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HS Code |
162897 |
| Product Name | 1,1,3,3-Tetrachloroacetone |
| Cas Number | 513-23-1 |
| Molecular Formula | C3H2Cl4O |
| Molecular Weight | 197.86 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Boiling Point | 129-132 °C |
| Melting Point | −4 °C |
| Density | 1.573 g/cm3 |
| Refractive Index | 1.479 |
| Flash Point | 66 °C |
| Solubility In Water | Slightly soluble |
| Purity | Typically ≥98% |
| Smiles | ClC(C(=O)C(Cl)Cl)Cl |
| Inchi | InChI=1S/C3H2Cl4O/c4-1(5)3(8)2(6)7/h1-2H |
As an accredited 1,1,3,3-Tetrachloroacetone factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | Amber glass bottle containing 100 grams of 1,1,3,3-Tetrachloroacetone, tightly sealed with a chemical-resistant cap, labeled appropriately. |
| Shipping | 1,1,3,3-Tetrachloroacetone should be shipped in tightly sealed, corrosion-resistant containers and clearly labeled according to hazardous material regulations. Transport must comply with local, national, and international regulations for toxic and corrosive substances, with appropriate safety documentation and emergency procedures. Avoid exposure to heat, moisture, and incompatible materials during transit. |
| Storage | **1,1,3,3-Tetrachloroacetone** should be stored in a tightly closed container, in a cool, dry, well-ventilated area, away from incompatible substances such as strong oxidizing agents and bases. Protect it from light, moisture, and sources of ignition. Properly label the storage container and ensure that safety showers and eyewash stations are easily accessible nearby. |
Applications of 1,1,3,3-Tetrachloroacetone in Industrial ManufacturingAs a specialized manufacturer with a long-standing focus on halogenated ketones, we supply 1,1,3,3-tetrachloroacetone for strictly defined industrial applications where its unique chlorinated structure provides controlled reactivity and distinct process outcomes. Below, we present core downstream scenarios in which our material is consistently utilized, alongside detailed parameters critical for success in high-value segments of the fine chemical industry. 1. Agrochemical Intermediate SynthesisChlorinated acetones serve as building blocks for the synthesis of specific crop protection actives, particularly for the construction of pyridine, triazole, and phenol derivative intermediates. Major agrochemical producers incorporate our product during early-stage condensation or acylation reactions, favoring high reactivity and selective halogen introduction for subsequent ring closure steps. Product purity and impurity profiles must meet downstream risk assessments for registration under global standards. Industry compliance standards
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2. Pharmaceutical Fine Intermediate ManufacturingThis material is frequently used by pharmaceutical custom synthesis operations for the manufacture of advanced intermediates, where its strong electron-withdrawing effect enables regioselective transformations required in the late-stage assembly of chlorinated heterocycles and azole compounds. The raw material must be validated on-site under strict impurity and trace metal specifications, with full documentation per audit trail for each batch integrated into regulated pharma supply. Industry compliance standards
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3. Specialty Polymer Modifier ManufactureSpecialty resin and polymer houses employ this chlorinated ketone as a reactive chain modifier or crosslinking moiety, particularly within fluoropolymer and speciality acrylic manufacturing lines. The defined halogen pattern enables controlled introduction of cross-linking sites, influencing glass transition and chemical resistance in final polymers. All process batches require in-line verification for halogen residuals according to polymer regulatory limits. Industry compliance standards
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4. Industrial Dye Intermediate PreparationDye and pigment manufacturers incorporate chlorinated acetones for acylation and halogen functionalization of aromatic rings, enabling the synthesis of intermediates for disperse, acid, and specialty dyes. Quality assurance must ensure batch-to-batch reproducibility in reactivity, with close monitoring for unwanted polycondensation byproducts. Compliance focuses on regulatory endpoints for residuals and toxicological safety in colorant supply chains. Industry compliance standards
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5. Analytical Reagents and Derivatization AgentsProducers of laboratory-grade reagents utilize this ketone as a derivatization agent for halogen introduction in both organic analytical standards and chromatography marker compounds. The requirement for trace-level impurity certification is critical, along with conformance to accredited reference material protocols. Usage occurs in the controlled production of high-purity derivatization reagents intended for professional laboratory and regulatory testing. Industry compliance standards
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Competitive 1,1,3,3-Tetrachloroacetone prices that fit your budget—flexible terms and customized quotes for every order.
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Inside the chemical industry, every compound comes with its own story—some span decades, others capture sudden demand spikes after a breakthrough in synthetic processes. 1,1,3,3-Tetrachloroacetone lands in the former category, quietly earning its place in the toolbox of organic chemists and industrial researchers. We produce this specialty reagent at scale, each batch shaped by years of experience handling halogenated ketones. Our familiarity lets us see where its real value lies, why customers single it out for sensitive syntheses, and what sets pure, well-made tetrachloroacetone apart from similar products on the market.
For those walking through a chemical plant, the talk seldom stays theoretical for long. Daily use means your 1,1,3,3-tetrachloroacetone has to hit certain standards or process lines stall out. We offer this compound in industrial and research scales, always aiming for high purity that meets the rigorous expectations of our core customers. Each drum, each smaller bottle gets tested by our in-house lab—the aim is purity above 98%, minimized trace impurities, tight moisture control, and a color profile that signals fresh stock. Lesser grades often sneak in hints of yellowing or odorous notes that seasoned chemists spot right away. Some manufacturers source precursors through less reliable supply chains—our decision to trace each raw material down to its origin keeps the specs tight and consistent from year to year.
Directly from the production floor, the focus lands on crystalline content, melting point, and chlorine load. Our method avoids residues left by sub-par chlorinating agents. You learn fast that even subtle variances in color or trace by-products shift reaction yields in downstream manufacturing, especially when customers run multi-step syntheses that make the by-products harder to separate. Each certificate of analysis draws on actual measurements, not a templated sheet. After years of scrutiny from customers running high-throughput syntheses, we've trimmed back not just the headline figures but also the rarely-discussed minor impurities that can affect scale-ups or regulatory filings down the line.
There’s a divide between how chemical handbooks describe uses and how industrial shops actually run their formulations. In our experience, most buyers for 1,1,3,3-tetrachloroacetone fall into a few clear categories. Research chemists use it as a building block—usually to introduce a polar carbonyl alongside robust chlorine substitution. The molecule sits at a sweet spot: it reacts readily with nucleophiles but avoids wild over-reactivity that would make handling or storage hazardous. Companies working in pharmaceutical intermediates, agrochemical actives, and performance polymers repeatedly request this specific ketone because it slots into complex reaction schemes where alternatives either don’t work or need too many additional protection and deprotection steps.
In production, technicians notice how the two pairs of chlorines provide both steric hindrance and increased electrophilicity at the ketone. When producing α-chlorinated derivatives or advanced enolate chemistry, that specific arrangement opens routes not available through more standard chloro ketones. While some try to substitute with trichloroacetone or 1,3-dichloroacetone in early screening, downstream yields drop or purification creates new headaches. In our own test labs, we’ve watched clients bring in competitive grades, only to face emulsion issues, inconsistent phase separation, or sticky residues in scaffolds that require high stereochemical purity.
We’ve watched this market for years, and real differentiation comes down to consistency and the daily reality of working with sensitive reagents. Some producers simply rebottle and relabel imported or old material. In contrast, our process starts with high-grade raw acetone, run through a controlled chlorination sequence held at precise temperatures and pressure. This isn’t always the cheapest method, but it sidesteps a host of downstream problems—fewer undesired by-products in the bottle means fewer headaches for chemists pushing for reliable output. Side-by-side, someone running a scale-up will spot where other lots fail: suspicious tints, volatile loss, container corrosion, or excessive acidity.
Our in-house containment and transfer systems protect the product from atmospheric moisture and keep the volatile ketone stable through the packaging process. We’ve invested for years in vapor-phase monitoring—ensuring the atmospheric vents on our drums won’t flood with vapor losses that shift the delivered net weight. Any container leaving our warehouse reflects system-wide diligence, not just a batch thrown together to fill a rush order.
In our day-to-day work, questions about substitutions and alternatives come up constantly. While at first glance, 1,1,3,3-tetrachloroacetone looks a lot like trichloroacetone or 1,3-dichloroacetone, detailed handling and synthetic results tell a different story. The quaternary halogenation pattern in our acetone drastically amplifies the electrophilicity of the carbonyl carbon, supporting syntheses impossible or unworkable with weaker chlorinated ketones. This proves crucial for cross-coupling protocols, specialized Michael additions, and many cyclization strategies—routes that cut down on the need for auxiliary protecting groups or super-stoichiometric reagents.
In-house testing shows competing products break down faster or give inconsistent output when subjected to bright laboratory lighting or trace base—even after only brief exposure to the open air. We field technical support calls where teams report differences not only in yield, but in the physical properties of intermediates and by-product spectrum, sometimes days after batch completion. Direct feedback has driven process changes over our years in business—maintaining lot tracking and technical reporting lets us pinpoint and eliminate sources of process variability before they reach the end user.
Laboratories aiming for high-reproducibility syntheses can’t afford unplanned downtime or unreliable inputs. In pharmaceutical and agricultural sectors, regulatory documentation often requests impurity profiles down to single-digit ppm levels, with full traceability for each raw input. We have set up data management and batch tracking systems that tie each kilogram of 1,1,3,3-tetrachloroacetone directly to its source lots and production parameters. This isn’t an afterthought or something tacked on for marketing—after seeing customers turned away during facility audits, we know firsthand how vital end-to-end transparency is for long-term relationships.
Our chemists work directly with clients’ technical teams to troubleshoot reaction issues, diagnose batch-to-batch variation, and decipher unusual NMR or GC-MS signals. Because we run our own analytical work, our feedback isn’t generic—real-world answers to questions about solubility, phase compatibility, or handling anomalies set our business apart. Over the years, we’ve found that many process innovations come not from white papers, but from the conversations that spring up between our team and the chemists actually running kilo lab or pilot plant lines.
In chemical manufacturing, success means not just delivering a product, but keeping the people using it safe. With tetrachloroacetone, volatility, reactivity, and chlorinated by-product formation anchor our approach to packaging and transportation. We use lined steel drums and high-density polyethylene containers suited for halogenated organics. In the plant, closed systems with scrubbers limit fugitive emissions, protecting both workers and the local environment.
Working at scale, we’ve seen how minor leaks and improper containment can spiral into both safety risk and regulatory nightmares. Multiple iterations of our containment design have evolved from years of learning the hard way. Our drum valves and secondary containment trays are selected specifically for the realities of handling tetrachloroacetone, not just generic compatibility charts. We maintain close ties with local emergency response teams, sharing MSDS and technical documentation qualifiers that reflect realistic worst-case scenarios rather than hypothetical risks.
Beyond compliance, we make a point of reclaiming halogenated waste streams and minimizing offcuts from each batch. The cost of proper waste handling affects the bottom line, but the industry’s reputation also depends on not contributing to local contamination issues. Our focus on solvent recycling and controlled disposal comes from firsthand experience with plant closures and fines faced by less careful operators.
There’s an instinct in chemical manufacturing to focus on product specs, but everyday challenges in development come down to trust and real-world troubleshooting. The chemists on our team regularly support customers facing stalled reaction steps or unexplained analytical blips. From guidance on safe blending (especially with nucleophilic bases and amines) to suggestions for phase transfer techniques, we approach each technical call as a chance to improve both our own product and the processes it supports.
Our team participates in collaborative research, both in-house and through partnerships with customers scaling up innovative syntheses. This collective experience creates a living knowledge base—not just for our own teams, but for researchers building the next generation of organic intermediates. Sometimes, the right answer involves modifying process temperature, swapping ligands, or upgrading lab glassware for better containment. Sharing practical advice helps move projects forward faster than any catalog sheet ever could.
In labs and on production floors, minute differences in reagent quality turn into hours lost hunting for the source of inconsistency. We know that clean, reproducible starting material often spells the difference between a single successful run and a reliable multi-year production lineage. Our analytical program combines regular GC-MS, NMR, and titrimetric checks—each batch is summarized in a technical report, not just a template certificate. Any deviation from the norm gets logged and addressed, with corrective actions tracked all the way through our system.
Our quality team tunes protocols based on feedback from technical staff, large-scale users, and pilot project chemists. This loop cuts down on rework, speeds up implementation of new safety and efficiency measures, and builds direct value for the end user. After years working with specialty and fine chemical plants, we recognize that even small changes in key solvents or reaction environments ripple throughout a facility. Our diligence guarantees the chemistry works as planned, day after day.
It’s easy for companies to view halogenated ketones as commodities, but the technical details tell another story. Subtle differences in purity and stability appear magnified over the full run of a drug synthesis or specialty polymer project. We have seen clients face regulatory scrutiny after failing to segregate volatile chlorinated by-products, or fight stubborn emulsions where microtraces of water crept into what should have been anhydrous material. Real solutions come only with production-scale familiarity, a hands-on approach that recognizes the laboratory isn’t separate from the plant—it’s part of a continuous chain.
End-users who demand more than a simple chemical building block drive our team to set a higher bar. The compounds leaving our facility aren’t just another batch in a global logistics chain—they reflect a deeper commitment to reliability, transparency, and technical support. This expectation for quality is shared with every chemist, operator, and logistics hand in our organization.
In specialty chemicals, no process ever really stands still. The needs of formulators, industrial chemists, and regulatory teams shift year by year as new applications and requirements come to the surface. What remains stable is the drive to supply materials that consistently deliver, with predictable properties and minimal surprises along the way. Over the years, we have learned that every investment in process control, documentation, and customer support returns dividends in product performance and client trust.
For 1,1,3,3-tetrachloroacetone, evolving synthesis strategies continue to open new research directions—whether in fine chemical manufacturing, material science, or life sciences. Our technical and manufacturing teams follow developments in reaction methodology, analytical technique, and safety benchmarks, adjusting our production practices to reflect industry best standards. Engaged, detail-oriented dialogue with our customers remains our best source of innovation and greatest guarantee that our product will meet the next generation of technical and regulatory demands.
Through every batch, test, and shipment, our core belief holds: real value in specialty chemicals comes from experience, care, and straightforward technical collaboration. Building long-term relationships with clients means answering hard questions, highlighting real differences between similar products, and always standing behind the chemistry we bring to the field. That’s how our team continues to shape the story of 1,1,3,3-tetrachloroacetone—for today’s users and the innovators still in the pipeline.
