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HS Code |
121071 |
| Chemical Name | 2-Chloro-4-Dimethylamino-6-Methylpyrimidine |
| Cas Number | 23615-14-5 |
| Molecular Formula | C7H10ClN3 |
| Molecular Weight | 171.63 g/mol |
| Appearance | White to off-white solid |
| Melting Point | 83-85°C |
| Solubility | Soluble in organic solvents such as DMSO and methanol |
| Purity | Typically ≥98% |
| Smiles | CN(C)C1=NC(=NC(=C1)Cl)C |
| Inchi | InChI=1S/C7H10ClN3/c1-5-4-11(2)7-9-6(8)3-10-5/h3-4H,1-2H3 |
| Storage Conditions | Store at room temperature, in a tightly closed container |
| Synonyms | 2-Chloro-4-(dimethylamino)-6-methylpyrimidine |
As an accredited 2-Chloro-4-Dimethylamino-6-Methylpyrimidine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | 100g of 2-Chloro-4-Dimethylamino-6-Methylpyrimidine is supplied in a sealed amber glass bottle with a tamper-evident cap. |
| Shipping | 2-Chloro-4-Dimethylamino-6-Methylpyrimidine is shipped in tightly sealed containers, protected from moisture and light. It is classified as a hazardous chemical, requiring proper labeling and documentation. Transportation must comply with relevant regulations (such as DOT or IATA), including safety measures for handling, storage, and potential spill response during transit. |
| Storage | Store 2-Chloro-4-dimethylamino-6-methylpyrimidine in a tightly sealed container, in a cool, dry, and well-ventilated area away from moisture, heat, and direct sunlight. Keep away from incompatible substances such as strong oxidizing agents and acids. Label the container clearly and handle using appropriate personal protective equipment (PPE) to avoid inhalation, ingestion, or skin contact. |
Applications of 2-Chloro-4-Dimethylamino-6-Methylpyrimidine in Industrial Manufacturing2-Chloro-4-Dimethylamino-6-Methylpyrimidine serves as a specialized heterocyclic intermediate in several high-value chemical industries. As a direct manufacturer, we support downstream partners in pharmaceuticals, crop protection, veterinary actives, and advanced material synthesis by providing consistent quality and batch-to-batch transparency. Below are the main application fields, each with industry-verified routes, integration points, compliance standards, and finished product relevancies, reflecting our continuous cooperation with global industrial producers. 1. Pharmaceutical API Intermediate for Anti-Viral AgentsThis pyrimidine derivative is widely used by pharmaceutical manufacturers as a key building block in the synthesis of antiviral drug molecules, particularly nucleoside analogues. The compound integrates into multi-step production routes where regioselectivity and purity directly impact the safety and activity profiles of the final actives. Production facilities using this intermediate must demonstrate precise documentation and adherence to critical Good Manufacturing Practice environments. Industry compliance standards
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2. Agrochemical Active Intermediate (Triazine and Pyrimidine Herbicides)Major agrochemical producers use this chlorinated pyrimidine in the synthesis of modern herbicidal actives and selective crop protection agents. The compound’s reactivity in nucleophilic aromatic substitution reactions allows for diverse herbicide scaffold development, essential to addressing resistant weed species. Quality requirements center on minimization of specific trace impurities that can carry over into environmental assessments. Industry compliance standards
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3. Veterinary Drug IntermediateAnimal health manufacturers use this compound as a raw material for veterinary pharmaceutical actives, especially where stable heterocyclic cores yield strong bioactivity and metabolic stability in livestock medications. The purity and control of side products are crucial, since veterinary APIs often undergo different downstream analytics than human pharmaceuticals but still require country-specific residue studies. Industry compliance standards
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4. Advanced Material Synthesis for Electronic ChemicalsTriazine and pyrimidine derivatives based on this compound are integral to the creation of specialty fine chemicals used in the electronics industry, including photoresist additives and charge-transport materials. Stringent control over trace metal and halogenated byproducts is necessary, as even minor impurities can disrupt device-layer uniformity and performance. Materials-grade certification is required for entry into chip manufacturing and printed circuit board materials supply chains. Industry compliance standards
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Our team has handled the synthesis and scale-up of 2-Chloro-4-Dimethylamino-6-Methylpyrimidine across several projects for pharmaceutical and chemical industries. We start from raw materials sourced for consistency. We use these not because it’s convenient, but so the entire downstream batch remains dependable from gram scale through multi-ton production. Our plant leans on decades of process data to keep chloride levels, water content, and residual solvents in check, batch after batch. Recrystallization, filtration, and purification steps follow strict, real-world workflows our chemists have refined through years of repetition and adaptation.
2-Chloro-4-Dimethylamino-6-Methylpyrimidine isn’t just another pyrimidine. The methyl group on the 6-position shifts reactivity for many nucleophilic substitutions. This isn’t a trivial molecular tweak: putting that methyl on the ring creates new handles for drug designers. From our experience working with medicinal chemists at the bench and on the plant floor, reactions involving this compound can open scaffold rearrangements or side-chain extensions that standard pyrimidines just can’t manage under realistic conditions. The chloride at the 2-position offers further avenues for substitution, especially in heterocyclic expansion and building block assembly.
Most of our clients operate in drug synthesis, with a smaller group working in fine chemical intermediates. Over the past year alone, several pharmaceutical teams have used this molecule to create dihydropyrimidine-based motifs—key steps for making new antiviral and anti-inflammatory agents. Some of these programs require single-digit ppm impurity profiles, and our production matches those requirements through process validation and repeated round-table troubleshooting. We have worked closely with in-house and partner R&D units to understand which contaminants affect their chemistry, so tailored purifications get rolled out ahead of time. Not every application looks the same: some pipeline projects require chlorination at the 2-position to remain untouched, while others use it as a leaving group. From large batch syntheses to high-purity, smaller lots, adapting isolation, drying, and storage methods remains an everyday task.
Compared with unsubstituted pyrimidines, the addition of the dimethylamino group at the 4-position changes the polarity, solubility, and electronic balance of the ring. We see firsthand how solubility profiles shift in acetonitrile, DMF, and other polar aprotic solvents—a change that often determines reaction speed and process patience. Unlike many other halogenated pyrimidines, 2-Chloro-4-Dimethylamino-6-Methylpyrimidine does not require toolkit expansions for chromatography or isolation; most purification trains can still use standard silica gel systems, which makes it popular among synthetic teams focused on scale and cost.
Some molecules need special glass or inert storage. Our product maintains shelf stability in double-bagged, HDPE-lined drums for routine handling. Employees at the plant routinely monitor for trace hydrolysis—a constant threat with this class of heterocycles—so real stability data gets gathered as batches mature on the shelf. By watching samples over months, we report the actual shelf life, not a hypothetical estimate. This feedback cycle—successful or not—translates to our handling protocols and shipment packaging, not just in the lab but deep in our logistics pipelines.
Not all projects need the same impurity tolerances. Our repeat procurement over the last five years comes largely from teams seeking both technical-grade and high-purity lots. We have had to design parallel quality systems to output both, because downstream needs for pharmaceutical actives and for industrial intermediates differ. Feedback from the floor—what works or fails in the next synthetic step—guides our lot acceptance, not just paperwork or spec sheets. In a recent case, one customer’s acidic work-up was sensitive to a minor oxidized impurity; a simple tweak in our crystallization regime cut the impurity below lab detection. That approach saves yields, reduces waste, and saves researchers time and frustration.
Real-world manufacturing involves more than checked boxes—it’s about controlling what happens day and night, shift to shift. Batch records, careful solvent recovery, and in-line testing keep the process tuned. Equipment maintenance isn’t just a chore; every agitation curve, every temperature probe feeds back into next week’s production. Our most experienced operators, some with nearly 20 years on the same equipment, know how to spot the early warning signs: sediment in the reactor, color shifts that mean an incoming raw material lot isn’t right. Whenever a run falls outside target, we troubleshoot root causes with the technical team and fix procedures upfront, merging best practices with what the plant floor really faces. That’s how process reliability grows over time, not overnight.
Chemists sometimes ask how this product compares with 2-Chloro-4,6-Dimethylpyrimidine or 2-Chloro-6-Methylpyrimidine. The position and choice of the dimethylamino substituent matter in reactivity and stability. The N,N-dimethylamino group at the 4-position draws electron density differently, shifting nucleophilic attack preferences. Regulators reviewing new molecules for Investigational New Drug (IND) filings know these electronic fingerprints, so avoiding cross-contamination or lookalike impurities from similar analogues forms part of our cleaning protocols. Our plant swaps between similar heterocycles regularly; we document every switchover to prevent mix-ups, and our teams get cross-trained specifically for this kind of careful operation.
Pharmaceutical innovation can stall over bottlenecks at the manufacturing level, not just the drawing board. Several clients presented us with late-stage scale-up obstacles for new antiviral scaffolds built on 2-Chloro-4-Dimethylamino-6-Methylpyrimidine. Real-world process guidance helped them jump from grams to hundreds of kilograms, dialing in filtration times, mixing rates, and endpoint detection. Our manufacturing staff’s regular communication with outside chemists, even sharing near-real-time process samples, has repeatedly shaved weeks off iterative optimization cycles. We believe in saving time and raw material waste through these close partnerships.
Chemical manufacture brings serious waste concerns. We design our process streams for reduced chlorinated side-product formation and solvent recycling wherever possible. We re-use process mother liquors after solvent stripping and careful monitoring, ensuring new batches stay within quality control limits. Regular audits, local and international, challenge us to track every kilogram of input and output. The solvents used in the process—mainly acetonitrile, dichloromethane, and a few others—get reclaimed, condensed, and reused through a closed-loop solvent distillation system we established in 2020. Our team’s hands-on maintenance of these systems—pulling columns, replacing seals—means every bit of solvent saved stays out of disposal and keeps batch costs in check. Energy use and emissions don’t vanish, but persistent effort makes real improvements.
Every few months, a new challenge crops up—a stuck filter, a slow reaction, a contaminant that slips into an otherwise perfect run. Instead of sticking to the manual, our senior plant operators call in process engineers for impromptu reviews, walking the floor, smelling, listening, and sometimes feeling for process irregularities. That practical sense, developed from years on the same lines, prevents more batch failures than any form or checklist can spot ahead. By combining process data with operator know-how, we close loops on issues quickly and share solutions across all shifts, not just management or quality units.
Research timetables rarely match manufacturing cycles. Over several years, customers have approached us with tight timelines or sudden surges in demand—both major pharmaceuticals and contract research organizations scaling up candidate molecules. Our planning team queues up reserve capacity to handle these swings, and flexible batch sizes let both start-ups and large firms draw from the same reactors and experienced team. Real flexibility doesn’t end at lot sizes—it means our team’s deep technical familiarity with every intermediate, ability to tweak drying times, and willingness to split shipments according to evolving customer demand.
Shipping 2-Chloro-4-Dimethylamino-6-Methylpyrimidine, especially across borders, places a premium on product traceability and packaging. Our logistics group tracks every lot from drum filling through to customs clearance, building documentation that meets not just minimum standards, but the practical questions customs and auditors raise. Each drum, each intermediate sample, follows a clear chain—real people at every step track batches by hand and digital system, bridging the gap between plant floor and regulatory filing. Some destinations require stability data, customs declarations for chemical libraries, or extra labeling; our QA and logistics teams handle these without delay or confusion, thanks to steady experience and regular debrief meetings with shippers.
Too often, chemical users get stuck with mismatched product grades, solvent residues that damage sensitive chemistry, or mystery impurities that only appear after scale-up. We regularly hear from frustrated customers looking for a reliable primary source—one that stands behind the actual manufacturing, not just paperwork. Our plant’s open-door policy encourages customer audits and process tours; nothing replaces the perspective gained by seeing actual equipment, operator expertise, and safety setups. Where early-stage customers spot new problems, joint investigations get organized on short notice, and everyone involved shares credit for solutions.
Batch certification by itself isn’t the goal. We look to constant adaptation—modifying crystallization protocols, rethinking storage setups, and revisiting analytical methods. Some new clients have introduced us to application-specific needs, like protection from trace amines or faster dissolution rates for high-throughput screening decks. Our analytical chemists develop new methods in response, sometimes overnight, to match these needs. By documenting every cycle of feedback, alteration, and improvement, we turn ad hoc fixes into better long-term operations for all future batches.
Few customer relationships run smoothly from the start. Adjustments in purity, drum size, or container type pop up unpredictably, often mid-project. Skilled customer support means more than just taking orders; it means regular check-ins, open troubleshooting, and redesigning delivery routines when schedules shift. Trust builds through this continual conversation—where feedback from both sides makes the product fit better with the evolving project aims, from pilot synthesis up to clinical or commercial scale.
Making and supplying 2-Chloro-4-Dimethylamino-6-Methylpyrimidine for high-value applications means more than just following the specs: it’s the accumulated practice of dozens of operators, chemists, and planners doing the job together over years. Each batch, each delivery, tells the story of training, discipline, and real openness with customers looking to innovate or upscale. The difference is visible—repeatability, transparency, and a product that supports not only stable chemistry, but also the confidence of every researcher and production line that relies on genuine, traceable material.
