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HS Code |
996282 |
| Cas Number | 532-27-4 |
| Molecular Formula | C8H7ClO |
| Molecular Weight | 154.60 |
| Iupac Name | 1-(2-chlorophenyl)ethan-1-one |
| Appearance | White to pale yellow crystalline solid |
| Melting Point | 23-25°C |
| Boiling Point | 245-247°C |
| Density | 1.204 g/cm3 |
| Solubility In Water | Slightly soluble |
| Flash Point | 110°C |
| Odor | Pungent irritating odor |
| Refractive Index | 1.576 |
As an accredited 2-Chloroacetophenone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 2-Chloroacetophenone, 500g: Supplied in an amber glass bottle with a secure screw cap, featuring clear hazard and handling labels. |
| Shipping | 2-Chloroacetophenone is classified as a hazardous material and must be shipped according to regulations for toxic substances. It requires secure, leak-proof packaging, clear hazard labeling, and appropriate documentation. Transport typically occurs via authorized carriers specializing in dangerous goods, ensuring compliance with local, national, and international chemical transport standards. |
| Storage | 2-Chloroacetophenone should be stored in a cool, dry, well-ventilated area, away from direct sunlight, heat sources, and incompatible substances such as strong oxidizers and bases. Keep the container tightly closed and properly labeled. Store in a secure chemical storage cabinet, ideally made of corrosion-resistant material, to prevent accidental contact, spill, or release. Follow all chemical safety regulations and guidelines. |
Applications of 2-Chloroacetophenone in Industrial Manufacturing2-Chloroacetophenone is widely utilized as a key chemical intermediate in multiple specialized industrial manufacturing sectors. Our facility supports diverse production lines, supplying this raw material in compliance with precise industry requirements. Below, we detail application scenarios where this compound provides critical value with clear compliance, usage methods, integration workflows, and final product outputs. 1. Synthesis of Tear Gas Agents for Law EnforcementOur clients in the defense and security supply chain use 2-chloroacetophenone as a principal precursor for the synthesis of riot control agents. It undergoes nitration, chlorination, and formulation, following controlled, traceable processes. The compound enters the formulation stage after purification, where batch documentation and sequential blending ensure active concentration targets are accurate. End-use requires robust stability, defined particle dispersion, and regulated irritant activity matching regional export rules. Stringent raw material tracking and contaminant minimization form part of our quality assurance protocols for defense manufacturers. Industry compliance standards
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2. Intermediate for Pharmaceutical Synthesis of AntihistaminesPharmaceutical manufacturers use this compound as an intermediate in the multi-step synthesis of select antihistamine APIs. The aromatic ketone group permits controlled derivatization, including coupling and reduction steps under GMP cleanroom conditions. Batch-level inspection, validated cleaning protocols, and analytical tracking using HPLC ensure no cross-contamination. The input mass of the raw material gets carefully recorded for accurate yield monitoring and subsequent purification, where only pharmaceutical-grade solvent systems are authorized. Finished actives undergo further downstream testing for pharmacopoeial compliance before entering the dosage form stage. Industry compliance standards
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3. Precursor for Dye and Pigment ManufactureIn the colorant production industry, this compound operates as a critical raw input for synthesizing high-purity dyes and pigments, particularly for specialty textile and industrial applications. The ketone and chloro functionality facilitate selective electrophilic reactions, yielding color bodies after diazotization and coupling. The process stage mandates continuous pH control and temperature monitoring to achieve uniform dye structure and shade consistency. We support direct delivery in drum, tote, or bulk modes under documented QA systems for trace-colour batch manufacturing. Industry compliance standards
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4. Chemical Intermediate for Agrochemical Active Ingredient ProductionLeading agrochemical formulators incorporate this raw material as a building block to synthesize specific herbicide and fungicide molecules. The raw input enters a sequence of nucleophilic substitution and hydrolysis steps aimed at generating functionalized intermediates. Our manufacturing batches address pesticide industry controls, with traceability from input weighing through to stabilization and packaging of downstream active salts and esters. Validation protocols focus on minimizing residual byproducts and maintaining reproducible yield for subsequent granulation or formulation stages. Industry compliance standards
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5. Raw Material for Synthesis of Fragrance IntermediatesHigh-purity grades serve as starting materials for the aroma chemicals sector, especially in the creation of musky and spicy olfactory notes. 2-Chloroacetophenone undergoes stepwise modification through Friedel-Crafts acylations, then further condensation and etherification to yield aromatic aldehydes and ketones. Production lines maintain food-grade and IFRA-compliant process controls, with monitored inert-atmosphere reactions to prevent contaminant formation. Documentation covers every transfer and addition, supporting downstream distillation and purification as required by specialty fragrance manufacturers. Industry compliance standards
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6. Precursor in Fine Chemical Synthesis for Laboratory ReagentsContract research organizations and fine chemical processors procure high-purity grades for further transformation into a range of analytical reagents and functionalized reference standards. The compound supports Grignard, Suzuki, or nucleophilic substitution experiments, where process chemists require tight input specification and trace-level impurity management. QC documentation aligns with ISO laboratory practices, and we support shipment to facilities equipped for handling regulated chemicals. Each input batch is numbered and supplied with an analytical certificate by our plant’s QA laboratory for customer records. Industry compliance standards
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In the daily rhythm of batch work, few compounds catch the attention quite like 2-Chloroacetophenone. Its chemical structure—marked by a chlorine atom attached to an acetophenone framework—has steered it into a spot held through decades of applied chemistry. Manufactured as a white crystalline solid under precise temperature ranges, its signature is not just in its appearance, but in the careful process built around it. This isn’t just a story of “production” but one of stewardship: raw material sourcing, meticulous distillation, constant checks against impurities, and strict procedural oversight, all to achieve results that users can depend on.
Here in our plant, we track every kilogram. Whether the target is a batch with a purity above 99.5% or a specific particle size to favor end-use conversions, the quality of 2-Chloroacetophenone lies as much in the unseen routines—careful weighing, stepwise heating, controlled atmospheres—as in the finished product itself. Each drum that goes out reflects an entire system centered on chemical accuracy.
People often associate 2-Chloroacetophenone with crowd control, and that’s valid—its use in tear gas formulations comes straight from its physiological effects. Yet that view only scratches the surface. The compound's active acyl chloride group also makes it a versatile intermediate, shaped by how willing it is to react with nucleophiles. Manufacturers and research teams turn to this molecule for organic synthesis, especially when building other fine chemicals and pharmaceuticals. Its predictable behavior helps ensure reactions reach yield targets more consistently—something that a copybook alternative seldom achieves.
Beyond the obvious, our partners in the pharmaceutical sectors request it for specialty syntheses. Sometimes they rely on its precise melting point or its solubility profile to drive multi-step production. Custom-tailored derivatives have come out of our reactors, ranging from analgesics to experimental crop protection agents. Through it all, the product’s fingerprint—stable production from consistent batches—keeps unnecessary troubleshooting off the schedule lines.
Let’s get specific. The most-requested model in our lineup features a purity specification at 99.5% minimum by gas chromatography. Moisture stays below 0.2%. We monitor for related chlorinated impurities, especially 4-chloroacetophenone, keeping them under 0.1%. End-users manufacturing sensitive downstream products won’t accept drifting specs; our lab doesn’t either. Refractive index, color, and residue on evaporation all get checked, batch to batch.
Handling this compound inside running reactors calls for more than just numbers on a page. We found early on that dust content and clumping can disrupt automated dosing equipment, so we tuned our crystallization and filtration steps to favor granular over fine-powder product. Packaging in lined steel drums keeps moisture out, but the real work comes from storage under controlled conditions back at the production site. That’s saved many headaches when opening inventory months later.
Chemically, we sit 2-Chloroacetophenone next to other substituted acetophenones—methyl, fluoro, or nitro analogs, for example. In the field, practitioners report clear differences. The chlorine atom on the alpha carbon brings higher reactivity, especially for nucleophilic substitution, which simplifies downstream synthesis. Unlike the commonly used acetophenone, which acts as a mere solvent or as a less reactive ketone precursor, this chlorinated analog opens up more synthetic possibilities without introducing excessive hazards common to some of the more aggressive halogenated compounds.
As for alternatives such as benzyl chloride or other alpha-haloketones, these can have unpleasant volatility or a propensity for self-condensation—2-Chloroacetophenone resists those tendencies if stored and handled correctly. Downstream, the process safety teams favor our product for its manageable toxicological profile relative to other strong lachrymators like o-chlorobenzylidene malononitrile (CS gas). The difference in handling protocols, required PPE, and storeroom controls reflect those choices. Feedback from users tells us that they find both performance and storage-risk profiles more predictable in day-to-day work.
Few things influence manufacturing as much as consistency. There’s nothing theoretical about it. If a batch ships with a purity drop—even by half a percent—customers who scaled synthesis to vapor pressure or reactivity have real interruptions. We’ve seen cases where out-of-spec material led to product recalls or night shifts spent scrubbing reactors of residue. These costs tend to dwarf what gets saved in short-cuts.
In our plant, reliability starts upstream. We vet raw materials for trace impurity patterns, react under steady pressure, and operate within tightly automated dosing. Results from the lab—HPLC, GC, titration—feed straight back into the batch record. Finished lots that don’t hit every mark don’t leave. That philosophy has cut customer returns to near zero for several years. Service teams who know how production works can take a call at any hour, run down a lot number, and find the answer in real time.
Shipping 2-Chloroacetophenone through hot summers brings lessons nobody learns from a catalog. We watched several early shipments struggle with caking and inconsistent pourability. Conversations with downstream users—particularly those who feed material through pneumatic lines—showed us where we missed the mark. We invested in better environmental controls, retooled silo storage to buffer temperature swings, and switched to drums lined with anti-static barriers. Quality improved, and so did customer feedback.
Transportation is never an afterthought. The regulations that govern shipment of hazardous materials carry real obligations. Precise labeling, certified leak testing, and custom documentation—these have been built into our protocols just to keep shipments running smoothly across borders. For international partners, differences in customs or regulatory language can be a sticking point. Our team tracks each order from port to warehouse.
During years when upstream feedstock supply tightens, or regulatory restrictions increase, we adjust operations in real time. Everyone in this field has felt supply shocks, but expertise keeps downtime to a minimum. Our procurement team sources raw materials from vetted partners with long-term histories, not just the lowest bidder. Buffer stocks remain on hand. Process adjustments let us switch between modern and legacy synthesis routes.
Shifts in environmental regulations—especially around chlorinated organics—are no surprise. Many countries require full lifecycle documentation, tracking each gram from raw material through to waste. We have built additional analytics into our QA chain. Customers in the pharmaceutical and agrochemical fields ask for batch-level traceability, and we supply it without extra paperwork delays.
No chemical production stays outside the reach of environmental controls. Our plant’s waste treatment circuits meet or exceed local standards for emission and water discharge. Solvent recovery systems capture volatiles before they leave the plant. Next-generation controls link waste streams directly to central logs for outside auditor access when needed. Annual reviews on site ensure our impact shrinks year to year.
Most partners want documentation for each delivery, confirming compliance and sustainable handling. We invite audits—sometimes with little notice—because the line staff know what’s at stake. Training cycles reinforce that safe handling and low impact don’t happen alone; they demand constant attention. Manufacturers who skip those steps typically won’t keep supply relationships for long.
Clients arrive at 2-Chloroacetophenone from different industries, motives, and levels of process complexity. Some formulate crowd dispersal devices, others create high-value intermediates for research. New users often call with questions about processing parameters or unexpected side reactions. Our technical support—drawn from the same engineers and chemists who oversee batches—can walk users through procedures based on what they see in daily operations, not theory alone.
Lessons from the floor have changed more workflows than any manual ever could. One partner found that unexpected trace acid in a shipment led to color changes in a final pharmaceutical API. We traced the source, modified a filtration step, and delivered the next order with corrected parameters. The fix wasn’t just a note on a QC report; it involved reworking a day’s flow through the plant’s filtration system, updating cleaning cycles, and validating it step-by-step. For us, solving issues means owning every aspect of the process.
2-Chloroacetophenone requires respect inside our facilities. Its potential as an irritant means plant teams keep dedicated air handling and emergency wash stations running continually. PPE, including gloves and respirators, becomes second nature. Containers never get mixed in common storage areas—segregation by both class and batch time prevents cross-contamination.
Training covers every shift. Routine drills verify that everyone, from new hires to senior operators, can handle emergencies. The result isn’t just lower injury rates. It keeps material from being wasted, and everyone stays ready when inspection dates arrive. Our teams aren’t just compliance-driven; they see the value of safe handling as a core part of professional responsibility. That focus translates into consistent output and reliable delivery times.
Few processes run indefinitely without challenges. Changes in upstream material purity, energy pricing, or new compliance checklists arrive regularly. During periods of volatility, the back-and-forth between production and QA ramps up, blending oversight with flexibility. For example, when one raw solvent source changed unexpectedly, batch-to-batch purity began drifting. We initiated dual sourcing, recalibrated detection methods, and pushed three trial batches through full-scale reactors before returning to schedule.
Feedback loops stay tight. Customers spotted slight scent differences before our own analytics picked up the cause. That kind of early notice lets us act quickly, saving whole shipments when necessary. Being “on call” isn’t a burden—our people draw pride from being the ones who resolve issues, not just track them.
Process optimization never stands still. Investments in automated sensor networks cut cycle times and trim waste rates. Advanced chromatography at-line now gives real-time insight into composition during key stages. We trial green chemistry alternatives when possible—exploring catalyst swaps or new purification resins—without sacrificing batch reliability.
End-user demands shape much of our research. Pharma partners push for added levels of impurity screening, while specialty chemical makers want custom pack sizes or freshly prepared lots to minimize storage time. The plant flexes to meet those requests: smaller reactors to accommodate shorter lead times, custom drum liners for fewer residue problems, and new cleaning protocols that nearly eliminate cross-contaminants. What drives these adaptations is never guesswork; it’s the dialogue with those who use the finished product every day.
As chemical manufacturers, we know that every shipment of 2-Chloroacetophenone carries consequence beyond our own doors. Clear communication, batch-to-batch transparency, and rapid support set the terms for durable partnerships. Inside our plant, teams rely on documented experience, skill, and investment in process controls to keep output steady. The aim has always been more than satisfying a set of specifications—it’s about supporting end users, innovators, and supply chains everywhere this compound finds its way.
