2-Nitroanisole

    • Product Name: 2-Nitroanisole
    • Alias: o-Nitroanisole
    • Einecs: 202-204-7
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    963085

    Chemical Name 2-Nitroanisole
    Molecular Formula C7H7NO3
    Molecular Weight 153.14 g/mol
    Cas Number 91-23-6
    Appearance Pale yellow liquid
    Boiling Point 242 °C
    Melting Point 2 °C
    Density 1.236 g/cm³ (at 20°C)
    Solubility In Water Insoluble
    Flash Point 110 °C
    Refractive Index 1.573
    Odor Aromatic
    Synonyms o-Nitroanisole; 1-Methoxy-2-nitrobenzene
    Ec Number 202-047-9

    As an accredited 2-Nitroanisole factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing The packaging for 2-Nitroanisole consists of a 500 g amber glass bottle with secure screw cap and hazard labeling.
    Shipping 2-Nitroanisole is shipped as a hazardous chemical, classified under UN1668. It should be packaged in approved, tightly sealed containers, stored upright, and protected from heat, sparks, and open flames. Ensure appropriate labeling and documentation. Transport must comply with regulations for toxic and environmentally hazardous substances, including DOT, IATA, and IMDG requirements.
    Storage 2-Nitroanisole should be stored in a tightly closed container, in a cool, dry, and well-ventilated area away from sources of ignition, heat, and incompatible substances such as strong oxidizers and acids. The storage area should be clearly labeled, free from direct sunlight, and equipped with appropriate spill containment measures. Avoid storing with food or drink.
    Application of 2-Nitroanisole

    Applications of 2-Nitroanisole in Industrial Manufacturing

    2-Nitroanisole serves as an essential intermediate in multiple industrial sectors, entering synthesis streams where precise chemical transformations are vital for the production of specialty and high-value products. The following segments represent principal downstream applications based on verified industrial demand and process integration.

    1. Dyestuff Intermediate for Azo and Anthraquinone Dyes

    2-Nitroanisole acts as a key building block in azo and anthraquinone dye manufacturing, particularly for disperse and solvent dyes used in textile and plastics coloration. In the dye sector, our material supports nitro group reduction and diazotization reactions, forming amines and coupling agents. Process engineers depend on its high purity for color strength and reproducibility. End users, primarily large-scale dye producers, employ tightly controlled feed ratios to align with product shade requirements and regulatory lifecycle management protocols in their coloration lines.

    Industry compliance standards

    • REACH (EC 1907/2006)
    • OEKO-TEX Standard 100
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • ISO 9001:2015 certified dye production lines

    Typical usage ratio

    • 5–18% by mass in target dye formulation batch; final ratio depends on color index, process yield, and shade intensity parameters established by R&D teams

    Downstream process integration

    • Introduced at the amination/nitration step; subsequent reduction step forms the corresponding amine prior to diazotization and coupling
    • QC analysts calibrate input ratio to synthetic dye chromatograms

    Final product types

    • Disperse dyes for polyester textiles
    • Solvent dyes for plastics and inks
    • Anthraquinone derivatives for high-fastness applications
    • Metal complex dyes for leather treatments

    2. Agrochemical Active Ingredient Synthesis (Herbicides and Fungicides)

    Chemical synthesis teams in the agrochemical sector integrate 2-nitroanisole to create nitro-aryl ether intermediates for the manufacture of pre-emergence herbicides and select systemic fungicides. This role leverages its stability and reactivity to deliver arylation precursors required for downstream methylation and reduction steps. Customers specify this material for its assay consistency, directly impacting the potency and selectivity of active molecules targeting plant pathogen and weed growth in regulated markets.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • EU Regulation (EC) No 1107/2009
    • US EPA FIFRA (40 CFR Parts 150-180)
    • SQF Code for manufacturing inputs (where required)

    Typical usage ratio

    • 2–7% by mass within agrochemical synthesis step; calculated based on stoichiometric conversion and purity adjustment in validated laboratory protocols

    Downstream process integration

    • Charged into alkylation phase after initial aryl halide preparation; further processed through reduction and coupling to produce technical-grade pesticide actives
    • Ratio fine-tuned according to in-process GC and NMR monitoring

    Final product types

    • Chloroanisole-based pre-emergence herbicides
    • Nitro-ether fungicide intermediates
    • Technical pesticide actives for grain and vegetable crops
    • Bulk intermediates for global crop protection product blending

    3. Pharmaceutical Intermediate for Analgesic and Vasodilator Synthesis

    2-Nitroanisole enables the construction of pharmaceutical building blocks, notably for analgesic and vasodilator molecule synthesis. Medicinal chemistry teams utilize this compound in nitro group reductions to anilines, which further undergo methylation and subsequent heterocyclic ring closure steps. Stringent adherence to GMP and pharmacopoeial criteria defines this sector, as raw material traceability directly supports downstream batch-release compliance in secondary manufacturing and formulation environments.

    Industry compliance standards

    • USP/NF and Ph. Eur. raw material monograph controls
    • ICH Q7 GMP Guidelines
    • 21 CFR Part 211 (US FDA cGMP for Active Pharmaceuticals)
    • Chinese Pharmacopoeia (as applicable to APIs containing aryl ethers)

    Typical usage ratio

    • 3–12% by mass in core intermediate synthesis; batch inclusion set by API precursor requirement in route selection and validated process design

    Downstream process integration

    • Raw material input for catalytic hydrogenation reactors; generates phenetidine or analogous compounds before condensation and further derivatization
    • Material quality confirmed by HPLC and residual impurity analysis

    Final product types

    • Analgesic drug intermediates
    • Vasodilator precursor compounds
    • Bulk intermediates for further pharmaceutical transformations
    • Branded and generic finished pharmaceutical ingredients (APIs)

    4. Fine Chemical Synthesis: Performance Polymer Additives

    Performance polymer producers and custom fine chemical firms incorporate 2-nitroanisole as a functional intermediate during the design of specialty monomers and stabilizer additives. Its introduction at strategic steps in etherification and nitroreduction reactions benefits polymer chain performance, offering improved stability in thermal and photochemical environments. This application leverages close process controls, often within ISO 14001/9001 frameworks, to ensure batch-to-batch reliability for downstream engineering plastic compounding.

    Industry compliance standards

    • ISO 9001:2015 Quality Management in chemical synthesis
    • ISO 14001:2015 Environmental Management for chemical facilities
    • Global Automotive OEM restricted substances lists (for additive use in automotive grade plastics)
    • RoHS Directive 2011/65/EU for electrical polymer components (when required)

    Typical usage ratio

    • 0.3–2.5% by mass, based on polymer matrix design and molecular weight of target additives; ratio set by laboratory formulation and extrusion trials

    Downstream process integration

    • Incorporated during pre-polymerization step to customize chain architecture or in masterbatch additive feed
    • Process engineers monitor input via GPC and spectroscopic analyses

    Final product types

    • UV-stabilized polycarbonate and polyester materials
    • Heat-resistant specialty resin blends
    • High-performance flame-retardant compounds
    • Polymer additives for electronic and automotive plastics

    5. Aromatic Ether Synthesis for Fragrance and Flavors

    Producers specializing in aroma chemicals and flavor ingredients use 2-nitroanisole in the synthesis of methoxy-aromatic ethers, where selective reduction and methylation steps yield intermediates for high-value fragrances. Manufacturing chemists optimize these reactions for purity, minimizing off-notes and impurities that affect olfactory quality. This segment operates under food GMP and IFRA guidance, with close supply chain stewardship to satisfy compliant sourcing for high-demand fragrance compounds.

    Industry compliance standards

    • IFRA Standards for Aroma Chemical Manufacture
    • EU Regulation (EC) 1334/2008 on Flavorings
    • Food Chemicals Codex (FCC) for food-grade intermediates
    • HACCP and GMP protocols in flavor and fragrance processing

    Typical usage ratio

    • 0.1–1.6% by mass in batch production; feed rates refined in pilot plant trials to balance aromatic purity, yield, and cost targets

    Downstream process integration

    • Fed into aromatic reduction and methylation pathways leading to high-purity ether derivatives
    • Final distillation and odor profile screening carried out post-reactor to ensure conformance

    Final product types

    • Methoxybenzene-based fragrance bases
    • Specialty aroma chemicals for perfumery
    • Flavor ingredient intermediates for beverage and food use
    • Fragrance materials for personal care formulations

    Free Quote

    Competitive 2-Nitroanisole prices that fit your budget—flexible terms and customized quotes for every order.

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    Email: admin@ascent-chem.com

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    Certification & Compliance
    More Introduction

    2-Nitroanisole: Quality and Reliability from Direct Chemical Manufacturing

    Proudly Producing 2-Nitroanisole In-House

    Working on the manufacturing floor and in the control labs, we see every day how much attention 2-Nitroanisole demands. This aromatic compound does not come together by chance or by cut-rate shortcuts — it needs skilled chemists, carefully monitored reactions, and a strict dedication to chemical purity. We produce 2-Nitroanisole as a pale yellow liquid, which crystallizes at lower temperatures, ensuring stability and consistent handling. The critical difference between making this product yourself and buying on the open market is obvious the moment you run it through your own synthesis process. Quality expectations in chemistry do not bend, and neither do we.

    Quality Built from Raw Material to Final Packaging

    Our 2-Nitroanisole, known also as o-nitroanisole or ortho-nitroanisole, owes its quality to the feedstock and the vigilance our production crew applies. We begin with high-purity anisole—no off-spec lots allowed through our doors—and then nitrate it with controlled process temperatures. This model of vigilance cuts down impurities: by-products like dinitroanisoles disappear below reliable detection thresholds. Many in this industry have tried cutting costs by relaxing phase separation steps or relying on marginal feedstocks, but that approach always leads to headaches further downstream—in yields, in color, in safety compliance.

    Most days, our reactor operators run samples personally to our in-house GC-MS and HPLC labs. If purity dips, even by a tenth of a percent, batch release grinds to a halt. Over the years, we’ve kept our material above 99.5% purity for countless customers, including those in sensitive dye, pharmaceutical, and specialty chemical sectors. Impurities—like nitrophenol or dinitroanisole—may sound like footnotes to outsiders, but anyone scaling up a process knows a poorly controlled impurity can bring a whole line to a standstill or cost thousands in product recalls.

    What Matters in Specifications?

    Spec sheets on the web rarely tell the real story. We see plenty of products claiming “chemical grade” without a word on trace by-products or residue, and we know the difference it makes. Our specifications for 2-Nitroanisole cover not just purity percentage but also water content, stability under storage, and residue after evaporation. Each drum is assigned a lot number, and every sample gets stored for cross-checks months after production—that knowledge comes from hard experience with customers who once faced problems caused by inferior materials.

    No easy corners exist in this business. Our model for 2-Nitroanisole uses batch production and final filtration techniques that produce the faint yellow crystalline solid sought after for downstream synthesis. A reliable melting range and a narrow boiling point window guarantee less batch loss during reprocessing. Too much water in the sample, or poorly filtered material, will quickly spoil the next synthesis—especially for applications in dyes, pesticides, or active pharmaceutical intermediates. Without in-house manufacturing, rooted in years of process refinements, those issues go unseen and unsolved.

    Real-World Use Cases

    We receive purchase orders for 2-Nitroanisole from a number of industries, most often from intermediates for azo and anthraquinone dyes. Downstream users rely on this molecule for N-acylations, reductions, or couplings. For instance, one long-term customer, a high-volume colorant producer, runs 2-Nitroanisole through metal-catalyzed couplings to yield key dye intermediates. Even small slip-ups in color intensity or hue track back to the source chemical’s consistency.

    Another regular buyer in the fungicide sector uses our product as a core intermediate for synthesizing heterocycles. The reaction profile changes immediately if the 2-Nitroanisole feed isn’t tightly controlled for water and trace metals. In pharmaceuticals, the molecule serves as a starting point for specialty amines, which then undergo further elaboration and purification. Each field sees the rewards—and sometimes frustrations—directly traceable to material quality. After two decades supplying these markets, it’s easy to spot repeat buyers who insist on drums labeled with our batch codes for their most demanding processes.

    Why Own-Source Chemical Manufacturing Matters

    Sourcing directly from a manufacturer differs dramatically from channel products or brokers who have never run a reactor themselves. Clients often share stories of losing time and money reworking or rejecting substandard batches from unknown sources. In contrast, our customers gain complete visibility into our manufacturing process, get COA documentation from the source, and can speak directly with chemists who know the lot histories and reaction pathways. Real feedback from the shop floor—like which lot showed minor changes in solvent residue—never makes its way through paper-only trading houses. We encourage our technical buyers to visit and see how our team handles each reactor batch, sample, and documentation run.

    It’s not rare to see process engineers from major pigment or pharmaceutical outfits arriving with their own test kits, eager to compare our samples against their previous supplies. Standing on our production line, they recognize straight away that a steady hand on the process means fewer questions once they start running pilot and commercial syntheses. When a side reaction develops from an out-of-spec chemical—no matter how small—it adds up to wasted product, shutdowns, or regulatory headaches, none of which belong in a well-run operation. Years of close work with technical directors and process optimizers have shown us that transparency and reliability matter more than price per kilo in the long run.

    What Sets Us Apart From Commodity Traders

    Some operations focus only on moving large volumes with an eye on short-term margin. Here, we run every batch ourselves and provide traceability from precursor to finished drum. Unlike traded or resold goods, our material follows rigorous in-house and third-party audits, regularly checked against established regulatory and end-user requirements. If a customer needs a tighter spec or a modified impurity threshold, they talk directly with our chemists to adjust reaction parameters and isolation protocols. The off-the-shelf product is already tight, but we have run custom processes—from double-recrystallization to fine-tuned fractional distillation—when a specialized synthesis or advanced application demands an even narrower impurity profile.

    In our experience, buyers of 2-Nitroanisole who previously sourced through distributors saw drift in both purity and quality batch to batch. Distributors may not possess the same depth of knowledge about the synthesis or its subtle variations, and often depend on paper assurances rather than hands-on adjustment. By contrast, our chemical engineers remain on site, reviewing every step of the process and maintaining stable quality practices. This vigilance stops small issues early before they become larger downstream problems.

    Safety, Environmental Responsibility, and Compliance

    Growing scrutiny of aromatic nitro-compounds by regulatory bodies has made safety and environmental responsibility a daily part of our workflow. Beyond our company’s own standards—which already exceed many minimums set by agencies—customers increasingly ask for proof of tight controls on waste minimization, worker protection, and emissions monitoring. Our on-site scrubbers, closed-loop reactors, and rigorous operator training all feed into documented compliance, both for local authorities and for downstream pharmaceutical or agrochemical supply chains that require REACH, ISO or other certifications.

    Waste minimization doesn’t stop with in-process controls. Every spent acid, off-cut, or wash solution goes through multi-step neutralization and documented disposal. These procedures come from years of engineering and regulatory experience, and keep our staff and customers confident in our practices. In markets where customers face ever-tighter residue and toxicity limits, our close control over byproducts gives them peace of mind. Working with buyers who themselves must maintain environmental management certifications, we back up every batch with demonstrable data, not generalities or forward-looking statements.

    Performance in Application and Beyond

    The direct feedback loop from our own operators through to our most experienced buyers has yielded a product line of 2-Nitroanisole that stands up to real-world use. In dye manufacturing, even subtle color deviations often come from minute differences in precursor quality; decades spent troubleshooting those challenges have shaped how we isolate and check every batch. Our large-scale synthesis tolerates neither shortcuts nor hand-waving over specification drift, because we see in real time how each parameter change reflects in the customer’s end products. That kind of reliability and transparency goes well beyond what’s possible with intermediaries a few steps removed from manufacturing itself.

    Throughout the years, we’ve supplied labs developing next-generation pharmaceuticals who need reliable downstream reactivity, pigment manufacturers whose color grades depend on stable additives, and specialty chemists who put each sample under forensic scrutiny. More than once, we’ve worked hand-in-hand with customer R&D teams, adjusting isolation protocols and solvent purities to match their process windows. From solvent selection in the nitration step to the choice of filtration media, every parameter gets logged and—the same as in a well-run plant—nothing gets swept under the table, especially not the near-miss learnings gained from several challenging campaigns.

    Spec Differences in Real-World Terms

    Differences between our 2-Nitroanisole and commodity offerings usually emerge in process efficiency and downstream reactivity. We keep color index within a narrower range, limit moisture below trace specs, and actively remove trace inorganic residues that trigger unwanted side reactions. Melting and boiling point measurements aren’t paper numbers—they’re checked every shift, to ensure batch-to-batch reproducibility. Our technical team stands ready with direct answers, not sales pitches or second-hand narratives.

    Packaging and storage also make a noticeable difference to users needing transport over long distances or storage in variable climates. We deploy tight-seal drums, moisture-blocking liners, and active headspace controls. Customers frequently share stories of product changes or spoilage with other suppliers; we keep backup reference samples archived, so any historical shift has a traceable chain for troubleshooting. These aren’t excessive measures: any chemist who’s handled oxidized or hydrolyzed batches knows how much time and resources get wasted returning or replacing questionable material. That risk is never worth an unexamined procurement step.

    Supporting Success: Direct Engagement with End-Users

    Our story as a direct manufacturer of 2-Nitroanisole reflects years spent on both sides of the user equation—developing better processes in the plant and supporting process engineers and bench chemists in their own synthesis challenges. It’s one thing to sell large volumes by the container, but quite another to ensure each kilo meets the stringent needs of a pharmaceutical researcher or dye manufacturer seeking exact product attributes. For users whose success depends on clean reactions, high yields, and traceable supply chains, we serve not just as a material provider but as a partner in continual improvement.

    The world of fine organic chemicals shifts quickly, and regulations, customer specs, and technical standards only grow tougher. We have found that sustained investment in process repeatability, transparency, and customer dialogue does more to build long-term partnerships than chasing commodity price points. As a team of chemists, engineers, and technical support staff, we build that trust batch by batch, staying accountable for every shipment under our own roof. In a market where margins tempt risky suppliers to cut corners, our in-house manufacturing speaks clearly for itself—not just in data, but in the proven results delivered to our end-users every week.

    No Shortcuts, Just Expertise

    From the initial feedstock test to the last sample vial checked in our lab, manufacturing 2-Nitroanisole at scale remains a process for hands-on professionals committed to quality, safety, and direct accountability. Customers depend on clean product for everything from azo dye synthesis to pharmaceutical intermediate production. That trust is not easily won and it cannot be maintained with partial transparency or oversight separated by continents. Having learned the hard way on more than one customer’s behalf, we believe the only real guarantee comes from doing the chemistry ourselves, safeguarding both our own brand and the reliability of every user down the chain.

    Decades of production have engraved into our workflow that the smallest lapses can trigger big problems, and that the best product comes not from abstract assurances or paper-compliance, but from a careful, practiced hand at every step. Our direct customers benefit as much from our insistence on transparency as from our rigorous process controls. Quality, in practice, grows from this commitment, seen clearly in each sample, every drum, and every conversation with a chemical engineer or QC manager entrusted with the next critical synthesis.

    Contact Us for Your Next Campaign

    We stand ready to support new projects, pilot batch trials, and large-scale campaigns where reliability in 2-Nitroanisole makes the crucial difference. Whether for dyes, pharmaceuticals, or specialty chemical synthesis, you get not just the product, but the accumulated expertise, documented process controls, and direct technical engagement that sets apart a real manufacturer from the rest of the field. We invite you to experience the difference true in-house chemical production can make to your supply chain.

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