Products

2-Methyl-4,6-Dinitrophenol

    • Product Name: 2-Methyl-4,6-Dinitrophenol
    • Alias: Dinitro-Ortho-Cresol
    • Einecs: 202-591-2
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    120033

    Chemical Name 2-Methyl-4,6-Dinitrophenol
    Cas Number 534-52-1
    Molecular Formula C7H6N2O5
    Molecular Weight 198.14
    Appearance Yellow crystalline powder
    Melting Point 108-110 °C
    Boiling Point 354.3 °C at 760 mmHg
    Solubility In Water Slightly soluble
    Density 1.57 g/cm³
    Pubchem Cid 86252
    Synonyms DNOC, Dinitro-o-cresol
    Flash Point 193.6 °C
    Logp 2.32
    Inchi Key XQSAKJMEFAPJMO-UHFFFAOYSA-N
    Ec Number 208-591-8

    As an accredited 2-Methyl-4,6-Dinitrophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 100 grams of 2-Methyl-4,6-Dinitrophenol, tightly sealed, labeled with hazard warnings and chemical specifications.
    Shipping 2-Methyl-4,6-Dinitrophenol must be shipped in compliance with hazardous materials regulations, as it is toxic and potentially explosive. Use tightly sealed, chemically resistant containers with appropriate labeling. Transport requires strong outer packaging, protection from heat, and documentation per local and international guidelines, such as UN transport codes and Safety Data Sheets (SDS).
    Storage **2-Methyl-4,6-Dinitrophenol** should be stored in a cool, dry, well-ventilated area away from sources of ignition and incompatible substances such as strong reducing agents and combustibles. Keep the container tightly closed and protected from light. Use explosion-proof equipment and ground containers. Store away from heat, sparks, and open flames to prevent fire or explosion risk due to its combustible nature.
    Application of 2-Methyl-4,6-Dinitrophenol

    Applications of 2-Methyl-4,6-Dinitrophenol in Industrial Manufacturing

    2-Methyl-4,6-Dinitrophenol serves as a specialized intermediate in industrial chemistry, participating in well-established sectors where rigorous process control and compliance are required. Below, we outline the main downstream application scenarios with concrete process, compliance, and end-use detail based on direct manufacturing experience.

    1. Agrochemical Intermediate Synthesis

    This compound acts as a critical nitroaromatic precursor during the synthesis of selective herbicides and insecticides, particularly for triazole and phenoxy-carboxylic acid families. Manufacturers integrate it at the nitration or amination stage to enhance biological activity of target actives. Its controlled reactivity makes it essential for consistent batch yields and meets stringent trace impurity limits set by agrochemical quality requirements.

    Industry compliance standards

    • FAO/WHO Specification for Pesticide Technical Material
    • ISO 9001:2015 for production traceability and impurity profiling
    • REACH Regulation (EC) No 1907/2006 Annex VII for registration and safe use
    • China GB 20812-2006 (National Pesticide Product Quality Standard)

    Typical usage ratio

    • Manufacturers typically dose at 10–25% by weight in the target synthetic step, adjusting based on molar requirements of downstream actives and impurity formation thresholds.

    Downstream process integration

    • The material enters during the nitration or aromatic substitution step, with strict monitoring via HPLC and GC to validate consumption and by-products before downstream condensation or cyclization reactions.

    Final product types

    • Phenoxyacid herbicides (ex: MCPA derivatives)
    • Triazole-based fungicides (active intermediates)
    • Nitroaromatic insecticides (synthetic intermediate forms)

    2. Dye and Pigment Manufacture

    2-Methyl-4,6-Dinitrophenol functions as a colorant intermediate in the synthesis of specialized azo dyes and pigment lakes for textiles, leather, and plastics applications. Producers value it for its nitro group contribution to shade intensity and dye fastness, especially in acid-dye and disperse-dye lines where molecular modification offers targeted color range extension while maintaining process purity.

    Industry compliance standards

    • Oeko-Tex Standard 100 (for restricted substances in finished dyes)
    • ZDHC MRSL (Zero Discharge of Hazardous Chemicals Manufacturing Restricted Substances List)
    • EN ISO 105-C06 (Textile color fastness)
    • EU REACH Substances of Very High Concern List (monitoring nitroaromatic residues)

    Typical usage ratio

    • Introduced at 5–18% by batch weight during diazotization; dosage is controlled according to targeted chromophore intensity and batch scale, with real-time adjustment for hue consistency.

    Downstream process integration

    • Added during the coupling stage to provide diazo or nitro substituents, followed by isolation of crude pigment, purification, and milling for particle size uniformity.

    Final product types

    • Disperse dyes for polyester and acetate fiber processing
    • Azo lake pigments for plastics masterbatch
    • Special effect pigments for coatings and inks

    3. Photographic Chemical Production

    As a key organic intermediate, 2-Methyl-4,6-Dinitrophenol is used in the manufacture of color couplers, developers, and image stabilizers within silver halide photographic film and paper production. Its electron-withdrawing properties enhance image development chemistry, ensuring precise reaction kinetics necessary for high-resolution imaging while keeping by-product formation within analytic control limits for sensitive emulsion systems.

    Industry compliance standards

    • ISO 18902:2013 (Imaging materials & chemistry specifications)
    • ANSI/ISO 10602 (Chemical requirements for photographic processing)
    • RoHS Directive 2011/65/EU (limitations on hazardous substances in electrical imaging products)
    • Photographic Activity Test (PAT) for residual chemical assessment

    Typical usage ratio

    • Formulators use concentrations in the range of 3–7% by total reactant mass in coupler or developer synthesis, adjusting by reaction sequence and emulsion batch size to maintain image clarity and minimize chemical fog.

    Downstream process integration

    • Inputted at the color-coupling or developer preparation stage, where it reacts with or modifies aromatic precursors under controlled pH and temperature to achieve target sensitivity and shelf life for imaging chemistry.

    Final product types

    • Photographic color couplers
    • Black-and-white and color developer concentrates
    • Light-stable image stabilizers for archival films and prints

    4. Pharmaceutical Intermediate for Specific API Synthesis

    This nitrophenol derivative finds application as a controlled intermediate in multistep synthesis of certain Active Pharmaceutical Ingredients (APIs), especially where aromatic nitration is required for forming bioactive scaffolds. Pharmaceutical manufacturers avoid direct nitroaromatic group introduction during late stage synthesis; thus, pre-manufactured intermediates using this compound help to optimize yield and maintain batch-to-batch consistency under global GMP frameworks.

    Industry compliance standards

    • ICH Q7 GMP for Active Pharmaceutical Ingredients
    • Ph. Eur./USP/JP compliance for impurity profiling
    • FDA 21 CFR Part 211 (Good Manufacturing Practice for Finished Pharmaceuticals)
    • Chinese Pharmacopoeia ChP 2020 for chemical APIs

    Typical usage ratio

    • Generally 8–15% in the core synthesis stage of intermediates, with the exact ratio set by target API molar stoichiometry and verified via in-process HPLC/UPLC analytics to ensure optimal conversion and impurity minimization.

    Downstream process integration

    • Charged during the nitration/condensation or aromatic substitution stages of multi-step pharmaceutical synthesis, prior to purification or salt formation, ensuring compliance with trace-level residual solvent and impurity requirements.

    Final product types

    • API nitro-intermediates for cardiovascular or anti-infective drugs
    • Specialty excipients incorporating nitroaromatic scaffolds
    • Fine chemical building blocks for generic pharmaceuticals

    5. Polymer Additive and Modifier Manufacturing

    The compound is incorporated as an additive in certain engineering plastics to impart UV-absorption or to function as a chain modifier in high-performance polymerization. Its chemical structure aids in tailoring the photo-stability or processability profiles in specialty plastics, with quality checks for migration and residual monomer content throughout the compounding steps.

    Industry compliance standards

    • FDA 21 CFR §177 (Indirect Food Additive Regulations for plastics in food contact)
    • REACH Regulation Annex XVII (restrictions on hazardous additives)
    • EN ISO 11357-1 (Plastics—Differential Scanning Calorimetry standard)
    • UL 94 (Flammability test for plastic materials)

    Typical usage ratio

    • Employed within 0.3–2% by resin weight, carefully titrated based on final performance requirements and migration assessment from finished product testing.

    Downstream process integration

    • Added into polymer batch during melt compounding or prepolymer synthesis, followed by extrusion and pelletization, with in-line IR or GPC monitoring for additive dispersion and residual presence in finished pellets or films.

    Final product types

    • UV-stabilized polyamides and PET films
    • Engineering resins for electronics casings
    • Plastic masterbatches for automotive and consumer goods

    Free Quote

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    Certification & Compliance
    More Introduction

    2-Methyl-4,6-Dinitrophenol: A Closer Look from the Manufacturer’s Floor

    Real Details Behind 2-Methyl-4,6-Dinitrophenol

    Every day on the plant floor, decisions around 2-Methyl-4,6-Dinitrophenol start with understanding its core purpose and performance. This isn’t just another entry on a chemical catalog. The substance’s clean yellow crystalline appearance reflects a precise synthesis pathway and careful quality controls. What matters most in our production isn’t just getting a batch out the door, but achieving high consistency in purity and handling properties to support industrial use.

    Model and Purity We Stand Behind

    Over the years, engineers and chemists here have worked out dense process flows where control of raw materials and reaction conditions stay tight at every step. In our controlled lines, we produce 2-Methyl-4,6-Dinitrophenol using established routes that ensure repeatability. Many of our customers require product at a purity higher than 98%. We frequently reach that, but we keep testing, adjusting, and benchmarking against previous runs. A solid melt point with reliable spectral signatures in every batch means less troubleshooting later.

    We don’t rely on generic, broad specifications. Our analytical chemists use real-world calibration, not old tables. Spectroscopy, chromatography, and regular spot checks keep every run inside customer margins. Even small shifts in moisture or incomplete nitration show up fast—we catch those so users don’t have to.

    In Plain Terms: Where 2-Methyl-4,6-Dinitrophenol Goes to Work

    In our experience, most demand for 2-Methyl-4,6-Dinitrophenol comes from dye intermediate synthesis, research, and sometimes specialty energetic formulations. Each user values its electron-withdrawing groups, which tune molecule reactivity for subsequent steps—especially nitro and methyl on the phenolic ring. Because of our fine control over these substituents, industrial chemists can push yields a bit higher and reduce their waste when they build on this core.

    Several customers in the interfacial polymer and pigment sectors select this compound because it threads a line between strong electron demand and moderate acidity. Unlike parent dinitrophenol or simple dinitrobenzenes, the methyl group provides a handle for further functionalization, which sets up more complex target molecules. This matters in applications where standard dinitrophenols fall short in selectivity or solubility. We’ve had conversations with researchers who appreciate what looks like a small tweak—the methyl group—for its sizable impact on enzyme inhibition studies, redox behavior, and aromatic substitution possibilities.

    Understanding Usage Through Workflow

    On paper, 2-Methyl-4,6-Dinitrophenol often lands in lists under “chemical intermediates” or “reductive dye precursors.” That phrase only scratches the surface. We have watched experienced process chemists pick this compound because it helps manage reaction rates where selectivity matters. In the dye sector, consistency in nitro substitution ensures fewer reprocessing cycles later, especially for high-fidelity yellow and orange shades. For labs optimizing for specialty applications, predictable reaction outcome saves time and resources.

    Equipment operators here know the material granularity and flow are just as critical, as these affect mixing and dissolution rates. We maintain strict process parameters on particle size during drying and sieving. Customers in continuous processing lines have pointed out that our product moves cleanly through feeders and doesn’t clump in silos—a difference from some imports. That smooth flow translates to fewer maintenance stops.

    Performance You Can Test, Not Just Trust

    Performance with this chemical starts with reproducibility. We’ve spent many years dialing in routines to hold batch-to-batch variation to tight tolerances—on color, melting behavior, and residual solvents. For users running scale-ups or regular campaigns, deviation in particle quality or reactivity means lost hours and wasted reagents. We run every shipment past our in-lab reference standards, not just paperwork reviews. Spectra, chromatograms, and impurity analyses go with every outgoing lot.

    On one of our recent reviews, we identified sub-percentage-level differences in a lot by direct side-by-side NMR with an internal reference. None of those details get glossed over in our release logs. Every time we innovate on the upstream purification, we rerun application tests in our on-site pilot lab, measuring how our improvements land for users—solubility in practical solvents, reactiveness in downstream operations, and residue on glassware. This disciplined routine lets us catch the rare off-spec sample before shipment.

    Distinctives: How It’s Different from Standard Dinitrophenol Lines

    A lot of outsiders treat 2-Methyl-4,6-Dinitrophenol just as another dinitrophenol cousin. Chemically, it stands out in several ways. The methyl group at the 2-position changes both the electronic pull and the steric pattern on the ring, which alters how the molecule interacts with bases, nucleophiles, and transition metal catalysts. For synthetic chemists in flavor and fragrance intermediates, this effect can mean cleaner reactions and faster turnovers.

    We’ve seen some users grab regular 2,4-dinitrophenol, only to run into solubility walls, redox stability issues, or unexpected side products. The tweak with methylation isn’t cosmetic; it matters for downstream yield and selectivity. The 4,6-nitro substitution offers unique resonance stabilization, unlike the more common 2,4 isomer, and its acidity profile simplifies washing and neutralization steps in recovery. Our experience has shown that this reduces the frequency of rework and solvent wash volumes on industrial lines.

    Going past just functional differences, our process brings extra robustness: no off-tint batches, no persistent organic impurities, no unpredictable fines content. We source only high-purity nitric and methylating starting materials, sidestepping common industrial contaminants. Our plant operators catch the difference in both smell and solution color—these checkpoints are hard to fake, and they matter to process engineers stuck with tough quality reviews.

    Safety, Handling, and Real-World Challenges

    Behind every batch, operators here respect 2-Methyl-4,6-Dinitrophenol for both its utility and its hazards. It remains a powerful irritant and can be acutely toxic with improper handling. Factory routines emphasize protective clothing and closed-system charging whenever possible. Every worker who loads a reactor or samples a dryer has training tailored to the materials at hand. We maintain tight control on airborne dust during packaging and dispatch, cutting down the odds of occupational exposure. Drums are sealed after nitrogen back-purge to exclude airborne moisture and keep material integrity intact.

    Buyers from regulated markets often ask about documentation and provenance. We don’t just rely on old COAs but keep real-time logs, including in-process controls and endpoint testing. In some regions, extra regulatory filings apply—our compliance officers review every outgoing batch to keep us in line with current standards. Our stances on safe handling aren’t just legal; they’re built from years of minimizing incidents under real operating conditions.

    What Matters Most: Reliability, Not Buzzwords

    In the chemistry business, buzzwords pop up fast. Out here, reliability is the factor that separates workable material from headache batches. Every process technician in our building knows the value in samples that pour cleanly, react as they should, and don’t gum up reactors or leave stray residues. Laboratories and plants have called us directly to describe how a slight impurity on a bulk order from another supplier ruined a week’s operation; we take that as a lesson to keep raising our bar.

    The market might treat 2-Methyl-4,6-Dinitrophenol as a “commodity,” but anyone who runs real syntheses knows the pitfalls of treating it that way. Process upsets, downstream discoloration, clogs during transfer—these nightmares often trace back to small gaps in quality control upstream. From the very first steps in our process design, the focus rests on points that matter most in live manufacturing: particle size distribution, residual mineral acids, potential for byproduct nitration, and off-odor sources. We design our campaigns for robust downstream compatibility, not just shelf life.

    Feedback loops with direct customers help us course-correct when practical issues show up in their new applications. Sometimes, a higher bulk density or a slightly adjusted melt range can improve plant throughput by cutting down on transfer losses. We keep one foot inside our own lab and one in the end-user’s process bay, so our tweaks are always guided by real-world data, not abstract “industry best practices.”

    Facing Challenges in Sourcing and Application

    Every year brings different sourcing headaches. Raw ingredient variability pressures costs and sometimes, overall output. Our long-term contracts with upstream suppliers help us weather swings in commodity prices and guarantee traceability at every step. Instead of broad specification sheets that hide margins, we release analytical results with each lot, demonstrating our batch’s performance within real margins that customers care about.

    Sometimes, new users with experience in similar compounds expect 2-Methyl-4,6-Dinitrophenol to behave identically. The difference in reactivity, volatility, and environmental behavior can catch a plant off guard. Our technical support team addresses these learning curves, sharing practical guidance rather than textbook theory—optimal solvent selection, filtration strategies, residual risk management, and even recycling techniques for side streams. These approaches don’t just save customers time—they cut unnecessary test runs and anxiety during audits.

    Beyond Commodity: Why Details Count

    One of the most underappreciated differences from other nitrophenol-based alternatives shows up in how 2-Methyl-4,6-Dinitrophenol responds in multi-step syntheses. Precision in methyl group placement creates an aromatic ring more resistant to undesired substitutions. For process chemists looking to control reaction windows or manage downstream functionalization, that difference means fewer side products and higher assay yields. We’ve listened to teams share stories of batch failures using imported off-brand material, wishing they’d traced problems back sooner to small differences in chemical structure and impurity profile.

    Our lab’s constant feedback cycle leads to tweaks in drying and packaging. For a material that absorbs moisture or starts to clump under less-than-ideal storage, losses mount fast in plants with automated delivery lines. We’re honest about these risks, offering practical storage and transfer hints to every customer. Regular lab stability checks under local climate conditions—hot, humid summers included—mean fewer surprises no matter where shipments land.

    Commitment to Transparency and Collaboration

    We invest in transparent process logs and open lines with technical teams at customer sites. Rather than sending out faceless bulk shipments, we keep relationships engaged, willing to roll up sleeves and find the root of any process hiccup or color deviation. Those connections often spark upgrades for everyone: we add a drying step; a customer finds a shortcut in dilution; another shares a small instrument tweak that tightens readings.

    Regulations shift every few years, along with broader concerns over environmental impact and process safety. We stay hands-on with any new compliance requirements, sending technical documents and procedural updates to downstream users instead of waiting for issues to arise. Most recently, as concerns around persistent organics in water and waste streams have grown, we’ve refined both end-stage purification and effluent strategies, giving users extra assurance that clean-up moves in the right direction.

    Solutions for Application and Process Issues

    Process optimization never winds up a one-and-done operation. We offer guidance on practical methods to limit process losses and keep recovery rates sharp. Tighter filtration set-ups, recommendations for solvent blends, and guidance on pH adjustment at key stages come directly from trial-and-error experience in both our own lines and user feedback. In some cases, customers found better throughput after switching feeder systems or altering agitator speed—sometimes, the difference lies in seemingly small choices, but the impact on downtime and overall yield is significant.

    On the analytical side, our chemists keep refining protocols for detecting minute byproducts, not just for our sake but for users verifying incoming material. We run comparison checks to catch trace organic salts or metallic residues that can hang up scaling operations. Far from just ticking boxes, this effort means we spot trouble early rather than allowing issues to snowball through multiple production campaigns.

    Environmental controls aren’t an afterthought. We’ve cut down on wastewater discharge by optimizing rinsing and limiting the need for solvent-intensive washing, especially after the nitration phase. These adjustments started out for our own compliance but now mean our downstream partners have less to manage or reroute into their own wastewater systems.

    Looking Forward with Practical Innovation

    Innovation doesn’t always mean a completely new molecule or technology. Here, it often arrives through better waste management, safer handling, and constant refinements in our process parameters. We take feedback from regulatory audits and incorporate direct feedback from operators, not just managers in offices. Ideas come up in morning meetings, sometimes sparked by as little as a technician’s comment about powder flow or an operator’s trick for quicker drum sealing.

    For users integrating 2-Methyl-4,6-Dinitrophenol into more complex syntheses or newer fields, we exchange knowledge freely—not as a sales technique, but out of shared interest in what works under fire. Researchers pushing the boundaries of specialty dyes or new energetic compounds reach out with needs for custom cuts on particle size, alternate handling formats, or modified drying profiles. We take these as challenges, running small-scale pilots before scaling up, watching for bottlenecks or contamination risks that wouldn’t show up on a spreadsheet.

    Adjustments in material handling, reaction conditions, or purification don’t take effect in a vacuum. We make sure that every tweak filters through both our own QA and customer processes, keeping surprises to a minimum at every link. Adaptability, rather than rigid adherence to legacy practices, keeps our process robust in changing market and regulatory environments.

    An Open Door for Feedback and Cooperation

    We keep moving by building partnerships—not just transactions. Clear communication with process chemists, operators, and technical teams generates improvements big and small. When issues come up—unexpected side products, tough-to-remove stains, or shipping delays—we respond directly, sending more than just a standard COA. Feedback cycles help everyone, ensuring that the compound lands smoothly not just in a warehouse, but in live production.

    The best outcomes come from sharing knowledge. Our support teams keep in touch long after delivery, checking in not for up-selling, but to trade updates on practical results and field challenges. We take pride in a transparent, traceable manufacturing approach, knowing that reliable chemistry comes from well-understood materials produced by people who take genuine pride in what they do. For us, 2-Methyl-4,6-Dinitrophenol is more than an entry in a database—it’s a testament to steady hands, informed adjustments, and direct dialogue across the supply chain.

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