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HS Code |
353657 |
| Chemical Name | 2-Bromoethyl Ethyl Ether |
| Cas Number | 592-09-6 |
| Molecular Formula | C4H9BrO |
| Molecular Weight | 153.02 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 117-120°C |
| Density | 1.287 g/mL at 25°C |
| Refractive Index | 1.4428 at 20°C |
| Flash Point | 28°C (closed cup) |
| Solubility | Insoluble in water; soluble in organic solvents |
| Smiles | CCOCCBr |
| Ec Number | 209-724-0 |
As an accredited 2-Bromoethyl Ethyl Ether factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle, 100 mL, tightly sealed with a screw cap, labeled with hazard warnings and chemical information for 2-Bromoethyl Ethyl Ether. |
| Shipping | 2-Bromoethyl Ethyl Ether should be shipped as a hazardous material, in accordance with local and international regulations. It must be packed in tightly sealed, chemically resistant containers, clearly labeled, and protected from heat, moisture, and incompatible substances. Ensure packaging minimizes leaks or breakage, and include appropriate hazard documentation during transport. |
| Storage | 2-Bromoethyl ethyl ether should be stored in a cool, dry, and well-ventilated area, away from sources of ignition, heat, and direct sunlight. Keep the container tightly closed and compatible with the chemical’s properties. Store separately from oxidizing agents, acids, and bases. Proper chemical labeling and secondary containment are recommended to prevent leaks or spills. |
Applications of 2-Bromoethyl Ethyl Ether in Industrial ManufacturingAs a direct manufacturer, we supply 2-Bromoethyl Ethyl Ether for controlled use in downstream industrial processes. The following sections detail authentic, regulated sectors integrating this intermediate, each with explicit technical and compliance requirements for real-world compound development and production. 1. Active Pharmaceutical Ingredient (API) SynthesisPharmaceutical companies utilize 2-Bromoethyl Ethyl Ether as a key alkylating agent during multi-step API synthesis, mainly for introducing ethoxyethyl groups into heterocyclic scaffolds or aromatic rings. Process engineers carefully control addition in closed systems to limit impurities and maintain product quality, as specified in batch records and validated protocols. The material is strictly handled under validated cGMP conditions for route-specific derivatizations essential in CNS agents, oncology drugs, and contrast media production. Industry compliance standards
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2. Agrochemical Intermediate Manufacture2-Bromoethyl Ethyl Ether functions as an electrophilic reactant in the production of advanced intermediates for herbicides and selective fungicides. Downstream users, such as crop protection companies, introduce this ether in controlled-alkylation protocols where selective activation of halogenated intermediates is crucial for efficacy and regulatory residue compliance. The chemical is supplied in accordance with batch registration data tied to agricultural regulatory authorities. Industry compliance standards
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3. Specialty Polymer Cross-Linking AgentManufacturers of specialty polymers and resins employ 2-Bromoethyl Ethyl Ether as a cross-linker to modify the physical and chemical characteristics of synthetic resins and block copolymers. During polymerization, technicians introduce the ether in carefully monitored, solvent-free processes designed for technical applications like ion-exchange membranes and electronic encapsulants. Exact addition protocols depend on required functional group density and downstream curing specifications. Industry compliance standards
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4. Fine Chemical Synthesis for Dye ManufacturingProducers of performance dyes and organic pigments use this material to introduce ethoxyethyl side chains, which improve solubility and fabric affinity. Dye synthesis lines employ sealed system addition to avoid moisture introduction, optimizing ether incorporation during substituted aromatic nucleophilic substitution. Quality departments monitor input ratio to control shade and fastness properties, working in strict alignment with end-user textile and plastics specifications. Industry compliance standards
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5. Laboratory Scale Custom SynthesisChemical R&D institutions and contract labs engage 2-Bromoethyl Ethyl Ether in gram- to kilogram-scale syntheses for medicinal chemistry, reference standard preparation, or SAR optimization development. Integration protocols always track via electronic lab notebooks, with real-time hazard communication for laboratory PPE and engineering controls. Documentation and lot traceability are maintained for synthesis reproducibility and downstream analytical qualification. Industry compliance standards
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Years of hands-on chemical manufacturing guide every batch we produce of 2-Bromoethyl Ethyl Ether—CAS: 4043-61-8, C4H9BrO. Genuine experience, not marketing hype, underpins the way this product rolls out of our reactors. Nearly every stage on our floor shapes its colorless appearance, faint ether-like scent, and tight assay standards. We configure each lot to deliver the reactivity and purity needed by organic synthesis labs, custom intermediates producers, and process engineers chasing efficient builds.
Our teams never treat chemical manufacturing as copy-paste science. 2-Bromoethyl Ethyl Ether is one of those intermediates where margins matter. The main route we follow, based on bromoethanol and ethylating agents, carries a simple idea: minimize side reactions, trap moisture, dial in the right reflux time. Our technical group monitors each distillation run to ensure that bromide content, refractive index, and density all line up. The physical outcome: a clear liquid, stable at room temperature, and loaded for quick use in alkylation or etherification projects.
Unlike the generic ether blends some traders bring in, what flows out of our columns is measured, confirmed, run through a battery of tests. Water content sits at typically less than 0.1%. Bromine purity gets checked before we ever think about forward integration. Each time we drop production temperature a hair, condensation can change rates, so our staff stays vigilant against unexpected color shifts or residue buildup.
Few compounds demand as much attention to small detail as 2-Bromoethyl Ethyl Ether. We target a minimum purity of 98%, most often in the upper 99% band, checked by GC with standards archived from our earliest pilot runs. Boiling range (almost always between 110°C and 113°C at atmospheric pressure) becomes a regular checkpoint to ensure downstream processes don’t suffer surprise deviations.
When weighing and filling, staff check for absence of halogenated side products. Our manufacturing history taught us that even minor traces of dibromo or diethyl ether muddle selectivity. Every bottle gets headspace analysis during QA to screen volatile residue. No step goes ignored; if the refractive index falls even two points outside our figure (n20D ~1.445), we halt drums and run checks.
Our clients don’t just want a bottle of liquid—they want reaction reliability, clean conversions, and process repeatability. In the lab, 2-Bromoethyl Ethyl Ether gets chosen for its role as a selective alkylating agent, where it bridges the gap between reactivity and mildness. The bromine atom on the ethyl shaft makes it more reactive than simple ethers for nucleophilic substitutions, yet less aggressive than many halides. Customers scale up pharmaceutical syntheses, dye precursors, and crop-protection intermediates confident that they’ll see fewer unwanted byproducts.
Practical stories echo across our order lines—a kilo of 2-Bromoethyl Ethyl Ether setting off a smooth Williamson ether synthesis, with downstream distillation showing a single tight boiling fraction, not the multiple tails and heads that can result from poorly purified stocks. University research labs regularly confirm that yields match literature standards, thanks to our strict byproduct limits.
From glassware to kilo-scale reactors, this ether slips into protocols that cannot tolerate high moisture or oxidizing agents. Any water left in-feed means hydrolysis and decomposition, so our moisture controls aren’t just box checks—they’re promises kept batch after batch. Delivery times matter; minimal lag between production and shipment means a fresher reagent, which often translates directly to higher reaction efficiency at customer sites.
Chemical work runs on precision and variability, and people ask every quarter—why choose this product over similar reagents? The closest benchmarks usually fall into two camps: other bromoalkyl ethers and concepts from the chloroethyl group. 2-Bromoethyl Ethyl Ether stands out for several reasons learned in practice.
First, compared to 2-chloroethyl ethyl ether, the bromo analog reacts faster in most substitution and alkylation reactions. The leaving group ability of bromine outpaces chlorine, which means users can often lower reaction temperatures or shorten times. In complex synthetic schemes, this flexibility can be the difference between pass and fail for a project on tight timelines.
Compared to simple ethyl ethers, the bromoethyl variant offers a step up in functional group installation. Plain diethyl ether may act as a solvent, but without a reactive halide, it never fits in as a true intermediate. 2-Bromoethyl Methyl Ether comes up in comparison as well. Based on trial runs and feedback, the ethyl analog tends to show better volatility control in fractional distillations, which users prefer when working under reduced pressure.
Truth learned on the floor: your yield, selectivity, and waste all flow from the initial purity and the presence or absence of side products. Where cheaper imports skimp on post-reaction cleanup, our fully integrated system cuts off tail fractions and ejects colored residues before packing. This isn’t just about best practices for their own sake. Our return customers—pharma, ag chem, and polymer researchers—point directly to lower re-analysis rates, fewer batch failures, and less need for repeat syntheses.
Consistent product isn’t an accident. At the start of every lot, the team reviews not just specifications, but the underlying process design. A controlled feed rate for ethylating agent, rigorous exclusion of air, and immediate removal of byproduct hydrobromic acid—these aren’t just stepwise instructions, but lessons learned from cleanup jobs when earlier runs went off track.
Plant managers watch for runaway exotherms in the reaction kettle, especially during summer months. Even a small shift in ambient temperature can throw off yields if not caught quickly. Weekly column maintenance schedules and regular calibration of analytical equipment bring confidence to each COA we issue. Most important, our batches never leave production unless they meet agreed point-to-point checks—density, GC fidelity, appearance, halide content, even packaging integrity confirmation.
We learned early that customer complaints often trace back to inconsistent handling—fluctuating storage temperatures, permeable seals, or unlabeled containers. Integrated production, filling, and packing at a single location give us a direct line of sight from reactor discharge to loading dock. Each drum goes out labeled fresh, with shipment documentation pulled straight from QA sign-offs.
Any genuine chemical manufacturer earns their keep by playing it straight about safety and stewardship. 2-Bromoethyl Ethyl Ether doesn’t behave like a solvent you can ignore; it demands care. Vapors release quickly once exposed to the open air. Protective gear isn’t just for show—the liquid acts as an irritant on contact. Splash controls, leak-tight transfers, good ventilation, and effective spill kits matter every single time.
Spills get neutralized and collected—no improvising or dumping down drains. Our teams follow strict air monitoring for bromide content. The plant ventilation system takes airborne exposure down to levels beneath regulatory concern. Waste handling’s another area where expertise pays off; all mother liquors from product workup get pumped to regulated incineration, not diluted and flushed. This isn’t about ticking a box; the next batch depends on a clean work environment.
Our company’s records show a clear downward trend in safety incidents since we installed sealed filling equipment, trained all staff with real accident case studies, and doubled on-site emergency resources. Environmental impact assessments drive us toward closed-loop processes and solvent recovery—buying less, spending less, and minimizing offsite waste. All spent glassware and filters pass through neutralization stations before final disposal.
Research chemists lean into 2-Bromoethyl Ethyl Ether for new route development, late-stage alkylations, and process optimization. We’ve supported projects ranging from chiral ether syntheses to pilot-scale runs for generic APIs. The tighter the purity controls we keep here, the fewer headaches pop up for chemists scaling from grams to kilograms.
Custom reactions sometimes call for modifications—alternative purities, tailored stabilizers, or specialty packaging. Our technical staff spend time on direct calls with users, making sure that test quantities mirror large-lot shipments. Snapshots from our support logs show questions from startups moving to their first five-kilo order, and multinational groups qualifying new intermediates under site audits. Most needed is straightforward info—no marketing shields, just solvent compatibility, material handling, and cleanup advice based on equipment we use ourselves.
We open up production logs, anonymize sensitive IP, and share key process challenges, balancing transparency with confidentiality. If a client asks for batch-specific impurity breakdown, everything’s on record. Real cooperation happens when both sides acknowledge the grunt work behind each successful delivery.
Product quality isn’t static; each quarter brings new improvements. After feedback about pour-out viscosity issues, we added inline filtration immediately before filling, reducing micro-residues. Lowering process emissions took a joint effort between process engineers and safety officers: tighter seals, updated scrubbers, and revamped cold traps cut atmospheric loss without hitting throughput.
The shift to digital batch files trimmed human error. Shop floor teams use tablet-based QC checks, cross-referencing each sample directly against master data. Maintenance logs, calibration records, and even incident reports tie right into product traceability. Any time an issue surfaces—even something as minor as a scratched drum or faint off-odor at point of use—we trace it, fix the root, and modify SOPs for future runs. The bottom line isn’t just compliance, but improvement that pays customers back in product results.
Our engineers stay active in cross-industry working groups, bringing real production data into technical standards development. Participation in roundtables on safe handling, intermediate purity, and sustainable manufacturing comes directly from the experiences gained in making chemicals like 2-Bromoethyl Ethyl Ether correctly, not chasing shortcuts for one-time sales bumps.
Our team learns just as much from customers. Practical case studies—unexpected decomposition during a scale-up, purification challenges in continuous flow setups, stability under variable storage conditions—each story feeds into our next production cycle. Site visits to university labs, pilot plants, and scale-up facilities help us see firsthand where supply pain points occur. These visits push us to refine everything from drum closures to moisture-barrier liners.
By keeping an open door with scientific partners, we tighten up real-world usage data, not just theoretical numbers. This feedback shapes labeling, shelf-life advice, and even process aids for stabilizing 2-Bromoethyl Ethyl Ether during long transit times or tough climate conditions. Each request for improvement gets routed back to our technical staff, driving either practical adjustment or pilot trials on new variants.
People sometimes focus on specs, but reliability in chemical intermediates comes from much more than printed numbers. The narrow control bands for 2-Bromoethyl Ethyl Ether mean nothing if temperature spikes are ignored or transit packaging breaks open. Each drum sent out represents our name, our reputation, and our commitment to long-term partners.
Quick fixes, cheap cuts, and corner-cutting practices always find their way back in product returns, re-analyses, or lost business. Experience taught us that every quality lapse, no matter how small, feeds a chain of problems—missed reaction yields, rushed repurchases, even whole campaign failures for end users.
In our view, a chemical intermediate succeeds only when it works batch after batch, across different customers and climate zones, standing up to whatever warehouse, dock, or laboratory conditions it lands in. That’s the return on investment—years of knowledge built into every liter, process, and safety sheet, and the direct connection between the floor staff who make it, and the scientists who create value from it.
As demand for cleaner processes, higher purity intermediates, and sustainable production climbs, we’re not standing still. Upgrading analytical labs, testing lower-impact synthesis routes, and reducing energy consumption by incremental design tweaks make better chemistry with every passing year. Feedback from universities, contract manufacturers, and multinational buyers sharpens focus for our capital spending; more automation, more traceability, and even tighter emission standards.
Our lessons with 2-Bromoethyl Ethyl Ether carry forward to the next generation of chemical intermediates—proving that real, sustained investment in people and processes beats empty marketing. Every day, our plant teams, QA group, and technical staff line up with one shared priority: create materials that work, that last, and that push the bar for quality in real-world chemistry.
What’s made in these tanks and reactors connects directly to thousands of downstream innovations—new drugs, advanced polymers, next-generation electronics. By keeping production grounded in hands-on expertise and real accountability, 2-Bromoethyl Ethyl Ether stands as a quiet, reliable cornerstone of modern chemical manufacturing, ready for the next breakthrough or challenge ahead.
