakes that prompt hard lessons. We hold sessions where operators detail process bottlenecks or show new hires how small temperature changes in the reactor impact the color and purity of 2-Nitrophenol. Everyone from plant manager to line worker can recall “problem batches.” Each of these moments led to pushing our standards forward—practical knowledge rooted in lived experience, not abstractions from a textbook. Our story includes supporting first-generation college graduates progressing through the ranks—proving that chemical manufacturing, for all its technical demands, thrives thanks to open doors and shared commitment. This side of the business rarely makes headlines but shapes every metric that matters.

    What Customers Value Most and How We Respond

    We talk daily with chemists, business owners, and logistics teams who order our 2-Nitrophenol. Speed isn’t the only concern; they want honest timelines, straight talk about raw material delays, and a real person who responds when problems arise. Our feedback loop starts at customer service and stretches all the way back to production planner. If there’s an issue—be it a delayed truck, questions about melting point, or application recommendations—we believe in immediate, transparent communication. Our return rate remains low due to direct ownership from each department. We ask for (and actually listen to) feedback—whether it comes in as email, phone call, or an old-fashioned note in a shipment box. Not everything gets solved the same day, but everything gets addressed. The best lessons sometimes come from an unexpected failure—a batch that caked during transit or an order that passed lab tests but disappointed in field application. Each situation adds to the reservoir of experience. Over time, patterns emerge that refine not just the quality of the product but the predictability of working with us.

    Logistical Realities: Storage, Handling, and Shipping

    Moving 2-Nitrophenol from plant to client remains a challenge, especially across borders. We store fresh product in climate-controlled areas, fill containers with gloves and dust masks, and label each drum or bag with strict traceability. Our trained staff adapts packaging based on customer feedback—some want small jars for lab use, while others require drums that hold up to weeks of ocean freight. Shipping regulations change frequently, and we keep up by continuous training and process updates. Years of experience taught us the importance of contingency planning—a shipment stuck in port due to incomplete paperwork can mean days of downtime for our customer. We work with reliable logistics partners, but always check and recheck documentation before release. When new regulations hit, we update procedures rather than waiting for someone to flag an issue downstream. Keeping complaints rare comes from being present at every handoff—not simply relying on paperwork moving through the chain.

    Looking Forward: Meeting Market and Regulatory Demands Together

    The chemical landscape doesn’t stand still. Research demands ever-tighter tolerances and new derivatives, while industry seeks both cost efficiency and reliability. More jurisdictions tighten their standards around environmental emissions and acceptable impurity levels. We invest in R&D both to improve process yield and to meet tougher regulatory targets. On the ground, this looks like incremental changes—upgrading reactors with tighter temperature control, selecting catalysts that cut residual content, and adopting closed-loop handling to minimize operator exposure. These practices started as solutions to internal challenges but now serve as selling points for discerning customers. We collaborate with buyers to keep applications “downstream safe”—whether they’re developing sensitive assays or scaling up dye production. Regulation isn’t a threat to our operations but an ongoing call to step up quality controls and offer better documentation, not just for auditors but for every user that places value on reliability and traceability in their supply chain.

    Final Reflections: Pride and Responsibility in Chemical Manufacturing

    Years in the business teach that manufacturing 2-Nitrophenol means more than shipping chemicals—it’s about building trust, staying vigilant to risks, and supporting those who move science and industry forward. Today’s 2-Nitrophenol buyers demand more than technical specs. They watch for consistency, transparency, and problem-solving. We stand behind every shipment, shaped by lessons learned on the line, in the lab, and from the voices of hundreds of customers. Our commitment doesn’t rest on slogans or certificates, but on daily choices driven by knowledge, experience, and pride in making a difference in a world that relies, often unnoticed, on the backbone of real chemical manufacturing.

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