| HS Code | 511356 |
| Iupac Name | 1-Hydroxycyclobut-1-ene-3,4-dione |
| Molecular Formula | C4H2O3 |
| Molar Mass | 98.06 g/mol |
| Cas Number | 4963-03-7 |
| Appearance | Solid (exact color may vary) |
| Melting Point | Decomposes above 70°C |
| Solubility In Water | Slightly soluble |
| Structure Type | Monocyclic (cyclobutene) with hydroxy and keto groups |
| Smiles | O=C1C(=O)C=C(O)C1 |
| Inchi | InChI=1S/C4H2O3/c5-2-1-4(7)3(2)6/h1,7H |
As an accredited 1-Hydroxycyclobut-1-Ene-3,4-Dione factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | The packaging is a 25-gram amber glass bottle with a secure screw cap, labeled with hazard symbols and detailed chemical information. |
| Shipping | 1-Hydroxycyclobut-1-ene-3,4-dione should be shipped in tightly sealed containers, protected from moisture and light. Handle as a potentially hazardous chemical, using appropriate labeling and documentation. Transport under controlled temperature, compliant with local and international regulations for laboratory chemicals. Ensure all packaging prevents leaks or accidental release during transit. |
| Storage | **1-Hydroxycyclobut-1-ene-3,4-dione** should be stored in a tightly sealed container, protected from light, moisture, and sources of ignition. Store in a cool, dry, well-ventilated area, away from incompatible substances such as strong bases and oxidizing agents. Proper chemical labeling, secondary containment, and access only to trained personnel are essential for safe storage. |
As an advanced producer of specialty diketone intermediates, we supply 1-Hydroxycyclobut-1-Ene-3,4-Dione for critical roles across high-value manufacturing sectors. Our deep integration with downstream processors ensures that material quality, batch consistency, and regulatory compatibility meet evolving application standards globally.
Pharmaceutical innovators incorporate this unique cyclobutenedione as a scaffold in synthesizing novel small-molecule drugs. Its strained ring and dual carbonyl groups facilitate regioselective modifications during lead compound optimization and route development. Chemists exploit the reactivity in key steps for constructing antiviral, anticancer, and CNS-active molecules, especially where chemoselective cyclization or ring contraction pathways are essential. Material purity, trace metal content, and polymorphism influence downstream reproducibility, impacting both preclinical and clinical batch integrity.
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Colorant manufacturers utilize its reactive diketone group in the synthesis of fused-ring pigments and functional dyes. The cyclobutene core enables tuning of chromophore geometry and shade by controlled condensation and coupling reactions. Process chemists prioritize color purity, thermal stability, and lightfastness, achieved through rigorous stoichiometric control and solvent management. End formulations maintain strong batch reproducibility for demanding applications in coatings and advanced plastics.
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Producers of specialty fluoropolymer materials leverage this diketone as a precursor for high-efficiency crosslinking additives. The strained ring architecture reacts with fluorinated co-monomers during melt processing, enhancing cure rate and end-use thermal stability. This integration supports advanced composites for electronics, wire insulation, and chemical process equipment. Process quality controls focus on precise stoichiometric feed, batch mixing uniformity, and minimization of residual acids.
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Agrochemical manufacturers select this cyclobutenedione intermediate in the design of selective herbicides and fungicides. Its versatility in nucleophilic additions and ring transformations enables the construction of heterocyclic pharmacophores essential for next-generation crop protection compounds. Quality assurance procedures ensure lot traceability, low residual solvents, and single-digit ppm impurity control for environmental registration.
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Producers of advanced organic semiconductors and dielectric resins integrate this diketone to build high performance molecular frameworks for OLEDs, OFETs, and printed electronics. Its electron-deficient ring supports donor-acceptor architecture fabrication, modulating charge transport and film-forming properties in thin-layer devices. Consistent composition, ultra-low trace metal content, and validated solubility enable precise layer deposition for demanding optoelectronic specifications.
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Competitive 1-Hydroxycyclobut-1-Ene-3,4-Dione prices that fit your budget—flexible terms and customized quotes for every order.
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From the earliest days in this lab, synthesizing specialized building blocks for organic synthesis has always felt equal parts challenge and art. When our chemists first reported success scaling up preparation of 1-Hydroxycyclobut-1-ene-3,4-dione, the genuine excitement was hard to hide. This molecule’s strained cyclobutene core and reactive diketone motif make it a stand-out intermediate for those exploring novel heterocycles, complex ligand design, or push-pull motifs. We’ve seen research groups push its boundaries, and in turn, the demand from process chemists seeking materials that can enable routes previously shut off by lack of reagents or poor selectivity.
We don't just talk purity—we keep analytical data tight, batches consistent, and maintain inventory so synthetic planning doesn’t get thrown off by supply. Our most requested format brings 1-Hydroxycyclobut-1-ene-3,4-dione at >98% purity, white to pale-yellow crystalline solid, tightly sealed to prevent hydrolysis, stored and shipped under refrigeration. We ship lab-scale packs for gram-quantity method development, and for pilot plant needs, our process lines produce kilogram lots with comparable quality controls.
Water content rarely surprises anyone working with small, sensitive diketones, but what many first-time users discover is just how much a touch of moisture can drag down the yield on downstream chemistry. That’s why we take water analysis, trace metal content, and residual solvent testing straight into our batch release checks. Over time, our focus on in-house purification methods let us shave down those trace contaminants that sometimes crop up from old glassware or drafty cleanrooms.
Even fine crystal size control matters for lab technicians and plant engineers calculating solubility curves. Loose powder lingers in the air; we encourage slow crystallization to get more manageable grains, cutting down loss and reducing static charges during transfer. Our packaging teams put time into feedback from bench chemists, so even such details as tamper-proof caps, argon headspace, and straightforward reconstitution protocols sprang up in answer to actual pain points.
We’ve often joked that if anyone tries to pin 1-Hydroxycyclobut-1-ene-3,4-dione to a single application, they’re missing the best part. This compound attracts method developers aiming to exploit ring strain for cycloadditions, photochemical rearrangements, or nucleophilic openings that stall using more rigid or less reactive scaffolds. More than once, we’ve fielded questions from postdocs who’ve mapped out divergent synthetic plans, starting with this single small ring. Its ketone and enol features pop with reactivity—both a blessing and a challenge when chasing selectivity.
What we notice most is how this molecule helps unlock otherwise inaccessible motifs, whether for specialty fine chemicals, materials science, or advanced ligands. The cyclobutene structure is rarely stable, let alone functionalized like this. Epimerization worries are less severe than with some chiral diketones, giving research teams confidence for scale-up.
We’ve tracked published projects that take advantage of the conjugation possibilities with this dione system. Late-stage functionalization, transition metal-catalyzed couplings, and synthesis of bridged or fused ring arrays—these have all traced their roots to chemists exploring cyclobutene dione’s utility in the lab. Drug discovery screens and photoinitiator design also occasionally make this one a key substrate. The decision to invest in further process R&D came straight from customer feedback and seeing repeat orders not just from academia but from several pilot facilities bringing new applications to patent stage.
Many chemists new to strained ring systems expect handling to feel much like working with more common open-chain or six-membered ring analogues. The reality, as we’ve seen in workflow after workflow, is that 1-Hydroxycyclobut-1-ene-3,4-dione reacts more rapidly and can support cascades other cyclic diketones can’t. Its unique structure combines a four-membered cyclobutene (prone to ring opening or cycloaddition) and vicinal diketone positions, so it enters into reactions that simply stall with other diones.
Compare this compound with 1,2-cyclobutanedione or 2,3-butanedione: the ring strain, positioning of the double bond, and potential for keto-enol tautomerism bring distinctly different reactivity. Epoxic cyclobutene derivatives and classical blue diketones fall short in terms of versatility, especially when seeking to insert new heteroatoms or induce ring expansion under mild conditions.
Several groups working on natural product analogues and supramolecular scaffolds have stated that access to the cyclobutene core using other approaches led to multi-step, low-yield routes, with purification bottlenecks and lingering side products. 1-Hydroxycyclobut-1-ene-3,4-dione arrives as a ready-to-go unit, saving weeks or even months of lead time for targeted molecule construction. This allows researchers to skip harsh oxidative steps or protection/deprotection sequences that often haunt syntheses based on simpler dione reagents.
Another aspect that surfaces frequently: the difference in safety profiles. Cyclobutene systems tend to be more volatile and sensitive than their saturated counterparts, yet the hydroxy-dione is stable enough under cold storage to permit meaningful scaling. Our packaging design and safety sheets derive directly from user feedback—over-ground jars and poorly vented stoppers caused headaches before we tightened up procedures to match the molecule’s quirks.
Some process chemists compare this compound to maleic anhydride or phthalic anhydride for certain [4+2] cycloadditions. In practice, our users found 1-Hydroxycyclobut-1-ene-3,4-dione can support milder, shorter reaction cycles, preserve delicate functional groups, and avoid downstream waste complications. This becomes crucial in pharmaceutical intermediate development, where green chemistry goals, yield optimization, and cost transparency have become more and more intertwined.
Early scale-up attempts, like many specialty chemicals, hit more than a few snags. Vapor pressure fluctuations led to product loss if atmospheric controls were lax, so we reworked how we controlled drying and packing lines. Crystalline product that clumped in earlier drums went straight back for reprocessing—since then, we’ve adopted an internal sieve-and-blend procedure.
Solubility sits higher in acetonitrile, acetone, and some ether solvents than in alcohols or water. That caught a few seasoned chemists by surprise, so we include a solubility chart with each pack, updated as we test new lots. Scaling also brings consistency challenges; trace organics from previous runs can carry over without batch-specific glassware management, a lesson learned after a few customer complaints and some hard looks at root-cause analyses.
Team experience shows that the molecule tolerates cooling and gentle warm-up cycles, but repeated warming worsens color. Investigation traced this to slow side reactions with steam or room-air handling, particularly in regions with elevated humidity. Now, most orders ship with ice packs and optional inert gas headspace kits, helping remote site users manage the compound without constant cold room access.
Our QA leads spend time each year reviewing every complaint, suggested tweak to isolation strategy, or hint about shelf-life shifts. This isn’t about hitting a “spec” for the sake of paperwork. Reliable batches mean faster synthesis downstream, less hands-on troubleshooting, and longer bench stability. Full traceability on source chemicals and reaction logs avoids any ambiguity, especially as regulatory scrutiny grows in both North American and European labs.
Over the past decade, more research teams have adopted a modular approach to molecule building. Rather than forcing older routes onto new targets, smart chemists choose building blocks with maximum divergent potential. 1-Hydroxycyclobut-1-ene-3,4-dione offers those jump-off points. Its structure allows easy grafting of functional groups via nucleophilic or electrophilic pathways, then supports further elaboration into spirocycles, photoreactive moieties, or even metal-chelating ligands.
Groups in organic electronics mention successful polymerization starting from this compound, linking small ring tension to improved charge transport features. Not every building block opens such doors. The subtle balance between stability and reactivity, honed by tweaking process parameters over dozens of production cycles, means we can support those pursuing both fundamental science and industrial application.
Having witnessed the pain points of supply chain disruptions—recalls, split batches, customs delays—we maintain both domestic and international stock. Supply instability has derailed too many syntheses for too many teams. Every delivery puts us right in the thick of ongoing research, project deadlines, and downstream innovation. Our batch records, COAs, and analytical reports build trust by making every lot traceable and repeatable.
Users demand more than a pure compound. Over a hundred user interviews and feedback forms point to pain points beyond purity and yield. Small changes—better lot documentation, easier label readability, comprehensive impurity disclosures, improved resealability—grew out of real frustrations ordinary chemists encountered at the bench. Roll these up, and it creates confidence to scale experimental reactions, not just theoretical ones.
We’ve invested in direct technical support. If a team struggles with unexpected behavior in scale-up, batch reactivity, or crystallization, our synthetic chemists field the call, drawing directly from our own process logs and production tweaks. As one bench chemist put it, the difference is being able to “call someone who’s made a few dozen kilograms of this, not just sold it out of a catalog.” That hands-on expertise, born of sweaty pilot runs and late-night purification troubleshooting, forms the core of our user guidance.
Analytical support also grows more sophisticated each cycle. Historically, NMR and HPLC were enough. Increasingly, teams want LC-MS traces, solvent residual panels, and even enantiopurity breakdowns, although this compound itself doesn’t introduce stereochemistry in its purest format. We’ve responded by integrating these assays into our QC workflow—backed by scale-up experience, not just theoretical benchmarking.
Nothing teaches faster than seeing what real users have published and patented. In recent years, 1-Hydroxycyclobut-1-ene-3,4-dione has powered projects in synthetic methodology, natural product analogues, and high-throughput screening libraries. Whether used to construct rare cyclobutane rings with embedded oxygen functions or as a scaffold for photochemical switches, each user finds a slightly different angle.
Polymer chemists tap into fast, controlled cross-linking runs, thanks to the dione’s high reactivity. Ligand designers stretch its chemistry toward modular attachment, exploiting differences in nucleophile addition rates over its dual carbonyls. We’ve seen it incorporated into the core of new fluorescent markers—unexpected directions sometimes come from materials science collaborations who chase rare ring topologies for charge transport.
Ironically, what sticks with us most is troubleshooting with teams who step into uncharted mechanisms: ring strain triggers pathways that remain closed to open-chain analogues, and its ketone/hydroxy groups balance reactivity that would otherwise fragment. By staying close to the core chemistry, adapting process tweaks, and investing real time into customer partnerships, we see not just what the molecule is, but what it makes possible in the hands of inventive chemists.
We built our entire business not just by supplying molecules, but by constantly learning from users—their triumphs and setbacks shape our own process evolution. Every crystallizer cleanout, every failed batch, every customer call about a surprise in their final product, has been a lesson. The fact is, specialized reagents reward those who understand their unpredictability and listen to every scrap of data, every complaint.
Our experience manufacturing 1-Hydroxycyclobut-1-ene-3,4-dione has made it clear that excellence depends on more than hitting technical specs. It demands a loop of observation, adaptation, and direct partnership, from gram to kilogram scale runs. The journey isn’t just about getting product out the door, but making sure each lot stands up to scrutiny—because what our users build with it is where real innovation happens.
