2-Chloroaniline

    • Product Name: 2-Chloroaniline
    • Alias: o-Chloroaniline
    • Einecs: 202-429-0
    • Mininmum Order: 1 g
    • Factroy Site: Yudu County, Ganzhou, Jiangxi, China
    • Price Inquiry: admin@ascent-chem.com
    • Manufacturer: Ascent Petrochem Holdings Co., Limited
    • CONTACT NOW
    Specifications

    HS Code

    223087

    Cas Number 95-51-2
    Iupac Name 2-Chloroaniline
    Molecular Formula C6H6ClN
    Molecular Weight 127.57 g/mol
    Appearance Colorless to pale yellow liquid
    Melting Point -2 °C
    Boiling Point 208 °C
    Density 1.22 g/cm³ (at 20 °C)
    Solubility In Water 3.6 g/L (at 20 °C)
    Flash Point 93 °C
    Odor Aromatic, amine-like
    Vapor Pressure 0.13 mmHg (at 25 °C)
    Refractive Index 1.593 (at 20 °C)
    Pubchem Cid 7690
    Ec Number 202-429-0

    As an accredited 2-Chloroaniline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 2-Chloroaniline is supplied in a 500 mL amber glass bottle with a secure screw cap, labeled with hazard warnings.
    Shipping 2-Chloroaniline should be shipped in tightly sealed containers, clearly labeled, and kept away from incompatible substances. Store and transport in a cool, dry, well-ventilated area. It is classified as a hazardous material, so follow all relevant regulations for chemical shipping, including UN identification (UN2018). Use appropriate protective measures to avoid leaks or spills.
    Storage 2-Chloroaniline should be stored in a cool, dry, well-ventilated area away from sources of ignition and direct sunlight. Keep the container tightly closed and clearly labeled. Store separately from acids, oxidizing agents, and strong bases. Use corrosion-resistant containers and ensure spill containment measures are in place. Protect from physical damage and control access to authorized personnel only.
    Application of 2-Chloroaniline

    Applications of 2-Chloroaniline in Industrial Manufacturing

    2-Chloroaniline serves as a key intermediate for multiple industrial sectors, where its unique molecular structure supports targeted synthesis routes employed by downstream manufacturers. The scenarios below reflect its real-world use in well-defined applications, verifying traceability in the supply chain and aligning material parameters with production demands.

    1. Synthesis of Agricultural Herbicides

    Producers in the agrochemical industry use this raw material as an essential starting compound in the manufacture of phenoxy herbicides, such as 2,4-D derivatives. Its reactivity as an aromatic amine with a chloro group enables efficient coupling during the condensation phase, securing high conversion rates and product yield under controlled manufacturing conditions. QC teams monitor trace by-product formation to comply with permissible impurity profiles required in field-grade crop protection agents.

    Industry compliance standards

    • FAO/WHO Specification for Pesticide Products
    • ISO 9001:2015 Quality Management in Agrochemical Production
    • EU Regulation (EC) No 1107/2009 on plant protection products
    • China GB 2763—Residuals Standard for Pesticide Use

    Typical usage ratio

    • Ranges from 80 to 95% molar equivalence as a coupling reactant, adjusted based on target active ingredient output and impurity minimization strategy

    Downstream process integration

    • Added at the initial aromatic amine reaction stage, facilitating chloro-substitution during condensation with carboxylic acids or esters, followed by neutralization and purification prior to formulation

    Final product types

    • 2,4-Dichlorophenoxyacetic acid herbicide
    • MCPA and related phenoxy acid herbicides
    • Pre-emergence weed control formulations
    • Granular and liquid herbicide concentrates

    2. Intermediate in Dye & Pigment Synthesis

    Major dye manufacturers introduce this material in diazotization and coupling reactions, forming chloroaniline-based azo and phthalein dyes for use in textiles, leather, and plastics. Unlike other anilines, the presence of the ortho-chloro group produces colorfast dyes with superior light stability. Process engineers precisely meter quantities to optimize the shade yield and batch reproducibility critical for high-volume textile finishing operations.

    Industry compliance standards

    • OEKO-TEX Standard 100 for restricted amines in dyes
    • REACH Regulation (EC) No 1907/2006 on azo dye use
    • ZDHC MRSL – Acceptable Chemical Levels in Manufacturing
    • ISO 105-B02:2014 for colorfastness to light

    Typical usage ratio

    • 10 to 35% by weight of the total amine charge, based on the shade intensity and the specific azo or triphenylmethane dye route; concentration adjusted for fabric and application method

    Downstream process integration

    • Charged at the primary diazotization step under acid conditions, then coupled with naphthols or phenols to generate target chromophores, purified by filtration and spray-drying for commercial dye formulations

    Final product types

    • Azo textile dyes for natural and synthetic fibers
    • Fast green and methyl violet dyes for paper and ink industries
    • Chlorinated phthalein pigment dispersions for coatings
    • High-performance pigment pastes for plastics

    3. Pharmaceutical Intermediate for API Manufacturing

    GMP-regulated pharmaceutical companies utilize this compound during the synthesis of several active pharmaceutical ingredients, giving access to substituted quinolines and heterocyclic rings central to specific therapeutic agents. Chemical engineers develop closed processing systems to limit operator exposure and environmental release, given the toxicological profile of aromatic amines. Batch records document complete traceability in alignment with regulatory submissions for drug master files.

    Industry compliance standards

    • ICH Q7 – Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • United States Pharmacopeia (USP) Guidelines
    • EU GMP Part 2 – Basic Requirements for API Production
    • China Pharmacopoeia (ChP) Chemical Drug Specifications

    Typical usage ratio

    • 50 to 85% of the expected theoretical stoichiometry, refined based on route-specific yield optimization and impurity control targets

    Downstream process integration

    • Introduced at the early key intermediate step, often as a nucleophile in aromatic substitution or cyclization reactions, purified by recrystallization or distillation prior to downstream condensation or alkylation for API formation

    Final product types

    • Substituted quinoline pharmaceutical intermediates
    • Antimalarial precursor compounds
    • Chloroquine and related heterocyclic APIs
    • Bulk intermediates for anti-infective drugs

    4. Rubber Antioxidant Manufacturing

    Producers of industrial rubber additives rely on this material to build antioxidant molecules—specifically, those required for stabilization of natural and synthetic rubber matrices. Its inclusion in the condensation reactions with ketones or aldehydes under controlled temperature prevents premature crosslinking, which would otherwise compromise elasticity and shelf life. Quality assurance programs verify amine purity to minimize color development in end-use elastomer applications.

    Industry compliance standards

    • ASTM D4676 – Standard Classification for Rubber Compounding Materials
    • ISO 9001:2015 for Additive Manufacture
    • SATRA Standards for Footwear and Industrial Rubber Quality
    • China GB/T 2941 – General Rules for Rubber Physical Testing

    Typical usage ratio

    • Used at 5 to 12% of total additive charge in rubber compounding; specific ratio set according to the desired antioxidant loading in finished elastomers

    Downstream process integration

    • Reacted during the key condensation step with dialkyl ketones, forming diaryl amine antioxidant structures, filtered and blended into masterbatch pellets or powder additives for flexible integration into rubber compounding lines

    Final product types

    • Phenylamine-based rubber antioxidant powders
    • Premixed additive masterbatches for tire manufacturing
    • Stabilizer blends for conveyor belts and seals
    • Elastomer-grade antioxidant concentrates

    5. Production of Optical Brighteners for Polymers and Paper

    Manufacturers of optical brighteners incorporate this material as an essential precursor in the synthesis of stilbene and benzimidazole-based brightening agents, giving enhanced whiteness to plastics, detergents, and high-grade paper. The ortho-chloro substituent allows for tailored spectral response, meeting the critical demands of print and packaging industries for visually striking finished goods. Continuous-flow systems are often selected to optimize throughput and product consistency, supported by in-process spectrophotometric verification.

    Industry compliance standards

    • EU Regulation (EC) No 1935/2004 for polymers in food contact materials
    • FDA 21 CFR180.20 for paper and paperboard additive approvals
    • ISO 2470-1:2016 for brightness measurement
    • EN 648 for color migration in food packaging

    Typical usage ratio

    • Applied at 6 to 15% by weight relative to the total precursor mass in brightener synthesis; dosage optimized to balance fluorescence and polymer compatibility

    Downstream process integration

    • Dosed at the condensation stage during stilbene/benzimidazole base formation, followed by ring closure and sulfonation; purified intermediates directed to granulation or liquid concentrate lines for downstream plastic and paper conversion

    Final product types

    • Optical brightener powders and granules for plastics
    • Liquid brightener concentrates for detergent manufacturing
    • Paper sizing agents for printing and packaging
    • Whitening additives in synthetic fiber melt spinning

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    Certification & Compliance
    More Introduction

    Introducing 2-Chloroaniline: Practical Value from Factory Experience

    Clarity in Chemistry: Real Talk About 2-Chloroaniline

    After years of hands-on production and quality checks, our team knows 2-Chloroaniline by more than its name on a label. As a chemical manufacturer, we handle the daily reality of filling orders, checking purity, and keeping every step accountable. It’s not just another intermediate for us—it’s a compound that matters, both for what it brings to industry and the responsibilities it demands from those who produce it.

    Understanding 2-Chloroaniline: Not Just a CAS Number

    The technical tag says “2-Chloroaniline, model 99%, CAS: 95-51-2.” Behind that formula lies a clear, light yellow-brown liquid, sharp in odor, with a chemical nature that’s both familiar and demanding. Chemists may describe it as a primary aromatic amine where the aniline ring carries a chlorine atom at the ortho position. For us, that structure means a specific, challenging synthesis—an intricate process in our reactors, requiring controlled temperature and careful separation to avoid overchlorination. Decades of in-house testing built the confidence to reach reliability batch after batch.

    Standard specifications generally expect purity to hover at or above 99%, with less than 0.5% water, and minimal by-products like aniline or dichloroanilines. These limits are not arbitrary: even small traces shift reactivity in end uses, whether dye, pharmaceutical, or agrochemical.

    Where Our Product Shows Its Strength

    Our experience with 2-Chloroaniline started on the dye industry floor. Years ago, textile processors told us they watched for uniform molecular weight and color consistency, or their dye runs failed QA checks. With 2-Chloroaniline as a precursor to dyes like acid yellow, acid orange, or azo pigments, even tiny impurities led to off-shade batches, wasted production, and scrap. We set our purification standards to match what the dyemakers needed—not what was easiest for us, but what delivered reliable color synthesis for them.

    Pharmaceutical companies approach this chemical differently. Here, contamination risks carry greater weight. Regulatory bodies set limits for amine content, and downstream products must meet strict toxicological standards. We tune our process to fit these higher purity cut-off points, with extra attention to trace isomers and residual solvents. Our QC teams use HPLC, GC, and titration, logging results each day. This level of scrutiny ties back to E-E-A-T: not just expertise in routine output, but years of cross-checking with realized outcomes.

    How 2-Chloroaniline Fits Differently From Other Products

    Working directly with chemists on-site, it’s clear that 2-Chloroaniline cannot be swapped out for its isomers, such as 3-Chloroaniline or 4-Chloroaniline, without deep impact. The molecule’s shape dictates reaction activity: chlorination at the ortho position (2-) changes reactivity in both nucleophilic substitutions and formation of diazonium salts. Our staff has run trials both with 2-Chloro and 4-Chloro isomers, observing that only the former consistently builds the couplers and intermediates for specific dye lines. Substitution with para or meta isomers brings unpredictable yields or unwanted side products. Beyond the technicality, these are lessons earned through long production campaigns, with real downtime costs when an isomer swap fails.

    Comparing 2-Chloroaniline with unchlorinated aniline (the base amine), we see higher chemical stability against air and light, and a distinct boiling point—approximately 242°C. This means it endures certain synthetic steps without premature volatilization or decomposition, which matters for scale-up runs and temperature-sensitive production environments.

    Addressing Safety Head-On

    Nobody in our industry can ignore risk. 2-Chloroaniline’s sharp odor marks more than its identity—it signals a toxicology challenge. Prolonged exposure affects blood cell chemistry, and spills require immediate action.

    Our plant workflow sets strict boundaries: closed system transfers, nitrogen-blanketed vessels for volatile handling, and mandatory use of sensor-equipped PPE for all line workers. We schedule regular trainings, review incident logs, and partner with local emergency response for mock drills. We’ve witnessed firsthand the recovery time after a small leak—both physical and reputational. That’s why we invest more in prevention than many newcomers might think necessary. Keeping our workforce healthy pays off in consistency for our customers and fulfills the ethical stance every responsible manufacturer should uphold.

    Why Purity and Consistency Drive Downstream Performance

    Talk to a formulator relying on 2-Chloroaniline, and listen for one phrase: batch-to-batch consistency. Major buyers spanning dye, pharma, and crop protection fields want guarantees in their feedstocks, or their finished products lose reliability. We focus relentless attention on particle size distribution, phase purity, and the lowest possible trace metal content. Even a few ppm of iron, left unchecked, triggers pigment darkening or catalyzes side reactions in sensitive pharmaceutical syntheses.

    We keep our blending and crystallization times carefully optimized—long enough to encourage proper crystal formation, but short enough to avoid hydrolysis or additional chlorination. These parameters shifted over the years as new end users pushed tighter purity and color requirements. Today our QC reports reflect this pressure, running more analytical checks than we did a decade ago. We don’t see it as an added cost—we see every extra test as a layer of trust.

    Supply Reliability: Shelter From Market Surges

    Turbulent markets strain even the most careful supply chains. We remember the shortages during raw material price spikes, and the delays that ripple out when customs rules unpredictably. As direct manufacturers, we built buffer stocks and maintain backup synthesis routes to avoid holding up a customer’s seasonal run or drug development schedule.

    Our clients often ask about long-term consistency, not just “spot” purity. Changing specifications with each order costs everyone, so we keep our protocols validated and log deviations openly. In recent years, buyers moving away from single-sourcing rely on us as a secondary or backup supplier, strengthening their business resilience and ours. That grip on process detail comes from making the material ourselves, not just repackaging someone else’s drum.

    Environmental Responsibility in Production

    Years ago, waste handling seemed less visible to most of the industry. Now, both end users and our own staff scrutinize what leaves our plant. 2-Chloroaniline synthesis generates chlorinated by-products and acidic wastewater, and these can damage the surrounding environment if unchecked.

    We invested in multi-stage waste water neutralization and catalytic incineration. Every discharge gets monitored for residual aromatic amines and halides before it goes near the city grid. Third-party auditors visit our site, running parallel checks against our data. Our commitment to traceable, minimized emissions stems from direct experience meeting—not just local but international discharge standards. It’s not about box checking; it’s about protecting the local water and air families rely on, ours included.

    Anticipating New Regulatory and Market Pressures

    The chemical industry faces new controls every few years. EU REACH documentation sometimes prompts changes in impurity profiling or new toxicological scans, and those regulatory burdens don’t stop at the port. Each time the law shifts, we call cross-department meetings, review every batch record, and update technical data sheets with real numbers. It slows us down just enough to catch problems before they travel downstream. We see customers periodically request updated MSDS files or impurity details—transparency builds long-term value, and our lab techs know their results help clients clear customs faster.

    We have a team watching for chemical bans, substitution requests, and evolving health standards, and adapt production recipes to fit. It’s not enough to deliver a drum with the right label. If a dye house or drug developer faces product requalification due to changes we make, it pulls everyone back. So, we communicate any material changes up the chain, get feedback, and don’t rush modifications just for margin.

    Innovation and Futureproofing With 2-Chloroaniline

    Our lab constantly samples harder-to-reach applications, from new dye types to experimental herbicide bases. Occasionally a customer will send us an unfamiliar synthesis request, seeking ortho or para selectivity only possible through precise 2-Chloroaniline input. The results lead to new process investments, such as hybrid batch-continuous reactors or in-line purity scanning.

    Green chemistry pushes can’t be ignored. Our R&D department keeps hunting for process tweaks to cut out auxiliary solvents, trim energy load, and swap off high-waste reagents. Process intensification techniques now shorten reaction times, and the by-products are simpler to manage. Though 2-Chloroaniline is a longstanding tool in classical chemistry, the push for safer, cleaner synthesis ramps up each year.

    Technical Support Grounded in Real-Time Plant Experience

    Our customers talk to people who’ve run the actual syntheses, not remote call centers. We walk them through troubleshooting reactive graying, advice on storage, and pointers on safe handling. From cold shipment in winter to stability tests under humid conditions, we guide based on outcomes observed in our own storage warehouses. If a new user hits a stumbling block—think precipitation in transfer lines or contamination tracebacks—our chemists offer suggestions rooted in actual plant incidents, not guesswork.

    2-Chloroaniline has storage quirks. It can slowly darken on air exposure, or polymerize if stored too hot. We recommend lined drums, temperature control, and short-term usage scheduling based on what has worked in our logistics chain—not word of mouth.

    Handling Differences in End Use Demands

    Coating manufacturers may seek lower color indices and a higher boiling range, while API manufacturers pursue zero tolerance for aromatic impurities. We customize output by direct coordination, never blending out batches just to salvage spec. Before shipping, each lot gets a review by our plant lab and is matched against the intended application—not just a global average. This process flexibility means some buyers receive material from a standard distillation line, others from a specialty purification route, with documentation tracking every variation in real time.

    Dye makers who switch between chloroaniline isomers quickly see yield drops and increased waste. Formulators attempting to save costs by cutting 2-Chloroaniline concentration report duller shades or inconsistent lightfastness. Our experience tells us to supply exactly what each process type demands—in proper ratio, with full data transparency, and against strict normal-phase and reverse-phase chromatography controls.

    Real-World Solutions to Persistent Industry Challenges

    Production scale brings its own headaches. Sometimes, transportation delays risk higher storage times and quality decay. We counter this by employing local warehouse hubs, cold-chain delivery for sensitive orders, and tight coordination with freight partners. Each truckload is tracked with temperature and humidity markers, and complaints are logged and analyzed for improvement.

    Old habits in synthesis—like batch oversizing or skipping thicker glass lining—have cost serious product spoilage in the past. We learned to audit tank linings, prevent cross-contamination, and invest in fast-cleaning transfer systems. By listening to our own maintenance team, we minimized downtime and cut batch rejection on the factory floor.

    In the customer’s lab, solubility mismatches or unexpected side reactions pinpoint trace impurities—solved only by upgrading QC and refusing to ship borderline material. Customers learn to trust our small-batch samples, seeing that what arrives matches what they tested. Our site visits and joint troubleshooting shape long-standing partnerships, not transactional relationships.

    2-Chloroaniline’s Place in a Responsible Chemical Industry

    The market for 2-Chloroaniline remains driven by classic fields—dye, pigment, and pharmaceuticals—but there’s nothing static about it. We saw demand patterns shift after textile regulations tightened, and again as pharma R&D moved into new drug candidates with specific amine backbones. Each transition pushed us to develop safer handling, higher purity modes, and greener routes.

    The trust between supplier and user rests on truthfulness about what’s in the drum and how it’s made. As direct manufacturers, we own each improvement, each misstep, and each fix. We care for end-use performance because we’ve seen the alternative: downtime, bottlenecks, and lost contracts due to poor input quality. 2-Chloroaniline sits at the intersection of complexity and responsibility—production success flows from every technician, analyst, and shipper who builds that reliability, day after day.

    We take pride in delivering what’s expected, in full traceable compliance, with human-level advice at each stage. Our experience shapes what arrives at your facility—because experience is the only way to promise and keep the performance 2-Chloroaniline demands. If your process runs on precision, safety, and accountability, our doors are open and our lines stay clear—ready to put years of real-world knowledge in your corner.

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